• 2901 Citations
  • 30 h-Index
20002020

Research output per year

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Research Output

Article

A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis

Yuan, F., Tabor, D. E., Nelson, R. K., Yuan, H., Zhang, Y., Nuxoll, J., Bynoté, K. K., Lele, S. M., Wang, D. & Gould, K. A., Nov 28 2013, In : PloS one. 8, 11, e81483.

Research output: Contribution to journalArticle

11 Scopus citations
8 Scopus citations

A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

Zhao, G., Wei, X., Wu, J., Eichele, D. D., Lele, S. M., Yang, L., Zhang, F. & Wang, D., Apr 1 2019, In : Pharmaceutical Research. 36, 4, 64.

Research output: Contribution to journalArticle

1 Scopus citations

Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates

Pan, H., Sima, M., Kopečková, P., Wu, K., Gao, S., Liu, J., Wang, D., Miller, S. C. & Kopeček, J., Jul 2008, In : Molecular Pharmaceutics. 5, 4, p. 548-558 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics

Miller, S. C., Wang, D., Kopečková, P. & Kopeček, J., Jan 2005, In : Journal of Bone and Mineral Metabolism. 23, SUPPL. 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice

Liu, Y., Jia, Z., Akhter, M. P., Gao, X., Wang, X., Wang, X., Zhao, G., Wei, X., Zhou, Y., Wang, X., Hartman, C. W., Fehringer, E. V., Cui, L. & Wang, D., Oct 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 7, p. 2271-2282 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

Wang, D., Li, W., Pechar, M., Kopečková, P., Brömme, D. & Kopeček, J., Jun 11 2004, In : International journal of pharmaceutics. 277, 1-2, p. 73-79 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
16 Scopus citations
4 Scopus citations

Development of a Janus Kinase Inhibitor Prodrug for the Treatment of Rheumatoid Arthritis

Wei, X., Wu, J., Zhao, G., Galdamez, J., Lele, S. M., Wang, X., Liu, Y., Soni, D. M., Purdue, P. E., Mikuls, T. R., Goldring, S. R. & Wang, D., Aug 6 2018, In : Molecular Pharmaceutics. 15, 8, p. 3456-3467 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

Quan, L. D., Purdue, P. E., Liu, X. M., Boska, M. D., Lele, S. M., Thiele, G. M., Mikuls, T. R., Dou, H., Goldring, S. R. & Wang, D., Sep 13 2010, In : Arthritis Research and Therapy. 12, 5, R170.

Research output: Contribution to journalArticle

44 Scopus citations

Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects

Yuan, F., Nelson, R. K., Tabor, D. E., Zhang, Y., Akhter, M. P., Gould, K. A. & Wang, D., Dec 2012, In : Arthritis and rheumatism. 64, 12, p. 4029-4039 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion

Zhang, D., Wang, D., Pipinos, I. I., Muelleman, R. L. & Li, Y. L., Feb 1 2017, In : Acta Physiologica. 219, 2, p. 453-464 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates

Ren, K., Purdue, P. E., Burton, L., Quan, L. D., Fehringer, E. V., Thiele, G. M., Goldring, S. R. & Wang, D., Aug 1 2011, In : Molecular Pharmaceutics. 8, 4, p. 1043-1051 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Early diagnosis of orthopedic implant failure using macromolecular imaging agents

Ren, K., Dusad, A., Zhang, Y., Purdue, P. E., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Aug 2014, In : Pharmaceutical Research. 31, 8, p. 2086-2094 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats

Knudsen, M., Bury, M., Holwegner, C., Reinhardt, A. L., Yuan, F., Zhang, Y., Giannini, P., Marx, D. B., Wang, D. & Reinhardt, R. A., Sep 24 2015, In : Arthritis Research and Therapy. 17, 1, 267.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of simvastatin prodrug on experimental periodontitis

Bradley, A. D., Zhang, Y., Jia, Z., Zhao, G., Wang, X., Pranke, L., Schmid, M. J., Wang, D. & Reinhardt, R. A., May 2016, In : Journal of periodontology. 87, 5, p. 577-582 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss

Price, U., Le, H. O. T., Powell, S. E., Schmid, M. J., Marx, D. B., Zhang, Y., Wang, D., Narayana, N. & Reinhardt, R. A., Oct 2013, In : Journal of Periodontal Research. 48, 5, p. 541-548 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Efficient synthesis of linear multifunctional poly(ethylene glycol) by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition

Liu, X. M., Thakur, A. & Wang, D., Sep 2007, In : Biomacromolecules. 8, 9, p. 2653-2658 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E1 to promote bone formation in aged, estrogen-deficient rats

Miller, S. C., Pan, H., Wang, D., Bowman, B. M., Kopečková, P. & Kopeček, J., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2889-2895 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Glucocorticoid-induced delayed fracture healing and impaired bone biomechanical properties in mice

Liu, Y. Z., Akhter, M. P., Gao, X., Wang, X. Y., Wang, X. B., Zhao, G., Wei, X., Wu, H. J., Chen, H., Wang, D. & Cui, L., 2018, In : Clinical interventions in aging. 13, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

Crielaard, B. J., Rijcken, C. J. F., Quan, L., Van Der Wal, S., Altintas, I., Van Der Pot, M., Kruijtzer, J. A. W., Liskamp, R. M. J., Schiffelers, R. M., Van Nostrum, C. F., Hennink, W. E., Wang, D., Lammers, T. & Storm, G., Jul 16 2012, In : Angewandte Chemie - International Edition. 51, 29, p. 7254-7258 5 p.

Research output: Contribution to journalArticle

79 Scopus citations

Head-to-head comparative pharmacokinetic and biodistribution (PK/BD) study of two dexamethasone prodrug nanomedicines on lupus-prone NZB/WF1 mice

Wei, X., Zhao, G., Wang, X., Gautam, N., Jia, Z., Zhao, Z., Kong, D., Zhang, F., Kumar, S., Sun, Y., Chen, N., Wang, X., Yang, L., Ren, R., Thiele, G. M., Bronich, T. K., O'Dell, J. R., Alnouti, Y. & Wang, D., Oct 2020, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 29, 102266.

Research output: Contribution to journalArticle

HPMA–copolymer nanocarrier targets tumor-associated macrophages in primary and metastatic breast cancer

Zimel, M. N., Horowitz, C. B., Rajasekhar, V. K., Christ, A. B., Wei, X., Wu, J., Wojnarowicz, P. M., Wang, D., Goldring, S. R., Purdue, P. E. & Healey, J. H., Dec 2017, In : Molecular cancer therapeutics. 16, 12, p. 2701-2710 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects

Killeen, A. C., Rakes, P. A., Schmid, M. J., Zhang, Y., Narayana, N., Marx, D. B., Payne, J. B., Wang, D. & Reinhardt, R. A., Dec 2012, In : Journal of periodontology. 83, 12, p. 1463-1471 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
6 Scopus citations

Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors

Wang, D., Pechar, M., Li, W., Kopečková, P., Brömme, D. & Kopeček, J., Jul 16 2002, In : Biochemistry. 41, 28, p. 8849-8859 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis

Wang, X., Jia, Z., Almoshari, Y., Lele, S. M., Reinhardt, R. A. & Wang, D., Aug 1 2018, In : Pharmaceutical Research. 35, 8, 164.

Research output: Contribution to journalArticle

4 Scopus citations

Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis

Ren, K., Yuan, H., Zhang, Y., Wei, X. & Wang, D., Sep 1 2015, In : Clinical Immunology. 160, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects

Ren, K., Dusad, A., Yuan, F., Yuan, H., Purdue, P. E., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Feb 10 2014, In : Journal of Controlled Release. 175, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration

Boda, S. K., Almoshari, Y., Wang, H., Wang, X., Reinhardt, R. A., Duan, B., Wang, D. & Xie, J., Feb 2019, In : Acta Biomaterialia. 85, p. 282-293 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Nanomedicines for inflammatory arthritis: Head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes

Quan, L., Zhang, Y., Crielaard, B. J., Dusad, A., Lele, S. M., Rijcken, C. J. F., Metselaar, J. M., Kostková, H., Etrych, T., Ulbrich, K., Kiessling, F., Mikuls, T. R., Hennink, W. E., Storm, G., Lammers, T. & Wang, D., Jan 28 2014, In : ACS Nano. 8, 1, p. 458-466 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

Novel aromatic azo-containing pH-sensitive hydrogels: Synthesis and characterization

Wang, D., Dušek, K., Kopečková, P., Dušková-Smrčková, M. & Kopeček, J., Sep 24 2002, In : Macromolecules. 35, 20, p. 7791-7803 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity

Liu, X. M., Lee, H. T., Reinhardt, R. A., Marky, L. A. & Wang, D., Sep 11 2007, In : Journal of Controlled Release. 122, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis

Wang, D., Miller, S. C., Liu, X. M., Anderson, B., Wang, X. S. & Goldring, S. R., 2007, In : Arthritis Research and Therapy. 9, R2.

Research output: Contribution to journalArticle

97 Scopus citations

Osteotropic peptide that differentiates functional domains of the skeleton

Wang, D., Miller, S. C., Shlyakhtenko, L. S., Portillo, A. M., Liu, X. M., Papangkorn, K., Kopečková, P., Lyubchenko, Y., Higuchi, W. I. & Kopeček, J., Sep 2007, In : Bioconjugate Chemistry. 18, 5, p. 1375-1378 4 p.

Research output: Contribution to journalArticle

71 Scopus citations

Osteotropic β-cyclodextrin for local bone regeneration

Liu, X. M., Wiswall, A. T., Rutledge, J. E., Akhter, M. P., Cullen, D. M., Reinhardt, R. A. & Wang, D., Apr 2008, In : Biomaterials. 29, 11, p. 1686-1692 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers

Wang, D., Sima, M., Mosley, R. L., Davda, J. P., Tietze, N., Miller, S. C., Gwilt, P. R., Kopečková, P. & Kopeček, J., Nov 2006, In : Molecular Pharmaceutics. 3, 6, p. 717-725 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

Wei, X., Li, F., Zhao, G., Chhonker, Y. S., Averill, C., Galdamez, J., Purdue, P. E., Wang, X., Fehringer, E. V., Garvin, K. L., Goldring, S. R., Alnouti, Y. & Wang, D., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pharmacokinetic and biodistribution studies of N -(2-hydroxypropyl) methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model

Quan, L. D., Yuan, F., Liu, X. M., Huang, J. G., Alnouti, Y. & Wang, D., Aug 2 2010, In : Molecular Pharmaceutics. 7, 4, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Pluronics-Formulated farnesol promotes efficient killing and demonstrates novel interactions with streptococcus mutans biofilms

Mogen, A. B., Chen, F., Ahn, S. J., Burne, R. A., Wang, D. & Rice, K. C., Jul 29 2015, In : PloS one. 10, 7, e0133886.

Research output: Contribution to journalArticle

13 Scopus citations

Prevention of orthopedic device-associated osteomyelitis using oxacillin-containing biomineral-binding liposomes

Liu, X. M., Zhang, Y., Chen, F., Khutsishvili, I., Fehringer, E. V., Marky, L. A., Bayles, K. W. & Wang, D., Nov 2012, In : Pharmaceutical Research. 29, 11, p. 3169-3179 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Rapid bone loss occurs as early as 2 days after complete spinal cord transection in young adult rats

Peng, Y., Zhao, W., Hu, Y., Li, F., Guo, X. E., Wang, D., Bauman, W. A. & Qin, W., Mar 1 2020, In : Spinal Cord. 58, 3, p. 309-317 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Simvastatin prodrug micelles target fracture and improve healing

Jia, Z., Zhang, Y., Chen, Y. H., Dusad, A., Yuan, H., Ren, K., Li, F., Fehringer, E. V., Purdue, P. E., Goldring, S. R., Daluiski, A. & Wang, D., Feb 28 2015, In : Journal of Controlled Release. 200, p. 23-34 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates

Pan, H., Kopečková, P., Liu, J., Wang, D., Miller, S. C. & Kopeček, J., Dec 2007, In : Pharmaceutical Research. 24, 12, p. 2270-2280 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Standardized rat model testing effects of inflammation and grafting on extraction healing

Willett, E. S., Liu, J., Berke, M., Giannini, P. J., Schmid, M., Jia, Z., Wang, X., Wang, X., Samson, K., Yu, F., Wang, D., Nawshad, A. & Reinhardt, R. A., Aug 2017, In : Journal of periodontology. 88, 8, p. 799-807 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural optimization of HPMA copolymer-based dexamethasone prodrug for improved treatment of inflammatory arthritis

Jia, Z., Zhao, G., Wei, X., Kong, D., Sun, Y., Zhou, Y., Lele, S. M., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Aug 10 2020, In : Journal of Controlled Release. 324, p. 560-573 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Syntheses of click PEG-dexamethasone conjugates for the treatment of rheumatoid arthritis

Liu, X. M., Quan, L. D., Tian, J., Laquer, F. C., Ciborowski, P. & Wang, D., Oct 11 2010, In : Biomacromolecules. 11, 10, p. 2621-2628 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels

Chivukula, P., Dušek, K., Wang, D., Dušková-Smršková, M., Kopečková, P. & Kopeček, J., Mar 2006, In : Biomaterials. 27, 7, p. 1140-1151 12 p.

Research output: Contribution to journalArticle

47 Scopus citations