• 1719 Citations
  • 23 h-Index
19962019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1719 Citations
  • 23 h-Index
  • 34 Article
  • 3 Review article
2019

PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response

Simhadri, S., Vincelli, G., Huo, Y., Misenko, S., Foo, T. K., Ahlskog, J., Sørensen, C. S., Oakley, G. G., Ganesan, S., Bunting, S. F. & Xia, B., Mar 7 2019, In : Oncogene. 38, 10, p. 1585-1596 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
10 Scopus citations
2018

Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress

Wang, F., Zhu, S., Fisher, L. A., Wang, W., Oakley, G. G., Li, C. & Peng, A., Dec 1 2018, In : Scientific reports. 8, 1, 2683.

Research output: Contribution to journalArticle

3 Scopus citations
2017

S4S8-RPA phosphorylation as an indicator of cancer progression in oral squamous cell carcinomas

Rector, J., Kapil, S., Treude, K. J., Kumm, P., Glanzer, J. G., Byrne, B. M., Liu, S., Smith, L. M., DiMaio, D. J., Giannini, P., Smith, R. B. & Oakley, G. G., Jan 1 2017, In : Oncotarget. 8, 6, p. 9243-9250 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Identification of inhibitors for single-stranded DNA-binding proteins in eubacteria

Glanzer, J. G., Endres, J. L., Byrne, B. M., Liu, S., Bayles, K. W. & Oakley, G. G., Jan 1 2016, In : Journal of Antimicrobial Chemotherapy. 71, 12, p. 3432-3440 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

In silico and in vitro methods to identify ebola virus VP35-dsRNA inhibitors

Glanzer, J. G., Byrne, B. M., McCoy, A. M., James, B. J., Frank, J. D. & Oakley, G. G., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5388-5392 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

Kijas, A. W., Lim, Y. C., Bolderson, E., Cerosaletti, K., Gatei, M., Jakob, B., Tobias, F., Taucher-Scholz, G., Gueven, N., Oakley, G., Concannon, P., Wolvetang, E., Khanna, K. K., Wiesmüller, L. & Lavin, M. F., Sep 30 2015, In : Nucleic acids research. 43, 17, p. 8352-8367 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

Phosphorylation and cellular function of the human Rpa2 N-terminus in the budding yeast Saccharomyces cerevisiae

Ghospurkar, P. L., Wilson, T. M., Liu, S., Herauf, A., Steffes, J., Mueller, E. N., Oakley, G. G. & Haring, S. J., Feb 1 2015, In : Experimental Cell Research. 331, 1, p. 183-199 17 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe

Ashley, A. K., Shrivastav, M., Nie, J., Amerin, C., Troksa, K., Glanzer, J. G., Liu, S., Opiyo, S. O., Dimitrova, D. D., Le, P., Sishc, B., Bailey, S. M., Oakley, G. G. & Nickoloff, J. A., Sep 2014, In : DNA Repair. 21, p. 131-139 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Interplay of DNA damage and cell cycle signaling at the level of human replication protein A

Borgstahl, G. E. O., Brader, K., Mosel, A., Liu, S., Kremmer, E., Goettsch, K. A., Kolar, C., Nasheuer, H. P. & Oakley, G. G., Sep 2014, In : DNA Repair. 21, p. 12-23 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

RPA inhibition increases replication stress and suppresses tumor growth

Glanzer, J. G., Liu, S., Wang, L., Mosel, A., Peng, A. & Oakley, G. G., Jul 28 2014, In : Cancer Research. 74, 18, p. 5165-5172 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2013

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A

Glanzer, J. G., Carnes, K. A., Soto, P., Liu, S., Parkhurst, L. J. & Oakley, G. G., Feb 1 2013, In : Nucleic acids research. 41, 3, p. 2047-2059 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer

Wang, L., Mosel, A. J., Oakley, G. G. & Peng, A., Nov 1 2012, In : Molecular cancer therapeutics. 11, 11, p. 2401-2409 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

Liu, S., Opiyo, S. O., Manthey, K., Glanzer, J. G., Ashley, A. K., Amerin, C., Troksa, K., Shrivastav, M., Nickoloff, J. A. & Oakley, G. G., Nov 1 2012, In : Nucleic acids research. 40, 21, p. 10780-10794 15 p.

Research output: Contribution to journalArticle

125 Scopus citations

Transforming growth factor-β activates c-Myc to promote palatal growth

Zhu, X., Ozturk, F., Liu, C., Oakley, G. G. & Nawshad, A., Oct 1 2012, In : Journal of Cellular Biochemistry. 113, 10, p. 3069-3085 17 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Hyaluronan suppresses prostate tumor cell proliferation through diminished expression of N-cadherin and aberrant growth factor receptor signaling

Bharadwaj, A. G., Goodrich, N. P., McAtee, C. O., Haferbier, K., Oakley, G. G., Wahl, J. K. & Simpson, M. A., May 1 2011, In : Experimental Cell Research. 317, 8, p. 1214-1225 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods

Glanzer, J. G., Liu, S. & Oakley, G. G., Apr 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 8, p. 2589-2595 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2010

Helicobacter hepaticus cytolethal distending toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway

Liyanage, N. P. M., Manthey, K. C., Dassanayake, R. P., Kuszynski, C. A., Oakley, G. G. & Duhamel, G. E., Apr 1 2010, In : Helicobacter. 15, 2, p. 98-107 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines

Manthey, K. C., Glanzer, J. G., Dimitrova, D. D. & Oakley, G. G., May 1 2010, In : Head and Neck. 32, 5, p. 636-645 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Replication protein A: Directing traffic at the intersection of replication and repair

Oakley, G. G. & Patrick, S. M., Jun 1 2010, In : Frontiers in Bioscience. 15, 3, p. 883-900 18 p.

Research output: Contribution to journalReview article

113 Scopus citations
2009

Human replication protein A-Rad52-single-stranded DNA complex: Stoichiometry and evidence for strand transfer regulation by phosphorylation

Deng, X., Prakash, A., Dhar, K., Baia, G. S., Kolar, C., Oakley, G. G. & Borgstahl, G. E. O., Jul 21 2009, In : Biochemistry. 48, 28, p. 6633-6643 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Physical interaction between replication protein A (RPA) and MRN: Involvement of RPA2 phosphorylation and the N-terminus of RPA1

Oakley, G. G., Tillison, K., Opiyo, S. A., Glanzer, J. G., Horn, J. M. & Patrick, S. M., Aug 11 2009, In : Biochemistry. 48, 31, p. 7473-7481 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing

Bharadwaj, A. G., Kovar, J. L., Loughman, E., Elowsky, C., Oakley, G. G. & Simpson, M. A., Mar 2009, In : American Journal of Pathology. 174, 3, p. 1027-1036 10 p.

Research output: Contribution to journalArticle

100 Scopus citations
2007

NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse

Manthey, K. C., Opiyo, S., Glanzer, J. G., Dimitrova, D., Elliott, J. & Oakley, G. G., Dec 1 2007, In : Journal of cell science. 120, 23, p. 4221-4229 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2006

UV-induced RPA phosphorylation is increased in the absence of DNA polymerase η and requires DNA-PK

Cruet-Hennequart, S., Coyne, S., Glynn, M. T., Oakley, G. G. & Carty, M. P., Apr 8 2006, In : DNA Repair. 5, 4, p. 491-504 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
2005

DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage

Nuss, J. E., Patrick, S. M., Oakley, G. G., Alter, G. M., Robison, J. G., Dixon, K. & Turchi, J. J., Jun 14 2005, In : Biochemistry. 44, 23, p. 8428-8437 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair

Patrick, S. M., Oakley, G. G., Dixon, K. & Turchi, J. J., Jun 14 2005, In : Biochemistry. 44, 23, p. 8438-8448 11 p.

Research output: Contribution to journalArticle

48 Scopus citations
2004

Replication protein A and the Mre11·Rad50·Nbs1 complex co-localize and interact at sites of stalled replication forks

Robison, J. G., Elliott, J., Dixon, K. & Oakley, G. G., Aug 13 2004, In : Journal of Biological Chemistry. 279, 33, p. 34802-34810 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes

Shertzer, H. G., Clay, C. D., Genter, M. B., Chames, M. C., Schneider, S. N., Oakley, G. G., Nebert, D. W. & Dalton, T. P., Mar 1 2004, In : Free Radical Biology and Medicine. 36, 5, p. 618-631 14 p.

Research output: Contribution to journalArticle

47 Scopus citations
2003

RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions

Oakley, G. G., Patrick, S. M., Yao, J., Carty, M. P., Turchi, J. J. & Dixon, K., Mar 25 2003, In : Biochemistry. 42, 11, p. 3255-3264 10 p.

Research output: Contribution to journalArticle

92 Scopus citations
2002

NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: A HuGE review

Nebert, D. W., Roe, A. L., Vandale, S. E., Bingham, E. & Oakley, G. G., Mar 1 2002, In : Genetics in Medicine. 4, 2, p. 62-70 9 p.

Research output: Contribution to journalReview article

148 Scopus citations
2001

Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts

Li, Y., Carty, M. P., Oakley, G. G., Seidman, M. M., Medvedovic, M. & Dixon, K., Jan 1 2001, In : Environmental and Molecular Mutagenesis. 37, 2, p. 128-140 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein

Oakley, G. G., Loberg, L. I., Yao, J., Risinger, M. A., Yunker, R. L., Zernik-Kobak, M., Khanna, K. K., Lavin, M. F., Carty, M. P. & Dixon, K., Jan 1 2001, In : Molecular biology of the cell. 12, 5, p. 1199-1213 15 p.

Research output: Contribution to journalArticle

78 Scopus citations

XPA protein alters the specificity of ultraviolet light-induced mutagenesis in vitro

King, N. M., Oakley, G. G., Medvedovic, M. & Dixon, K., Jul 24 2001, In : Environmental and Molecular Mutagenesis. 37, 4, p. 329-339 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
1996

Analysis of polychlorinated biphenyl-DNA adducts by 32P-postlabeling

Oakley, G. G., Robertson, L. W. & Gupta, R. C., Jan 1996, In : Carcinogenesis. 17, 1, p. 109-114 6 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Metabolic activation of PCBs to quinones: Reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase

Amaro, A. R., Oakley, G. G., Bauer, U., Peter Spielmann, H. & Robertson, L. W., Apr 1 1996, In : Chemical Research in Toxicology. 9, 3, p. 623-629 7 p.

Research output: Contribution to journalArticle

118 Scopus citations

Oxidative dna damage induced by activation of polychlorinated biphenyls (pcbs): Implications for pcb-induced oxidative stress in breast cancer

Oakley, G. G., Devanaboyina, D., Robertson, L. W. & Gupta, R. C., Dec 14 1996, In : Chemical Research in Toxicology. 9, 8, p. 1285-1292 8 p.

Research output: Contribution to journalArticle

149 Scopus citations