Edward N Harris

  • 1136 Citations
  • 18 h-Index
19992020

Research output per year

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Research Output

  • 1136 Citations
  • 18 h-Index
  • 40 Article
  • 3 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2020

Sex Differences in the Reward-Enhancing Effects of Nicotine on Ethanol Reinforcement: A Reinforcer Demand Analysis

Barrett, S. T., Thompson, B. M., Emory, J. R., Larsen, C. E., Pittenger, S. T., Harris, E. N. & Bevins, R. A., Feb 6 2020, In : Nicotine and Tobacco Research. 22, 2, p. 238-247 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

A Panel of Protein Kinase Chemosensors Distinguishes Different Types of Fatty Liver Disease

Beck, J. R., Cabral, F., Rasineni, K., Casey, C. A., Harris, E. N. & Stains, C. I., Sep 17 2019, In : Biochemistry. 58, 37, p. 3911-3917 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
4 Scopus citations

Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue

Natarajan, G., Perriotte-Olson, C., Casey, C. A., Donohue, T. M., Talmon, G. A., Harris, E. N., Kabanov, A. V. & Saraswathi, V., Sep 2019, In : Alcohol. 79, p. 71-79 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Ligand binding and signaling of HARE/Stabilin-2

Harris, E. N. & Cabral, F., Jul 2019, In : Biomolecules. 9, 7, 273.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

3-O sulfation of heparin leads to hepatotropism and longer circulatory half-life

Miller, C. M., Xu, Y., Kudrna, K. M., Hass, B. E., Kellar, B. M., Egger, A. W., Liu, J. & Harris, E. N., Jul 2018, In : Thrombosis Research. 167, p. 80-87 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors

Srivastava, T., Diba, P., Dean, J. M., Banine, F., Shaver, D., Hagen, M., Gong, X., Su, W., Emery, B., Marks, D. L., Harris, E. N., Baggenstoss, B., Weigel, P. H., Sherman, L. S. & Back, S. A., May 1 2018, In : Journal of Clinical Investigation. 128, 5, p. 2025-2041 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 during Endosomal Maturation

Miller, C. M., Wan, W. B., Seth, P. P. & Harris, E. N., Apr 2018, In : Nucleic Acid Therapeutics. 28, 2, p. 86-96 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

Pirie, E., Ray, S., Pan, C., Fu, W., Powers, A. F., Polikoff, D., Miller, C. M., Kudrna, K. M., Harris, E. N., Lusis, A. J., Crooke, R. M. & Lee, R. G., Oct 2018, In : PLoS genetics. 14, 10, e1007732.

Research output: Contribution to journalArticle

3 Scopus citations

Purification of hepatocytes and sinusoidal endothelial cells from mouse liver perfusion

Cabral, F., Miller, C. M., Kudrna, K. M., Hass, B. E., Daubendiek, J. G., Kellar, B. M. & Harris, E. N., Feb 12 2018, In : Journal of Visualized Experiments. 2018, 132, e56993.

Research output: Contribution to journalArticle

12 Scopus citations

Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver

Miller, C. M., Tanowitz, M., Donner, A. J., Prakash, T. P., Swayze, E. E., Harris, E. N. & Seth, P. P., Jun 2018, In : Nucleic Acid Therapeutics. 28, 3, p. 119-127 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Single-Molecule Unbinding Forces between the Polysaccharide Hyaluronan and Its Binding Proteins

Bano, F., Tammi, M. I., Kang, D. W., Harris, E. N. & Richter, R. P., Jun 19 2018, In : Biophysical journal. 114, 12, p. 2910-2922 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor

Gaus, H., Miller, C. M., Seth, P. P. & Harris, E. N., Apr 10 2018, In : Biochemistry. 57, 14, p. 2061-2064 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Hyaluronan synthase control of synthesis rate and hyaluronan product size are independent functions differentially affected by mutations in a conserved tandem B-X7-B motif

Baggenstoss, B. A., Harris, E. N., Washburn, J. L., Medina, A. P., Nguyen, L. & Weigel, P. H., 2017, In : Glycobiology. 27, 1, p. 154-164 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Activation of ERK and NF-κB during HARE-mediated heparin uptake require only one of the four endocytic motifs

Pandey, M. S., Miller, C. M., Harris, E. N. & Weigel, P. H., Apr 2016, In : PloS one. 11, 4, e0154124.

Research output: Contribution to journalArticle

5 Scopus citations
8 Scopus citations

Interrogating Endogenous Protein Phosphatase Activity with Rationally Designed Chemosensors

Beck, J. R., Lawrence, A., Tung, A. S., Harris, E. N. & Stains, C. I., Jan 15 2016, In : ACS chemical biology. 11, 1, p. 284-290 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

Miller, C. M., Donner, A. J., Blank, E. E., Egger, A. W., Kellar, B. M., Østergaard, M. E., Seth, P. P. & Harris, E. N., Feb 22 2016, In : Nucleic acids research. 44, 6, p. 2782-2794 13 p.

Research output: Contribution to journalArticle

55 Scopus citations
2015

HARE-mediated endocytosis of hyaluronan and heparin is targeted by different subsets of three endocytic motifs

Pandey, M. S., Harris, E. N. & Weigel, P. H., 2015, In : International Journal of Cell Biology. 2015, 524707.

Research output: Contribution to journalArticle

7 Scopus citations

In vivo selection to identify bacterial strains with enhanced ecological performance in synbiotic applications

Krumbeck, J. A., Maldonado-Gomez, M. X., Martínez, I., Frese, S. A., Burkey, T. E., Rasineni, K., Ramer-Tait, A. E., Harris, E. N., Hutkins, R. W. & Walter, J., 2015, In : Applied and environmental microbiology. 81, 7, p. 2455-2465 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
9 Scopus citations
2014

Homogeneous low-molecular-weight heparins with reversible anticoagulant activity

Xu, Y., Cai, C., Chandarajoti, K., Hsieh, P. H., Li, L., Pham, T. Q., Sparkenbaugh, E. M., Sheng, J., Key, N. S., Pawlinski, R., Harris, E. N., Linhardt, R. J. & Liu, J., Apr 2014, In : Nature Chemical Biology. 10, 4, p. 248-250 3 p.

Research output: Contribution to journalArticle

111 Scopus citations
2012

Probing structural selectivity of synthetic heparin binding to stabilin protein receptors

Pempe, E. H., Xu, Y., Gopalakrishnan, S., Liu, J. & Harris, E. N., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20774-20783 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2011

In vivo liver endocytosis followed by purification of liver cells by liver perfusion

Gopalakrishnan, S. & Harris, E. N., Nov 2011, In : Journal of Visualized Experiments. 57, e3138.

Research output: Contribution to journalArticle

14 Scopus citations
2010

N-Glycans on the link domain of human HARE/Stabilin-2 are needed for hyaluronan binding to purified ecto-domain, but not for cellular endocytosis of hyaluronan

Harris, E. N., Parry, S., Sutton-Smith, M., Pandey, M. S., Panico, M., Morris, H. R., Haslam, S. M., Dell, A. & Weigel, P. H., Apr 14 2010, In : Glycobiology. 20, 8, p. 991-1001 11 p., cwq057.

Research output: Contribution to journalArticle

13 Scopus citations
2009

Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins

Harris, E. N., Baggenstoss, B. A. & Weigel, P. H., Jun 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 6, p. G1191-G1199

Research output: Contribution to journalArticle

28 Scopus citations
2008

The cytoplasmic domain of the hyaluronan receptor for endocytosis (hare) contains multiple endocytic motifs targeting coated pit-mediated internalization

Pandey, M. S., Harris, E. N., Weigel, J. A. & Weigel, P. H., Aug 1 2008, In : Journal of Biological Chemistry. 283, 31, p. 21453-21461 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

The human hyaluronan receptor for endocytosis (HARE/stabilin-2) is a systemic clearance receptor for heparin

Harris, E. N., Weigel, J. A. & Weigel, P. H., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17341-17350 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases

Kyosseva, S. V., Harris, E. N. & Weigel, P. H., May 30 2008, In : Journal of Biological Chemistry. 283, 22, p. 15047-15055 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
60 Scopus citations
2007

Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa Hyaluronic Acid Receptor for Endocytosis (HARE)

Harris, E. N., Kyosseva, S. V., Weigel, J. A. & Weigel, P. H., Jan 2 2007, In : Journal of Biological Chemistry. 282, 5, p. 2785-2797 13 p.

Research output: Contribution to journalArticle

91 Scopus citations
2004

Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE)

Harris, E. N., Weigel, J. A. & Weigel, P. H., Aug 27 2004, In : Journal of Biological Chemistry. 279, 35, p. 36201-36209 9 p.

Research output: Contribution to journalArticle

56 Scopus citations
2003

RacB regulates cytoskeletal function in Dictyostelium spp.

Lee, E., Seastone, D. J., Harris, E., Cardelli, J. A. & Knecht, D. A., Jun 2003, In : Eukaryotic Cell. 2, 3, p. 474-485 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
2002

Dictyostelium LvsB mutants model the lysosomal defects associated with Chediak-Higashi syndrome

Harris, E., Wang, N., Wu, W. L., Weatherford, A., De Lozanne, A. & Cardelli, J., 2002, In : Molecular biology of the cell. 13, 2, p. 656-669 14 p.

Research output: Contribution to journalArticle

56 Scopus citations

RabD, a Dictyostelium Rab14-related GTPase, regulates phagocytosis and homotypic phagosome and lysosome fusion

Harris, E. & Cardelli, J., Sep 15 2002, In : Journal of cell science. 115, 18, p. 3703-3713 11 p.

Research output: Contribution to journalArticle

51 Scopus citations
2001

Monoclonal light chain-mesangial cell interactions: Early signaling events and subsequent pathologic effects

Russell, W. J., Cardelli, J., Harris, E., Baier, R. J. & Herrera, G. A., May 2001, In : Laboratory Investigation. 81, 5, p. 689-703 15 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

Rab11-like GTPase associates with and regulates the structure and function of the contractile vacuole system in Dictyostelium

Harris, E., Yoshida, K., Cardelli, J. & Bush, J., 2001, In : Journal of cell science. 114, 16, p. 3035-3045 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

The WASp-like protein scar regulates macropinocytosis, phagocytosis and endosomal membrane flow in Dictyostelium

Seastone, D. J., Harris, E., Temesvari, L. A., Bear, J. E., Saxe, C. L. & Cardelli, J., 2001, In : Journal of cell science. 114, 14, p. 2673-2683 11 p.

Research output: Contribution to journalArticle

51 Scopus citations
1999

Early and late endosomal compartments of Entamoeba histolytica are enriched in cysteine proteases, acid phosphatase and several Ras-related Rab GTPases

Temesvari, L. A., Harris, E. N., Stanley, S. L. & Cardelli, J. A., Oct 15 1999, In : Molecular and Biochemical Parasitology. 103, 2, p. 225-241 17 p.

Research output: Contribution to journalArticle

46 Scopus citations