• 6163 Citations
  • 41 h-Index
19962020

Research output per year

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Research Output

2020

Combined Hydrophobization of Polyethylenimine with Cholesterol and Perfluorobutyrate Improves siRNA Delivery

Wu, P., Luo, X., Wu, H., Zhang, Q., Wang, K., Sun, M. & Oupicky, D., Mar 18 2020, In : Bioconjugate Chemistry. 31, 3, p. 698-707 10 p.

Research output: Contribution to journalArticle

Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy

Wang, Y., Xie, Y., Kilchrist, K. V., Li, J., Duvall, C. L. & Oupický, D., Jan 29 2020, In : ACS Applied Materials and Interfaces. 12, 4, p. 4308-4322 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury

Jang, H. S., Noh, M. R., Jung, E. M., Kim, W. Y., Southekal, S., Guda, C., Foster, K. W., Oupicky, D., Ferrer, F. A. & Padanilam, B. J., Feb 2020, In : Kidney International. 97, 2, p. 327-339 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy

Xie, Y., Hang, Y., Wang, Y., Sleightholm, R., Prajapati, D. R., Bader, J., Yu, A., Tang, W., Jaramillo, L., Li, J., Singh, R. K. & Oupický, D., Jan 28 2020, In : ACS Nano. 14, 1, p. 255-271 17 p.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti–PD-L1 immunotherapy

Li, Z., Wang, Y., Shen, Y., Qian, C., Oupicky, D. & Sun, M., May 2020, In : Science Advances. 6, 20, eaaz9240.

Research output: Contribution to journalArticle

Open Access

Use of polymeric CXCR4 inhibitors as siRNA delivery vehicles for the treatment of acute myeloid leukemia

Wang, Y., Xie, Y., Williams, J., Hang, Y., Richter, L., Becker, M., Amador, C., Oupický, D. & Hyde, R. K., Feb 1 2020, In : Cancer Gene Therapy. 27, 1-2, p. 45-55 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Correction to: Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy (ACS Nano (2017) 11:2 (2227-2238) DOI: 10.1021/acsnano.6b08731)

Wang, Y., Xie, Y., Li, J., Peng, Z. H., Sheinin, Y., Zhou, J. & Oupický, D., Apr 23 2019, In : ACS Nano. 13, 4, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

CXCR4-targeted liposomal mediated co-delivery of pirfenidone and AMD3100 for the treatment of TGFΒ-induced HSC-T6 cells activation

Ullah, A., Wang, K., Wu, P., Oupicky, D. & Sun, M., 2019, In : International journal of nanomedicine. 14, p. 2927-2944 18 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Determinants of preferential renal accumulation of synthetic polymers in acute kidney injury

Chen, Y., Tang, W., Yu, F., Xie, Y., Jaramillo, L., Jang, H. S., Li, J., Padanilam, B. J. & Oupický, D., Sep 10 2019, In : International journal of pharmaceutics. 568, 118555.

Research output: Contribution to journalArticle

Highly Aggressive and Radiation-Resistant, "atypical" and Silent Pituitary Corticotrophic Carcinoma: A Case Report and Review of the Literature

Flores, L., Sleightholm, R., Neilsen, B., Baine, M., Drincic, A., Thorell, W., Shonka, N., Oupicky, D. & Zhang, C., Jan 1 2019, In : Case Reports in Oncology. 12, 1, p. 139-146 8 p.

Research output: Contribution to journalReview article

Open Access

Increased Survival by Pulmonary Treatment of Established Lung Metastases with Dual STAT3/CXCR4 Inhibition by siRNA Nanoemulsions

Li, Z., Chen, G., Ding, L., Wang, Y., Zhu, C., Wang, K., Li, J., Sun, M. & Oupicky, D., Dec 4 2019, In : Molecular Therapy. 27, 12, p. 2100-2110 11 p.

Research output: Contribution to journalArticle

In situ AFM analysis investigating disassembly of DNA nanoparticles and nanofilms

Zou, Y., Wan, L., Blacklock, J., Xie, L., Carroll, S., Oupicky, D. & Mao, G., 2019, Methods in Molecular Biology. Humana Press Inc., p. 199-209 11 p. (Methods in Molecular Biology; vol. 1943).

Research output: Chapter in Book/Report/Conference proceedingChapter

Promise of chemokine network-targeted nanoparticles in combination nucleic acid therapies of metastatic cancer

Xie, Y., Wang, Y., Li, J., Hang, Y. & Oupický, D., Mar 1 2019, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 11, 2, e1528.

Research output: Contribution to journalReview article

5 Scopus citations
Open Access
3 Scopus citations

Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration

Yu, F., Wang, Y., Hang, Y., Tang, W., Zhao, Z. & Oupický, D., Nov 15 2019, In : Journal of Polymer Science, Part A: Polymer Chemistry. 57, 22, p. 2235-2242 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis of bioreducible polycations with controlled topologies

You, Y. Z., Yan, J. J., Yu, F., Yu, Z. Q. & Oupicky, D., 2019, Methods in Molecular Biology. Humana Press Inc., p. 27-38 12 p. (Methods in Molecular Biology; vol. 1943).

Research output: Chapter in Book/Report/Conference proceedingChapter

Treatment of acute lung injury and early- and late-stage pulmonary fibrosis with combination emulsion siRNA polyplexes

Wang, Y., Ding, L., Li, Z., Chen, G., Sun, M. & Oupicky, D., Nov 28 2019, In : Journal of Controlled Release. 314, p. 12-24 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids

Sun, M., Wang, K. & Oupický, D., Feb 21 2018, In : Advanced Healthcare Materials. 7, 4, 1701070.

Research output: Contribution to journalArticle

17 Scopus citations

A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy

Li, H., Zhou, Z., Zhang, F., Guo, Y., Yang, X., Jiang, H., Tan, F., Oupicky, D. & Sun, M., Sep 1 2018, In : Nano Research. 11, 9, p. 4627-4642 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

ATP-activated decrosslinking and charge-reversal vectors for siRNA delivery and cancer therapy

Zhou, Z., Zhang, Q., Zhang, M., Li, H., Chen, G., Qian, C., Oupicky, D. & Sun, M., 2018, In : Theranostics. 8, 17, p. 4604-4619 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Bioreduction-ruptured nanogel for switch on/off release of Bcl2 siRNA in breast tumor therapy

Li, H., Yang, X., Gao, F., Qian, C., Li, C., Oupicky, D. & Sun, M., Dec 28 2018, In : Journal of Controlled Release. 292, p. 78-90 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Charge and Assembly Reversible Micelles Fueled by Intracellular ATP for Improved siRNA Transfection

Zhou, Z., Li, C., Zhang, M., Zhang, Q., Qian, C., Oupicky, D. & Sun, M., Sep 26 2018, In : ACS Applied Materials and Interfaces. 10, 38, p. 32026-32037 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness

Xie, Y., Wang, Y., Li, J., Hang, Y., Jaramillo, L., Wehrkamp, C. J., Phillippi, M. A., Mohr, A. M., Chen, Y., Talmon, G. A., Mott, J. L. & Oupicky, D., 2018, In : Theranostics. 8, 16, p. 4305-4320 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cholesterol Modification Enhances Antimetastatic Activity and siRNA Delivery Efficacy of Poly(ethylenimine)-Based CXCR4 Antagonists

Wu, P., Luo, X., Wu, H., Yu, F., Wang, K., Sun, M. & Oupicky, D., Nov 2018, In : Macromolecular Bioscience. 18, 11, 1800234.

Research output: Contribution to journalArticle

3 Scopus citations

Conjugate Polyplexes with Anti-Invasive Properties and Improved siRNA Delivery in Vivo

Chen, Y., Li, J. & Oupický, D., Feb 21 2018, In : Bioconjugate Chemistry. 29, 2, p. 296-305 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Coordination-driven assembly of catechol-modified chitosan for the kidney-specific delivery of salvianolic acid B to treat renal fibrosis

Li, J., Zhang, C., He, W., Qiao, H., Chen, J., Wang, K., Oupický, D. & Sun, M., Jan 2018, In : Biomaterials Science. 6, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cyclam-Modified PEI for Combined VEGF siRNA Silencing and CXCR4 Inhibition to Treat Metastatic Breast Cancer

Zhou, Y., Yu, F., Zhang, F., Chen, G., Wang, K., Sun, M., Li, J. & Oupický, D., Feb 12 2018, In : Biomacromolecules. 19, 2, p. 392-401 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Development of fluorinated polyplex nanoemulsions for improved small interfering RNA delivery and cancer therapy

Chen, G., Wang, K., Wu, P., Wang, Y., Zhou, Z., Yin, L., Sun, M. & Oupický, D., Jul 1 2018, In : Nano Research. 11, 7, p. 3746-3761 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Fluorination Enhances Serum Stability of Bioreducible Poly(amido amine) Polyplexes and Enables Efficient Intravenous siRNA Delivery

Chen, G., Wang, K., Wang, Y., Wu, P., Sun, M. & Oupický, D., Mar 7 2018, In : Advanced Healthcare Materials. 7, 5, 1700978.

Research output: Contribution to journalArticle

14 Scopus citations

Histone Deacetylase Inhibitor (HDACi) Conjugated Polycaprolactone for Combination Cancer Therapy

Kularatne, R. N., Washington, K. E., Bulumulla, C., Calubaquib, E. L., Biewer, M. C., Oupicky, D. & Stefan, M. C., 2018, In : Biomacromolecules. 19, 3, p. 1082-1089 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Near-infrared light-activated IR780-loaded liposomes for anti-tumor angiogenesis and Photothermal therapy

Yang, X., Li, H., Qian, C., Guo, Y., Li, C., Gao, F., Yang, Y., Wang, K., Oupicky, D. & Sun, M., Oct 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 7, p. 2283-2294 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease

Kanvinde, S., Chhonker, Y. S., Ahmad, R., Yu, F., Sleightholm, R., Tang, W., Jaramillo, L., Chen, Y., Sheinin, Y., Li, J., Murry, D. J., Singh, A. B. & Oupicky, D., Dec 2018, In : Acta Biomaterialia. 82, p. 158-170 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Polymeric micelleplexes for improved photothermal endosomal escape and delivery of siRNA

Chen, G., Ding, L., Wu, P., Zhou, Y., Sun, M., Wang, K. & Oupický, D., Oct 2018, In : Polymers for Advanced Technologies. 29, 10, p. 2593-2600 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Polymeric Prodrugs Targeting Polyamine Metabolism Inhibit Zika Virus Replication

Routhu, N. K., Xie, Y., Dunworth, M., Casero, R. A., Oupicky, D. & Byrareddy, S. N., Sep 4 2018, In : Molecular Pharmaceutics. 15, 9, p. 4284-4295 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pulmonary delivery of polyplexes for combined PAI-1 gene silencing and CXCR4 inhibition to treat lung fibrosis

Ding, L., Zhu, C., Yu, F., Wu, P., Chen, G., Ullah, A., Wang, K., Sun, M., Li, J. & Oupický, D., Aug 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 6, p. 1765-1776 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Reversible Covalent Cross-Linked Polycations with Enhanced Stability and ATP-Responsive Behavior for Improved siRNA Delivery

Zhou, Z., Zhang, M., Liu, Y., Li, C., Zhang, Q., Oupicky, D. & Sun, M., Sep 10 2018, In : Biomacromolecules. 19, 9, p. 3776-3787 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Reversibly Stabilized Polycation Nanoparticles for Combination Treatment of Early- and Late-Stage Metastatic Breast Cancer

Chen, G., Wang, Y., Wu, P., Zhou, Y., Yu, F., Zhu, C., Li, Z., Hang, Y., Wang, K., Li, J., Sun, M. & Oupicky, D., Jul 24 2018, In : ACS Nano. 12, 7, p. 6620-6636 17 p.

Research output: Contribution to journalArticle

13 Scopus citations
8 Scopus citations

Synthesis and Evaluation of Chloroquine-Containing DMAEMA Copolymers as Efficient Anti-miRNA Delivery Vectors with Improved Endosomal Escape and Antimigratory Activity in Cancer Cells

Xie, Y., Yu, F., Tang, W., Alade, B. O., Peng, Z. H., Wang, Y., Li, J. & Oupický, D., Jan 2018, In : Macromolecular Bioscience. 18, 1, 1700194.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Arginine-Modified Nanostructured Lipid Carriers with Charge-Reversal and pH-Sensitive Membranolytic Properties for Anticancer Drug Delivery

Sun, M., Li, J., Zhang, C., Xie, Y., Qiao, H., Su, Z., Oupický, D. & Ping, Q., Apr 19 2017, In : Advanced Healthcare Materials. 6, 8, 1600693.

Research output: Contribution to journalArticle

11 Scopus citations

Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano 11047

Murray-Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., Apr 2017, In : PloS one. 12, 4, e0175917.

Research output: Contribution to journalArticle

8 Scopus citations

Bioreducible Cross-Linked Hyaluronic Acid/Calcium Phosphate Hybrid Nanoparticles for Specific Delivery of siRNA in Melanoma Tumor Therapy

Zhou, Z., Li, H., Wang, K., Guo, Q., Li, C., Jiang, H., Hu, Y., Oupicky, D. & Sun, M., May 3 2017, In : ACS Applied Materials and Interfaces. 9, 17, p. 14576-14589 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

Chloroquine-Modified Hydroxyethyl Starch as a Polymeric Drug for Cancer Therapy

Sleightholm, R., Yang, B., Yu, F., Xie, Y. & Oupický, D., Aug 14 2017, In : Biomacromolecules. 18, 8, p. 2247-2257 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Combining Fluorination and Bioreducibility for Improved siRNA Polyplex Delivery

Chen, G., Wang, K., Hu, Q., Ding, L., Yu, F., Zhou, Z., Zhou, Y., Li, J., Sun, M. & Oupický, D., Feb 8 2017, In : ACS Applied Materials and Interfaces. 9, 5, p. 4457-4466 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Correction: Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047 (PLoS ONE (2017) 12:4 (e0175917) DOI: 10.1371/journal.pone.0175917)

Murray-Stewart, T., Ferrari, E., Xie, Y., Yu, F., Marton, L. J., Oupicky, D. & Casero, R. A., May 2017, In : PloS one. 12, 5, e0178102.

Research output: Contribution to journalComment/debate

CXCR4-Targeted and Redox Responsive Dextrin Nanogel for Metastatic Breast Cancer Therapy

Zhang, F., Gong, S., Wu, J., Li, H., Oupicky, D. & Sun, M., Jun 12 2017, In : Biomacromolecules. 18, 6, p. 1793-1802 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dual-function nanostructured lipid carriers to deliver IR780 for breast cancer treatment: Anti-metastatic and photothermal anti-tumor therapy

Li, H., Wang, K., Yang, X., Zhou, Y., Ping, Q., Oupicky, D. & Sun, M., Apr 15 2017, In : Acta Biomaterialia. 53, p. 399-413 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Dual-Function Polymeric HPMA Prodrugs for the Delivery of miRNA

Peng, Z. H., Xie, Y., Wang, Y., Li, J. & Oupický, D., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1395-1404 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy

Sleightholm, R. L., Neilsen, B. K., Li, J., Steele, M. M., Singh, R. K., Hollingsworth, M. A. & Oupicky, D., Nov 2017, In : Pharmacology and Therapeutics. 179, p. 158-170 13 p.

Research output: Contribution to journalReview article

37 Scopus citations

HDAC inhibitor conjugated polymeric prodrug micelles for doxorubicin delivery

Senevirathne, S. A., Washington, K. E., Miller, J. B., Biewer, M. C., Oupicky, D., Siegwart, D. J. & Stefan, M. C., 2017, In : Journal of Materials Chemistry B. 5, 11, p. 2106-2114 9 p.

Research output: Contribution to journalArticle

9 Scopus citations