Ishwor Thapa, MS

  • 166 Citations
  • 8 h-Index
20072020

Research output per year

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Research Output

  • 166 Citations
  • 8 h-Index
  • 18 Conference contribution
  • 15 Article
  • 1 Review article
2020

Computational Approaches for Drug Design: A Focus on Drug Repurposing

Kim, S., Thapa, I., Samadi, F. & Ali, H., 2020, Bioinformatics and Biomedical Engineering - 8th International Work-Conference, IWBBIO 2020, Proceedings. Rojas, I., Valenzuela, O., Rojas, F., Herrera, L. J. & Ortuño, F. (eds.). Springer, p. 213-223 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 12108 LNBI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3)

Kanchan, R. K., Perumal, N., Atri, P., Chirravuri Venkata, R., Thapa, I., Klinkebiel, D. L., Donson, A. M., Perry, D., Punsoni, M., Talmon, G. A., Coulter, D. W., Boue’, D. R., Snuderl, M., Nasser, M. W., Batra, S. K., Vibhakar, R. & Mahapatra, S., Jul 1 2020, In : Brain Pathology. 30, 4, p. 732-745 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

A Graph-Theoretic Approach for Identifying Bacterial Inter-correlations and Functional Pathways in Microbiome Data

Kim, S., Thapa, I. & Ali, H. H., Jan 21 2019, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. Schmidt, H., Griol, D., Wang, H., Baumbach, J., Zheng, H., Callejas, Z., Hu, X., Dickerson, J. & Zhang, L. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 405-411 7 p. 8621179. (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

A novel graph theoretical approach for modeling microbiomes and inferring microbial ecological relationships

Kim, S., Thapa, I., Zhang, L. & Ali, H., Dec 20 2019, In : BMC genomics. 20, 945.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
4 Scopus citations
Open Access
1 Scopus citations

Identifying Structural Changes in Correlation Networks Models of Cancer Gene Expression by Stage

Li, Q., Ghersi, D., Thapa, I., Zhang, L., Ali, H. & Cooper, K., Nov 2019, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. Yoo, I., Bi, J. & Hu, X. T. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 2075-2082 8 p. 8983069. (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Multiplatform biomarker identification using a data-driven approach enables single-sample classification

Zhang, L., Thapa, I., Haas, C. & Bastola, D., Nov 21 2019, In : BMC bioinformatics. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression Data

Kim, S., Thapa, I., Zhang, L. & Ali, H., 2019, Bioinformatics and Biomedical Engineering - 7th International Work-Conference, IWBBIO 2019, Proceedings. Valenzuela, O., Rojas, F., Ortuño, F., Ortuño, F. & Rojas, I. (eds.). Springer Verlag, p. 513-521 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11465 LNBI).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations
2018

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Nimmakayala, R. K., Seshacharyulu, P., Lakshmanan, I., Rachagani, S., Chugh, S., Karmakar, S., Rauth, S., Vengoji, R., Atri, P., Talmon, G. A., Lele, S. M., Smith, L. M., Thapa, I., Bastola, D., Ouellette, M. M., Batra, S. K. & Ponnusamy, M. P., Sep 2018, In : Gastroenterology. 155, 3, p. 892-908.e6

Research output: Contribution to journalArticle

20 Scopus citations

Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice

Chugh, S., Barkeer, S., Rachagani, S., Nimmakayala, R. K., Perumal, N., Pothuraju, R., Atri, P., Mahapatra, S., Thapa, I., Talmon, G. A., Smith, L. M., Yu, X., Neelamegham, S., Fu, J., Xia, L., Palanimuthu Ponnusamy, M. & Batra, S. K., Nov 2018, In : Gastroenterology. 155, 5, p. 1608-1624 17 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

A study of bias and increasing organismal complexity from their post-translational modifications and reaction site interplays

Bonham-Carter, O., Thapa, I., From, S. & Bastola, D., 2017, In : Briefings in bioinformatics. 18, 1, p. 69-84 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

A systems biology approach for modeling microbiomes using split graphs

Kim, S., Thapa, I., Lu, G., Zhu, L. & Ali, H. H., Dec 15 2017, Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017. Yoo, I., Zheng, J. H., Gong, Y., Hu, X. T., Shyu, C-R., Bromberg, Y., Gao, J. & Korkin, D. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 2062-2068 7 p. (Proceedings - 2017 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2017; vol. 2017-January).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations
2016

Identifying enriched drug fragments as possible candidates for metabolic engineering

Sharma, S., Karri, K., Thapa, I., Bastola, D. & Ghersi, D., Oct 8 2016, In : BMC Medical Genomics. 9, 46.

Research output: Contribution to journalArticle

5 Scopus citations
2015

A novel approach to identify shared fragments in drugs and natural products

Balasubramanya, A., Thapa, I., Bastola, D. & Ghersi, D., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Schapranow, L. M., Zhou, J., Hu, X. T., Ma, B., Rajasekaran, S., Miyano, S., Yoo, I., Pierce, B., Shehu, A., Gombar, V. K., Chen, B., Pai, V. & Huan, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 575-580 6 p. 7359746. (Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Guilt-by association approach to identify novel human aging-related genes using protein domains

Banwait, J. K., Dougherty, S. P., Thapa, I. & Bastola, D. K., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Schapranow, L. M., Zhou, J., Hu, X. T., Ma, B., Rajasekaran, S., Miyano, S., Yoo, I., Pierce, B., Shehu, A., Gombar, V. K., Chen, B., Pai, V. & Huan, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 301-304 4 p. 7359698. (Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Next generation sequence assembler mis-assembly of phage genomes with terminal redundancy

Warnke-Sommer, J., Thapa, I. & Ali, H., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Schapranow, L. M., Zhou, J., Hu, X. T., Ma, B., Rajasekaran, S., Miyano, S., Yoo, I., Pierce, B., Shehu, A., Gombar, V. K., Chen, B., Pai, V. & Huan, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 1102-1108 7 p. 7359836. (Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Transcriptome analysis of HIV-1 virus in understanding the effect of antiretroviral drugs (cART) and methamphetamine on the virus

Thapa, S., Fox, O. S. & Bastola, H. R., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Schapranow, L. M., Zhou, J., Hu, X. T., Ma, B., Rajasekaran, S., Miyano, S., Yoo, I., Pierce, B., Shehu, A., Gombar, V. K., Chen, B., Pai, V. & Huan, J. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 962-968 7 p. 7359813. (Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2014

Evidence of post translational modification bias extracted from the tRNA and corresponding amino acid interplay across a set of diverse organisms

Bonham-Carter, O., Thapa, I. & Bastola, D., Sep 20 2014, ACM BCB 2014 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics. Association for Computing Machinery, Inc, p. 774-781 8 p. (ACM BCB 2014 - 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins

Yelamanchili, S. V., Morsey, B., Harrison, E. B., Rennard, D. A., Emanuel, K., Thapa, I., Bastola, D. R. & Fox, H. S., Jan 2014, In : Cell Death and Disease. 5, 1, e982.

Research output: Contribution to journalArticle

18 Scopus citations
2013
36 Scopus citations

On identifying and analyzing significant nodes in protein-protein interaction networks

Khazanchi, R., Dempsey, K., Thapa, I. & Ali, H., 2013, Proceedings - IEEE 13th International Conference on Data Mining Workshops, ICDMW 2013. IEEE Computer Society, p. 343-348 6 p. 6753940

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

On mining biological signals using correlation networks

Dempsey, K., Thapa, I., Cortes, C., Eriksen, Z., Bastola, D. K. & Ali, H., 2013, Proceedings - IEEE 13th International Conference on Data Mining Workshops, ICDMW 2013. IEEE Computer Society, p. 327-334 8 p. 6753938

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations
2012

A comparison between hierarchical clustering and community detection method in the collection of gene targets for molecular identification of pathogenic fungi

Thapa, I., Bhowmick, S. & Bastola, D. R., 2012, Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012. p. 756-761 6 p. 6470234. (Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

A comparison of computational approaches in the molecular identification of pathogenic organisms

Bastola, D. R., McGrath, S., Bhowmick, S. & Thapa, I., 2012, Proceedings - 2012 IEEE 2nd Conference on Healthcare Informatics, Imaging and Systems Biology, HISB 2012. 1 p. 6366198. (Proceedings - 2012 IEEE 2nd Conference on Healthcare Informatics, Imaging and Systems Biology, HISB 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bio-Logic Builder: A Non-Technical Tool for Building Dynamical, Qualitative Models

Helikar, T., Kowal, B., Madrahimov, A., Shrestha, M., Pedersen, J., Limbu, K., Thapa, I., Rowley, T., Satalkar, R., Kochi, N., Konvalina, J. & Rogers, J. A., Oct 17 2012, In : PloS one. 7, 10, e46417.

Research output: Contribution to journalArticle

9 Scopus citations
6 Scopus citations

Image analysis of DETECHIP® - A molecular sensing array

Lyon, M., Wilson, M. V., Rouhier, K. A., Symonsbergen, D. J., Bastola, K., Thapa, I., Holmes, A. E., Sikich, S. M. & Jackson, A., 2012, Advances in Computer Science, Engineering and Applications - Proceedings of the Second International Conference on Computer Science, Engineering and Applications, ICCSEA 2012. VOL. 1 ed. p. 145-158 14 p. (Advances in Intelligent and Soft Computing; vol. 166 AISC, no. VOL. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations
2011

Identifying modular function via edge annotation in gene correlation networks using Gene Ontology search

Dempsey, K., Thapa, I., Bastola, D. & Ali, H., 2011, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. p. 255-261 7 p. 6112384. (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations
9 Scopus citations
2010

Assessing the impact of refactoring activities on the JHotDraw project

Thapa, I. & Siy, H., 2010, APPLIED COMPUTING 2010 - The 25th Annual ACM Symposium on Applied Computing. p. 2369-2370 2 p. (Proceedings of the ACM Symposium on Applied Computing).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations
2007

Sambad - Computer interfaces for non-literates

Dhakhwa, S., Hall, P. A. V., Ghimire, G. B., Manandhar, P. & Thapa, I., 2007, Human-Computer Interaction: Interaction Design and Usability - 12th International Conference, HCI International 2007, Proceedings. PART 1 ed. Springer Verlag, p. 721-730 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 4550 LNCS, no. PART 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations