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20002020

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Article
2000

Synthesis of starlike N-(2-hydroxypropyl)methacrylamide copolymers: Potential drug carriers

Wang, D., Kopečková, P., Minko, T., Nanayakkara, V. & Kopeček, J., 2000, In : Biomacromolecules. 1, 3, p. 313-319 7 p.

Research output: Contribution to journalArticle

91 Scopus citations
2002

Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors

Wang, D., Pechar, M., Li, W., Kopečková, P., Brömme, D. & Kopeček, J., Jul 16 2002, In : Biochemistry. 41, 28, p. 8849-8859 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Novel aromatic azo-containing pH-sensitive hydrogels: Synthesis and characterization

Wang, D., Dušek, K., Kopečková, P., Dušková-Smrčková, M. & Kopeček, J., Sep 24 2002, In : Macromolecules. 35, 20, p. 7791-7803 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
2003

Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems

Wang, D., Miller, S., Sima, M., Kopečková, P. & Kopeček, J., Sep 2003, In : Bioconjugate Chemistry. 14, 5, p. 853-859 7 p.

Research output: Contribution to journalArticle

137 Scopus citations
2004

Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

Wang, D., Li, W., Pechar, M., Kopečková, P., Brömme, D. & Kopeček, J., Jun 11 2004, In : International journal of pharmaceutics. 277, 1-2, p. 73-79 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: A preliminary study

Wang, D., Miller, S. C., Sima, M., Parker, D., Buswell, H., Goodrich, K. C., Kopečková, P. & Kopeček, J., Oct 2004, In : Pharmaceutical Research. 21, 10, p. 1741-1749 9 p.

Research output: Contribution to journalArticle

50 Scopus citations
2005

Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics

Miller, S. C., Wang, D., Kopečková, P. & Kopeček, J., Jan 2005, In : Journal of Bone and Mineral Metabolism. 23, SUPPL. 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2006

Pharmacokinetic and biodistribution studies of a bone-targeting drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers

Wang, D., Sima, M., Mosley, R. L., Davda, J. P., Tietze, N., Miller, S. C., Gwilt, P. R., Kopečková, P. & Kopeček, J., Nov 2006, In : Molecular Pharmaceutics. 3, 6, p. 717-725 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels

Chivukula, P., Dušek, K., Wang, D., Dušková-Smršková, M., Kopečková, P. & Kopeček, J., Mar 2006, In : Biomaterials. 27, 7, p. 1140-1151 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Water-soluble HPMA copolymer - Prostaglandin E1 conjugates containing a cathepsin K sensitive spacer

Pan, H., Kopečková, P., Wang, D., Yang, J., Miller, S. & Kopeček, J., Jul 2006, In : Journal of Drug Targeting. 14, 6, p. 425-435 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2007

Efficient synthesis of linear multifunctional poly(ethylene glycol) by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition

Liu, X. M., Thakur, A. & Wang, D., Sep 2007, In : Biomacromolecules. 8, 9, p. 2653-2658 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity

Liu, X. M., Lee, H. T., Reinhardt, R. A., Marky, L. A. & Wang, D., Sep 11 2007, In : Journal of Controlled Release. 122, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis

Wang, D., Miller, S. C., Liu, X. M., Anderson, B., Wang, X. S. & Goldring, S. R., 2007, In : Arthritis Research and Therapy. 9, R2.

Research output: Contribution to journalArticle

97 Scopus citations

Osteotropic peptide that differentiates functional domains of the skeleton

Wang, D., Miller, S. C., Shlyakhtenko, L. S., Portillo, A. M., Liu, X. M., Papangkorn, K., Kopečková, P., Lyubchenko, Y., Higuchi, W. I. & Kopeček, J., Sep 2007, In : Bioconjugate Chemistry. 18, 5, p. 1375-1378 4 p.

Research output: Contribution to journalArticle

71 Scopus citations

Stability in plasmas of various species of HPMA copolymer-PGE1 conjugates

Pan, H., Kopečková, P., Liu, J., Wang, D., Miller, S. C. & Kopeček, J., Dec 2007, In : Pharmaceutical Research. 24, 12, p. 2270-2280 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2008

Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates

Pan, H., Sima, M., Kopečková, P., Wu, K., Gao, S., Liu, J., Wang, D., Miller, S. C. & Kopeček, J., Jul 2008, In : Molecular Pharmaceutics. 5, 4, p. 548-558 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Feasibility of using a bone-targeted, macromolecular delivery system coupled with prostaglandin E1 to promote bone formation in aged, estrogen-deficient rats

Miller, S. C., Pan, H., Wang, D., Bowman, B. M., Kopečková, P. & Kopeček, J., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2889-2895 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Osteotropic β-cyclodextrin for local bone regeneration

Liu, X. M., Wiswall, A. T., Rutledge, J. E., Akhter, M. P., Cullen, D. M., Reinhardt, R. A. & Wang, D., Apr 2008, In : Biomaterials. 29, 11, p. 1686-1692 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis

Liu, X. M., Quan, L. D., Tian, J., Alnouti, Y., Fu, K., Thiele, G. M. & Wang, D., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2910-2919 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

Targeted delivery for musculoskeletal diseases

Wang, D., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2878-2880 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
2009

Tooth-binding micelles for dental caries prevention

Chen, F., Liu, X. M., Rice, K. C., Li, X., Yu, F., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2009, In : Antimicrobial Agents and Chemotherapy. 53, 11, p. 4898-4902 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2010

Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

Quan, L. D., Purdue, P. E., Liu, X. M., Boska, M. D., Lele, S. M., Thiele, G. M., Mikuls, T. R., Dou, H., Goldring, S. R. & Wang, D., Sep 13 2010, In : Arthritis Research and Therapy. 12, 5, R170.

Research output: Contribution to journalArticle

44 Scopus citations

Pharmacokinetic and biodistribution studies of N -(2-hydroxypropyl) methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model

Quan, L. D., Yuan, F., Liu, X. M., Huang, J. G., Alnouti, Y. & Wang, D., Aug 2 2010, In : Molecular Pharmaceutics. 7, 4, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Syntheses of click PEG-dexamethasone conjugates for the treatment of rheumatoid arthritis

Liu, X. M., Quan, L. D., Tian, J., Laquer, F. C., Ciborowski, P. & Wang, D., Oct 11 2010, In : Biomacromolecules. 11, 10, p. 2621-2628 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

The Synthesis of a Multiblock Osteotropic Polyrotaxane by Copper(I)-Catalyzed Huisgen 1,3-Dipolar Cycloaddition

Hein, C. D., Liu, X. M., Chen, F., Cullen, D. M. & Wang, D., 2010, In : Macromolecular Bioscience. 10, 12, p. 1544-1556 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm

Chen, F., Rice, K. C., Liu, X. M., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2010, In : Pharmaceutical Research. 27, 11, p. 2356-2364 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2011

Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates

Ren, K., Purdue, P. E., Burton, L., Quan, L. D., Fehringer, E. V., Thiele, G. M., Goldring, S. R. & Wang, D., Aug 1 2011, In : Molecular Pharmaceutics. 8, 4, p. 1043-1051 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2012
16 Scopus citations

Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects

Yuan, F., Nelson, R. K., Tabor, D. E., Zhang, Y., Akhter, M. P., Gould, K. A. & Wang, D., Dec 2012, In : Arthritis and rheumatism. 64, 12, p. 4029-4039 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

Crielaard, B. J., Rijcken, C. J. F., Quan, L., Van Der Wal, S., Altintas, I., Van Der Pot, M., Kruijtzer, J. A. W., Liskamp, R. M. J., Schiffelers, R. M., Van Nostrum, C. F., Hennink, W. E., Wang, D., Lammers, T. & Storm, G., Jul 16 2012, In : Angewandte Chemie - International Edition. 51, 29, p. 7254-7258 5 p.

Research output: Contribution to journalArticle

79 Scopus citations

Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects

Killeen, A. C., Rakes, P. A., Schmid, M. J., Zhang, Y., Narayana, N., Marx, D. B., Payne, J. B., Wang, D. & Reinhardt, R. A., Dec 2012, In : Journal of periodontology. 83, 12, p. 1463-1471 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Prevention of orthopedic device-associated osteomyelitis using oxacillin-containing biomineral-binding liposomes

Liu, X. M., Zhang, Y., Chen, F., Khutsishvili, I., Fehringer, E. V., Marky, L. A., Bayles, K. W. & Wang, D., Nov 2012, In : Pharmaceutical Research. 29, 11, p. 3169-3179 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis

Yuan, F., Tabor, D. E., Nelson, R. K., Yuan, H., Zhang, Y., Nuxoll, J., Bynoté, K. K., Lele, S. M., Wang, D. & Gould, K. A., Nov 28 2013, In : PloS one. 8, 11, e81483.

Research output: Contribution to journalArticle

11 Scopus citations

Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss

Price, U., Le, H. O. T., Powell, S. E., Schmid, M. J., Marx, D. B., Zhang, Y., Wang, D., Narayana, N. & Reinhardt, R. A., Oct 2013, In : Journal of Periodontal Research. 48, 5, p. 541-548 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

The development of dentotropic micelles with biodegradable tooth-binding moieties

Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2013, In : Pharmaceutical Research. 30, 11, p. 2808-2817 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Early diagnosis of orthopedic implant failure using macromolecular imaging agents

Ren, K., Dusad, A., Zhang, Y., Purdue, P. E., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Aug 2014, In : Pharmaceutical Research. 31, 8, p. 2086-2094 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
6 Scopus citations

Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects

Ren, K., Dusad, A., Yuan, F., Yuan, H., Purdue, P. E., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Feb 10 2014, In : Journal of Controlled Release. 175, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Nanomedicines for inflammatory arthritis: Head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes

Quan, L., Zhang, Y., Crielaard, B. J., Dusad, A., Lele, S. M., Rijcken, C. J. F., Metselaar, J. M., Kostková, H., Etrych, T., Ulbrich, K., Kiessling, F., Mikuls, T. R., Hennink, W. E., Storm, G., Lammers, T. & Wang, D., Jan 28 2014, In : ACS Nano. 8, 1, p. 458-466 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

The development of drug-free therapy for prevention of dental caries

Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2014, In : Pharmaceutical Research. 31, 11, p. 3031-3037 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015
8 Scopus citations

Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats

Knudsen, M., Bury, M., Holwegner, C., Reinhardt, A. L., Yuan, F., Zhang, Y., Giannini, P., Marx, D. B., Wang, D. & Reinhardt, R. A., Sep 24 2015, In : Arthritis Research and Therapy. 17, 1, 267.

Research output: Contribution to journalArticle

3 Scopus citations

Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis

Ren, K., Yuan, H., Zhang, Y., Wei, X. & Wang, D., Sep 1 2015, In : Clinical Immunology. 160, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pluronics-Formulated farnesol promotes efficient killing and demonstrates novel interactions with streptococcus mutans biofilms

Mogen, A. B., Chen, F., Ahn, S. J., Burne, R. A., Wang, D. & Rice, K. C., Jul 29 2015, In : PloS one. 10, 7, e0133886.

Research output: Contribution to journalArticle

13 Scopus citations

Simvastatin prodrug micelles target fracture and improve healing

Jia, Z., Zhang, Y., Chen, Y. H., Dusad, A., Yuan, H., Ren, K., Li, F., Fehringer, E. V., Purdue, P. E., Goldring, S. R., Daluiski, A. & Wang, D., Feb 28 2015, In : Journal of Controlled Release. 200, p. 23-34 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Vitamin D supplementation protects against bone loss following inhalant organic dust and lipopolysaccharide exposures in mice

Dusad, A., Thiele, G. M., Klassen, L. W., Wang, D., Duryee, M. J., Mikuls, T. R., Staab, E. B., Wyatt, T. A., West, W. W., Reynolds, S. J., Romberger, D. & Poole, J. A., May 1 2015, In : Immunologic Research. 62, 1, p. 46-59 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Effect of simvastatin prodrug on experimental periodontitis

Bradley, A. D., Zhang, Y., Jia, Z., Zhao, G., Wang, X., Pranke, L., Schmid, M. J., Wang, D. & Reinhardt, R. A., May 2016, In : Journal of periodontology. 87, 5, p. 577-582 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

The Evaluation of Therapeutic Efficacy and Safety Profile of Simvastatin Prodrug Micelles in a Closed Fracture Mouse Model

Zhang, Y., Jia, Z., Yuan, H., Dusad, A., Ren, K., Wei, X., Fehringer, E. V., Purdue, P. E., Daluiski, A., Goldring, S. R. & Wang, D., Aug 1 2016, In : Pharmaceutical Research. 33, 8, p. 1959-1971 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model

Quan, L., Zhang, Y., Dusad, A., Ren, K., Purdue, P. E., Goldring, S. R. & Wang, D., Jan 1 2016, In : Pharmaceutical Research. 33, 1, p. 186-193 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Toll-like receptor 4 signaling pathway mediates inhalant organic dust-induced bone loss

Staab, E., Thiele, G. M., Clarey, D., Wyatt, T. A., Romberger, D., Wells, A. D., Dusad, A., Wang, D., Klassen, L. W., Mikuls, T. R., Duryee, M. J. & Poole, J. A., Aug 1 2016, In : PloS one. 11, 8, e0158735.

Research output: Contribution to journalArticle

4 Scopus citations