Haizhen Andrew Zhong, PhD

  • 851 Citations
  • 17 h-Index
20042020

Research output per year

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Research Output

  • 851 Citations
  • 17 h-Index
  • 37 Article
  • 4 Review article
  • 3 Editorial
  • 2 Chapter
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Article
2020

Ligand-based design of GLUT inhibitors as potential antitumor agents

Almahmoud, S., Jin, W., Geng, L., Wang, J., Wang, X., Vennerstrom, J. L. & Zhong, H. A., Apr 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 7, 115395.

Research output: Contribution to journalArticle

2019

Conformational studies of glucose transporter 1 (GLUT1) as an anticancer drug target

Almahmoud, S., Wang, X., Vennerstrom, J. L. & Zhong, H. A., Jun 7 2019, In : Molecules. 24, 11, 2159.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts

Daszynski, D. M., Santhoshkumar, P., Phadte, A. S., Sharma, K. K., Zhong, H. A., Lou, M. F. & Kador, P. F., Dec 1 2019, In : Scientific reports. 9, 1, 8459.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Ligand-based drug design: Synthesis and biological evaluation of substituted benzoin derivatives as potential antitumor agents

Sabbah, D. A., Ibrahim, A. H., Talib, W. H., Alqaisi, K. M., Sweidan, K., Bardaweel, S. K., Sheikha, G. A., Zhong, H. A., Al-Shalabi, E., Khalaf, R. A. & Mubarak, M. S., 2019, In : Medicinal Chemistry. 15, 4, p. 417-429 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular modeling studies on the binding mode of the PD-1/PD-L1 complex inhibitors

Almahmoud, S. & Zhong, H. A., Sep 2 2019, In : International journal of molecular sciences. 20, 18, 4654.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Benzoin schiff bases: Design, synthesis, and biological evaluation as potential antitumor agents

Sabbah, D. A., Al-Tarawneh, F., Talib, W. H., Sweidan, K., Bardaweel, S. K., Al-Shalabi, E., Zhong, H. A., Sheikha, G. A., Khalaf, R. A. & Mubarak, M. S., 2018, In : Medicinal Chemistry. 14, 7, p. 695-708 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Free-Energy-Based Protein Design: Re-Engineering Cellular Retinoic Acid Binding Protein II Assisted by the Moveable-Type Approach

Zhong, H. A., Santos, E. M., Vasileiou, C., Zheng, Z., Geiger, J. H., Borhan, B. & Merz, K. M., Mar 14 2018, In : Journal of the American Chemical Society. 140, 10, p. 3483-3486 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structure-based design: Synthesis, X-ray crystallography, and biological evaluation of N-substituted-4-hydroxy-2-quinolone-3-carboxamides as potential cytotoxic agents

Sabbah, D. A., Hishmah, B., Sweidan, K., Bardaweel, S., AlDamen, M., Zhong, H. A., Khalaf, R. A., Hasan Ibrahim, A., Al-Qirim, T., Abu Sheikha, G. & Mubarak, M. S., 2018, In : Anti-Cancer Agents in Medicinal Chemistry. 18, 2, p. 263-276 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

The simple system of fixing CO2 to synthesize benzimidazolones at atmospheric pressure

Cao, X., Zhong, H. A., Zhang, P. & Zheng, H., Mar 2018, In : Journal of CO2 Utilization. 24, p. 250-255 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

Kumar, V., Chaudhary, A. K., Dong, Y., Zhong, H. A., Mondal, G., Lin, F., Kumar, V. & Mahato, R. I., Dec 1 2017, In : Scientific reports. 7, 1, 1665.

Research output: Contribution to journalArticle

14 Scopus citations

Simple synthesis of endophenazine G and other phenazines and their evaluation as anti-methicillin-resistant Staphylococcus aureus agents

Conda-Sheridan, M., Udumula, V., Endres, J. L., Harper, C. N., Jaramillo, L., Zhong, H. A. & Bayles, K. W., 2017, In : European Journal of Medicinal Chemistry. 125, p. 710-721 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Drug design targeting the CXCR4/CXCR7/CXCL12 pathway

Xu, D., Li, R., Wu, J., Jiang, L. & Zhong, H. A., May 1 2016, In : Current Topics in Medicinal Chemistry. 16, 13, p. 1441-1451 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Methionine aminopeptidase type-2 inhibitors targeting angiogenesis

Ehlers, T., Furness, S., Robinson, T. P., Zhong, H. A., Goldsmith, D., Aribser, J. & Bowen, J. P., May 1 2016, In : Current Topics in Medicinal Chemistry. 16, 13, p. 1478-1488 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
15 Scopus citations

Perspectives in medicinal chemistry: The evolution of medicinal chemistry

Phillip Bowen, J. & Zhong, H. A., Jan 1 2016, In : Current Topics in Medicinal Chemistry. 16, 9, p. 897-898 2 p.

Research output: Contribution to journalArticle

2014

Molecular phylogeny and evolutionary dynamics of influenza A nonstructural (NS) gene

Xu, J., Zhong, H. A., Madrahimov, A., Helikar, T. & Lu, G., Mar 2014, In : Infection, Genetics and Evolution. 22, p. 192-200 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Selectivity, binding affinity, and ionization state of matrix metalloproteinase inhibitors

Zhong, H. A., Arbiser, J. & Bowen, J. P., 2013, In : Current Pharmaceutical Design. 19, 26, p. 4701-4713 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Synthesis and self-assembly of triphenylene-containing conjugated macrocycles

Dutta, T., Che, Y., Zhong, H., Laity, J. H., Dusevich, V., Murowchick, J. B., Zang, L. & Peng, Z., May 7 2013, In : RSC Advances. 3, 17, p. 6008-6015 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Understanding the molecular properties and metabolism of top prescribed drugs

Zhong, H. A., Mashinson, V., Woolman, T. A. & Zha, M., 2013, In : Current Topics in Medicinal Chemistry. 13, 11, p. 1290-1307 18 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Binding selectivity studies of phosphoinositide 3-kinases using free energy calculations

Sabbah, D. A., Vennerstrom, J. L. & Zhong, H. A., Dec 21 2012, In : Journal of Chemical Information and Modeling. 52, 12, p. 3213-3224 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases

Sabbah, D. A., Simms, N. A., Brattain, M. G., Vennerstrom, J. L. & Zhong, H., Jan 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 2, p. 876-880 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
3 Scopus citations

Evolutionary history and phylodynamics of influenza A and B neuraminidase (NA) genes inferred from large-scale sequence analyses

Xu, J., Davis, C. T., Christman, M. C., Rivailler, P., Zhong, H., Donis, R. O. & Lu, G., Jul 11 2012, In : PloS one. 7, 7, e38665.

Research output: Contribution to journalArticle

24 Scopus citations

N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)

Sabbah, D. A., Simms, N. A., Wang, W., Dong, Y., Ezell, E. L., Brattain, M. G., Vennerstrom, J. L. & Zhong, H. A., Dec 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 24, p. 7175-7183 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Synthesis and optical properties of perylene diimide derivatives with triphenylene-based dendrons linked at the bay positions through a conjugated ethynyl linkage

Bagui, M., Dutta, T., Zhong, H., Li, S., Chakraborty, S., Keightley, A. & Peng, Z., Apr 1 2012, In : Tetrahedron. 68, 13, p. 2806-2818 13 p.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Dual inhibitors of PI3K/mTOR or mTOR-selective inhibitors: Which way shall we go?

Sabbah, D. A., Brattain, M. G. & Zhong, H., Dec 2011, In : Current medicinal chemistry. 18, 36, p. 5528-5544 17 p.

Research output: Contribution to journalArticle

42 Scopus citations

Synthesis and optical properties of triphenylene-based dendritic donor perylene diimide acceptor systems

Bagui, M., Dutta, T., Chakraborty, S., Melinger, J. S., Zhong, H., Keightley, A. & Peng, Z., Mar 10 2011, In : Journal of Physical Chemistry A. 115, 9, p. 1579-1592 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

The impact of ionization states of matrix metalloproteinase inhibitors on docking-based inhibitor design

Zhong, H., Wees, M. A., Faure, T. D., Carrillo, C., Arbiser, J. & Bowen, J. P., Jun 9 2011, In : ACS Medicinal Chemistry Letters. 2, 6, p. 455-460 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2010

Docking studies on isoform-specific inhibition of phosphoinositide-3- kinases

Sabbah, D. A., Vennerstrom, J. L. & Zhong, H., Oct 25 2010, In : Journal of Chemical Information and Modeling. 50, 10, p. 1887-1898 12 p.

Research output: Contribution to journalArticle

44 Scopus citations
2009

Induced-fit docking studies of the active and inactive states of protein tyrosine kinases

Zhong, H., Tran, L. M. & Stang, J. L., Nov 2009, In : Journal of Molecular Graphics and Modelling. 28, 4, p. 336-346 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
2008

Binding free energy calculation for duocarmycin/DNA complex based on the QPLD-derived partial charge model

Zhong, H., Kirschner, K. N., Lee, M. & Bowen, J. P., Jan 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 2, p. 542-545 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2007

Small molecule inhibitors of the MDM2-p53 interaction discovered by ensemble-based receptor models

Bowman, A. L., Nikolovska-Coleska, Z., Zhong, H., Wang, S. & Carlson, H. A., Oct 24 2007, In : Journal of the American Chemical Society. 129, 42, p. 12809-12814 6 p.

Research output: Contribution to journalArticle

114 Scopus citations
2006

Conformational studies of polyprolines

Zhong, H. & Carlson, H. A., 2006, In : Journal of Chemical Theory and Computation. 2, 2, p. 342-353 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
2005

Ab initio and DFT conformational studies of propanal, 2-butanone, and analogous imines and enamines

Zhong, H., Stewart, E. L., Kontoyianni, M. & Bowen, J. P., 2005, In : Journal of Chemical Theory and Computation. 1, 2, p. 230-238 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Computational studies and peptidomimetic design for the human p53-MDM2 complex

Zhong, H. & Carlson, H. A., Jan 1 2005, In : Proteins: Structure, Function and Genetics. 58, 1, p. 222-234 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Theoretical study of stereoselective reduction controlled by NADH analogs

Zhong, H. & Bowen, J. P., Sep 2005, In : Journal of Molecular Graphics and Modelling. 24, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2004

Structure and dynamics of a predicted ferredoxin-like selenoprotein in Japanese encephalitis virus

Zhong, H. & Taylor, E. W., Dec 2004, In : Journal of Molecular Graphics and Modelling. 23, 3, p. 223-231 9 p.

Research output: Contribution to journalArticle

3 Scopus citations