• 2901 Citations
  • 30 h-Index
20002020

Research output per year

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Research Output

2011

The bone, the joints and the balm of gilead

Wang, D. & Goldring, S. R., Aug 1 2011, In : Molecular Pharmaceutics. 8, 4, p. 991-993 3 p.

Research output: Contribution to journalReview article

26 Scopus citations
2010

Beyond oncology - Application of HPMA copolymers in non-cancerous diseases

Liu, X. M., Miller, S. C. & Wang, D., Feb 17 2010, In : Advanced Drug Delivery Reviews. 62, 2, p. 258-271 14 p.

Research output: Contribution to journalReview article

30 Scopus citations

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

Quan, L. D., Purdue, P. E., Liu, X. M., Boska, M. D., Lele, S. M., Thiele, G. M., Mikuls, T. R., Dou, H., Goldring, S. R. & Wang, D., Sep 13 2010, In : Arthritis Research and Therapy. 12, 5, R170.

Research output: Contribution to journalArticle

44 Scopus citations

Novel technologies for the prevention and treatment of dental caries: A patent survey

Chen, F. & Wang, D., May 2010, In : Expert Opinion on Therapeutic Patents. 20, 5, p. 681-694 14 p.

Research output: Contribution to journalReview article

55 Scopus citations

Pharmacokinetic and biodistribution studies of N -(2-hydroxypropyl) methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model

Quan, L. D., Yuan, F., Liu, X. M., Huang, J. G., Alnouti, Y. & Wang, D., Aug 2 2010, In : Molecular Pharmaceutics. 7, 4, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Syntheses of click PEG-dexamethasone conjugates for the treatment of rheumatoid arthritis

Liu, X. M., Quan, L. D., Tian, J., Laquer, F. C., Ciborowski, P. & Wang, D., Oct 11 2010, In : Biomacromolecules. 11, 10, p. 2621-2628 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)-Catalyzed Huisgen 1,3-Dipolar Cycloaddition

Hein, C. D., Liu, X. M., Chen, F., Cullen, D. M. & Wang, D., 2010, In : Macromolecular Bioscience. 10, 12, p. 1544-1556 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm

Chen, F., Rice, K. C., Liu, X. M., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2010, In : Pharmaceutical Research. 27, 11, p. 2356-2364 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2009

Tooth-binding micelles for dental caries prevention

Chen, F., Liu, X. M., Rice, K. C., Li, X., Yu, F., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2009, In : Antimicrobial Agents and Chemotherapy. 53, 11, p. 4898-4902 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates

Pan, H., Sima, M., Kopečková, P., Wu, K., Gao, S., Liu, J., Wang, D., Miller, S. C. & Kopeček, J., Jul 2008, In : Molecular Pharmaceutics. 5, 4, p. 548-558 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Click chemistry, a powerful tool for pharmaceutical sciences

Hein, C. D., Liu, X. M. & Wang, D., Oct 2008, In : Pharmaceutical Research. 25, 10, p. 2216-2230 15 p.

Research output: Contribution to journalReview article

462 Scopus citations

Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E1 to promote bone formation in aged, estrogen-deficient rats

Miller, S. C., Pan, H., Wang, D., Bowman, B. M., Kopečková, P. & Kopeček, J., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2889-2895 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Osteotropic β-cyclodextrin for local bone regeneration

Liu, X. M., Wiswall, A. T., Rutledge, J. E., Akhter, M. P., Cullen, D. M., Reinhardt, R. A. & Wang, D., Apr 2008, In : Biomaterials. 29, 11, p. 1686-1692 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis

Liu, X. M., Quan, L. D., Tian, J., Alnouti, Y., Fu, K., Thiele, G. M. & Wang, D., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2910-2919 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Targeted delivery for musculoskeletal diseases

Wang, D., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2878-2880 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

The design and synthesis of an osteotropic polyrotaxane for the treatment of skeletal diseases

Hein, C. D., Liu, X. M. & Wang, D., 2008, American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 1 ed. Vol. 49. p. 248-249 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The development of novel therapies for rheumatoid arthritis

Quan, L. D., Thiele, G. M., Tian, J. & Wang, D., Jul 2008, In : Expert Opinion on Therapeutic Patents. 18, 7, p. 723-738 16 p.

Research output: Contribution to journalReview article

103 Scopus citations
2007

Efficient synthesis of linear multifunctional poly(ethylene glycol) by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition

Liu, X. M., Thakur, A. & Wang, D., Sep 2007, In : Biomacromolecules. 8, 9, p. 2653-2658 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity

Liu, X. M., Lee, H. T., Reinhardt, R. A., Marky, L. A. & Wang, D., Sep 11 2007, In : Journal of Controlled Release. 122, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis

Wang, D., Miller, S. C., Liu, X. M., Anderson, B., Wang, X. S. & Goldring, S. R., 2007, In : Arthritis Research and Therapy. 9, R2.

Research output: Contribution to journalArticle

97 Scopus citations

Osteotropic peptide that differentiates functional domains of the skeleton

Wang, D., Miller, S. C., Shlyakhtenko, L. S., Portillo, A. M., Liu, X. M., Papangkorn, K., Kopečková, P., Lyubchenko, Y., Higuchi, W. I. & Kopeček, J., Sep 2007, In : Bioconjugate Chemistry. 18, 5, p. 1375-1378 4 p.

Research output: Contribution to journalArticle

71 Scopus citations

Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates

Pan, H., Kopečková, P., Liu, J., Wang, D., Miller, S. C. & Kopeček, J., Dec 2007, In : Pharmaceutical Research. 24, 12, p. 2270-2280 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2006

Drug delivery strategies for common orofacial diseases

Liu, X. M., Reinhardt, R. A. & Wang, D., Sep 2006, In : Journal of Drug Targeting. 14, 8, p. 583-597 15 p.

Research output: Contribution to journalReview article

7 Scopus citations

Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers

Wang, D., Sima, M., Mosley, R. L., Davda, J. P., Tietze, N., Miller, S. C., Gwilt, P. R., Kopečková, P. & Kopeček, J., Nov 2006, In : Molecular Pharmaceutics. 3, 6, p. 717-725 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels

Chivukula, P., Dušek, K., Wang, D., Dušková-Smršková, M., Kopečková, P. & Kopeček, J., Mar 2006, In : Biomaterials. 27, 7, p. 1140-1151 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Water-soluble HPMA copolymer - Prostaglandin E1 conjugates containing a cathepsin K sensitive spacer

Pan, H., Kopečková, P., Wang, D., Yang, J., Miller, S. & Kopeček, J., Jul 2006, In : Journal of Drug Targeting. 14, 6, p. 425-435 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2005

Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics

Miller, S. C., Wang, D., Kopečková, P. & Kopeček, J., Jan 2005, In : Journal of Bone and Mineral Metabolism. 23, SUPPL. 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Bone-targeting macromolecular therapeutics

Wang, D., Miller, S. C., Kopečková, P. & Kopeček, J., May 25 2005, In : Advanced Drug Delivery Reviews. 57, 7, p. 1049-1076 28 p.

Research output: Contribution to journalReview article

146 Scopus citations

Drug delivery strategies for cathepsin inhibitors in joint diseases

Wang, D. & Brömme, D., Nov 2005, In : Expert Opinion on Drug Delivery. 2, 6, p. 1015-1028 14 p.

Research output: Contribution to journalReview article

17 Scopus citations

Targeted drug delivery for musculoskeletal diseases

Wang, D., Miller, S. C. & Kopeček, J., May 25 2005, In : Advanced Drug Delivery Reviews. 57, 7, p. 935-937 3 p.

Research output: Contribution to journalEditorial

9 Scopus citations
2004

Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

Wang, D., Li, W., Pechar, M., Kopečková, P., Brömme, D. & Kopeček, J., Jun 11 2004, In : International journal of pharmaceutics. 277, 1-2, p. 73-79 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: A preliminary study

Wang, D., Miller, S. C., Sima, M., Parker, D., Buswell, H., Goodrich, K. C., Kopečková, P. & Kopeček, J., Oct 2004, In : Pharmaceutical Research. 21, 10, p. 1741-1749 9 p.

Research output: Contribution to journalArticle

50 Scopus citations
2003

Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems

Wang, D., Miller, S., Sima, M., Kopečková, P. & Kopeček, J., Sep 2003, In : Bioconjugate Chemistry. 14, 5, p. 853-859 7 p.

Research output: Contribution to journalArticle

137 Scopus citations
2002

Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors

Wang, D., Pechar, M., Li, W., Kopečková, P., Brömme, D. & Kopeček, J., Jul 16 2002, In : Biochemistry. 41, 28, p. 8849-8859 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Novel aromatic azo-containing pH-sensitive hydrogels: Synthesis and characterization

Wang, D., Dušek, K., Kopečková, P., Dušková-Smrčková, M. & Kopeček, J., Sep 24 2002, In : Macromolecules. 35, 20, p. 7791-7803 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
2000

Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: Potential drug carriers

Wang, D., Kopečková, P., Minko, T., Nanayakkara, V. & Kopeček, J., 2000, In : Biomacromolecules. 1, 3, p. 313-319 7 p.

Research output: Contribution to journalArticle

91 Scopus citations

Synthesis of star-like poly[N-(2-hydroxypropyl)methacrylamide] using PAMAM dendrimer as the core

Wang, D., Kapečková, P., Minko, T., Nanayakkara, V. & Kopeček, J., Mar 2000, In : American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 41, 1, p. 994-995 2 p.

Research output: Contribution to journalConference article

9 Scopus citations