Janos Zempleni, PhD

  • 4549 Citations
  • 38 h-Index
1974 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Article

A 96-well plate assay for high-throughput analysis of holocarboxylase synthetase activity

Rios-Avila, L., Prince, S. A., Wijeratne, S. S. K. & Zempleni, J., Apr 11 2011, In : Clinica Chimica Acta. 412, 9-10, p. 735-739 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

A cell death assay for assessing the mitochondrial targeting of proteins

Camara Teixeira, D., Cordonier, E. L., Wijeratne, S. S. K., Huebbe, P., Jamin, A., Jarecke, S., Wiebe, M. & Zempleni, J., Jun 2018, In : Journal of Nutritional Biochemistry. 56, p. 48-54 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
Open Access
19 Scopus citations

An avidin-based assay for histone debiotinylase activity in human cell nuclei

Chew, Y. C., Sarath, G. & Zempleni, J., Jul 2007, In : Journal of Nutritional Biochemistry. 18, 7, p. 475-481 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Ändert sich das Vitaminangebot an den Feten im Verlauf der Schwangerschaft?

Link, G., Zempleni, J., Kübler, W. & Künzel, W., Dec 1993, In : Archives of Gynecology and Obstetrics. 254, 1-4, p. 1389-1391 3 p.

Research output: Contribution to journalArticle

Beeinflußt die Vitaminversorgung der Mutter die Vitaminkonzentration des Feten?

Link, G., Zempleni, J. & Maghsudi, M., Jul 1989, In : Archives of Gynecology and Obstetrics. 245, 1-4, p. 354-357 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Biliary excretion of biotin and biotin metabolites is quantitatively minor in rats and pigs

Zempleni, J., Green, G. M., Spannagel, A. W. & Mock, D. M., 1997, In : Journal of Nutrition. 127, 8, p. 1496-1500 5 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Bioavailability of biotin given orally to humans in pharmacologic doses

Zempleni, J. & Mock, D. M., Mar 1999, In : American Journal of Clinical Nutrition. 69, 3, p. 504-508 5 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Biokinetic analysis of vitamin absorption and disposition in humans

Zempleni, J., 1997, In : Methods in enzymology. 281, p. 405-425 21 p.

Research output: Contribution to journalArticle

1 Scopus citations

Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants

Zempleni, J., Aguilar-Lozano, A., Sadri, M., Sukreet, S., Manca, S., Wu, D., Zhou, F. & Mutai, E., 2017, In : Journal of Nutrition. 147, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Biological functions of biotinylated histones

Kothapalli, N., Camporeale, G., Kueh, A., Chew, Y. C., Oommen, A. M., Griffin, J. B. & Zempleni, J., Jul 2005, In : Journal of Nutritional Biochemistry. 16, 7, p. 446-448 3 p.

Research output: Contribution to journalArticle

59 Scopus citations

Biotin availability regulates expression of the sodium-dependent multivitamin transporter and the rate of biotin uptake in HepG2 cells

Pacheco-Alvarez, D., Solórzano-Vargas, R. S., González-Noriega, A., Michalak, C., Zempleni, J. & León-Del-Río, A., Aug 2005, In : Molecular Genetics and Metabolism. 85, 4, p. 301-307 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

Landenberger, A., Kabil, H., Harshman, L. G. & Zempleni, J., Oct 2004, In : Journal of Nutritional Biochemistry. 15, 10, p. 591-600 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Biotin deficiency stimulates survival pathways in human lymphoma cells exposed to antineoplastic drugs

Griffin, J. B. & Zempleni, J., Feb 2005, In : Journal of Nutritional Biochemistry. 16, 2, p. 96-103 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Biotin dependency due to a defect in biotin transport

Mardach, R., Zempleni, J., Wolf, B., Cannon, M. J., Jennings, M. L., Cress, S., Boylan, J., Roth, S., Cederbaum, S. & Mock, D. M., 2002, In : Journal of Clinical Investigation. 109, 12, p. 1617-1623 7 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Biotinidase catalyzes debiotinylation of histones

Ballard, T. D., Wolff, J., Griffin, J. B., Stanley, J. S., Van Calcar, S. & Zempleni, J., 2002, In : European Journal of Nutrition. 41, 2, p. 78-84 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Biotin regulates the expression of holocarboxylase synthetase in the miR-539 pathway in HEK-293 cells

Bao, B., Rodriguez-Melendez, R., Wijeratne, S. S. K. & Zempleni, J., Sep 2010, In : Journal of Nutrition. 140, 9, p. 1546-1551 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Biotin requirements are lower in human Jurkat lymphoid cells but homeostatic mechanisms are similar to those of HepG2 liver cells

Mall, G. K., Chew, Y. C. & Zempleni, J., Jun 2010, In : Journal of Nutrition. 140, 6, p. 1086-1092 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Biotin supplementation decreases the expression of the SERCA3 gene (ATP2A3) in Jurkat cells, thus, triggering unfolded protein response

Griffin, J. B., Rodriguez-Melendez, R., Dode, L., Wuytack, F. & Zempleni, J., Apr 2006, In : Journal of Nutritional Biochemistry. 17, 4, p. 272-281 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
Open Access
36 Scopus citations

Biotin supplementation increases expression of the cytochrome P 450 1B1 gene in Jurkat cells, increasing the occurrence of single-stranded DNA breaks

Rodriguez-Melendez, R., Griffin, J. B. & Zempleni, J., Sep 2004, In : Journal of Nutrition. 134, 9, p. 2222-2228 7 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Biotin supply affects expression of biotin transporters, biotinylation of carboxylases and metabolism of interleukin-2 in Jurkat cells

Manthey, K. C., Griffin, J. B. & Zempleni, J., 2002, In : Journal of Nutrition. 132, 5, p. 887-892 6 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Biotin supply affects rates of cell proliferation, biotinylation of carboxylases and histones, and expression of the gene encoding the sodium-dependent multivitamin transporter in JAr choriocarcinoma cells

Crisp, S. E. R. H., Griffin, J. B., White, B. R., Toombs, C. F., Camporeale, G., Said, H. M. & Zempleni, J., Feb 2004, In : European Journal of Nutrition. 43, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Biotin uptake into human peripheral blood mononuclear cells increases early in the cell cycle, increasing carboxylase activities

Steven Stanley, J., Mock, D. M., Griffin, J. B. & Zempleni, J., 2002, In : Journal of Nutrition. 132, 7, p. 1854-1859 6 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Biotinylation is a natural, albeit rare, modification of human histones

Kuroishi, T., Rios-Avila, L., Pestinger, V., Wijeratne, S. S. K. & Zempleni, J., Dec 2011, In : Molecular Genetics and Metabolism. 104, 4, p. 537-545 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Biotinylation of histones in human cells: Effects of cell proliferation

Steven Stanley, J., Griffin, J. B. & Zempleni, J., 2001, In : European Journal of Biochemistry. 268, 20, p. 5424-5429 6 p.

Research output: Contribution to journalArticle

136 Scopus citations

Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster

Yap, C. C., West, J. T., Kratzer, S. J., Ilvarsonn, A. M., Eissenberg, J. C., Dave, B. J., Klinkebiel, D., Christman, J. K. & Zempleni, J., Dec 2008, In : Journal of Nutrition. 138, 12, p. 2316-2322 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Biotinylation of K12 in histone H4 decreases in response to DNA double-strand breaks in human JAr choriocarcinoma cells

Kothapalli, N., Sarath, G. & Zempleni, J., Oct 2005, In : Journal of Nutrition. 135, 10, p. 2337-2342 6 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Biotinylation of lysine 16 in histone H4 contributes toward nucleosome condensation

Singh, M. P., Wijeratne, S. S. K. & Zempleni, J., Jan 15 2013, In : Archives of Biochemistry and Biophysics. 529, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase

Kobza, K. A., Chaiseeda, K., Sarath, G., Takacs, J. M. & Zempleni, J., Dec 2008, In : Journal of Nutritional Biochemistry. 19, 12, p. 826-832 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
10 Scopus citations

Bovine milk extracellular vesicles (EVs) modification elicits skeletal muscle growth in rats

Parry, H. A., Brooks Mobley, C., Mumford, P. W., Romero, M. A., Haun, C. T., Zhang, Y., Roberson, P. A., Zempleni, J., Ferrando, A. A., Vechetti, I. J., McCarthy, J. J., Young, K. C., Roberts, M. D. & Kavazis, A. N., 2019, In : Frontiers in Physiology. 10, MAR, 436.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
16 Scopus citations

Clusters of biotin-responsive genes in human peripheral blood mononuclear cells

Wiedmann, S., Rodriguez-Melendez, R., Ortega-Cuellar, D. & Zempleni, J., Jul 2004, In : Journal of Nutritional Biochemistry. 15, 7, p. 433-439 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Computational characterization of exogenous microRNAs that can be transferred into human circulation

Shu, J., Chiang, K., Zempleni, J. & Cui, J., Nov 3 2015, In : PloS one. 10, 11, e0140587.

Research output: Contribution to journalArticle

32 Scopus citations

Concentrations of purine metabolites are elevated in fluids from adults and infants and in livers from mice fed diets depleted of bovine milk exosomes and their RNA cargos

Aguilar-Lozano, A., Baier, S., Grove, R., Shu, J., Giraud, D., Leiferman, A., Mercer, K. E., Cui, J., Badger, T. M., Adamec, J., Andres, A. & Zempleni, J., 2018, In : Journal of Nutrition. 148, 12, p. 1886-1894 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
8 Scopus citations
24 Scopus citations

Development of an internet based system for modeling biotin metabolism using Bayesian networks

Zhou, J., Wang, D., Schlegel, V. & Zempleni, J., Nov 2011, In : Computer Methods and Programs in Biomedicine. 104, 2, p. 254-259 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Diaminobiotin and desthiobiotin have biotin-like activities in Jurkat cells

Rodriguez-Melendez, R., Lewis, B., McMahon, R. J. & Zempleni, J., May 1 2003, In : Journal of Nutrition. 133, 5, p. 1259-1264 6 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
11 Scopus citations

Dietary microRNA database (DMD): An archive database and analytic tool for food-borne microRNAs

Chiang, K., Shu, J., Zempleni, J. & Cui, J., Jun 1 2015, In : PloS one. 10, 6, e0128089.

Research output: Contribution to journalArticle

21 Scopus citations

Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance

Camporeale, G., Giordano, E., Rendina, R., Zempleni, J. & Eissenberg, J. C., Nov 2006, In : Journal of Nutrition. 136, 11, p. 2735-2742 8 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Effects of single-nucleotide polymorphisms in the human holocarboxylase synthetase gene on enzyme catalysis

Esaki, S., Malkaram, S. A. & Zempleni, J., Apr 2012, In : European Journal of Human Genetics. 20, 4, p. 428-433 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Enrichment of meiotic recombination hotspot sequences by avidin capture technology

Camara Teixeira, D., Malkaram, S. A. & Zempleni, J., Mar 1 2013, In : Gene. 516, 1, p. 101-106 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Epigenetic regulation of chromatin structure and gene function by biotin

Hassan, Y. I. & Zempleni, J., 2006, In : Journal of Nutrition. 136, 7, p. 1763-1765 3 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations

Epigenetic regulation of chromatin structure and gene function by biotin: Are biotin requirements being met?

Zempleni, J., Chew, Y. C., Hassan, Y. I. & Wijeratne, S. S. K., Aug 2008, In : Nutrition Reviews. 66, SUPPL.1, p. S46-S48

Research output: Contribution to journalArticle

17 Scopus citations

Epigenetic Synergies Between Biotin and Folate in the Regulation of Pro-Inflammatory Cytokines and Repeats

Xue, J. & Zempleni, J., Nov 2013, In : Scandinavian Journal of Immunology. 78, 5, p. 419-425 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Exposure to UV light causes increased biotinylation of histones in Jurkat cells

Peters, D. M., Griffin, J. B., Steven Stanley, J., Beck, M. M. & Zempleni, J., Sep 2002, In : American Journal of Physiology - Cell Physiology. 283, 3 52-3, p. C878-C884

Research output: Contribution to journalArticle

53 Scopus citations