Janos Zempleni, PhD

  • 4464 Citations
  • 38 h-Index
1974 …2020

Research output per year

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Research Output

2020
Open Access
1 Scopus citations
2019
8 Scopus citations

Bovine milk extracellular vesicles (EVs) modification elicits skeletal muscle growth in rats

Parry, H. A., Brooks Mobley, C., Mumford, P. W., Romero, M. A., Haun, C. T., Zhang, Y., Roberson, P. A., Zempleni, J., Ferrando, A. A., Vechetti, I. J., McCarthy, J. J., Young, K. C., Roberts, M. D. & Kavazis, A. N., 2019, In : Frontiers in Physiology. 10, MAR, 436.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
9 Scopus citations

Milk-Derived Exosomes and Metabolic Regulation

Zempleni, J., Sukreet, S., Zhou, F., Wu, D. & Mutai, E., Feb 15 2019, In : Annual Review of Animal Biosciences. 7, p. 245-262 18 p.

Research output: Contribution to journalReview article

13 Scopus citations

NIH workshop on human milk composition: Summary and visions

Casavale, K. O., Ahuja, J. K. C., Wu, X., Li, Y., Quam, J., Olson, R., Pehrsson, P., Allen, L., Balentine, D., Hanspal, M., Hayward, D., Hines, E. P., McClung, J. P., Perrine, C. G., Belfort, M. B., Dallas, D., German, B., Kim, J., McGuire, M., McGuire, M. & 6 others, Morrow, A. L., Neville, M., Nommsen-Rivers, L., Rasmussen, K. M., Zempleni, J. & Lynch, C. J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 769-779 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

A cell death assay for assessing the mitochondrial targeting of proteins

Camara Teixeira, D., Cordonier, E. L., Wijeratne, S. S. K., Huebbe, P., Jamin, A., Jarecke, S., Wiebe, M. & Zempleni, J., Jun 2018, In : Journal of Nutritional Biochemistry. 56, p. 48-54 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Concentrations of purine metabolites are elevated in fluids from adults and infants and in livers from mice fed diets depleted of bovine milk exosomes and their RNA cargos

Aguilar-Lozano, A., Baier, S., Grove, R., Shu, J., Giraud, D., Leiferman, A., Mercer, K. E., Cui, J., Badger, T. M., Adamec, J., Andres, A. & Zempleni, J., 2018, In : Journal of Nutrition. 148, 12, p. 1886-1894 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

Manca, S., Upadhyaya, B., Mutai, E., Desaulniers, A. T., Cederberg, R. A., White, B. R. & Zempleni, J., Dec 1 2018, In : Scientific reports. 8, 1, 11321.

Research output: Contribution to journalArticle

39 Scopus citations

Reply to B Fromm et al

Cui, J. & Zempleni, J., Sep 1 2018, In : The Journal of nutrition. 148, 9, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
17 Scopus citations
2017

Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants

Zempleni, J., Aguilar-Lozano, A., Sadri, M., Sukreet, S., Manca, S., Wu, D., Zhou, F. & Mutai, E., 2017, In : Journal of Nutrition. 147, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Milk exosomes: beyond dietary microRNAs

Zempleni, J., Jun 22 2017, In : Genes and Nutrition. 12, 1, 12.

Research output: Contribution to journalComment/debate

13 Scopus citations

Nutrition, microRNAs, and human health

Cui, J., Zhou, B., Ross, S. A. & Zempleni, J., 2017, In : Advances in Nutrition. 8, 1, p. 105-112 8 p.

Research output: Contribution to journalReview article

56 Scopus citations
2016

Glucocorticoid cell priming enhances transfection outcomes in adult human mesenchymal stem cells

Kelly, A. M., Plautz, S. A., Zempleni, J. & Pannier, A. K., Feb 1 2016, In : Molecular Therapy. 24, 2, p. 331-341 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human vascular endothelial cells transport foreign exosomes from cow’s milk by endocytosis

Kusuma, R. J., Manca, S., Frieme, T., Sukreet, S., Nguyen, C. & Zempleni, J., May 15 2016, In : American Journal of Physiology - Cell Physiology. 310, 10, p. C800-C807

Research output: Contribution to journalArticle

61 Scopus citations

Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells

Cordonier, E. L., Jarecke, S. K., Hollinger, F. E. & Zempleni, J., Jun 5 2016, In : European Journal of Pharmacology. 780, p. 202-208 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Molecular aspects of physical performance and nutritional assessment

Hassan, Y. I. & Zempleni, J., Apr 19 2016, Nutritional Assessment of Athletes: Second Edition. CRC Press, p. 213-232 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Riboflavin

Pinto, J. T. & Zempleni, J., 2016, In : Advances in Nutrition. 7, 5, p. 973-975 3 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Computational characterization of exogenous microRNAs that can be transferred into human circulation

Shu, J., Chiang, K., Zempleni, J. & Cui, J., Nov 3 2015, In : PloS one. 10, 11, e0140587.

Research output: Contribution to journalArticle

32 Scopus citations

Dietary microRNA database (DMD): An archive database and analytic tool for food-borne microRNAs

Chiang, K., Shu, J., Zempleni, J. & Cui, J., Jun 1 2015, In : PloS one. 10, 6, e0128089.

Research output: Contribution to journalArticle

21 Scopus citations

Diet-responsive MicroRNAs are likely exogenous

Zempleni, J., Baier, S. R. & Hirschi, K., Oct 9 2015, In : Journal of Biological Chemistry. 290, 41, 1 p.

Research output: Contribution to journalLetter

17 Scopus citations

Gene regulation by dietary microRNAs

Zempleni, J., Baier, S. R., Howard, K. M. & Cui, J., Sep 25 2015, In : Canadian journal of physiology and pharmacology. 93, 12, p. 1097-1102 6 p.

Research output: Contribution to journalReview article

26 Scopus citations

Loss of miRNAs during processing and storage of cow's (Bos taurus) milk

Howard, K. M., Jati Kusuma, R., Baier, S. R., Friemel, T., Markham, L., Vanamala, J. & Zempleni, J., Jan 21 2015, In : Journal of Agricultural and Food Chemistry. 63, 2, p. 588-592 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster

Cordonier, E. L., Adjam, R., Teixeira, D. C., Onur, S., Zbasnik, R., Read, P. E., Döring, F., Schlegel, V. L. & Zempleni, J., Nov 2015, In : Journal of Nutritional Biochemistry. 26, 11, p. 1379-1384 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
99 Scopus citations
2014
8 Scopus citations
16 Scopus citations
9 Scopus citations
185 Scopus citations

Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism

Zempleni, J., Liu, D., Teixeira Camara, D. & Cordonier, E. L., Jun 2014, In : Nutrition Reviews. 72, 6, p. 369-376 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nuclear receptors and epigenetic regulation: Opportunities for nutritional targeting and disease prevention

Romagnolo, D. F., Zempleni, J. & Selmin, O. I., 2014, In : Advances in Nutrition. 5, 4, p. 373-385 13 p.

Research output: Contribution to journalReview article

20 Scopus citations

Off-target effects of sulforaphane include the derepression of long terminal repeats through histone acetylation events

Baier, S. R., Zbasnik, R., Schlegel, V. & Zempleni, J., Jun 2014, In : Journal of Nutritional Biochemistry. 25, 6, p. 665-668 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reply to witwer

Baier, S. R., Nguyen, C., Xie, F., Wood, J. R. & Zempleni, J., 2014, In : Journal of Nutrition. 144, 11, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

Reply to Witwer

Baier, S. R., Xie, F. & Zempleni, J., Nov 1 2014, In : The Journal of nutrition. 144, 11, p. 1882 1 p.

Research output: Contribution to journalArticle

6 Scopus citations

β-Keto and β-hydroxyphosphonate analogs of biotin-5′-AMP are inhibitors of holocarboxylase synthetase

Sittiwong, W., Cordonier, E. L., Zempleni, J. & Dussault, P. H., Dec 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 24, p. 5568-5571 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Biotinylation of lysine 16 in histone H4 contributes toward nucleosome condensation

Singh, M. P., Wijeratne, S. S. K. & Zempleni, J., Jan 15 2013, In : Archives of Biochemistry and Biophysics. 529, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enrichment of meiotic recombination hotspot sequences by avidin capture technology

Camara Teixeira, D., Malkaram, S. A. & Zempleni, J., Mar 1 2013, In : Gene. 516, 1, p. 101-106 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Epigenetic Synergies Between Biotin and Folate in the Regulation of Pro-Inflammatory Cytokines and Repeats

Xue, J. & Zempleni, J., Nov 2013, In : Scandinavian Journal of Immunology. 78, 5, p. 419-425 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
6 Scopus citations
15 Scopus citations

Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats

Xue, J., Wijeratne, S. S. K. & Zempleni, J., May 2013, In : Epigenetics. 8, 5, p. 504-511 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Identification and assessment of markers of biotin status in healthy adults

Eng, W. K., Giraud, D., Schlegel, V. L., Wang, D., Lee, B. H. & Zempleni, J., Jul 28 2013, In : British Journal of Nutrition. 110, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mechanisms of gene transcriptional regulation through biotin and biotin-binding proteins in mammals

Zempleni, J., Liu, D., Teixeira, D. C. & Singh, M. P., Jan 1 2013, Vitamin-Binding Proteins: Functional Consequences. CRC Press, p. 219-228 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Three promoters regulate the transcriptional activity of the human holocarboxylase synthetase gene

Xia, M., Malkaram, S. A. & Zempleni, J., Nov 2013, In : Journal of Nutritional Biochemistry. 24, 11, p. 1963-1969 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012

Biotin

Zempleni, J., Wijeratne, S. S. K. & Kuroishi, T., Jun 18 2012, Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, p. 359-374 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations

Biotin

Zempleni, J. & Kuroishi, T., Mar 2012, In : Advances in Nutrition. 3, 2, p. 213-214 2 p.

Research output: Contribution to journalComment/debate

20 Scopus citations

Biotin requirements for DNA damage prevention

Zempleni, J., Teixeira, D. C., Kuroishi, T., Cordonier, E. L. & Baier, S., May 1 2012, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 733, 1-2, p. 58-60 3 p.

Research output: Contribution to journalReview article

16 Scopus citations