Howard Eliot Gendelman, MD

Chairperson

  • 30009 Citations
  • 88 h-Index
1982 …2020

Research output per year

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Research Output

2020

Amplification of Replication Competent HIV-1 by Adoptive Transfer of Human Cells From Infected Humanized Mice

Su, H., Sravanam, S., Gorantla, S., Kaminski, R., Khalili, K., Poluektova, L., Gendelman, H. E. & Dash, P. K., Feb 11 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 38.

Research output: Contribution to journalArticle

Open Access

A year-long extended release nanoformulated cabotegravir prodrug

Kulkarni, T. A., Bade, A. N., Sillman, B., Shetty, B. L. D., Wojtkiewicz, M. S., Gautam, N., Hilaire, J. R., Sravanam, S., Szlachetka, A., Lamberty, B. G., Morsey, B. M., Fox, H. S., Alnouti, Y., McMillan, J. E. M., Mosley, R. L., Meza, J., Domanico, P. L., Yue, T. Y., Moore, G., Edagwa, B. J. & 1 others, Gendelman, H. E., Jan 1 2020, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

Immunotherapy for Parkinson's disease

Schwab, A. D., Thurston, M. J., Machhi, J., Olson, K. E., Namminga, K. L., Gendelman, H. E. & Mosley, R. L., Apr 2020, In : Neurobiology of Disease. 137, 104760.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Pathways towards human immunodeficiency virus elimination

Dash, P. K., Kevadiya, B. D., Su, H., Banoub, M. G. & Gendelman, H. E., Mar 2020, In : EBioMedicine. 53, 102667.

Research output: Contribution to journalReview article

Open Access

Predictive biomarkers for cognitive decline during progressive HIV infection

Gendelman, H. E., Jan 2020, In : EBioMedicine. 51, 102538.

Research output: Contribution to journalComment/debate

Open Access

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

Muraoka, S., DeLeo, A. M., Sethi, M. K., Yukawa-Takamatsu, K., Yang, Z., Ko, J., Hogan, J. D., Ruan, Z., You, Y., Wang, Y., Medalla, M., Ikezu, S., Chen, M., Xia, W., Gorantla, S., Gendelman, H. E., Issadore, D., Zaia, J. & Ikezu, T., Jan 1 2020, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Open Access

Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking

Mukadam, I. Z., Machhi, J., Herskovitz, J., Hasan, M., Oleynikov, M. D., Blomberg, W. R., Svechkarev, D., Mohs, A. M., Zhou, Y., Dash, P., McMillan, J. E., Gorantla, S., Garrison, J., Gendelman, H. E. & Kevadiya, B. D., Feb 2020, In : Biomaterials. 231, 119669.

Research output: Contribution to journalArticle

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues

Kevadiya, B. D., Ottemann, B., Mukadam, I. Z., Castellanos, L., Sikora, K., Hilaire, J. R., Machhi, J., Herskovitz, J., Soni, D., Hasan, M., Zhang, W., Anandakumar, S., Garrison, J., McMillan, J. E., Edagwa, B., Mosley, R. L., Vachet, R. W. & Gendelman, H. E., Jan 1 2020, In : Theranostics. 10, 2, p. 630-656 27 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Synthesis and Characterization of Long-Acting Darunavir Prodrugs

Banoub, M. G., Bade, A. N., Lin, Z., Cobb, D., Gautam, N., Dyavar Shetty, B. L., Wojtkiewicz, M., Alnouti, Y., McMillan, J., Gendelman, H. E. & Edagwa, B., Jan 6 2020, In : Molecular Pharmaceutics. 17, 1, p. 155-166 12 p.

Research output: Contribution to journalArticle

2019

A long acting nanoformulated lamivudine ProTide

Smith, N., Bade, A. N., Soni, D., Gautam, N., Alnouti, Y., Herskovitz, J., Ibrahim, I. M., Wojtkiewicz, M. S., Dyavar Shetty, B. L., McMillan, J. E., Gendelman, H. E. & Edagwa, B., Dec 2019, In : Biomaterials. 223, 119476.

Research output: Contribution to journalArticle

2 Scopus citations

A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease

Mosley, R. L., Lu, Y., Olson, K. E., Machhi, J., Yan, W., Namminga, K. L., Smith, J. R., Shandler, S. J. & Gendelman, H. E., Sep 18 2019, In : Frontiers in Cellular Neuroscience. 13, 421.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages

Saminathan, P., Kevadiya, B. D., Marker, D. F., Gendelman, H. E., Gorantla, S. & Gelbard, H. A., Mar 15 2019, In : Journal of Neuroimmune Pharmacology. 14, 1, p. 44-51 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Creation of a long-acting rilpivirine prodrug nanoformulation

Hilaire, J. R., Bade, A. N., Sillman, B., Gautam, N., Herskovitz, J., Dyavar Shetty, B. L., Wojtkiewicz, M. S., Szlachetka, A., Lamberty, B. G., Sravanam, S., Fox, H. S., Alnouti, Y., Dash, P. K., McMillan, J. E. M., Edagwa, B. J. & Gendelman, H. E., Oct 2019, In : Journal of Controlled Release. 311-312, p. 201-211 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

HIV and the Macrophage: From Cell Reservoirs to Drug Delivery to Viral Eradication

Herskovitz, J. & Gendelman, H. E., Mar 15 2019, In : Journal of Neuroimmune Pharmacology. 14, 1, p. 52-67 16 p.

Research output: Contribution to journalReview article

10 Scopus citations

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice

Mathews, S., Branch Woods, A., Katano, I., Makarov, E., Thomas, M. B., Gendelman, H. E., Poluektova, L. Y., Ito, M. & Gorantla, S., Mar 5 2019, In : Molecular neurodegeneration. 14, 1, 12.

Research output: Contribution to journalArticle

6 Scopus citations

Immune activations and viral tissue compartmentalization during progressive HIV-1 infection of humanized mice

Su, H., Cheng, Y., Sravanam, S., Mathews, S., Gorantla, S., Poluektova, L. Y., Dash, P. K. & Gendelman, H. E., Jan 1 2019, In : Frontiers in immunology. 10, FEB, 340.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

In Appreciation for a Job Well Done!

Gendelman, H. E. & Taylor, R., Mar 15 2019, In : Journal of Neuroimmune Pharmacology. 14, 1

Research output: Contribution to journalLetter

1 Scopus citations

Moving toward tuberculosis elimination critical issues for research in diagnostics and therapeutics for tuberculosis infection

Keshavjee, S., Amanullah, F., Cattamanchi, A., Chaisson, R., Dobos, K. M., Fox, G. J., Gendelman, H. E., Gordon, R., Hesseling, A., Le Van, H., Kampmann, B., Kana, B., Khuller, G., Lewinsohn, D. M., Lewinsohn, D. A., Lin, P. L., Lu, L. L., Maartens, G., Owen, A., Protopopova, M. & 12 others, Rengarajan, J., Rubin, E., Salgame, P., Schurr, E., Seddon, J. A., Swindells, S., Tobin, D. M., Udwadia, Z., Walzl, G., Srinivasan, S., Rustomjee, R. & Nahid, P., Mar 1 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 5, p. 564-571 8 p.

Research output: Contribution to journalReview article

2 Scopus citations

Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress

Montenegro-Burke, J. R., Woldstad, C. J., Fang, M., Bade, A. N., McMillan, J. E., Edagwa, B., Boska, M. D., Gendelman, H. E. & Siuzdak, G., Apr 1 2019, In : Molecular Neurobiology. 56, 4, p. 2896-2907 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Neurotheranostics as personalized medicines

Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J. E., Gorantla, S., Bronich, T. K., Edagwa, B. & Gendelman, H. E., Aug 2019, In : Advanced Drug Delivery Reviews. 148, p. 252-289 38 p.

Research output: Contribution to journalReview article

3 Scopus citations

Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques

McMillan, J., Szlachetka, A., Zhou, T., Morsey, B., Lamberty, B., Callen, S., Gautam, N., Alnouti, Y., Edagwa, B., Gendelman, H. E. & Fox, H. S., Mar 1 2019, In : AIDS. 33, 3, p. 585-588 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Dash, P. K., Kaminski, R., Bella, R., Su, H., Mathews, S., Ahooyi, T. M., Chen, C., Mancuso, P., Sariyer, R., Ferrante, P., Donadoni, M., Robinson, J. A., Sillman, B., Lin, Z., Hilaire, J. R., Banoub, M., Elango, M., Gautam, N., Mosley, R. L., Poluektova, L. Y. & 12 others, McMillan, J. E., Bade, A. N., Gorantla, S., Sariyer, I. K., Burdo, T. H., Young, W. B., Amini, S., Gordon, J., Jacobson, J. M., Edagwa, B., Khalili, K. & Gendelman, H. E., Dec 1 2019, In : Nature communications. 10, 1, 2753.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases

Tomitaka, A., Kaushik, A., Kevadiya, B. D., Mukadam, I., Gendelman, H. E., Khalili, K., Liu, G. & Nair, M., Mar 2019, In : Drug Discovery Today. 24, 3, p. 873-882 10 p.

Research output: Contribution to journalReview article

8 Scopus citations

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation

Ibrahim, I. M., Bade, A. N., Lin, Z., Soni, D., Wojtkiewicz, M., Shetty, B. L. D., Gautam, N., McMillan, J. M., Alnouti, Y., Edagwa, B. J. & Gendelman, H. E., Jan 1 2019, In : International journal of nanomedicine. 14, p. 6231-6247 17 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Synthesis of a long acting nanoformulated emtricitabine ProTide

Soni, D., Bade, A. N., Gautam, N., Herskovitz, J., Ibrahim, I. M., Smith, N., Wojtkiewicz, M. S., Dyavar Shetty, B. L., Alnouti, Y., McMillan, J. E., Gendelman, H. E. & Edagwa, B. J., Nov 2019, In : Biomaterials. 222, 119441.

Research output: Contribution to journalArticle

3 Scopus citations

The Promise of Long-Acting Antiretroviral Therapies: From Need to Manufacture

Gendelman, H. E., McMillan, J. E., Bade, A. N., Edagwa, B. & Kevadiya, B. D., Jul 2019, In : Trends in Microbiology. 27, 7, p. 593-606 14 p.

Research output: Contribution to journalReview article

10 Scopus citations
2018

Antimicrobials: Broad-spectrum antivirals

Edagwa, B. J. & Gendelman, H. E., Jan 23 2018, In : Nature Materials. 17, 2, p. 114-116 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Antiretroviral drug metabolism in humanized PXR-CAR-CYP3A-NOG mice

McMillan, J. E. M., Cobb, D. A., Lin, Z., Banoub, M. G., Dagur, R. S., Branch Woods, A. A., Wang, W., Makarov, E., Kocher, T., Joshi, P. S., Quadros, R. M., Harms, D. W., Cohen, S. M., Gendelman, H. E., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., May 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery

Brenza, T. M., Schlichtmann, B. W., Bhargavan, B., Vela Ramirez, J. E., Nelson, R. D., Panthani, M. G., McMillan, J. E. M., Kalyanaraman, B., Gendelman, H. E., Anantharam, V., Kanthasamy, A. G., Mallapragada, S. K., Narasimhan, B. & Kanmogne, G. D., Nov 2018, In : Journal of Biomedical Materials Research - Part A. 106, 11, p. 2881-2890 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities

Ottemann, B. M., Helmink, A. J., Zhang, W., Mukadam, I., Woldstad, C., Hilaire, J. R., Liu, Y., McMillan, J. E. M., Edagwa, B. J., Mosley, R. L., Garrison, J. C., Kevadiya, B. D. & Gendelman, H. E., Dec 2018, In : Biomaterials. 185, p. 174-193 20 p.

Research output: Contribution to journalArticle

10 Scopus citations

Creation of a long-acting nanoformulated dolutegravir

Sillman, B., Bade, A. N., Dash, P. K., Bhargavan, B., Kocher, T., Mathews, S., Su, H., Kanmogne, G. D., Poluektova, L. Y., Gorantla, S., McMillan, J., Gautam, N., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Dec 1 2018, In : Nature communications. 9, 1, 443.

Research output: Contribution to journalArticle

32 Scopus citations

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

Zhou, T., Su, H., Dash, P., Lin, Z., Dyavar Shetty, B. L., Kocher, T., Szlachetka, A., Lamberty, B., Fox, H. S., Poluektova, L., Gorantla, S., McMillan, J. E., Gautam, N., Mosley, R. L., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Jan 2018, In : Biomaterials. 151, p. 53-65 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Design of mannosylated oral amphotericin B nanoformulation: efficacy and safety in visceral leishmaniasis

Sarwar, H. S., Sohail, M. F., Saljoughian, N., Rehman, A. U., Akhtar, S., Nadhman, A., Yasinzai, M., Gendelman, H. E., Satoskar, A. R. & Shahnaz, G., Oct 31 2018, In : Artificial Cells, Nanomedicine and Biotechnology. 46, sup1, p. 521-531 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment

Gu, C. J., Borjabad, A., Hadas, E., Kelschenbach, J., Kim, B. H., Chao, W., Arancio, O., Suh, J., Polsky, B., McMillan, J. E., Edagwa, B., Gendelman, H. E., Potash, M. J. & Volsky, D. J., Jun 2018, In : PLoS pathogens. 14, 6, e1007061.

Research output: Contribution to journalArticle

8 Scopus citations

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice

Kiyota, T., Machhi, J., Lu, Y., Dyavarshetty, B., Nemati, M., Yokoyama, I., Lee Mosley, R. & Gendelman, H. E., Jun 15 2018, In : Journal of Neuroimmunology. 319, p. 80-92 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Modulating cellular autophagy for controlled antiretroviral drug release

Thomas, M. B., Gnanadhas, D. P., Dash, P. K., Machhi, J., Lin, Z., McMillan, J., Edagwa, B., Gelbard, H., Gendelman, H. E. & Gorantla, S., Sep 1 2018, In : Nanomedicine. 13, 17, p. 2139-2154 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

Multimodal theranostic nanoformulations permit magnetic resonance bioimaging of antiretroviral drug particle tissue-cell biodistribution

Kevadiya, B. D., Woldstad, C., Ottemann, B. M., Dash, P., Sajja, B. R., Lamberty, B., Morsey, B., Kocher, T., Dutta, R., Bade, A. N., Liu, Y., Callen, S. E., Fox, H. S., Byrareddy, S. N., McMillan, J. E. M., Bronich, T. K., Edagwa, B. J., Boska, M. D. & Gendelman, H. E., Jan 1 2018, In : Theranostics. 8, 1, p. 256-276 21 p.

Research output: Contribution to journalArticle

22 Scopus citations

Neuropathogenesis of human immunodeficiency virus infection

Sillman, B., Woldstad, C., Mcmillan, J. & Gendelman, H. E., 2018, Handbook of Clinical Neurology. Elsevier B.V., p. 21-40 20 p. (Handbook of Clinical Neurology; vol. 152).

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals

Zhou, T., Lin, Z., Puligujja, P., Palandri, DI., Hilaire, J., Araínga, M., Smith, N., Gautam, N., McMillan, J., Alnouti, Y., Liu, X., Edagwa, B. & Gendelman, H. E., Apr 2018, In : Nanomedicine. 13, 8, p. 871-885 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

Olson, K. E., Bade, A. N., Namminga, K. L., Potash, M. J., Mosley, R. L., Poluektova, L. Y., Volsky, D. J. & Gendelman, H. E., Aug 1 2018, In : Journal of neurovirology. 24, 4, p. 398-410 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pharmacokinetics of a long-acting nanoformulated dolutegravir prodrug in rhesus macaques

McMillan, J. E., Szlachetka, A., Slack, L., Sillman, B., Lamberty, B., Morsey, B., Callen, S., Gautam, N., Alnouti, Y., Edagwa, B., Gendelman, H. E. & Fox, H. S., Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01316-17.

Research output: Contribution to journalArticle

15 Scopus citations

ProTide generated long-acting abacavir nanoformulations

Lin, Z., Gautam, N., Alnouti, Y., McMillan, J., Bade, A. N., Gendelman, H. E. & Edagwa, B., Jan 1 2018, In : Chemical Communications. 54, 60, p. 8371-8374 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Simultaneous quantification of intracellular lamivudine and abacavir triphosphate metabolites by LC–MS/MS

Gautam, N., Lin, Z., Banoub, M. G., Smith, N. A., Maayah, A., McMillan, J. E., Gendelman, H. E. & Alnouti, Y., May 10 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 153, p. 248-259 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
9 Scopus citations

URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease

Kiyota, T., Machhi, J., Lu, Y., Dyavarshetty, B., Nemati, M., Zhang, G., Lee Mosley, R., Gelbard, H. A. & Gendelman, H. E., May 5 2018, In : Journal of Neuroinflammation. 15, 1, 137.

Research output: Contribution to journalArticle

7 Scopus citations
2017
46 Scopus citations

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

Gnanadhas, D. P., Dash, P. K., Sillman, B., Bade, A. N., Lin, Z., Palandri, D. L., Gautam, N., Alnouti, Y., Gelbard, H. A., McMillan, J. M., Mosley, R. L., Edagwa, B. J., Gendelman, H. E. & Gorantla, S., Mar 1 2017, In : Journal of Clinical Investigation. 127, 3, p. 857-873 17 p.

Research output: Contribution to journalArticle

25 Scopus citations

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease

Embury, C. M., Dyavarshetty, B., Lu, Y., Wiederin, J. L., Ciborowski, P., Gendelman, H. E. & Kiyota, T., Jun 1 2017, In : Journal of Neuroimmune Pharmacology. 12, 2, p. 340-352 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Creation of a long-acting nanoformulated 29,39-dideoxy-39-thiacytidine

Guo, D., Zhou, T., Araínga, M., Palandri, D., Gautam, N., Bronich, T., Alnouti, Y., McMillan, J., Edagwa, B. & Gendelman, H. E., Mar 1 2017, In : Journal of Acquired Immune Deficiency Syndromes. 74, 3, p. e75-e83

Research output: Contribution to journalArticle

24 Scopus citations

Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging

Kevadiya, B. D., Bade, A. N., Woldstad, C., Edagwa, B. J., McMillan, J. E. M., Sajja, B. R., Boska, M. D. & Gendelman, H. E., Feb 1 2017, In : Acta Biomaterialia. 49, p. 507-520 14 p.

Research output: Contribution to journalArticle

20 Scopus citations