Janos Zempleni, PhD

  • 4549 Citations
  • 38 h-Index
1974 …2020

Research output per year

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Research Output

2012

Biotin requirements for DNA damage prevention

Zempleni, J., Teixeira, D. C., Kuroishi, T., Cordonier, E. L. & Baier, S., May 1 2012, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 733, 1-2, p. 58-60 3 p.

Research output: Contribution to journalReview article

16 Scopus citations
8 Scopus citations

Effects of single-nucleotide polymorphisms in the human holocarboxylase synthetase gene on enzyme catalysis

Esaki, S., Malkaram, S. A. & Zempleni, J., Apr 2012, In : European Journal of Human Genetics. 20, 4, p. 428-433 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
9 Scopus citations

Online tools for bioinformatics analyses in nutrition sciences

Malkaram, S. A., Hassan, Y. I. & Zempleni, J., Sep 2012, In : Advances in Nutrition. 3, 5, p. 654-665 12 p.

Research output: Contribution to journalReview article

9 Scopus citations
2011

A 96-well plate assay for high-throughput analysis of holocarboxylase synthetase activity

Rios-Avila, L., Prince, S. A., Wijeratne, S. S. K. & Zempleni, J., Apr 11 2011, In : Clinica Chimica Acta. 412, 9-10, p. 735-739 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Biotinylation is a natural, albeit rare, modification of human histones

Kuroishi, T., Rios-Avila, L., Pestinger, V., Wijeratne, S. S. K. & Zempleni, J., Dec 2011, In : Molecular Genetics and Metabolism. 104, 4, p. 537-545 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Development of an internet based system for modeling biotin metabolism using Bayesian networks

Zhou, J., Wang, D., Schlegel, V. & Zempleni, J., Nov 2011, In : Computer Methods and Programs in Biomedicine. 104, 2, p. 254-259 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18

Bao, B., Pestinger, V., Hassan, Y. I., Borgstahl, G. E. O., Kolar, C. & Zempleni, J., May 2011, In : Journal of Nutritional Biochemistry. 22, 5, p. 470-475 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Human holocarboxylase synthetase with a start site at methionine-58 is the predominant nuclear variant of this protein and has catalytic activity

Bao, B., Wijeratne, S. S. K., Rodriguez-Melendez, R. & Zempleni, J., Aug 19 2011, In : Biochemical and Biophysical Research Communications. 412, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
9 Scopus citations

Novel histone biotinylation marks are enriched in repeat regions and participate in repression of transcriptionally competent genes

Pestinger, V., Wijeratne, S. S. K., Rodriguez-Melendez, R. & Zempleni, J., Apr 2011, In : Journal of Nutritional Biochemistry. 22, 4, p. 328-333 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

The role of histone H4 biotinylation in the structure of nucleosomes

Filenko, N. A., Kolar, C., West, J. T., Abbie Smith, S., Hassan, Y. I., Borgstahl, G. E. O., Zempleni, J. & Lyubchenko, Y. L., 2011, In : PloS one. 6, 1, e16299.

Research output: Contribution to journalArticle

26 Scopus citations

The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events

Zempleni, J., Li, Y., Xue, J. & Cordonier, E. L., Jul 2011, In : Epigenetics. 6, 7, p. 892-894 3 p.

Research output: Contribution to journalArticle

6 Scopus citations
2010

Biotin regulates the expression of holocarboxylase synthetase in the miR-539 pathway in HEK-293 cells

Bao, B., Rodriguez-Melendez, R., Wijeratne, S. S. K. & Zempleni, J., Sep 2010, In : Journal of Nutrition. 140, 9, p. 1546-1551 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Biotin requirements are lower in human Jurkat lymphoid cells but homeostatic mechanisms are similar to those of HepG2 liver cells

Mall, G. K., Chew, Y. C. & Zempleni, J., Jun 2010, In : Journal of Nutrition. 140, 6, p. 1086-1092 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

K12-biotinylated histone H4 is enriched in telomeric repeats from human lung IMR-90 fibroblasts

Wijeratne, S. S. K., Camporeale, G. & Zempleni, J., Apr 2010, In : Journal of Nutritional Biochemistry. 21, 4, p. 310-316 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
5 Scopus citations
2009

Biotin

Zempleni, J., Wijeratne, S. S. K. & Hassan, Y. I., Jan 2009, In : BioFactors. 35, 1, p. 36-46 11 p.

Research output: Contribution to journalReview article

169 Scopus citations

N- and C-terminal domains in human holocarboxylase synthetase participate in substrate recognition

Hassan, Y. I., Moriyama, H., Olsen, L. J., Bi, X. & Zempleni, J., Apr 2009, In : Molecular Genetics and Metabolism. 96, 4, p. 183-188 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Nitric oxide signaling depends on biotin in Jurkat human lymphoma cells

Rodriguez-Melendez, R. & Zempleni, J., Mar 2009, In : Journal of Nutrition. 139, 3, p. 429-433 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Overview to symposium "Nutrients and epigenetic regulation of gene expression"

Ho, E. & Zempleni, J., Dec 2009, In : Journal of Nutrition. 139, 12, p. 2387-2388 2 p.

Research output: Contribution to journalArticle

16 Scopus citations

Repression of transposable elements by histone biotinylation

Zempleni, J., Chew, Y. C., Bao, L., Pestinger, V. & Wijeratne, S. S. K., Dec 2009, In : Journal of Nutrition. 139, 12, p. 2389-2392 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sodium-dependent multivitamin transporter gene is regulated at the chromatin level by histone biotinylation in human jurkat lymphoblastoma cells

Zempleni, J., Gralla, M., Camporeale, G. & Hassan, Y. I., Jan 2009, In : Journal of Nutrition. 139, 1, p. 163-166 4 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

A novel, enigmatic histone modification: Biotinylation of histones by holocarboxylase synthetase

Hassan, Y. I. & Zempleni, J., Dec 2008, In : Nutrition Reviews. 66, 12, p. 721-725 5 p.

Research output: Contribution to journalReview article

34 Scopus citations

Biotin and biotinidase deficiency

Zempleni, J., Hassan, Y. I. & Wijeratne, S. S. K., 2008, In : Expert Review of Endocrinology and Metabolism. 3, 6, p. 715-724 10 p.

Research output: Contribution to journalReview article

84 Scopus citations

Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster

Yap, C. C., West, J. T., Kratzer, S. J., Ilvarsonn, A. M., Eissenberg, J. C., Dave, B. J., Klinkebiel, D., Christman, J. K. & Zempleni, J., Dec 2008, In : Journal of Nutrition. 138, 12, p. 2316-2322 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase

Kobza, K. A., Chaiseeda, K., Sarath, G., Takacs, J. M. & Zempleni, J., Dec 2008, In : Journal of Nutritional Biochemistry. 19, 12, p. 826-832 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Epigenetic regulation of chromatin structure and gene function by biotin: Are biotin requirements being met?

Zempleni, J., Chew, Y. C., Hassan, Y. I. & Wijeratne, S. S. K., Aug 2008, In : Nutrition Reviews. 66, SUPPL.1, p. S46-S48

Research output: Contribution to journalArticle

17 Scopus citations

Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus

Gralla, M., Camporeale, G. & Zempleni, J., Jun 2008, In : Journal of Nutritional Biochemistry. 19, 6, p. 400-408 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Prokaryotic bira ligase biotinylates K4, K9, K18 and K23 in histone H3

Kobza, K., Sarath, G. & Zempleni, J., 2008, In : BMB Reports. 41, 4, p. 310-315 6 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations
2007

An avidin-based assay for histone debiotinylase activity in human cell nuclei

Chew, Y. C., Sarath, G. & Zempleni, J., Jul 2007, In : Journal of Nutritional Biochemistry. 18, 7, p. 475-481 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns

Smith, E. M., Hoi, J. T., Eissenberg, J. C., Shoemaker, J. D., Neckameyer, W. S., Ilvarsonn, A. M., Harshman, L. G., Schlegel, V. L. & Zempleni, J., Sep 2007, In : Journal of Nutrition. 137, 9, p. 2006-2012 7 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Genomic implications of H2O2 for cell proliferation and growth of Caco-2 cells

Herring, T. A., Cuppett, S. L. & Zempleni, J., Nov 2007, In : Digestive Diseases and Sciences. 52, 11, p. 3005-3015 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

K12-biotinylated histone H4 marks heterochromatin in human lymphoblastoma cells

Camporeale, G., Oommen, A. M., Griffin, J. B., Sarath, G. & Zempleni, J., Nov 2007, In : Journal of Nutritional Biochemistry. 18, 11, p. 760-768 9 p.

Research output: Contribution to journalArticle

57 Scopus citations
Open Access
30 Scopus citations

Use of synthetic peptides for identifying biotinylation sites in human histones

Camporeale, G., Yap, C. C., Kueh, A., Sarath, G. & Zempleni, J., Dec 15 2007, Avidin-Biotin Interactions - Methods and Applications. Humana Press, p. 139-148 10 p. (Methods in Molecular Biology; vol. 418).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2006

Biotin supplementation decreases the expression of the SERCA3 gene (ATP2A3) in Jurkat cells, thus, triggering unfolded protein response

Griffin, J. B., Rodriguez-Melendez, R., Dode, L., Wuytack, F. & Zempleni, J., Apr 2006, In : Journal of Nutritional Biochemistry. 17, 4, p. 272-281 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance

Camporeale, G., Giordano, E., Rendina, R., Zempleni, J. & Eissenberg, J. C., Nov 2006, In : Journal of Nutrition. 136, 11, p. 2735-2742 8 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Epigenetic regulation of chromatin structure and gene function by biotin

Hassan, Y. I. & Zempleni, J., 2006, In : Journal of Nutrition. 136, 7, p. 1763-1765 3 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations

Lysine residues in N-terminal and C-terminal regions of human histone H2A are targets for biotinylation by biotinidase

Chew, Y. C., Camporeale, G., Kothapalli, N., Sarath, G. & Zempleni, J., Apr 2006, In : Journal of Nutritional Biochemistry. 17, 4, p. 225-233 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Riboflavin deficiency causes protein and DNA damage in HepG2 cells, triggering arrest in G1 phase of the cell cycle

Manthey, K. C., Rodriguez-Melendez, R., Hoi, J. T. & Zempleni, J., Apr 2006, In : Journal of Nutritional Biochemistry. 17, 4, p. 250-256 7 p.

Research output: Contribution to journalArticle

44 Scopus citations
14 Scopus citations
2005

Biological functions of biotinylated histones

Kothapalli, N., Camporeale, G., Kueh, A., Chew, Y. C., Oommen, A. M., Griffin, J. B. & Zempleni, J., Jul 2005, In : Journal of Nutritional Biochemistry. 16, 7, p. 446-448 3 p.

Research output: Contribution to journalArticle

59 Scopus citations

Biotin availability regulates expression of the sodium-dependent multivitamin transporter and the rate of biotin uptake in HepG2 cells

Pacheco-Alvarez, D., Solórzano-Vargas, R. S., González-Noriega, A., Michalak, C., Zempleni, J. & León-Del-Río, A., Aug 2005, In : Molecular Genetics and Metabolism. 85, 4, p. 301-307 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Biotin deficiency stimulates survival pathways in human lymphoma cells exposed to antineoplastic drugs

Griffin, J. B. & Zempleni, J., Feb 2005, In : Journal of Nutritional Biochemistry. 16, 2, p. 96-103 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Biotinylation of K12 in histone H4 decreases in response to DNA double-strand breaks in human JAr choriocarcinoma cells

Kothapalli, N., Sarath, G. & Zempleni, J., Oct 2005, In : Journal of Nutrition. 135, 10, p. 2337-2342 6 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium

Werner, R., Manthey, K. C., Griffin, J. B. & Zempleni, J., Oct 2005, In : Journal of Nutritional Biochemistry. 16, 10, p. 617-624 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

High-throughput immunoblotting identifies biotin-dependent signaling proteins in HepG2 hepatocarcinoma cells

Rodriguez-Melendez, R., Griffin, J. B., Sarath, G. & Zempleni, J., Jul 2005, In : Journal of Nutrition. 135, 7, p. 1659-1666 8 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

K4, K9 and K18 in human histone H3 are targets for biotinylation by biotinidase

Kobza, K., Camporeale, G., Rueckert, B., Kueh, A., Griffin, J. B., Sarath, G. & Zempleni, J., Aug 2005, In : FEBS Journal. 272, 16, p. 4249-4259 11 p.

Research output: Contribution to journalArticle

68 Scopus citations