Dominic E Cosgrove, PhD

  • 4430 Citations
  • 33 h-Index
1987 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

1987

Dual effects of 2-deoxyglucose on synthesis of the glycoprotein hormone common α-subunit in butyrate-treated HeLa cells

Cox, G. S., McClure, D. S. & Cosgrove, D. E., 1987, In : Molecular and cellular biology. 7, 5, p. 1592-1601 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
1989
40 Scopus citations
1990
28 Scopus citations
11 Scopus citations

Induction by cycloheximide of the glycoprotein hormone α-subunit gene in human tumor cell lines and identification of a possible negative regulatory factor

Cox, G. S., Cosgrove, D. E., Sullivan, T. T. & Haas, M. J., 1990, In : Journal of Biological Chemistry. 265, 22, p. 13190-13197 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
1991

Mice lacking MHC class II molecules

Cosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C. & Mathis, D., Sep 6 1991, In : Cell. 66, 5, p. 1051-1066 16 p.

Research output: Contribution to journalArticle

781 Scopus citations
1992

Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes

Cosgrove, D., Bodmer, H., Bogue, M., Benoist, C. & Mathis, D., Aug 1 1992, In : Journal of Experimental Medicine. 176, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

The thymic compartment responsible for positive selection of CD4+ T cells

Cosgrove, D., Chan, S. H., Waltzinger, C., Benoist, C. & Mathis, D., Jun 1992, In : International Immunology. 4, 6, p. 707-710 4 p.

Research output: Contribution to journalArticle

73 Scopus citations
1993

Another view of the selective model of thymocyte selection

Chan, S. H., Cosgrove, D., Waltzinger, C., Benoist, C. & Mathis, D., Apr 23 1993, In : Cell. 73, 2, p. 225-236 12 p.

Research output: Contribution to journalArticle

262 Scopus citations

Knock-out mice: A new tool for transplantation immunologists

Hergueux, J., Bodmer, H., Cardell, S., Chan, S. H., Cosgrove, D., Benoist, C. & Mathis, D., 1993, In : Transplantation Proceedings. 25, 1, p. 30-32 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Patent activity table: Transgenic animals

Grunkemeyer, J. A. & Cosgrove, D. E., Jul 1 1993, In : Expert Opinion on Therapeutic Patents. 3, 7, p. 1073-1077 5 p.

Research output: Contribution to journalArticle

The Immune System of Mice Lacking Conventional MHC Class II Molecules

Cardell, S., Merkenschlager, M., Bodmer, H., Chan, S., Cosgrove, D., Benoist, C. & Mathis, D., Jan 1 1993, In : Advances in Immunology. 55, C, p. 423-440 18 p.

Research output: Contribution to journalArticle

36 Scopus citations

Transgenic animals

Grunkemeyer, J. A. & Cosgrove, D. E., 1993, In : Current Opinion in Therapeutic Patents. 3, 7, p. 1073-1075 3 p.

Research output: Contribution to journalComment/debate

1994

Patent update biologicals and immunologicals: Transgenic animal models and gene therapy

Cosgrove, D. E., Chakraborty, A. K. & Hodgson, C. P., Mar 1 1994, In : Expert Opinion on Therapeutic Patents. 4, 3, p. 237-245 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
1996

Collagen COL4A3 knockout: A mouse model for autosomal Alport syndrome

Cosgrove, D., Meehan, D. T., Grunkemeyer, J. A., Kornak, J. M., Sayers, R., Hunter, W. J. & Samuelson, G. C., 1996, In : Genes and Development. 10, 23, p. 2981-2992 12 p.

Research output: Contribution to journalArticle

Open Access
260 Scopus citations

Expression of basement membrane type IV collagen chains during postnatal development in the murine cochlea

Cosgrove, D., Kornak, J. M. & Samuelson, G., Oct 1996, In : Hearing Research. 100, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: A novel model for human polyarthritis

Nabozny, G. H., Baisch, J. M., Cheng, S., Cosgrove, D., Griffiths, M. M., Luthra, H. S. & David, C. S., Jan 1 1996, In : Journal of Experimental Medicine. 183, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

178 Scopus citations

Immunohistochemical localization of basement membrane collagens and associated proteins in the murine cochlea

Cosgrove, D., Samuelson, G. & Pinnt, J., Aug 1996, In : Hearing Research. 97, 1-2, p. 54-65 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
1997

Expression of the major basement membrane-associated proteins during postnatal development in the murine cochlea

Cosgrove, D. & Rodgers, K. D., Mar 1997, In : Hearing Research. 105, 1-2, p. 159-170 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

MspI restriction fragment length polymorphism at the glycoprotein hormone α-subunit locus. Association of certain genotypes with neoplasia

Cox, G. S., Cosgrove, D. E., Haas, M. J., Stiles, W. & McIntosh, D. G., Oct 1997, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1354, 1, p. 83-96 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
1998

Isolation of an Alu repetitive DNA binding protein and effect of CpG methylation on binding to its recognition sequence

Cox, G. S., Gutkin, D. W., Haas, M. J. & Cosgrove, D. E., Mar 4 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1396, 1, p. 67-87 21 p.

Research output: Contribution to journalArticle

26 Scopus citations

Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome

Cosgrove, D., Samuelson, G., Meehan, D. T., Miller, C., McGee, J., Walsh, E. J. & Siegel, M., Jul 1998, In : Hearing Research. 121, 1-2, p. 84-98 15 p.

Research output: Contribution to journalArticle

69 Scopus citations
1999

Role for transforming growth factor-β1 in Alport renal disease progression

Sayers, R., Kalluri, R., Rodgers, K. D., Shield, C. F., Meehan, D. T. & Cosgrove, D., 1999, In : Kidney International. 56, 5, p. 1662-1673 12 p.

Research output: Contribution to journalArticle

67 Scopus citations
4 Scopus citations
2000

Assembly of Type IV collagen. Insights from α3(IV) collagen-deficient mice

Kalluri, R. & Cosgrove, D., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 12719-12724 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Integrin α1β1 and transforming growth factor-β1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy

Cosgrove, D., Rodgers, K., Meehan, D., Miller, C., Bovard, K., Gilroy, A., Gardner, H., Kotelianski, V., Gotwals, P., Amatucci, A. & Kalluri, R., 2000, In : American Journal of Pathology. 157, 5, p. 1649-1659 11 p.

Research output: Contribution to journalArticle

151 Scopus citations

Modular retro-vectors for transgenic and therapeutic use

Solaiman, F., Zink, M. A., Xu, G., Grunkemeyer, J., Cosgrove, D., Saenz, J. & Hodgson, C. P., 2000, In : Molecular Reproduction and Development. 56, 2 SUPPL., p. 309-315 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2001

Global Gene Expression Analysis Reveals a Role for the α1 Integrin in Renal Pathogenesis

Sampson, N. S., Ryan, S. T., Enke, D. A., Cosgrove, D., Koteliansky, V. & Gotwals, P., Sep 7 2001, In : Journal of Biological Chemistry. 276, 36, p. 34182-34188 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

The laminins in the murine inner ear: Developmental transitions and expression in cochlear basement membranes

Rodgers, K. D., Barritt, L., Miner, J. H. & Cosgrove, D., 2001, In : Hearing Research. 158, 1-2, p. 39-50 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
2002

Determinants of vascular permeability in the kidney glomerulus

Hamano, Y., Grunkemeyer, J. A., Sudhakar, A., Zeisberg, M., Cosgrove, D., Morello, R., Lee, B., Sugimoto, H. & Kalluri, R., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 31154-31162 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

Localization and expression of usherin: A novel basement membrane protein defective in people with Usher's syndrome type IIa

Bhattacharya, G., Miller, C., Kimberling, W. J., Jablonski, M. M. & Cosgrove, D., 2002, In : Hearing Research. 163, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Strial marginal cells play a role in basement membrane homeostasis: In vitro and in vivo evidence

Gratton, M. A., Meehan, D. T., Smyth, B. J. & Cosgrove, D., 2002, In : Hearing Research. 163, 1-2, p. 27-36 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Usherin expression is highly conserved in mouse and human tissues

Pearsall, N., Bhattacharya, G., Wisecarver, J., Adams, J., Cosgrove, D. & Kimberling, W., Dec 2002, In : Hearing Research. 174, 1-2, p. 55-63 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2003

Clinical and immunohistochemical evidence for an X linked retinitis pigmentosa syndrome with recurrent infections and hearing loss in association with an RPGR mutation.

Iannaccone, A., Breuer, D. K., Wang, X. F., Kuo, S. F., Normando, E. M., Filippova, E., Baldi, A., Hiriyanna, S., MacDonald, C. B., Baldi, F., Cosgrove, D., Morton, C. C., Swaroop, A. & Jablonski, M. M., Nov 2003, In : Journal of medical genetics. 40, 11, p. e118

Research output: Contribution to journalComment/debate

Open Access
83 Scopus citations

Increased expression of MMP-2, MMP-9 (type IV collagenases/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS)

Rao, V. H., Lees, G. E., Kashtan, C. E., Nemori, R., Singh, R. K., Meehan, D. T., Rodgers, K., Berridge, B. R., Bhattacharya, G. & Cosgrove, D. E., May 1 2003, In : Kidney International. 63, 5, p. 1736-1748 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis

Rodgers, K. D., Rao, V., Meehan, D. T., Fager, N., Gotwals, P., Ryan, S. T., Koteliansky, V., Nemori, R. & Cosgrove, D., Apr 1 2003, In : Kidney International. 63, 4, p. 1338-1355 18 p.

Research output: Contribution to journalArticle

38 Scopus citations

Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria

Sugimoto, H., Hamanog, Y., Charytan, D., Cosgrove, D., Kieran, M., Sudhakar, A. & Kalluri, R., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 12605-12608 4 p.

Research output: Contribution to journalArticle

433 Scopus citations
2004

A domain-specific usherin/collagen IV interaction may be required for stable integration into the basement membrane superstructure

Bhattacharya, G., Kalluri, R., Orten, D. J., Kimberling, W. J. & Cosgrove, D., Jan 15 2004, In : Journal of cell science. 117, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Immunohistochemistry and reverse transcriptase-polymerase chain reaction as methods for diagnostic determination of Usher syndrome type IIa

Cohn, E., Bhattacharya, G., Pearsall, N., Shendrik, I., Kimberling, W. & Cosgrove, D., Jul 2004, In : Laryngoscope. 114, 7, p. 1310-1314 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Increasing evidence for syndromic phenotypes associated with RPGR mutations [3] (multiple letters)

Iannaccone, A., Wang, X., Jablonski, M. M., Kuo, S. F., Baldi, A., Cosgrove, D., Morton, C. C., Swaroop, A. & Koenekoop, R. K., Apr 2004, In : American journal of ophthalmology. 137, 4, p. 785-786 2 p.

Research output: Contribution to journalLetter

22 Scopus citations

Lack of integrin α1β1 leads to severe glomerulosclerosis after glomerular injury

Chen, X., Moeckel, G., Morrow, J. D., Cosgrove, D., Harris, R. C., Fogo, A. B., Zent, R. & Pozzi, A., Aug 2004, In : American Journal of Pathology. 165, 2, p. 617-630 14 p.

Research output: Contribution to journalArticle

75 Scopus citations
2005

Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome

Rao, V. H., Lees, G. E., Kashtan, C. E., Delimont, D. C., Singh, R., Meehan, D. T., Bhattacharya, G., Berridge, B. R. & Cosgrove, D., Jun 2005, In : Pediatric Nephrology. 20, 6, p. 732-739 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Evidence for functional importance of usherin/fibronectin interactions in retinal basement membranes

Bhattacharya, G. & Cosgrove, D., Aug 30 2005, In : Biochemistry. 44, 34, p. 11518-11524 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Extracellular matrix and inner ear development and function

Cosgrove, D. & Anne Gratton, M., 2005, In : Advances in Developmental Biology. 15, p. 169-201 33 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin

Sudhakar, A., Nyberg, P., Keshamouni, V. G., Mannam, A. P., Li, J., Sugimoto, H., Cosgrove, D. & Kalluri, R., Oct 2005, In : Journal of Clinical Investigation. 115, 10, p. 2801-2810 10 p.

Research output: Contribution to journalArticle

130 Scopus citations

Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: Implications for capillary basement membrane pathology

Gratton, M. A., Rao, V. H., Meehan, D. T., Askew, C. & Cosgrove, D., May 2005, In : American Journal of Pathology. 166, 5, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2006

Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease

Sugimoto, H., Mundel, T. M., Sund, M., Xie, L., Cosgrove, D. & Kalluri, R., May 9 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 19, p. 7321-7326 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

Role for macrophage metalloelastase in glomerular basement membrane damage associated with Alport syndrome

Rao, V. H., Meehan, D. T., Delimont, D., Nakajima, M., Wada, T., Gratton, M. A. & Cosgrove, D., Jul 2006, In : American Journal of Pathology. 169, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease

Zeisberg, M., Khurana, M., Rao, V. H., Cosgrove, D., Rougier, J. P., Werner, M. C., Shield, C. F., Werb, Z. & Kalluri, R., Apr 2006, In : PLoS Medicine. 3, 4, p. 535-546 12 p.

Research output: Contribution to journalArticle

110 Scopus citations
2007
2 Scopus citations