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20002020

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Article
2020

Rapid bone loss occurs as early as 2 days after complete spinal cord transection in young adult rats

Peng, Y., Zhao, W., Hu, Y., Li, F., Guo, X. E., Wang, D., Bauman, W. A. & Qin, W., Mar 1 2020, In : Spinal Cord. 58, 3, p. 309-317 9 p.

Research output: Contribution to journalArticle

Structural optimization of HPMA copolymer-based dexamethasone prodrug for improved treatment of inflammatory arthritis

Jia, Z., Zhao, G., Wei, X., Kong, D., Sun, Y., Zhou, Y., Lele, S. M., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Aug 10 2020, In : Journal of Controlled Release. 324, p. 560-573 14 p.

Research output: Contribution to journalArticle

2019

A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

Zhao, G., Wei, X., Wu, J., Eichele, D. D., Lele, S. M., Yang, L., Zhang, F. & Wang, D., Apr 1 2019, In : Pharmaceutical Research. 36, 4, 64.

Research output: Contribution to journalArticle

Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration

Boda, S. K., Almoshari, Y., Wang, H., Wang, X., Reinhardt, R. A., Duan, B., Wang, D. & Xie, J., Feb 2019, In : Acta Biomaterialia. 85, p. 282-293 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

The Development of a Macromolecular Analgesic for Arthritic Pain

Weber, L., Wang, X., Ren, R., Wei, X., Zhao, G., Yang, J., Yuan, H., Pang, H., Wang, H. & Wang, D., Mar 4 2019, In : Molecular Pharmaceutics. 16, 3, p. 1234-1244 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice

Liu, Y., Jia, Z., Akhter, M. P., Gao, X., Wang, X., Wang, X., Zhao, G., Wei, X., Zhou, Y., Wang, X., Hartman, C. W., Fehringer, E. V., Cui, L. & Wang, D., Oct 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 7, p. 2271-2282 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Development of a Janus Kinase Inhibitor Prodrug for the Treatment of Rheumatoid Arthritis

Wei, X., Wu, J., Zhao, G., Galdamez, J., Lele, S. M., Wang, X., Liu, Y., Soni, D. M., Purdue, P. E., Mikuls, T. R., Goldring, S. R. & Wang, D., Aug 6 2018, In : Molecular Pharmaceutics. 15, 8, p. 3456-3467 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Glucocorticoid-induced delayed fracture healing and impaired bone biomechanical properties in mice

Liu, Y. Z., Akhter, M. P., Gao, X., Wang, X. Y., Wang, X. B., Zhao, G., Wei, X., Wu, H. J., Chen, H., Wang, D. & Cui, L., 2018, In : Clinical interventions in aging. 13, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis

Wang, X., Jia, Z., Almoshari, Y., Lele, S. M., Reinhardt, R. A. & Wang, D., Aug 1 2018, In : Pharmaceutical Research. 35, 8, 164.

Research output: Contribution to journalArticle

3 Scopus citations
5 Scopus citations
2017

Dexamethasone promotes long-term functional recovery of neuromuscular junction in a murine model of tourniquet-induced ischaemia–reperfusion

Zhang, D., Wang, D., Pipinos, I. I., Muelleman, R. L. & Li, Y. L., Feb 1 2017, In : Acta Physiologica. 219, 2, p. 453-464 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

HPMA–copolymer nanocarrier targets tumor-associated macrophages in primary and metastatic breast cancer

Zimel, M. N., Horowitz, C. B., Rajasekhar, V. K., Christ, A. B., Wei, X., Wu, J., Wojnarowicz, P. M., Wang, D., Goldring, S. R., Purdue, P. E. & Healey, J. H., Dec 2017, In : Molecular cancer therapeutics. 16, 12, p. 2701-2710 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

Wei, X., Li, F., Zhao, G., Chhonker, Y. S., Averill, C., Galdamez, J., Purdue, P. E., Wang, X., Fehringer, E. V., Garvin, K. L., Goldring, S. R., Alnouti, Y. & Wang, D., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Standardized rat model testing effects of inflammation and grafting on extraction healing

Willett, E. S., Liu, J., Berke, M., Giannini, P. J., Schmid, M., Jia, Z., Wang, X., Wang, X., Samson, K., Yu, F., Wang, D., Nawshad, A. & Reinhardt, R. A., Aug 2017, In : Journal of periodontology. 88, 8, p. 799-807 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Systemic IL-6 effector response in mediating systemic bone loss following inhalation of organic dust

Wells, A., Romberger, D., Thiele, G. M., Wyatt, T. A., Staab, E., Heires, A. J., Klassen, L. W., Duryee, M. J., Mikuls, T. R., Dusad, A., West, W. W., Wang, D. & Poole, J. A., Jan 1 2017, In : Journal of Interferon and Cytokine Research. 37, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Effect of simvastatin prodrug on experimental periodontitis

Bradley, A. D., Zhang, Y., Jia, Z., Zhao, G., Wang, X., Pranke, L., Schmid, M. J., Wang, D. & Reinhardt, R. A., May 2016, In : Journal of periodontology. 87, 5, p. 577-582 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model

Zhang, Y., Jia, Z., Yuan, H., Dusad, A., Ren, K., Wei, X., Fehringer, E. V., Purdue, P. E., Daluiski, A., Goldring, S. R. & Wang, D., Aug 1 2016, In : Pharmaceutical Research. 33, 8, p. 1959-1971 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model

Quan, L., Zhang, Y., Dusad, A., Ren, K., Purdue, P. E., Goldring, S. R. & Wang, D., Jan 1 2016, In : Pharmaceutical Research. 33, 1, p. 186-193 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Toll-like receptor 4 signaling pathway mediates inhalant organic dust-induced bone loss

Staab, E., Thiele, G. M., Clarey, D., Wyatt, T. A., Romberger, D., Wells, A. D., Dusad, A., Wang, D., Klassen, L. W., Mikuls, T. R., Duryee, M. J. & Poole, J. A., Aug 1 2016, In : PloS one. 11, 8, e0158735.

Research output: Contribution to journalArticle

4 Scopus citations
2015
8 Scopus citations

Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats

Knudsen, M., Bury, M., Holwegner, C., Reinhardt, A. L., Yuan, F., Zhang, Y., Giannini, P., Marx, D. B., Wang, D. & Reinhardt, R. A., Sep 24 2015, In : Arthritis Research and Therapy. 17, 1, 267.

Research output: Contribution to journalArticle

3 Scopus citations

Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis

Ren, K., Yuan, H., Zhang, Y., Wei, X. & Wang, D., Sep 1 2015, In : Clinical Immunology. 160, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pluronics-Formulated farnesol promotes efficient killing and demonstrates novel interactions with streptococcus mutans biofilms

Mogen, A. B., Chen, F., Ahn, S. J., Burne, R. A., Wang, D. & Rice, K. C., Jul 29 2015, In : PloS one. 10, 7, e0133886.

Research output: Contribution to journalArticle

12 Scopus citations

Simvastatin prodrug micelles target fracture and improve healing

Jia, Z., Zhang, Y., Chen, Y. H., Dusad, A., Yuan, H., Ren, K., Li, F., Fehringer, E. V., Purdue, P. E., Goldring, S. R., Daluiski, A. & Wang, D., Feb 28 2015, In : Journal of Controlled Release. 200, p. 23-34 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Vitamin D supplementation protects against bone loss following inhalant organic dust and lipopolysaccharide exposures in mice

Dusad, A., Thiele, G. M., Klassen, L. W., Wang, D., Duryee, M. J., Mikuls, T. R., Staab, E. B., Wyatt, T. A., West, W. W., Reynolds, S. J., Romberger, D. & Poole, J. A., May 1 2015, In : Immunologic Research. 62, 1, p. 46-59 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Early diagnosis of orthopedic implant failure using macromolecular imaging agents

Ren, K., Dusad, A., Zhang, Y., Purdue, P. E., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Aug 2014, In : Pharmaceutical Research. 31, 8, p. 2086-2094 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
6 Scopus citations

Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects

Ren, K., Dusad, A., Yuan, F., Yuan, H., Purdue, P. E., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Feb 10 2014, In : Journal of Controlled Release. 175, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Nanomedicines for inflammatory arthritis: Head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes

Quan, L., Zhang, Y., Crielaard, B. J., Dusad, A., Lele, S. M., Rijcken, C. J. F., Metselaar, J. M., Kostková, H., Etrych, T., Ulbrich, K., Kiessling, F., Mikuls, T. R., Hennink, W. E., Storm, G., Lammers, T. & Wang, D., Jan 28 2014, In : ACS Nano. 8, 1, p. 458-466 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

The development of drug-free therapy for prevention of dental caries

Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2014, In : Pharmaceutical Research. 31, 11, p. 3031-3037 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis

Yuan, F., Tabor, D. E., Nelson, R. K., Yuan, H., Zhang, Y., Nuxoll, J., Bynoté, K. K., Lele, S. M., Wang, D. & Gould, K. A., Nov 28 2013, In : PloS one. 8, 11, e81483.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss

Price, U., Le, H. O. T., Powell, S. E., Schmid, M. J., Marx, D. B., Zhang, Y., Wang, D., Narayana, N. & Reinhardt, R. A., Oct 2013, In : Journal of Periodontal Research. 48, 5, p. 541-548 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

The development of dentotropic micelles with biodegradable tooth-binding moieties

Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2013, In : Pharmaceutical Research. 30, 11, p. 2808-2817 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012
16 Scopus citations

Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects

Yuan, F., Nelson, R. K., Tabor, D. E., Zhang, Y., Akhter, M. P., Gould, K. A. & Wang, D., Dec 2012, In : Arthritis and rheumatism. 64, 12, p. 4029-4039 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

Crielaard, B. J., Rijcken, C. J. F., Quan, L., Van Der Wal, S., Altintas, I., Van Der Pot, M., Kruijtzer, J. A. W., Liskamp, R. M. J., Schiffelers, R. M., Van Nostrum, C. F., Hennink, W. E., Wang, D., Lammers, T. & Storm, G., Jul 16 2012, In : Angewandte Chemie - International Edition. 51, 29, p. 7254-7258 5 p.

Research output: Contribution to journalArticle

75 Scopus citations

Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects

Killeen, A. C., Rakes, P. A., Schmid, M. J., Zhang, Y., Narayana, N., Marx, D. B., Payne, J. B., Wang, D. & Reinhardt, R. A., Dec 2012, In : Journal of periodontology. 83, 12, p. 1463-1471 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Prevention of orthopedic device-associated osteomyelitis using oxacillin-containing biomineral-binding liposomes

Liu, X. M., Zhang, Y., Chen, F., Khutsishvili, I., Fehringer, E. V., Marky, L. A., Bayles, K. W. & Wang, D., Nov 2012, In : Pharmaceutical Research. 29, 11, p. 3169-3179 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2011

Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates

Ren, K., Purdue, P. E., Burton, L., Quan, L. D., Fehringer, E. V., Thiele, G. M., Goldring, S. R. & Wang, D., Aug 1 2011, In : Molecular Pharmaceutics. 8, 4, p. 1043-1051 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2010

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

Quan, L. D., Purdue, P. E., Liu, X. M., Boska, M. D., Lele, S. M., Thiele, G. M., Mikuls, T. R., Dou, H., Goldring, S. R. & Wang, D., Sep 13 2010, In : Arthritis Research and Therapy. 12, 5, R170.

Research output: Contribution to journalArticle

44 Scopus citations

Pharmacokinetic and biodistribution studies of N -(2-hydroxypropyl) methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model

Quan, L. D., Yuan, F., Liu, X. M., Huang, J. G., Alnouti, Y. & Wang, D., Aug 2 2010, In : Molecular Pharmaceutics. 7, 4, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Syntheses of click PEG-dexamethasone conjugates for the treatment of rheumatoid arthritis

Liu, X. M., Quan, L. D., Tian, J., Laquer, F. C., Ciborowski, P. & Wang, D., Oct 11 2010, In : Biomacromolecules. 11, 10, p. 2621-2628 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)-Catalyzed Huisgen 1,3-Dipolar Cycloaddition

Hein, C. D., Liu, X. M., Chen, F., Cullen, D. M. & Wang, D., 2010, In : Macromolecular Bioscience. 10, 12, p. 1544-1556 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm

Chen, F., Rice, K. C., Liu, X. M., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2010, In : Pharmaceutical Research. 27, 11, p. 2356-2364 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2009

Tooth-binding micelles for dental caries prevention

Chen, F., Liu, X. M., Rice, K. C., Li, X., Yu, F., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2009, In : Antimicrobial Agents and Chemotherapy. 53, 11, p. 4898-4902 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
2008

Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates

Pan, H., Sima, M., Kopečková, P., Wu, K., Gao, S., Liu, J., Wang, D., Miller, S. C. & Kopeček, J., Jul 2008, In : Molecular Pharmaceutics. 5, 4, p. 548-558 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E1 to promote bone formation in aged, estrogen-deficient rats

Miller, S. C., Pan, H., Wang, D., Bowman, B. M., Kopečková, P. & Kopeček, J., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2889-2895 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Osteotropic β-cyclodextrin for local bone regeneration

Liu, X. M., Wiswall, A. T., Rutledge, J. E., Akhter, M. P., Cullen, D. M., Reinhardt, R. A. & Wang, D., Apr 2008, In : Biomaterials. 29, 11, p. 1686-1692 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis

Liu, X. M., Quan, L. D., Tian, J., Alnouti, Y., Fu, K., Thiele, G. M. & Wang, D., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2910-2919 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Targeted delivery for musculoskeletal diseases

Wang, D., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2878-2880 3 p.

Research output: Contribution to journalArticle

2 Scopus citations