Dominic E Cosgrove, PhD

  • 4421 Citations
  • 33 h-Index
1987 …2020

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Article
2020

Pericyte abnormalities precede strial capillary basement membrane thickening in Alport mice

Dufek, B., Meehan, D. T., Delimont, D., Samuelson, G., Madison, J., Shi, X., Boettcher, F., Trosky, V., Gratton, M. A. & Cosgrove, D., May 2020, In : Hearing Research. 390, 107935.

Research output: Contribution to journalArticle

RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis

Dufek, B., Meehan, D. T., Delimont, D., Wilhelm, K., Samuelson, G., Coenen, R., Madison, J., Doyle, E., Smyth, B., Phillips, G., Gratton, M. A. & Cosgrove, D., 2020, In : PloS one. 15, 8, p. e0237907

Research output: Contribution to journalArticle

Open Access
2018

Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice

Cosgrove, D., Dufek, B., Meehan, D. T., Delimont, D., Hartnett, M., Samuelson, G., Gratton, M. A., Phillips, G., MacKenna, D. A. & Bain, G., Aug 2018, In : Kidney International. 94, 2, p. 303-314 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice

Meehan, D. T., Delimont, D., Dufek, B., Zallocchi, M., Phillips, G., Gratton, M. A. & Cosgrove, D., Nov 1 2016, In : Hearing Research. 341, p. 100-108 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease

Dufek, B., Meehan, D. T., Delimont, D., Cheung, L., Gratton, M. A., Phillips, G., Song, W., Liu, S. & Cosgrove, D., Aug 1 2016, In : Kidney International. 90, 2, p. 300-310 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

X-linked alport dogs demonstrate mesangial filopodial invasion of the capillary tuft as an early event in glomerular damage

Clark, S. D., Nabity, M. B., Cianciolo, R. E., Dufek, B. & Cosgrove, D., Dec 2016, In : PloS one. 11, 12, e0168343.

Research output: Contribution to journalArticle

5 Scopus citations
2014

EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: Development of UshStat

Zallocchi, M., Binley, K., Lad, Y., Ellis, S., Widdowson, P., Iqball, S., Scripps, V., Kelleher, M., Loader, J., Miskin, J., Peng, Y. W., Wang, W. M., Cheung, L., Delimont, D., Mitrophanous, K. A. & Cosgrove, D., Apr 4 2014, In : PloS one. 9, 4, e94272.

Research output: Contribution to journalArticle

59 Scopus citations

Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis

Delimont, D., Dufek, B. M., Meehan, D. T., Zallocchi, M., Gratton, M. A., Phillips, G. & Cosgrove, D., Jun 10 2014, In : PloS one. 9, 6, e99083.

Research output: Contribution to journalArticle

26 Scopus citations

Photoreceptors in whirler mice show defective transducin translocation and are susceptible to short-term light/dark changes-induced degeneration

Tian, M., Wang, W., Delimont, D., Cheung, L., Zallocchi, M., Cosgrove, D. & Peng, Y. W., Jan 2014, In : Experimental Eye Research. 118, p. 145-153 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Light-Induced Translocation of RGS9-1 and Gβ5L in Mouse Rod Photoreceptors

Tian, M., Zallocchi, M., Wang, W., Chen, C. K., Palczewski, K., Delimont, D., Cosgrove, D. & Peng, Y. W., Mar 28 2013, In : PloS one. 8, 3, e58832.

Research output: Contribution to journalArticle

6 Scopus citations

α1β1 Integrin/rac1-dependent mesangial invasion of glomerular capillaries in alport syndrome

Zallocchi, M., Johnson, B. M., Meehan, D. T., Delimont, D. & Cosgrove, D., Oct 2013, In : American Journal of Pathology. 183, 4, p. 1269-1280 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells

Zallocchi, M., Delimont, D., Meehan, D. T. & Cosgrove, D., Oct 3 2012, In : Journal of Neuroscience. 32, 40, p. 13841-13859 19 p.

Research output: Contribution to journalArticle

17 Scopus citations

Role for a novel Usher protein complex in hair cell synaptic maturation

Zallocchi, M., Meehan, D. T., Delimont, D., Rutledge, J., Gratton, M. A., Flannery, J. & Cosgrove, D., Feb 17 2012, In : PloS one. 7, 2, e30573.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Moderate Light-Induced Degeneration of Rod Photoreceptors with Delayed Transducin Translocation in shaker1 Mice

Peng, Y. W., Zallocchi, M., Wang, W. M., Delimont, D. & Cosgrove, D., Aug 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6421-6427 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
2010

Biochemical characterization of native usher protein complexes from a vesicular subfraction of tracheal epithelial cells

Zallocchi, M., Sisson, J. H. & Cosgrove, D., Feb 16 2010, In : Biochemistry. 49, 6, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Collagen XIII induced in vascular endothelium mediates α1β1 integrin-dependent transmigration of monocytes in renal fibrosis

Dennis, J., Meehan, D. T., Delimont, D., Zallocchi, M., Perry, G. A., O'Brien, S., Tu, H., Pihlajaniemi, T. & Cosgrove, D., Nov 2010, In : American Journal of Pathology. 177, 5, p. 2527-2540 14 p.

Research output: Contribution to journalArticle

26 Scopus citations
2009

Biomechanical strain causes maladaptive gene regulation, contributing to alport glomerular disease

Meehan, D. T., Delimont, D., Cheung, L., Zallocchi, M., Sansom, S. C., Holzclaw, J. D., Rao, V. & Cosgrove, D., Nov 2009, In : Kidney International. 76, 9, p. 968-976 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

FAK and p38-MAP kinase-dependent activation of apoptosis and caspase-3 in retinal endothelial cells by α1(IV)NC1

Boosani, C. S., Nalabothula, N., Munugalavadla, V., Cosgrove, D., Keshamoun, V. G., Sheibani, N. & Sudhakar, A., 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4567-4575 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors

Zallocchi, M., Meehan, D. T., Delimont, D., Askew, C., Garige, S., Gratton, M. A., Rothermund-Franklin, C. A. & Cosgrove, D., Sep 2009, In : Hearing Research. 255, 1-2, p. 109-120 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Stem cell therapy for Alport syndrome: The hope beyond the hype

Gross, O., Borza, D. B., Anders, H. J., Licht, C., Weber, M., Segerer, S., Torra, R., Gubler, M. C., Heidet, L., Harvey, S., Cosgrove, D., Lees, G., Kashtan, C., Gregory, M., Savige, J., Ding, J., Thorner, P., Abrahamson, D. R., Antignac, C., Tryggvason, K. & 2 others, Hudson, B. & Miner, J. H., Mar 2009, In : Nephrology Dialysis Transplantation. 24, 3, p. 731-734 4 p.

Research output: Contribution to journalArticle

35 Scopus citations
2008

Integrin α1β1 regulates matrix metalloproteinases via p38 mitogen-activated protein kinase in mesangial cells: Implications for alport syndrome

Cosgrove, D., Meehan, D. T., Delimont, D., Pozzi, A., Chen, X., Rodgers, K. D., Tempero, R. M., Zallocchi, M. & Rao, V. H., Mar 2008, In : American Journal of Pathology. 172, 3, p. 761-773 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Progressive morphological and functional defects in retinas from α1 integrin-null mice

Peng, Y. W., Zallocchi, M., Meehan, D. T., Delimont, D., Chang, B., Hawes, N., Wang, W. & Cosgrove, D., Oct 2008, In : Investigative Ophthalmology and Visual Science. 49, 10, p. 4647-4654 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2007

Regulation of COX-2-mediated signaling by α3 type IV noncollagenous domain in tumor angiogenesis

Boosani, C. S., Mannam, A. P., Cosgrove, D., Silva, R., Hodivala-Dilke, K. M., Keshamouni, V. G. & Sudhakar, A., Aug 15 2007, In : Blood. 110, 4, p. 1168-1177 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2006

Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease

Sugimoto, H., Mundel, T. M., Sund, M., Xie, L., Cosgrove, D. & Kalluri, R., May 9 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 19, p. 7321-7326 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

Role for macrophage metalloelastase in glomerular basement membrane damage associated with Alport syndrome

Rao, V. H., Meehan, D. T., Delimont, D., Nakajima, M., Wada, T., Gratton, M. A. & Cosgrove, D., Jul 2006, In : American Journal of Pathology. 169, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease

Zeisberg, M., Khurana, M., Rao, V. H., Cosgrove, D., Rougier, J. P., Werner, M. C., Shield, C. F., Werb, Z. & Kalluri, R., Apr 2006, In : PLoS Medicine. 3, 4, p. 535-546 12 p.

Research output: Contribution to journalArticle

110 Scopus citations
2005

Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome

Rao, V. H., Lees, G. E., Kashtan, C. E., Delimont, D. C., Singh, R., Meehan, D. T., Bhattacharya, G., Berridge, B. R. & Cosgrove, D., Jun 2005, In : Pediatric Nephrology. 20, 6, p. 732-739 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Evidence for functional importance of usherin/fibronectin interactions in retinal basement membranes

Bhattacharya, G. & Cosgrove, D., Aug 30 2005, In : Biochemistry. 44, 34, p. 11518-11524 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Extracellular matrix and inner ear development and function

Cosgrove, D. & Anne Gratton, M., 2005, In : Advances in Developmental Biology. 15, p. 169-201 33 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human α1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by α1β1 integrin

Sudhakar, A., Nyberg, P., Keshamouni, V. G., Mannam, A. P., Li, J., Sugimoto, H., Cosgrove, D. & Kalluri, R., Oct 2005, In : Journal of Clinical Investigation. 115, 10, p. 2801-2810 10 p.

Research output: Contribution to journalArticle

130 Scopus citations

Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: Implications for capillary basement membrane pathology

Gratton, M. A., Rao, V. H., Meehan, D. T., Askew, C. & Cosgrove, D., May 2005, In : American Journal of Pathology. 166, 5, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2004

A domain-specific usherin/collagen IV interaction may be required for stable integration into the basement membrane superstructure

Bhattacharya, G., Kalluri, R., Orten, D. J., Kimberling, W. J. & Cosgrove, D., Jan 15 2004, In : Journal of cell science. 117, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Immunohistochemistry and reverse transcriptase-polymerase chain reaction as methods for diagnostic determination of Usher syndrome type IIa

Cohn, E., Bhattacharya, G., Pearsall, N., Shendrik, I., Kimberling, W. & Cosgrove, D., Jul 2004, In : Laryngoscope. 114, 7, p. 1310-1314 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lack of integrin α1β1 leads to severe glomerulosclerosis after glomerular injury

Chen, X., Moeckel, G., Morrow, J. D., Cosgrove, D., Harris, R. C., Fogo, A. B., Zent, R. & Pozzi, A., Aug 2004, In : American Journal of Pathology. 165, 2, p. 617-630 14 p.

Research output: Contribution to journalArticle

74 Scopus citations
2003

Increased expression of MMP-2, MMP-9 (type IV collagenases/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS)

Rao, V. H., Lees, G. E., Kashtan, C. E., Nemori, R., Singh, R. K., Meehan, D. T., Rodgers, K., Berridge, B. R., Bhattacharya, G. & Cosgrove, D. E., May 1 2003, In : Kidney International. 63, 5, p. 1736-1748 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis

Rodgers, K. D., Rao, V., Meehan, D. T., Fager, N., Gotwals, P., Ryan, S. T., Koteliansky, V., Nemori, R. & Cosgrove, D., Apr 1 2003, In : Kidney International. 63, 4, p. 1338-1355 18 p.

Research output: Contribution to journalArticle

38 Scopus citations

Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria

Sugimoto, H., Hamanog, Y., Charytan, D., Cosgrove, D., Kieran, M., Sudhakar, A. & Kalluri, R., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 12605-12608 4 p.

Research output: Contribution to journalArticle

432 Scopus citations
2002

Determinants of vascular permeability in the kidney glomerulus

Hamano, Y., Grunkemeyer, J. A., Sudhakar, A., Zeisberg, M., Cosgrove, D., Morello, R., Lee, B., Sugimoto, H. & Kalluri, R., Aug 23 2002, In : Journal of Biological Chemistry. 277, 34, p. 31154-31162 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

Localization and expression of usherin: A novel basement membrane protein defective in people with Usher's syndrome type IIa

Bhattacharya, G., Miller, C., Kimberling, W. J., Jablonski, M. M. & Cosgrove, D., 2002, In : Hearing Research. 163, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Strial marginal cells play a role in basement membrane homeostasis: In vitro and in vivo evidence

Gratton, M. A., Meehan, D. T., Smyth, B. J. & Cosgrove, D., 2002, In : Hearing Research. 163, 1-2, p. 27-36 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Usherin expression is highly conserved in mouse and human tissues

Pearsall, N., Bhattacharya, G., Wisecarver, J., Adams, J., Cosgrove, D. & Kimberling, W., Dec 2002, In : Hearing Research. 174, 1-2, p. 55-63 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2001

Global Gene Expression Analysis Reveals a Role for the α1 Integrin in Renal Pathogenesis

Sampson, N. S., Ryan, S. T., Enke, D. A., Cosgrove, D., Koteliansky, V. & Gotwals, P., Sep 7 2001, In : Journal of Biological Chemistry. 276, 36, p. 34182-34188 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

The laminins in the murine inner ear: Developmental transitions and expression in cochlear basement membranes

Rodgers, K. D., Barritt, L., Miner, J. H. & Cosgrove, D., 2001, In : Hearing Research. 158, 1-2, p. 39-50 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
2000

Assembly of Type IV collagen. Insights from α3(IV) collagen-deficient mice

Kalluri, R. & Cosgrove, D., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 12719-12724 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Integrin α1β1 and transforming growth factor-β1 play distinct roles in alport glomerular pathogenesis and serve as dual targets for metabolic therapy

Cosgrove, D., Rodgers, K., Meehan, D., Miller, C., Bovard, K., Gilroy, A., Gardner, H., Kotelianski, V., Gotwals, P., Amatucci, A. & Kalluri, R., 2000, In : American Journal of Pathology. 157, 5, p. 1649-1659 11 p.

Research output: Contribution to journalArticle

151 Scopus citations

Modular retro-vectors for transgenic and therapeutic use

Solaiman, F., Zink, M. A., Xu, G., Grunkemeyer, J., Cosgrove, D., Saenz, J. & Hodgson, C. P., 2000, In : Molecular Reproduction and Development. 56, 2 SUPPL., p. 309-315 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
1999

Role for transforming growth factor-β1 in Alport renal disease progression

Sayers, R., Kalluri, R., Rodgers, K. D., Shield, C. F., Meehan, D. T. & Cosgrove, D., 1999, In : Kidney International. 56, 5, p. 1662-1673 12 p.

Research output: Contribution to journalArticle

67 Scopus citations
4 Scopus citations
1998

Isolation of an Alu repetitive DNA binding protein and effect of CpG methylation on binding to its recognition sequence

Cox, G. S., Gutkin, D. W., Haas, M. J. & Cosgrove, D. E., Mar 4 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1396, 1, p. 67-87 21 p.

Research output: Contribution to journalArticle

26 Scopus citations

Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome

Cosgrove, D., Samuelson, G., Meehan, D. T., Miller, C., McGee, J., Walsh, E. J. & Siegel, M., Jul 1998, In : Hearing Research. 121, 1-2, p. 84-98 15 p.

Research output: Contribution to journalArticle

69 Scopus citations