Ghribi Othman, PhD

  • 3413 Citations
  • 36 h-Index
1992 …2019

Research output per year

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Research Output

27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer

Marwarha, G., Raza, S., Hammer, K. & Ghribi, O., Oct 2017, In : Chemistry and Physics of Lipids. 207, p. 108-126 19 p.

Research output: Contribution to journalReview article

17 Scopus citations

27-hydroxycholesterol decreases cell proliferation in colon cancer cell lines

Warns, J., Marwarha, G., Freking, N. & Ghribi, O., Oct 2018, In : Biochimie. 153, p. 171-180 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons

Schommer, J., Marwarha, G., Schommer, T., Flick, T., Lund, J. & Ghribi, O., Apr 3 2018, In : BMC Neuroscience. 19, 1, 17.

Research output: Contribution to journalArticle

3 Scopus citations

27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells

Raza, S., Meyer, M., Schommer, J., Hammer, K. D. P., Guo, B. & Ghribi, O., Feb 1 2016, In : Medical Oncology. 33, 2, p. 1-9 9 p., 12.

Research output: Contribution to journalArticle

12 Scopus citations

A Diet Enriched in Palmitate and Deficient in Linoleate Exacerbates Oxidative Stress and Amyloid-β Burden in the Hippocampus of 3xTg-AD Mouse Model of Alzheimer's Disease

Marwarha, G., Claycombe-Larson, K., Lund, J., Schommer, J. & Ghribi, O., Jan 1 2019, In : Journal of Alzheimer's Disease. 68, 1, p. 219-237 19 p.

Research output: Contribution to journalArticle

1 Scopus citations

Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment

Calon, F., Morissette, M., Ghribi, O., Goulet, M., Grondin, R., Blanchet, P. J., Bédard, P. J. & DiPaolo, T., Jan 18 2002, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 26, 1, p. 127-138 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Aluminium and neuronal cell injury: Inter-relationships between neurofilamentous arrays and apoptosis

Savory, J., Ghribi, O., Forbes, M. S. & Herman, M. M., Nov 21 2001, In : Journal of Inorganic Biochemistry. 87, 1, p. 15-19 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Aluminum-induced dendritic pathology revisited: Cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons

Forbes, M. S., Ghribi, O., Herman, M. M. & Savory, J., Feb 20 2002, In : Annals of Clinical and Laboratory Science. 32, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release

Griffioen, K. J. S., Ghribi, O., Fox, N., Savory, J. & Dewitt, D. A., Sep 1 2004, In : NeuroToxicology. 25, 5, p. 859-867 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

AMPA receptor regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice

Valastro, B., Ghribi, O., Poirier, J., Krzywkowski, P. & Massicotte, G., May 2 2001, In : Neurobiology of Aging. 22, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Aβ(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of gadd 153 and NF-κB

Ghribi, O., Herman, M. M., DeWitt, D. A., Forbes, M. S. & Savory, J., Nov 30 2001, In : Molecular Brain Research. 96, 1-2, p. 30-38 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Aβ(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau

Ghribi, O., Prammonjago, P., Herman, M. M., Spaulding, N. K. & Savory, J., Nov 26 2003, In : Molecular Brain Research. 119, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Blockers of NMDA‐operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats

Ghribi, O., Callebert, J., Verrecchia, C., Plotkine, M. & Boulu, RG., Jan 1 1995, In : Fundamental & Clinical Pharmacology. 9, 2, p. 141-146 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits

Wu, M., Audet, A., Cusic, J., Seeger, D., Cochran, R. & Ghribi, O., Nov 1 2009, In : Journal of Neurochemistry. 111, 4, p. 1011-1021 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

Chen, X., Gawryluk, J. W., Wagener, J. F., Ghribi, O. & Geiger, J. D., Apr 3 2008, In : Journal of Neuroinflammation. 5, 12.

Research output: Contribution to journalArticle

95 Scopus citations
75 Scopus citations

Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet

Prasanthi, J. R. P., Dasari, B., Marwarha, G., Larson, T., Chen, X., Geiger, J. D. & Ghribi, O., Oct 1 2010, In : Free Radical Biology and Medicine. 49, 7, p. 1212-1220 9 p.

Research output: Contribution to journalArticle

99 Scopus citations
13 Scopus citations

Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity

Gongol, B., Marin, T. L., Jeppson, J. D., Mayagoitia, K., Shin, S., Sanchez, N., Kirsch, W. M., Vinters, H. V., Wilson, C. G., Ghribi, O. & Soriano, S., Dec 1 2017, In : Scientific reports. 7, 1, 13898.

Research output: Contribution to journalArticle

3 Scopus citations

Cellular model of Alzheimer's disease - Relevance to therapeutic testing

Marwarha, G. & Ghribi, O., Feb 1 2012, In : Experimental Neurology. 233, 2, p. 733-739 7 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina

Dasari, B., Prasanthi, J. R., Marwarha, G., Singh, B. B. & Ghribi, O., Aug 22 2011, In : BMC Ophthalmology. 11, 1, 22.

Research output: Contribution to journalArticle

37 Scopus citations

Cholesterol-enriched diet disrupts the blood-testis barrier in rabbits

Morgan, D. H., Ghribi, O., Hui, L., Geiger, J. D. & Chen, X., Dec 15 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 307, 12, p. E1125-E1130

Research output: Contribution to journalArticle

14 Scopus citations

Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice

Krzywkowski, P., Ghribi, O., Gagné, J., Chabot, C., Kar, S., Rochford, J., Massicotte, G. & Poirier, J., Jun 1 1999, In : Neuroscience. 92, 4, p. 1273-1286 14 p.

Research output: Contribution to journalArticle

61 Scopus citations

Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: Changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits

Ghribi, O., DeWitt, D. A., Forbes, M. S., Herman, M. M. & Savory, J., Jun 8 2001, In : Brain Research. 903, 1-2, p. 66-73 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia

Ghribi, O., Callebert, J., Plotkine, M. & Boulu, R. G., Jun 1994, In : NeuroReport. 5, 10, p. 1253-1255 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Controle de qualite des monodoses de 7 principes actifs

Translated title of the contribution: Quality control of 7 drugs unit dosesFeldman, D., Ghribi, O., Ouary, J., Dumortier, G., Degrassat, K. & Leverge, R., Dec 1 1998, In : Journal de Pharmacie Clinique. 17, 4, p. 268-271 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits

Ghribi, O., Dewitt, D. A., Forbes, M. S., Arad, A., Herman, M. M. & Savory, J., Jan 1 2001, In : Journal of Alzheimer's Disease. 3, 4, p. 387-391 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet

Prasanthi, J. R. P., Schrag, M., Dasari, B., Marwarha, G., Dickson, A., Kirsch, W. M. & Ghribi, O., 2012, In : Journal of Alzheimer's Disease. 30, 1, p. 167-182 16 p.

Research output: Contribution to journalArticle

32 Scopus citations

Deposition of iron and β-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets

Ghribi, O., Golovko, M. Y., Larsen, B., Schrag, M. & Murphy, E. J., Oct 1 2006, In : Journal of Neurochemistry. 99, 2, p. 438-449 12 p.

Research output: Contribution to journalArticle

105 Scopus citations

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells

Rantham Prabhakara, J. P., Feist, G., Thomasson, S., Thompson, A., Schommer, E. & Ghribi, O., Dec 1 2008, In : Journal of Neurochemistry. 107, 6, p. 1722-1729 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

Prasanthi, J. R. P., Huls, A., Thomasson, S., Thompson, A., Schommer, E. & Ghribi, O., Mar 18 2009, In : Molecular neurodegeneration. 4, 1, 1.

Research output: Contribution to journalArticle

88 Scopus citations

Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells

Dasari, B., Prasanthi, J. R. P., Meiers, C., Singh, B. B. & Ghribi, O., Nov 1 2013, In : Current Eye Research. 38, 11, p. 1159-1171 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

DISPENSATION DE LA CLOZAPINE AU CHS DE VILLE-EVRARD: DESCRIPTION DE SEPT EFFETS INDESIRABLES HEMATOLOGIQUES

Translated title of the contribution: Dispensing clozapine at the specialized hospital of Ville-Evrard: Report of seven hematological side effectsBeaudeux, C., Dumortier, G., Ghribi, O. & Degrassat, K., Dec 1 1993, In : Journal de Pharmacie Clinique. 12, 4, p. 312-313 2 p.

Research output: Contribution to journalArticle

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?

Marwarha, G. & Ghribi, O., Aug 1 2015, In : Experimental Gerontology. 68, p. 13-18 6 p.

Research output: Contribution to journalReview article

38 Scopus citations

Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum

Ghribi, O., Callebert, J., Plotkine, M. & Boulu, R. G., Jan 1994, In : NeuroReport. 5, 4, p. 435-437 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Elevated clozapine plasma concentrations after fluvoxamine initiation [12]

Dumortier, G., Lochu, A., De Melo, P. C., Ghribi, O., Rabreau, D. R., Degrassat, K. & Desce, J. M., May 14 1996, In : American Journal of Psychiatry. 153, 5, p. 738-739 2 p.

Research output: Contribution to journalLetter

35 Scopus citations

Endolysosome mechanisms associated with Alzheimer's disease-like pathology in rabbits ingesting cholesterol-enriched diet

Chen, X., Wagener, J. F., Morgan, D. H., Hui, L., Ghribi, O. & Geiger, J. D., 2010, In : Journal of Alzheimer's Disease. 22, 4, p. 1289-1303 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
35 Scopus citations

Epigenetics of inflammation, maternal infection, and nutrition

Claycombe, K. J., Brissette, C. A. & Ghribi, O., Jan 1 2015, In : Journal of Nutrition. 145, 5, p. 1109S-1115S

Research output: Contribution to journalArticle

26 Scopus citations

Erratum: Deposition of iron and β-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets (Journal of Neurochemistry (2006) 99, (435-449))

Ghribi, O., Golovko, M. Y., Larsen, B., Schrag, M. & Murphy, E. J., Oct 1 2007, In : Journal of Neurochemistry. 103, 1, p. 423-424 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Gadd153 and NF-κB Crosstalk Regulates 27-Hydroxycholesterol-Induced Increase in BACE1 and β-Amyloid Production in Human Neuroblastoma SH-SY5Y Cells

Marwarha, G., Raza, S., Prasanthi, J. R. P. & Ghribi, O., Aug 9 2013, In : PloS one. 8, 8, e70773.

Research output: Contribution to journalArticle

49 Scopus citations

GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation

Ghribi, O., Herman, M. M., Forbes, M. S., DeWitt, D. A. & Savory, J., Jan 1 2001, In : Neurobiology of Disease. 8, 5, p. 764-773 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

GDNF regulates the Aβ-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases

Ghribi, O., Herman, M. M., Pramoonjago, P., Spaulding, N. K. & Savory, J., Jul 1 2004, In : Neurobiology of Disease. 16, 2, p. 417-427 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

High cholesterol content in neurons increases BACE, β-amyloid, and phosphorylated tau levels in rabbit hippocampus

Ghribi, O., Larsen, B., Schrag, M. & Herman, M. M., Aug 1 2006, In : Experimental Neurology. 200, 2, p. 460-467 8 p.

Research output: Contribution to journalArticle

132 Scopus citations

Hippocampus of Ames dwarf mice is resistant to β-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels

Schrag, M., Sharma, S., Brown-Borg, H. & Ghribi, O., Mar 25 2008, In : Hippocampus. 18, 3, p. 239-244 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling

Sharma, S., Prasanthi R.P., J., Schommer, E., Feist, G. & Ghribi, O., Dec 1 2008, In : Neurobiology of Disease. 32, 3, p. 426-432 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Hypoxia-induced loss of synaptic transmission is exacerbated in hippocampal slices of transgenic mice expressing C-terminal fragments of Alzheimer amyloid precursor protein

Ghribi, O., Lapierre, L., Girard, M., Ohayon, M., Nalbantoglu, J. & Massicotte, G., Jul 12 1999, In : Hippocampus. 9, 3, p. 201-205 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of microRNAs involved in Alzheimer’s progression using a rabbit model of the disease

Liu, Q. Y., Chang, M. N. V., Lei, J. X., Koukiekolo, R., Smith, B., Zhang, D. & Ghribi, O., Jan 1 2014, In : American Journal of Neurodegenerative Diseases. 3, 1, p. 33-44 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice

Furling, D., Ghribi, O., Lahsaini, A., Mirault, M. E. & Massicotte, G., Apr 11 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 8, p. 4351-4356 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

IMPLICATION DE L'ACIDE GLUTAMIQUE ET DE L'ADENOSINE DANS LES CONSEQUENCES D'UNE ISCHEMIE TELENCEPHALIQUE CHEZ LE RAT

Translated title of the contribution: Involvement of glutamic acid and adenosine in the consequences of forebrain ischemia in the ratLekieffre, D., Ghribi, O., Callebert, J., Plotkine, M. & Boulu, R. G., Jan 1 1992, In : Circulation et Metabolisme du Cerveau. 9, 1, p. 31-46 16 p.

Research output: Contribution to journalArticle

2 Scopus citations