Dario Ghersi, MD, PhD

  • 729 Citations
  • 14 h-Index
20042020

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Article
2020

Epstein-barr virus epitope-major histocompatibility complex interaction combined with convergent recombination drives selection of diverse T cell receptor α and β repertoires

Gil, A., Kamga, L., Chirravuri-Venkata, R., Aslan, N., Clark, F., Ghersi, D., Luzuriaga, K. & Selin, L. K., Mar 1 2020, In : mBio. 11, 2, e00250-20.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Presence and structure-activity relationship of intrinsically disordered regions across mucins

Carmicheal, J., Atri, P., Sharma, S., Kumar, S., Chirravuri Venkata, R., Kulkarni, P., Salgia, R., Ghersi, D., Kaur, S. & Batra, S. K., Feb 1 2020, In : FASEB Journal. 34, 2, p. 1939-1957 19 p.

Research output: Contribution to journalArticle

Open Access
2019

CDR3α drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection

Kamga, L., Gil, A., Song, I., Brody, R., Ghersi, D., Aslan, N., Stern, L. J., Selin, L. K. & Luzuriaga, K., 2019, In : PLoS pathogens. 15, 11, e1008122.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Computer modeling of clonal dominance: Memory-anti-naïve and its curbing by attrition

Castiglione, F., Ghersi, D. & Celada, F., 2019, In : Frontiers in immunology. 10, JUL, 1513.

Research output: Contribution to journalArticle

Open Access
Open Access
4 Scopus citations
Open Access
2018

Two critical positions in zinc finger domains are heavily mutated in three human cancer types

Munro, D., Ghersi, D. & Singh, M., Jun 2018, In : PLoS computational biology. 14, 6, e1006290.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope

Song, I. Y., Gil, A., Mishra, R., Ghersi, D., Selin, L. K. & Stern, L. J., Apr 1 2017, In : Nature Structural and Molecular Biology. 24, 4, p. 395-406 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
5 Scopus citations

Severity of acute infectious mononucleosis correlates with cross-reactive influenza CD8 T-cell receptor repertoires

Aslan, N., Watkin, L. B., Gil, A., Mishra, R., Clark, F. G., Welsh, R. M., Ghersi, D., Luzuriaga, K. & Selina, L. K., Nov 1 2017, In : mBio. 8, 6, e01841-17.

Research output: Contribution to journalArticle

13 Scopus citations

Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion

Watkin, L. B., Mishra, R., Gil, A., Aslan, N., Ghersi, D., Luzuriaga, K. & Selin, L. K., Oct 2017, In : Journal of Allergy and Clinical Immunology. 140, 4, p. 1206-1210 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016
2 Scopus citations

Identifying enriched drug fragments as possible candidates for metabolic engineering

Sharma, S., Karri, K., Thapa, I., Bastola, D. & Ghersi, D., Oct 8 2016, In : BMC Medical Genomics. 9, 46.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Genome-Wide Detection and Analysis of Multifunctional Genes

Pritykin, Y., Ghersi, D. & Singh, M., 2015, In : PLoS computational biology. 11, 10, e1004467.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Interaction-based discovery of functionally important genes in cancers

Ghersi, D. & Singh, M., Feb 2014, In : Nucleic acids research. 42, 3, p. e18

Research output: Contribution to journalArticle

16 Scopus citations

MolBLOCKS: Decomposing small molecule sets and uncovering enriched fragments

Ghersi, D. & Singh, M., Jul 15 2014, In : Bioinformatics. 30, 14, p. 2081-2083 3 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Disentangling function from topology to infer the network properties of disease genes

Ghersi, D. & Singh, M., Jan 16 2013, In : BMC systems biology. 7, 5.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Automated identification of binding sites for phosphorylated ligands in protein structures

Ghersi, D. & Sanchez, R., Oct 2012, In : Proteins: Structure, Function and Bioinformatics. 80, 10, p. 2347-2358 12 p.

Research output: Contribution to journalArticle

2011
32 Scopus citations

Computer simulations of heterologous immunity: Highlights of an interdisciplinary cooperation

Calcagno, C., Puzone, R., Pearson, Y. E., Cheng, Y., Ghersi, D., Selin, L. K., Welsh, R. M. & Celada, F., Jun 2011, In : Autoimmunity. 44, 4, p. 304-314 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Systematic assessment of accuracy of comparative model of proteins belonging to different structural fold classes

Chakravarty, S., Ghersi, D. & Sanchez, R., Nov 2011, In : Journal of Molecular Modeling. 17, 11, p. 2831-2837 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2010

Biochemical profiling of histone binding selectivity of the yeast bromodomain family

Zhang, Q., Chakravarty, S., Ghersi, D., Zeng, L., Plotnikov, A. N., Sanchez, R. & Zhou, M. M., Jan 26 2010, In : PloS one. 5, 1, e8903.

Research output: Contribution to journalArticle

25 Scopus citations
2009

A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses

Cheng, Y., Ghersi, D., Calcagno, C., Selin, L. K., Puzone, R. & Celada, F., Feb 5 2009, In : Vaccine. 27, 6, p. 833-845 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

EasyMIFs and SiteHound: A toolkit for the identification of ligand-binding sites in protein structures

Ghersi, D. & Sanchez, R., Sep 29 2009, In : Bioinformatics. 25, 23, p. 3185-3186 2 p., btp562.

Research output: Contribution to journalArticle

47 Scopus citations
52 Scopus citations

SITEHOUND-web: A server for ligand binding site identification in protein structures

Hernandez, M., Ghersi, D. & Sanchez, R., 2009, In : Nucleic acids research. 37, SUPPL. 2, p. W413-W416

Research output: Contribution to journalArticle

121 Scopus citations
2006

IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections

Bahl, K., Kim, S. K., Calcagno, C., Ghersi, D., Puzone, R., Celada, F., Selin, L. K. & Welsh, R. M., Apr 1 2006, In : Journal of Immunology. 176, 7, p. 4284-4295 12 p.

Research output: Contribution to journalArticle

Open Access
85 Scopus citations

Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity

Cornberg, M., Chen, A. T., Wilkinson, L. A., Brehm, M. A., Kim, S. K., Calcagno, C., Ghersi, D., Puzone, R., Celada, F., Welsh, R. M. & Selin, L. K., May 1 2006, In : Journal of Clinical Investigation. 116, 5, p. 1443-1456 14 p.

Research output: Contribution to journalArticle

102 Scopus citations
2004

CD8 memory T cells: Cross-reactivity and heterologous immunity

Selin, L. K., Cornberg, M., Brehm, M. A., Kim, S. K., Calcagno, C., Ghersi, D., Puzone, R., Celada, F. & Welsh, R. M., Oct 2004, In : Seminars in Immunology. 16, 5, p. 335-347 13 p.

Research output: Contribution to journalArticle

84 Scopus citations