Dominic E Cosgrove, PhD

  • 4421 Citations
  • 33 h-Index
1987 …2020

Research output per year

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Research Output

2 Scopus citations

A domain-specific usherin/collagen IV interaction may be required for stable integration into the basement membrane superstructure

Bhattacharya, G., Kalluri, R., Orten, D. J., Kimberling, W. J. & Cosgrove, D., Jan 15 2004, In : Journal of cell science. 117, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Another view of the selective model of thymocyte selection

Chan, S. H., Cosgrove, D., Waltzinger, C., Benoist, C. & Mathis, D., Apr 23 1993, In : Cell. 73, 2, p. 225-236 12 p.

Research output: Contribution to journalArticle

261 Scopus citations

Assembly of Type IV collagen. Insights from α3(IV) collagen-deficient mice

Kalluri, R. & Cosgrove, D., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 12719-12724 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Biochemical characterization of native usher protein complexes from a vesicular subfraction of tracheal epithelial cells

Zallocchi, M., Sisson, J. H. & Cosgrove, D., Feb 16 2010, In : Biochemistry. 49, 6, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Biomechanical strain causes maladaptive gene regulation, contributing to alport glomerular disease

Meehan, D. T., Delimont, D., Cheung, L., Zallocchi, M., Sansom, S. C., Holzclaw, J. D., Rao, V. & Cosgrove, D., Nov 2009, In : Kidney International. 76, 9, p. 968-976 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease

Sugimoto, H., Mundel, T. M., Sund, M., Xie, L., Cosgrove, D. & Kalluri, R., May 9 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 19, p. 7321-7326 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis

Cosgrove, D., Kalluri, R., Miner, J. H., Segal, Y. & Borza, D. B., Apr 2007, In : Kidney International. 71, 7, p. 615-618 4 p.

Research output: Contribution to journalShort survey

37 Scopus citations
40 Scopus citations

Clarin-1 protein expression in photoreceptors

Cosgrove, D. & Zallocchi, M., Jan 2010, In : Hearing Research. 259, 1-2, p. 117 1 p.

Research output: Contribution to journalLetter

2 Scopus citations

Clinical and immunohistochemical evidence for an X linked retinitis pigmentosa syndrome with recurrent infections and hearing loss in association with an RPGR mutation.

Iannaccone, A., Breuer, D. K., Wang, X. F., Kuo, S. F., Normando, E. M., Filippova, E., Baldi, A., Hiriyanna, S., MacDonald, C. B., Baldi, F., Cosgrove, D., Morton, C. C., Swaroop, A. & Jablonski, M. M., Nov 2003, In : Journal of medical genetics. 40, 11, p. e118

Research output: Contribution to journalComment/debate

Open Access
82 Scopus citations

Collagen COL4A3 knockout: A mouse model for autosomal Alport syndrome

Cosgrove, D., Meehan, D. T., Grunkemeyer, J. A., Kornak, J. M., Sayers, R., Hunter, W. J. & Samuelson, G. C., 1996, In : Genes and Development. 10, 23, p. 2981-2992 12 p.

Research output: Contribution to journalArticle

Open Access
260 Scopus citations

Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome

Cosgrove, D. & Liu, S., Jan 1 2017, In : Matrix Biology. 57-58, p. 45-54 10 p.

Research output: Contribution to journalReview article

32 Scopus citations

Collagen XIII induced in vascular endothelium mediates α1β1 integrin-dependent transmigration of monocytes in renal fibrosis

Dennis, J., Meehan, D. T., Delimont, D., Zallocchi, M., Perry, G. A., O'Brien, S., Tu, H., Pihlajaniemi, T. & Cosgrove, D., Nov 2010, In : American Journal of Pathology. 177, 5, p. 2527-2540 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Determinants of vascular permeability in the kidney glomerulus

Hamano, Y., Grunkemeyer, J. A., Sudhakar, A., Zeisberg, M., Cosgrove, D., Morello, R., Lee, B., Sugimoto, H. & Kalluri, R., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 31154-31162 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

Dual effects of 2-deoxyglucose on synthesis of the glycoprotein hormone common α-subunit in butyrate-treated HeLa cells

Cox, G. S., McClure, D. S. & Cosgrove, D. E., 1987, In : Molecular and cellular biology. 7, 5, p. 1592-1601 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome

Rao, V. H., Lees, G. E., Kashtan, C. E., Delimont, D. C., Singh, R., Meehan, D. T., Bhattacharya, G., Berridge, B. R. & Cosgrove, D., Jun 2005, In : Pediatric Nephrology. 20, 6, p. 732-739 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
28 Scopus citations

EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: Development of UshStat

Zallocchi, M., Binley, K., Lad, Y., Ellis, S., Widdowson, P., Iqball, S., Scripps, V., Kelleher, M., Loader, J., Miskin, J., Peng, Y. W., Wang, W. M., Cheung, L., Delimont, D., Mitrophanous, K. A. & Cosgrove, D., Apr 4 2014, In : PloS one. 9, 4, e94272.

Research output: Contribution to journalArticle

59 Scopus citations

Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice

Meehan, D. T., Delimont, D., Dufek, B., Zallocchi, M., Phillips, G., Gratton, M. A. & Cosgrove, D., Nov 1 2016, In : Hearing Research. 341, p. 100-108 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease

Dufek, B., Meehan, D. T., Delimont, D., Cheung, L., Gratton, M. A., Phillips, G., Song, W., Liu, S. & Cosgrove, D., Aug 1 2016, In : Kidney International. 90, 2, p. 300-310 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
11 Scopus citations

Erratum: Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin (Journal of Clinical Investigation (2005) 115:10 (2801–2810) DOI: 10.1172/JCI24813)

Sudhakar, A., Nyberg, P., Keshamouni, V. G., Mannam, A. P., Li, J., Sugimoto, H., Cosgrove, D. & Kalluri, R., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 552 1 p.

Research output: Contribution to journalComment/debate

Open Access

Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes

Cosgrove, D., Bodmer, H., Bogue, M., Benoist, C. & Mathis, D., Aug 1 1992, In : Journal of Experimental Medicine. 176, 2, p. 629-634 6 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Evidence for functional importance of usherin/fibronectin interactions in retinal basement membranes

Bhattacharya, G. & Cosgrove, D., Aug 30 2005, In : Biochemistry. 44, 34, p. 11518-11524 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Expression of basement membrane type IV collagen chains during postnatal development in the murine cochlea

Cosgrove, D., Kornak, J. M. & Samuelson, G., Oct 1996, In : Hearing Research. 100, 1-2, p. 21-32 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Expression of the major basement membrane-associated proteins during postnatal development in the murine cochlea

Cosgrove, D. & Rodgers, K. D., Mar 1997, In : Hearing Research. 105, 1-2, p. 159-170 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Extracellular matrix and inner ear development and function

Cosgrove, D. & Anne Gratton, M., 2005, In : Advances in Developmental Biology. 15, p. 169-201 33 p.

Research output: Contribution to journalArticle

1 Scopus citations

FAK and p38-MAP kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by α1(IV)NC1

Boosani, C. S., Nalabothula, N., Munugalavadla, V., Cosgrove, D., Keshamoun, V. G., Sheibani, N. & Sudhakar, A., 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4567-4575 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Global Gene Expression Analysis Reveals a Role for the α1 Integrin in Renal Pathogenesis

Sampson, N. S., Ryan, S. T., Enke, D. A., Cosgrove, D., Koteliansky, V. & Gotwals, P., Sep 7 2001, In : Journal of Biological Chemistry. 276, 36, p. 34182-34188 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Glomerular pathology in Alport syndrome: A molecular perspective

Cosgrove, D., Jun 2012, In : Pediatric Nephrology. 27, 6, p. 885-890 6 p.

Research output: Contribution to journalReview article

24 Scopus citations

HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: A novel model for human polyarthritis

Nabozny, G. H., Baisch, J. M., Cheng, S., Cosgrove, D., Griffiths, M. M., Luthra, H. S. & David, C. S., Jan 1 1996, In : Journal of Experimental Medicine. 183, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

177 Scopus citations

Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin

Sudhakar, A., Nyberg, P., Keshamouni, V. G., Mannam, A. P., Li, J., Sugimoto, H., Cosgrove, D. & Kalluri, R., Oct 2005, In : Journal of Clinical Investigation. 115, 10, p. 2801-2810 10 p.

Research output: Contribution to journalArticle

130 Scopus citations

Immunohistochemical localization of basement membrane collagens and associated proteins in the murine cochlea

Cosgrove, D., Samuelson, G. & Pinnt, J., Aug 1996, In : Hearing Research. 97, 1-2, p. 54-65 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Immunohistochemistry and reverse transcriptase-polymerase chain reaction as methods for diagnostic determination of Usher syndrome type IIa

Cohn, E., Bhattacharya, G., Pearsall, N., Shendrik, I., Kimberling, W. & Cosgrove, D., Jul 2004, In : Laryngoscope. 114, 7, p. 1310-1314 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Increased expression of MMP-2, MMP-9 (type IV collagenases/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS)

Rao, V. H., Lees, G. E., Kashtan, C. E., Nemori, R., Singh, R. K., Meehan, D. T., Rodgers, K., Berridge, B. R., Bhattacharya, G. & Cosgrove, D. E., May 1 2003, In : Kidney International. 63, 5, p. 1736-1748 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Increasing evidence for syndromic phenotypes associated with RPGR mutations [3] (multiple letters)

Iannaccone, A., Wang, X., Jablonski, M. M., Kuo, S. F., Baldi, A., Cosgrove, D., Morton, C. C., Swaroop, A. & Koenekoop, R. K., Apr 2004, In : American journal of ophthalmology. 137, 4, p. 785-786 2 p.

Research output: Contribution to journalLetter

22 Scopus citations

Induction by cycloheximide of the glycoprotein hormone α-subunit gene in human tumor cell lines and identification of a possible negative regulatory factor

Cox, G. S., Cosgrove, D. E., Sullivan, T. T. & Haas, M. J., 1990, In : Journal of Biological Chemistry. 265, 22, p. 13190-13197 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Integrin α1β1 and transforming growth factor-β1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy

Cosgrove, D., Rodgers, K., Meehan, D., Miller, C., Bovard, K., Gilroy, A., Gardner, H., Kotelianski, V., Gotwals, P., Amatucci, A. & Kalluri, R., 2000, In : American Journal of Pathology. 157, 5, p. 1649-1659 11 p.

Research output: Contribution to journalArticle

151 Scopus citations

Integrin α1β1 regulates matrix metalloproteinases via p38 mitogen-activated protein kinase in mesangial cells: Implications for alport syndrome

Cosgrove, D., Meehan, D. T., Delimont, D., Pozzi, A., Chen, X., Rodgers, K. D., Tempero, R. M., Zallocchi, M. & Rao, V. H., Mar 2008, In : American Journal of Pathology. 172, 3, p. 761-773 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Isolation of an Alu repetitive DNA binding protein and effect of CpG methylation on binding to its recognition sequence

Cox, G. S., Gutkin, D. W., Haas, M. J. & Cosgrove, D. E., Mar 4 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1396, 1, p. 67-87 21 p.

Research output: Contribution to journalArticle

26 Scopus citations

Knock-out mice: A new tool for transplantation immunologists

Hergueux, J., Bodmer, H., Cardell, S., Chan, S. H., Cosgrove, D., Benoist, C. & Mathis, D., 1993, In : Transplantation Proceedings. 25, 1, p. 30-32 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Lack of integrin α1β1 leads to severe glomerulosclerosis after glomerular injury

Chen, X., Moeckel, G., Morrow, J. D., Cosgrove, D., Harris, R. C., Fogo, A. B., Zent, R. & Pozzi, A., Aug 2004, In : American Journal of Pathology. 165, 2, p. 617-630 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis

Delimont, D., Dufek, B. M., Meehan, D. T., Zallocchi, M., Gratton, M. A., Phillips, G. & Cosgrove, D., Jun 10 2014, In : PloS one. 9, 6, e99083.

Research output: Contribution to journalArticle

26 Scopus citations

Light-Induced Translocation of RGS9-1 and Gβ5L in Mouse Rod Photoreceptors

Tian, M., Zallocchi, M., Wang, W., Chen, C. K., Palczewski, K., Delimont, D., Cosgrove, D. & Peng, Y. W., Mar 28 2013, In : PloS one. 8, 3, e58832.

Research output: Contribution to journalArticle

6 Scopus citations

Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors

Zallocchi, M., Meehan, D. T., Delimont, D., Askew, C., Garige, S., Gratton, M. A., Rothermund-Franklin, C. A. & Cosgrove, D., Sep 2009, In : Hearing Research. 255, 1-2, p. 109-120 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Localization and expression of usherin: A novel basement membrane protein defective in people with Usher's syndrome type IIa

Bhattacharya, G., Miller, C., Kimberling, W. J., Jablonski, M. M. & Cosgrove, D., 2002, In : Hearing Research. 163, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice

Cosgrove, D., Dufek, B., Meehan, D. T., Delimont, D., Hartnett, M., Samuelson, G., Gratton, M. A., Phillips, G., MacKenna, D. A. & Bain, G., Aug 2018, In : Kidney International. 94, 2, p. 303-314 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: Implications for capillary basement membrane pathology

Gratton, M. A., Rao, V. H., Meehan, D. T., Askew, C. & Cosgrove, D., May 2005, In : American Journal of Pathology. 166, 5, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Mice lacking MHC class II molecules

Cosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C. & Mathis, D., Sep 6 1991, In : Cell. 66, 5, p. 1051-1066 16 p.

Research output: Contribution to journalArticle

781 Scopus citations