Ghribi Othman, PhD

  • 3413 Citations
  • 36 h-Index
1992 …2019

Research output per year

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Research Output

2008

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells

Rantham Prabhakara, J. P., Feist, G., Thomasson, S., Thompson, A., Schommer, E. & Ghribi, O., Dec 1 2008, In : Journal of Neurochemistry. 107, 6, p. 1722-1729 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Hippocampus of Ames dwarf mice is resistant to β-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels

Schrag, M., Sharma, S., Brown-Borg, H. & Ghribi, O., Mar 25 2008, In : Hippocampus. 18, 3, p. 239-244 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling

Sharma, S., Prasanthi R.P., J., Schommer, E., Feist, G. & Ghribi, O., Dec 1 2008, In : Neurobiology of Disease. 32, 3, p. 426-432 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
41 Scopus citations
19 Scopus citations

Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease

Jaya Prasanthi, R. P., Schommer, E., Thomasson, S., Thompson, A., Feist, G. & Ghribi, O., Nov 1 2008, In : Mechanisms of Ageing and Development. 129, 11, p. 649-655 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
2007
13 Scopus citations

Erratum: Deposition of iron and β-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets (Journal of Neurochemistry (2006) 99, (435-449))

Ghribi, O., Golovko, M. Y., Larsen, B., Schrag, M. & Murphy, E. J., Oct 1 2007, In : Journal of Neurochemistry. 103, 1, p. 423-424 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2006

Deposition of iron and β-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets

Ghribi, O., Golovko, M. Y., Larsen, B., Schrag, M. & Murphy, E. J., Oct 1 2006, In : Journal of Neurochemistry. 99, 2, p. 438-449 12 p.

Research output: Contribution to journalArticle

105 Scopus citations

High cholesterol content in neurons increases BACE, β-amyloid, and phosphorylated tau levels in rabbit hippocampus

Ghribi, O., Larsen, B., Schrag, M. & Herman, M. M., Aug 1 2006, In : Experimental Neurology. 200, 2, p. 460-467 8 p.

Research output: Contribution to journalArticle

132 Scopus citations

Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease

Savory, J., Herman, M. M. & Ghribi, O., Jan 1 2006, In : Journal of Alzheimer's Disease. 10, 2-3, p. 135-144 10 p.

Research output: Contribution to journalReview article

82 Scopus citations

Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis

DeWitt, D. A., Hurd, J. A., Fox, N., Townsend, B. E., Griffioen, K. J. S., Ghribi, O. & Savory, J., Jan 1 2006, In : Journal of Alzheimer's Disease. 9, 2, p. 195-205 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
6 Scopus citations

Supplementation of the diet with silicic acid to reduce body burden of aluminum: A miracle cure or useless treatment for Alzheimer's disease?

Savory, J., Herman, M. M. & Ghribi, O., Jan 1 2006, In : Journal of Alzheimer's Disease. 10, 1, p. 25-27 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

The role of the endoplasmic reticulum in the accumulation of β-amyloid peptide in Alzheimer's disease

Ghribi, O., Feb 1 2006, In : Current Molecular Medicine. 6, 1, p. 119-133 15 p.

Research output: Contribution to journalReview article

37 Scopus citations
2004

Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release

Griffioen, K. J. S., Ghribi, O., Fox, N., Savory, J. & Dewitt, D. A., Sep 1 2004, In : NeuroToxicology. 25, 5, p. 859-867 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

GDNF regulates the Aβ-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases

Ghribi, O., Herman, M. M., Pramoonjago, P., Spaulding, N. K. & Savory, J., Jul 1 2004, In : Neurobiology of Disease. 16, 2, p. 417-427 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
2003

Aβ(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau

Ghribi, O., Prammonjago, P., Herman, M. M., Spaulding, N. K. & Savory, J., Nov 26 2003, In : Molecular Brain Research. 119, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain

Savory, J., Herman, M. M. & Ghribi, O., Sep 15 2003, In : Journal of Inorganic Biochemistry. 97, 1, p. 151-154 4 p.

Research output: Contribution to journalArticle

89 Scopus citations
61 Scopus citations

MPP+ Induces the Endoplasmic Reticulum Stress Response in Rabbit Brain Involving Activation of the ATF-6 and NF-κB Signaling Pathways

Ghribi, O., Herman, M. M., Pramoonjago, P. & Savory, J., Nov 2003, In : Journal of Neuropathology and Experimental Neurology. 62, 11, p. 1144-1153 10 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations
2002

Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment

Calon, F., Morissette, M., Ghribi, O., Goulet, M., Grondin, R., Blanchet, P. J., Bédard, P. J. & DiPaolo, T., Jan 18 2002, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 26, 1, p. 127-138 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Aluminum-induced dendritic pathology revisited: Cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons

Forbes, M. S., Ghribi, O., Herman, M. M. & Savory, J., Feb 20 2002, In : Annals of Clinical and Laboratory Science. 32, 1, p. 75-86 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Is amyloid β-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?

Savory, J., Ghribi, O. & Herman, M. M., Nov 1 2002, In : Neurobiology of Aging. 23, 6, p. 1089-1092 4 p.

Research output: Contribution to journalComment/debate

10 Scopus citations

Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation

Ghribi, O., Herman, M. M., Spaulding, N. K. & Savory, J., Jul 22 2002, In : Journal of Neurochemistry. 82, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus

Ghribi, O., Herman, M. M. & Savory, J., May 24 2002, In : Neuroscience Letters. 324, 3, p. 217-221 5 p.

Research output: Contribution to journalArticle

34 Scopus citations
2001

Aluminium and neuronal cell injury: Inter-relationships between neurofilamentous arrays and apoptosis

Savory, J., Ghribi, O., Forbes, M. S. & Herman, M. M., Nov 21 2001, In : Journal of Inorganic Biochemistry. 87, 1, p. 15-19 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

AMPA receptor regulation and LTP in the hippocampus of young and aged apolipoprotein E-deficient mice

Valastro, B., Ghribi, O., Poirier, J., Krzywkowski, P. & Massicotte, G., May 2 2001, In : Neurobiology of Aging. 22, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Aβ(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of gadd 153 and NF-κB

Ghribi, O., Herman, M. M., DeWitt, D. A., Forbes, M. S. & Savory, J., Nov 30 2001, In : Molecular Brain Research. 96, 1-2, p. 30-38 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: Changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits

Ghribi, O., DeWitt, D. A., Forbes, M. S., Herman, M. M. & Savory, J., Jun 8 2001, In : Brain Research. 903, 1-2, p. 66-73 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits

Ghribi, O., Dewitt, D. A., Forbes, M. S., Arad, A., Herman, M. M. & Savory, J., Jan 1 2001, In : Journal of Alzheimer's Disease. 3, 4, p. 387-391 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation

Ghribi, O., Herman, M. M., Forbes, M. S., DeWitt, D. A. & Savory, J., Jan 1 2001, In : Neurobiology of Disease. 8, 5, p. 764-773 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

Ovarian steroids and selective estrogen receptor modulators activity on rat brain NMDA and AMPA receptors

Cyr, M., Ghribi, O., Thibault, C., Morissette, M., Landry, M. & Di Paolo, T., Dec 1 2001, In : Brain Research Reviews. 37, 1-3, p. 153-161 9 p.

Research output: Contribution to journalArticle

128 Scopus citations
2000

Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice

Furling, D., Ghribi, O., Lahsaini, A., Mirault, M. E. & Massicotte, G., Apr 11 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 8, p. 4351-4356 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Regional and selective effects of oestradiol and progesterone on NMDA and AMPA receptors in the rat brain

Cyr, M., Ghribi, O. & Di Paolo, T., May 9 2000, In : Journal of Neuroendocrinology. 12, 5, p. 445-452 8 p.

Research output: Contribution to journalArticle

94 Scopus citations
1999

Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice

Krzywkowski, P., Ghribi, O., Gagné, J., Chabot, C., Kar, S., Rochford, J., Massicotte, G. & Poirier, J., Jun 1 1999, In : Neuroscience. 92, 4, p. 1273-1286 14 p.

Research output: Contribution to journalArticle

61 Scopus citations

Hypoxia-induced loss of synaptic transmission is exacerbated in hippocampal slices of transgenic mice expressing C-terminal fragments of Alzheimer amyloid precursor protein

Ghribi, O., Lapierre, L., Girard, M., Ohayon, M., Nalbantoglu, J. & Massicotte, G., Jul 12 1999, In : Hippocampus. 9, 3, p. 201-205 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
1998

Controle de qualite des monodoses de 7 principes actifs

Translated title of the contribution: Quality control of 7 drugs unit dosesFeldman, D., Ghribi, O., Ouary, J., Dumortier, G., Degrassat, K. & Leverge, R., Dec 1 1998, In : Journal de Pharmacie Clinique. 17, 4, p. 268-271 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
1996

Elevated clozapine plasma concentrations after fluvoxamine initiation [12]

Dumortier, G., Lochu, A., De Melo, P. C., Ghribi, O., Rabreau, D. R., Degrassat, K. & Desce, J. M., May 14 1996, In : American Journal of Psychiatry. 153, 5, p. 738-739 2 p.

Research output: Contribution to journalLetter

35 Scopus citations
1995

Blockers of NMDA‐operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats

Ghribi, O., Callebert, J., Verrecchia, C., Plotkine, M. & Boulu, RG., Jan 1 1995, In : Fundamental & Clinical Pharmacology. 9, 2, p. 141-146 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
1994

Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia

Ghribi, O., Callebert, J., Plotkine, M. & Boulu, R. G., Jun 1994, In : NeuroReport. 5, 10, p. 1253-1255 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum

Ghribi, O., Callebert, J., Plotkine, M. & Boulu, R. G., Jan 1994, In : NeuroReport. 5, 4, p. 435-437 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

l-NAME modulates glutamate accumulation induced by K+-depolarization but not by forebrain ischaemia in the rat striatum

Ghribi, O., Callebert, J., Plotkine, M. & Boulu, R. G., Jun 6 1994, In : Neuroscience Letters. 174, 1, p. 34-38 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
1993

DISPENSATION DE LA CLOZAPINE AU CHS DE VILLE-EVRARD: DESCRIPTION DE SEPT EFFETS INDESIRABLES HEMATOLOGIQUES

Translated title of the contribution: Dispensing clozapine at the specialized hospital of Ville-Evrard: Report of seven hematological side effectsBeaudeux, C., Dumortier, G., Ghribi, O. & Degrassat, K., Dec 1 1993, In : Journal de Pharmacie Clinique. 12, 4, p. 312-313 2 p.

Research output: Contribution to journalArticle

1992

IMPLICATION DE L'ACIDE GLUTAMIQUE ET DE L'ADENOSINE DANS LES CONSEQUENCES D'UNE ISCHEMIE TELENCEPHALIQUE CHEZ LE RAT

Translated title of the contribution: Involvement of glutamic acid and adenosine in the consequences of forebrain ischemia in the ratLekieffre, D., Ghribi, O., Callebert, J., Plotkine, M. & Boulu, R. G., Jan 1 1992, In : Circulation et Metabolisme du Cerveau. 9, 1, p. 31-46 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia

Lekieffre, D., Ghribi, O., Callebert, J., Allix, M., Plotkine, M. & Boulu, R. G., Oct 2 1992, In : Brain Research. 592, 1-2, p. 333-337 5 p.

Research output: Contribution to journalArticle

16 Scopus citations