• 2746 Citations
  • 29 h-Index
1978 …2017

Research output per year

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Research Output

  • 2746 Citations
  • 29 h-Index
  • 78 Article
  • 2 Conference contribution
  • 2 Review article
  • 1 Comment/debate
2017

Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis

Bennett, R. G., Simpson, R. L. & Hamel, F. G., Jun 14 2017, In : World Journal of Gastroenterology. 23, 22, p. 3999-4006 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Tacrolimus and sirolimus have distinct effects on insulin signaling in male and female rats

Shivaswamy, V., Bennett, R. G., Clure, C. C., Ottemann, B., Davis, J. S., Larsen, J. L. & Hamel, F. G., Mar 2014, In : Translational Research. 163, 3, p. 221-231 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2013

Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats

Shivaswamy, V., Bennett, R. G., Clure, C. C., Larsen, J. L. & Hamel, F. G., Jan 27 2013, In : Transplantation. 95, 2, p. 280-284 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Gene expression of vitamin d metabolic enzymes at baseline and in response to vitamin d treatment in thyroid cancer cell lines

Bennett, R. G., Wakeley, S. E., Hamel, F. G., High, R. R., Korch, C. & Goldner, W. S., Sep 2012, In : Oncology (Switzerland). 83, 5, p. 264-272 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011
1 Scopus citations

Redox regulation of insulin degradation by insulin-degrading enzyme

Cordes, C. M., Bennett, R. G., Siford, G. L. & Hamel, F. G., 2011, In : PloS one. 6, 3, e18138.

Research output: Contribution to journalArticle

19 Scopus citations

Role of inflammation and insulin resistance in endothelial progenitor cell dysfunction

Desouza, C. V., Hamel, F. G., Bidasee, K. & O'Connell, K., Apr 2011, In : Diabetes. 60, 4, p. 1286-1294 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Tacrolimus and sirolimus induce reproductive abnormalities in female rats

Shivaswamy, V., Ochsner, L., Maroni, D., Wang, C., Passer, J., Clure, C. E., Hamel, F. G., Davis, J. S. & Larsen, J., Jun 27 2011, In : Transplantation. 91, 12, p. 1333-1339 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

Hyperglycemia induced by tacrolimus and sirolimus is reversible in normal sprague-dawley rats

Shivaswamy, V., McClure, M., Passer, J., Frahm, C., Ochsner, L., Erickson, J., Bennett, R. G., Hamel, F. G. & Larsen, J. L., Jun 2010, In : Endocrine. 37, 3, p. 489-496 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Insulin degrading enzyme induces a conformational change in varicella-zoster virus gE, and enhances virus infectivity and stability

Li, Q., Ali, M. A., Wang, K., Sayre, D., Hamel, F. G., Fischer, E. R., Bennett, R. G. & Cohen, J. I., 2010, In : PloS one. 5, 6, e11327.

Research output: Contribution to journalArticle

12 Scopus citations

Telomeres and type 2 diabetes

Hamel, F. G., Apr 2010, In : Translational Research. 155, 4, p. 164-165 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations
2009

Degradation of relaxin family peptides by insulin-degrading enzyme

Bennett, R. G., Heimann, D. G. & Hamel, F. G., Apr 2009, Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., p. 38-41 4 p. (Annals of the New York Academy of Sciences; vol. 1160).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Effects of a PPAR-gamma agonist, on growth factor and insulin stimulated endothelial cells

Desouza, C. V., Gerety, M. & Hamel, F. G., Aug 2009, In : Vascular Pharmacology. 51, 2-3, p. 162-168 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation

Cordes, C. M., Bennett, R. G., Siford, G. L. & Hamel, F. G., Mar 15 2009, In : Biochemical Pharmacology. 77, 6, p. 1064-1073 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Preliminary report: inhibition of cellular proteasome activity by free fatty acids

Hamel, F. G., Aug 2009, In : Metabolism: Clinical and Experimental. 58, 8, p. 1047-1049 3 p.

Research output: Contribution to journalArticle

20 Scopus citations
2007
12 Scopus citations

Relaxin receptors in hepatic stellate cells and cirrhotic liver

Bennett, R. G., Dalton, S. R., Mahan, K. J., Gentry-Nielsen, M. J., Hamel, F. G. & Tuma, D. J., Apr 1 2007, In : Biochemical Pharmacology. 73, 7, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
2006

Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells

Hamel, F. G., Fawcett, J., Tsui, B. T., Bennett, R. G. & Duckworth, W. C., Nov 2006, In : Diabetes, Obesity and Metabolism. 8, 6, p. 661-668 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
16 Scopus citations

Tacrolimus and sirolimus cause insulin resistance in normal Sprague Dawley rats

Larsen, J. L., Bennett, R. G., Burkman, T., Ramirez, A. L., Yamamoto, S., Gulizia, J., Radio, S. & Hamel, F. G., Aug 2006, In : Transplantation. 82, 4, p. 466-470 5 p.

Research output: Contribution to journalArticle

62 Scopus citations
2005

Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines

Freeman, T. L., Haver, A., Duryee, M. J., Tuma, D. J., Klassen, L. W., Hamel, F. G., White, R. L., Rennard, S. I. & Thiele, G. M., May 2005, In : Chemical Research in Toxicology. 18, 5, p. 817-824 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2004

Biological activity of a fragment of insulin

Duckworth, W. C., Fawcett, J., Tsui, B. T., Bennett, R. G. & Hamel, F. G., Jun 11 2004, In : Biochemical and Biophysical Research Communications. 318, 4, p. 1019-1024 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Control of proteolysis: Hormones, nutrients, and the changing role of the proteasome

Hamel, F. G., Fawcett, J., Bennett, R. G. & Duckworth, W. C., May 2004, In : Current Opinion in Clinical Nutrition and Metabolic Care. 7, 3, p. 255-258 4 p.

Research output: Contribution to journalReview article

17 Scopus citations

Effects of chronic alcohol consumption on dermal penetration of pesticides in rats

Brand, R. M., Charron, A. R., Dutton, L., Gavlik, T. L., Mueller, C., Hamel, F. G., Chakkalakal, D. & Donohue, T. M., Jan 2004, In : Journal of Toxicology and Environmental Health - Part A. 67, 2, p. 153-161 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2003
77 Scopus citations

Inhibition of proteasome activity by selected amino acids

Hamel, F. G., Upward, J. L., Siford, G. L. & Duckworth, W. C., Jul 1 2003, In : Metabolism: Clinical and Experimental. 52, 7, p. 810-814 5 p.

Research output: Contribution to journalArticle

37 Scopus citations

Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors

Hamel, F. G., Fawcett, J., Andersen, C. I., Berhanu, P., Bennett, R. G. & Duckworth, W. C., Nov 2003, In : Journal of Endocrinological Investigation. 26, 11, p. 1088-1094 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme

Bennett, R. G., Fawcett, J., Kruer, M. C., Duckworth, W. C. & Hamel, F. G., Jun 1 2003, In : Journal of Endocrinology. 177, 3, p. 399-405 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters

Hamel, F. G., Upward, J. L. & Bennett, R. G., Jun 1 2003, In : Endocrinology. 144, 6, p. 2404-2408 5 p.

Research output: Contribution to journalArticle

53 Scopus citations
2002

Relaxin stimulates bronchial epithelial cell PKA activation, migration, and ciliary beating

Wyatt, T. A., Sisson, J. H., Forgèt, M. A., Bennett, R. G., Hamel, F. G. & Spurzem, J. R., Dec 2002, In : Experimental Biology and Medicine. 227, 11, p. 1047-1053 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2001

Characterization of the inhibition of protein degradation by insulin in L6 cells

Fawcett, J., Hamel, F. G. & Duckworth, W. C., Jan 15 2001, In : Archives of Biochemistry and Biophysics. 385, 2, p. 357-363 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Insulin and analogue effects on protein degradation in different cell types. Dissociation between binding and activity

Fawcett, J., Hamel, F. G., Bennett, R. G., Vajo, Z. & Duckworth, W. C., Apr 13 2001, In : Journal of Biological Chemistry. 276, 15, p. 11552-11558 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes

Hamel, F. G., Bennett, R. G., Upward, J. L. & Duckworth, W. C., 2001, In : Endocrinology. 142, 6, p. 2702-2706 5 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations
2000

A combination of iontophoresis and the chelating agent 1,10 phenanthroline act synergistically as penetration enhancers

Brand, R. M., Hannah, T. L. & Hamel, F. G., 2000, In : AAPS Journal. 2, 4, p. xv-xvi

Research output: Contribution to journalArticle

A combination of iontophoresis and the chelating agent 1,10 phenanthroline act synergistically as penetration enhancers

Brand, R. M., Hannah, T. L. & Hamel, F. G., 2000, In : AAPS PharmSci. 2, 4, p. 1-5 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Degradation of amylin by insulin-degrading enzyme

Bennett, R. G., Duckworth, W. C. & Hamel, F. G., Nov 24 2000, In : Journal of Biological Chemistry. 275, 47, p. 36621-36625 5 p.

Research output: Contribution to journalArticle

116 Scopus citations

Effects of paraventricular nucleus injection of CCK-8 on plasma CCK-8 levels in rats

Blevins, J. E., Hamel, F. G., Fairbairn, E., Stanley, B. G. & Reidelberger, R. D., Mar 31 2000, In : Brain Research. 860, 1-2, p. 11-20 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Insulin inhibits the ubiquitin-dependent degrading activity of the 26S proteasome

Bennett, R. G., Hamel, F. G. & Duckworth, W. C., 2000, In : Endocrinology. 141, 7, p. 2508-2517 10 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Novel system to study the impact of epithelial barriers on cellular metabolism

Brand, R. M., Hannah, T. L., Mueller, C., Cetin, Y. & Hamel, F. G., 2000, In : Annals of biomedical engineering. 28, 10, p. 1210-1217 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
1999

Differences in the cellular processing of Asp(B10) human insulin compared with human insulin and Lys(B28)Pro(B29) human insulin

Hamel, F. G., Siford, G. L., Fawcett, J., Chance, R. E., Frank, B. H. & Duckworth, W. C., 1999, In : Metabolism: Clinical and Experimental. 48, 5, p. 611-617 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Novel system to study dermal-hepatic interactions in vitro

Brand, R. M., Hannah, T. L. & Hamel, F. G., 1999, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. IEEE, 1 p. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Transdermally delivered peroxovanadium can lower blood glucose levels in diabetic rats

Brand, R. M. & Hamel, F. G., Jun 25 1999, In : International journal of pharmaceutics. 183, 2, p. 117-123 7 p.

Research output: Contribution to journalArticle

41 Scopus citations
1998

Insulin acts intracellularly on proteasomes through insulin-degrading enzyme

Duckworth, W. C., Bennett, R. G. & Hamel, F. G., Mar 17 1998, In : Biochemical and Biophysical Research Communications. 244, 2, p. 390-394 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Insulin degradation: Progress and potential

Duckworth, W. C., Bennett, R. G. & Hamel, F. G., 1998, In : Endocrine reviews. 19, 5, p. 608-624 17 p.

Research output: Contribution to journalReview article

586 Scopus citations

Regulation of multicatalytic enzyme activity by insulin and the insulin- degrading enzyme

Hamel, F. G., Bennett, R. G. & Duckworth, W. C., 1998, In : Endocrinology. 139, 10, p. 4061-4066 6 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations
1997

Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex

Bennett, R. G., Hamel, F. G. & Duckworth, W. C., Feb 1997, In : Diabetes. 46, 2, p. 197-203 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Identification of the cleavage sites of transforming growth factor α by insulin-degrading enzymes

Hamel, F. G., Gehm, B. D., Rosner, M. R. & Duckworth, W. C., Apr 4 1997, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1338, 2, p. 207-214 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Insulin inhibition of proteasome activity in intact cells

Hamel, F. G., Bennett, R. G., Harmon, K. S. & Duckworth, W. C., May 29 1997, In : Biochemical and Biophysical Research Communications. 234, 3, p. 671-674 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Intraendosomal degradation of transforming growth factor alpha

Hamel, F. G., Siford, G. L., Jones, J. & Duckworth, W. C., Feb 7 1997, In : Molecular and Cellular Endocrinology. 126, 2, p. 185-192 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Iontophoretic delivery of an insulin-mimetic peroxovanadium compound

Brand, R. M., Duensing, G. & Hamel, F. G., Jan 1 1997, In : International journal of pharmaceutics. 146, 1, p. 115-122 8 p.

Research output: Contribution to journalArticle

15 Scopus citations