Jaekwon Lee

  • 5212 Citations
  • 28 h-Index
19982019

Research output per year

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Research Output

  • 5212 Citations
  • 28 h-Index
  • 46 Article
  • 2 Review article
  • 1 Chapter
2019

A novel functional role of nickel in sperm motility and eukaryotic cell growth

Bian, J., Shi, X., Li, Q., Zhao, M., Wang, L., Lee, J., Tao, M. & Wu, X., Jul 2019, In : Journal of Trace Elements in Medicine and Biology. 54, p. 142-149 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Roles for intracellular cation transporters in respiratory growth of yeast

Zhang, F., Bian, J., Chen, X., Huang, J., Smith, N., Lu, W., Xu, Y., Lee, J. & Wu, X., Oct 2019, In : Metallomics. 11, 10, p. 1667-1678 12 p.

Research output: Contribution to journalArticle

2018

CHCA-1 is a copper-regulated CTR1 homolog required for normal development, copper accumulation, and copper-sensing behavior in Caenorhabditis elegans

Yuan, S., Sharma, A. K., Richart, A., Lee, J. & Kim, B. E., Jul 13 2018, In : Journal of Biological Chemistry. 293, 28, p. 10911-10925 15 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

A role for the ATP7A copper transporter in tumorigenesis and cisplatin resistance

Zhu, S., Shanbhag, V., Wang, Y., Lee, J. & Petris, M., 2017, In : Journal of Cancer. 8, 11, p. 1952-1958 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan Copper transporters Ctr1 and Ctr2

Logeman, B. L., Wood, L. K., Lee, J. & Thiele, D. J., Jul 7 2017, In : Journal of Biological Chemistry. 292, 27, p. 11531-11546 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis

Chun, H., Catterton, T., Kim, H., Lee, J. & Kim, B. E., Dec 1 2017, In : Scientific reports. 7, 1, 12001.

Research output: Contribution to journalArticle

5 Scopus citations

The intestinal copper exporter CUA-1 is required for systemic copper homeostasis in Caenorhabditis elegans

Chun, H., Sharma, A. K., Lee, J., Chan, J., Jia, S. & Kim, B. E., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Cadmium and secondary structure-dependent function of a degron in the pca1p cadmium exporter

Smith, N., Wei, W., Zhao, M., Qin, X., Seravalli, J., Kim, H. & Lee, J., Jun 3 2016, In : Journal of Biological Chemistry. 291, 23, p. 12420-12431 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Endoplasmic reticulum-associated degradation of pca1p, a polytopic protein, via interaction with the proteasome at the membrane

Smith, N., Adle, D. J., Zhao, M., Qin, X., Kim, H. & Lee, J., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 15082-15092 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oma1 links mitochondrial protei quality control and TOR signaling to modulaten physiological plasticity and cellular stress responses

Bohovych, I., Kastor, S., Christianson, S., Topil, D., Kim, H., Fangman, T., Zhou, Y. J., Barrientos, A., Lee, J., Brown, A. J. P. & Khalimonchuk, O., 2016, In : Molecular and cellular biology. 36, 17, p. 2300-2312 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Potassium and the K+/H+ exchanger Kha1p promote binding of copper to ApoFet3p multi-copper ferroxidase

Wu, X., Kim, H., Seravalli, J., Barycki, J. J., Hart, P. J., Gohara, D. W., Cera, E. D., Jung, W. H., Kosman, D. J. & Lee, J., 2016, In : Journal of Biological Chemistry. 291, 18, p. 9796-9806 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Autonomous requirements of the Menkes disease protein in the nervous system

Hodgkinson, V. L., Zhu, S., Wang, Y., Ladomersky, E., Nickelson, K., Weisman, G. A., Lee, J., Gitlin, J. D. & Petris, M. J., 2015, In : American Journal of Physiology - Cell Physiology. 309, 10, p. 660-668 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation

Zarruk, J. G., Berard, J. L., Passos dos Santos, R., Kroner, A., Lee, J., Arosio, P. & David, S., Sep 1 2015, In : Neurobiology of Disease. 81, p. 93-107 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways

Anandhan, A., Rodriguez-Rocha, H., Bohovych, I., Griggs, A. M., Zavala-Flores, L., Reyes-Reyes, E. M., Seravalli, J., Stanciu, L. A., Lee, J., Rochet, J. C., Khalimonchuk, O. & Franco, R., Sep 1 2015, In : Neurobiology of Disease. 81, p. 76-92 17 p.

Research output: Contribution to journalArticle

36 Scopus citations

X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron

Hodgkinson, V. L., Dale, J. M., Garcia, M. L., Weisman, G. A., Lee, J., Gitlin, J. D. & Petris, M. J., Jun 1 2015, In : Journal of Pathology. 236, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase

Frey, A. G., Nandal, A., Park, J. H., Smith, P. M., Yabe, T., Ryu, M. S., Ghosh, M. C., Lee, J., Rouault, T. A., Park, M. H. & Philpott, C. C., Jun 3 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 22, p. 8031-8036 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes

Wei, W., Smith, N., Wu, X., Kim, H., Seravalli, J., Khalimonchuk, O. & Lee, J., Oct 1 2014, In : Antioxidants and Redox Signaling. 21, 10, p. 1475-1489 15 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Copper-zinc superoxide dismutase-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis induced with myelin oligodendrocyte glycoprotein 35-55

Massilamany, C., Gangaplara, A., Kim, H., Stanford, C., Rathnaiah, G., Steffen, D., Lee, J. & Reddy, J., Mar 15 2013, In : Journal of Neuroimmunology. 256, 1-2, p. 19-27 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α

Ghosh, M. C., Zhang, D. L., Jeong, S. Y., Kovtunovych, G., Ollivierre-Wilson, H., Noguchi, A., Tu, T., Senecal, T., Robinson, G., Crooks, D. R., Tong, W. H., Ramaswamy, K., Singh, A., Graham, B. B., Tuder, R. M., Yu, Z. X., Eckhaus, M., Lee, J., Springer, D. A. & Rouault, T. A., Feb 5 2013, In : Cell Metabolism. 17, 2, p. 271-281 11 p.

Research output: Contribution to journalArticle

103 Scopus citations

SLC31 (CTR) family of copper transporters in health and disease

Kim, H., Wu, X. & Lee, J., Apr 2013, In : Molecular Aspects of Medicine. 34, 2-3, p. 561-570 10 p.

Research output: Contribution to journalReview article

36 Scopus citations
2012

Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load

Gray, L. W., Peng, F., Molloy, S. A., Pendyala, V. S., Muchenditsi, A., Muzik, O., Lee, J., Kaplan, J. H. & Lutsenko, S., Jun 22 2012, In : PloS one. 7, 6, e38327.

Research output: Contribution to journalArticle

35 Scopus citations
2011

Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits

Willis, M. N., Liu, Y., Biterova, E. I., Simpson, M. A., Kim, H., Lee, J. & Barycki, J. J., Jul 26 2011, In : Biochemistry. 50, 29, p. 6508-6517 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice

Jeong, S. Y., Crooks, D. R., Wilson-Ollivierre, H., Ghosh, M. C., Sougrat, R., Lee, J., Cooperman, S., Mitchell, J. B., Beaumont, C. & Rouault, T. A., Oct 7 2011, In : PloS one. 6, 10, e25404.

Research output: Contribution to journalArticle

40 Scopus citations
2010

Altered microglial copper homeostasis in a mouse model of Alzheimer's disease

Zheng, Z., White, C., Lee, J., Peterson, T. S., Bush, A. I., Sun, G. Y., Weisman, G. A. & Petris, M. J., Sep 2010, In : Journal of Neurochemistry. 114, 6, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2009

A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity

White, C., Lee, J., Kambe, T., Fritsche, K. & Petris, M. J., Dec 4 2009, In : Journal of Biological Chemistry. 284, 49, p. 33949-33956 8 p.

Research output: Contribution to journalArticle

274 Scopus citations

Cadmium-mediated rescue from ER-associated degradation induces expression of its exporter

Adle, D. J., Wei, W., Smith, N., Bies, J. J. & Lee, J., Jun 23 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 25, p. 10189-10194 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Copper transport activity of yeast Ctr1 is down-regulated via its C terminus in response to excess copper

Wu, X., Sinani, D., Kim, H. & Lee, J., Feb 13 2009, In : Journal of Biological Chemistry. 284, 7, p. 4112-4122 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Copper transport into the secretory pathway is regulated by oxygen in macrophages

White, C., Kambe, T., Fulcher, Y. G., Sachdev, S. W., Bush, A. I., Fritsche, K., Lee, J., Quinn, T. P. & Petris, M. J., May 1 2009, In : Journal of cell science. 122, 9, p. 1315-1321 7 p.

Research output: Contribution to journalArticle

64 Scopus citations
60 Scopus citations
2008

Expressional control of a cadmium-transporting P1B-type ATPase by a metal sensing degradation signal

Adle, D. J. & Lee, J., Nov 14 2008, In : Journal of Biological Chemistry. 283, 46, p. 31460-31468 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae

Adle, D. J., Sinani, D., Kim, H. & Lee, J., Jan 12 2007, In : Journal of Biological Chemistry. 282, 2, p. 947-955 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Distinct mechanisms for Ctr1-mediated copper and cisplatin transport

Sinani, D., Adle, D. J., Kim, H. & Lee, J., Sep 14 2007, In : Journal of Biological Chemistry. 282, 37, p. 26775-26785 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Redox Regulation of Physiological Processes

Rovira, I. I., Finkel, T., Masters, B. S., Dickman, M. B., Lee, J., Ragsdale, S. W. & Lee, C. C., Mar 14 2007, Redox Biochemistry. John Wiley & Sons, Inc., p. 135-182 48 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2006

Molecular mechanisms of copper homeostasis in yeast

Lee, J., Adle, D. & Kim, H., 2006, In : Topics in Current Genetics. 14, p. 1-36 36 p.

Research output: Contribution to journalArticle

4 Scopus citations
2004

Identification of Methionine-rich Clusters That Regulate Copper-stimulated Endocytosis of the Human Ctr1 Copper Transporter

Guo, Y., Smith, K., Lee, J., Thiele, D. J. & Petris, M. J., Apr 23 2004, In : Journal of Biological Chemistry. 279, 17, p. 17428-17433 6 p.

Research output: Contribution to journalArticle

136 Scopus citations

Metal accumulation and transport in the ovary of the lizard Podarcis sicula

Riggio, M., Scudiero, R., Lee, J., Thiele, D. J., Parisi, E. & Filosa, S., 2004, In : Italian Journal of Zoology. 71, SUPPL.2, p. 59-62 4 p.

Research output: Contribution to journalArticle

Mobilization of intracellular copper stores by the Ctr2 vacuolar copper transporter

Rees, E. M., Lee, J. & Thiele, D. J., Dec 24 2004, In : Journal of Biological Chemistry. 279, 52, p. 54221-54229 9 p.

Research output: Contribution to journalArticle

140 Scopus citations
2003

Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1

Petris, M. J., Smith, K., Lee, J. & Thiele, D. J., Mar 14 2003, In : Journal of Biological Chemistry. 278, 11, p. 9639-9646 8 p.

Research output: Contribution to journalArticle

217 Scopus citations
2002

Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake

Puig, S., Lee, J., Lau, M. & Thiele, D. J., Jul 19 2002, In : Journal of Biological Chemistry. 277, 29, p. 26021-26030 10 p.

Research output: Contribution to journalArticle

280 Scopus citations

Biochemical characterization of the human copper transporter Ctr1

Lee, J., Peña, M. M. O., Nose, Y. & Thiele, D. J., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4380-4387 8 p.

Research output: Contribution to journalArticle

420 Scopus citations

Characterization of mouse embryonic cells deficient in the Ctr1 high affinity copper transporter: Identification of a Ctr1-independent copper transport system

Lee, J., Petris, M. J. & Thiele, D. J., Oct 25 2002, In : Journal of Biological Chemistry. 277, 43, p. 40253-40259 7 p.

Research output: Contribution to journalArticle

167 Scopus citations
22 Scopus citations

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

Ishida, S., Lee, J., Thiele, D. J. & Herskowitz, I., Oct 29 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 22, p. 14298-14302 5 p.

Research output: Contribution to journalArticle

590 Scopus citations
2001

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development

Lee, J., Prohaska, J. R. & Thiele, D. J., Jun 5 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 12, p. 6842-6847 6 p.

Research output: Contribution to journalArticle

329 Scopus citations
2000

Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant

Lee, J., Prohaska, J. R., Dagenais, S. L., Glover, T. W. & Thiele, D. J., Aug 22 2000, In : Gene. 254, 1-2, p. 87-96 10 p.

Research output: Contribution to journalArticle

162 Scopus citations
1999

A delicate balance: Homeostatic control of copper uptake and distribution

Peña, M. M. O., Lee, J. & Thiele, D. J., 1999, In : Journal of Nutrition. 129, 7, p. 1251-1260 10 p.

Research output: Contribution to journalReview article

Open Access
556 Scopus citations

A new antioxidant with alkyl hydroperoxide defense properties in yeast

Lee, J., Spector, D., Godon, C., Labarre, J. & Toledano, M. B., Feb 19 1999, In : Journal of Biological Chemistry. 274, 8, p. 4537-4544 8 p.

Research output: Contribution to journalArticle

144 Scopus citations

Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast

Lee, J., Godon, C., Lagniel, G., Spector, D., Garin, J., Labarre, J. & Toledano, M. B., Jun 4 1999, In : Journal of Biological Chemistry. 274, 23, p. 16040-16046 7 p.

Research output: Contribution to journalArticle

428 Scopus citations
1998

The H2O2 stimulon in Saccharomyces cerevisiae

Godon, C., Lagniel, G., Lee, J., Buhler, J. M., Kieffer, S., Perrot, M., Boucherie, H., Toledano, M. B. & Labarre, J., Aug 28 1998, In : Journal of Biological Chemistry. 273, 35, p. 22480-22489 10 p.

Research output: Contribution to journalArticle

480 Scopus citations