Janos Zempleni, PhD

  • 4549 Citations
  • 38 h-Index
1974 …2020

Research output per year

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Research Output

2005

Nutrients and cell signaling

Zempleni, J. & Dakshinamurti, K., Jan 1 2005, CRC Press. 733 p.

Research output: Book/ReportBook

Pantothenic acid and biotin

Camporeale, G., Rodríguez-Meléndez, R. & Zempleni, J., Jan 1 2005, Sports Nutrition: Vitamins and Trace Elements, Second Edition. CRC Press, p. 123-138 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Preface

Zempleni, J. & Dakshinamurti, K., Jan 1 2005, Nutrients and Cell Signaling. CRC Press, p. xi-xii

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Riboflavin deficiency impairs oxidative folding and secretion of apolipoprotein B-100 in HepG2 cells, triggering stress response systems

Manthey, K. C., Yap, C. C. & Zempleni, J., May 2005, In : Journal of Nutrition. 135, 5, p. 978-982 5 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

Roles for biotinylation of histones in chromatin structure

Camporeale, G., Kothapalli, N., Sarath, G. & Zempleni, J., Jan 1 2005, Nutrients and Cell Signaling. CRC Press, p. 277-296 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Roles for nutrients in epigenetic events

Oommen, A. M., Griffin, J. B., Sarath, G. & Zempleni, J., Feb 2005, In : Journal of Nutritional Biochemistry. 16, 2, p. 74-77 4 p.

Research output: Contribution to journalArticle

79 Scopus citations

Uptake, localization, and noncarboxylase roles of biotin

Zempleni, J., 2005, In : Annual Review of Nutrition. 25, p. 175-196 22 p.

Research output: Contribution to journalReview article

131 Scopus citations
2004

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

Landenberger, A., Kabil, H., Harshman, L. G. & Zempleni, J., Oct 2004, In : Journal of Nutritional Biochemistry. 15, 10, p. 591-600 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Biotin supplementation increases expression of the cytochrome P 450 1B1 gene in Jurkat cells, increasing the occurrence of single-stranded DNA breaks

Rodriguez-Melendez, R., Griffin, J. B. & Zempleni, J., Sep 2004, In : Journal of Nutrition. 134, 9, p. 2222-2228 7 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Biotin supply affects rates of cell proliferation, biotinylation of carboxylases and histones, and expression of the gene encoding the sodium-dependent multivitamin transporter in JAr choriocarcinoma cells

Crisp, S. E. R. H., Griffin, J. B., White, B. R., Toombs, C. F., Camporeale, G., Said, H. M. & Zempleni, J., Feb 2004, In : European Journal of Nutrition. 43, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Clusters of biotin-responsive genes in human peripheral blood mononuclear cells

Wiedmann, S., Rodriguez-Melendez, R., Ortega-Cuellar, D. & Zempleni, J., Jul 2004, In : Journal of Nutritional Biochemistry. 15, 7, p. 433-439 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Jurkat cells respond to biotin deficiency with increased nuclear translocation of NF-κB, mediating cell survival

Rodriguez-Melendez, R., Schwab, L. D. & Zempleni, J., May 2004, In : International Journal for Vitamin and Nutrition Research. 74, 3, p. 209-216 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

K8 and K12 are biotinylated in human histone H4

Camporeale, G., Shubert, E. E., Sarath, G., Cerny, R. & Zempleni, J., Jun 2004, In : European Journal of Biochemistry. 271, 11, p. 2257-2263 7 p.

Research output: Contribution to journalArticle

81 Scopus citations
2003
Open Access
36 Scopus citations

Diaminobiotin and desthiobiotin have biotin-like activities in Jurkat cells

Rodriguez-Melendez, R., Lewis, B., McMahon, R. J. & Zempleni, J., May 1 2003, In : Journal of Nutrition. 133, 5, p. 1259-1264 6 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Expression of Oncogenes Depends on Biotin in Human Small Cell Lung Cancer Cells NCl-H69

Scheerger, S. B. & Zempleni, J., Dec 2003, In : International Journal for Vitamin and Nutrition Research. 73, 6, p. 461-467 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Interleukin-2 receptor-γ-dependent endocytosis depends on biotin in jurkat cells

Rodriguez-Melendez, R., Camporeale, G., Griffin, J. B. & Zempleni, J., Feb 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 2 53-2, p. C415-C421

Research output: Contribution to journalArticle

28 Scopus citations

Monocarboxylate transporter 1 mediates biotin uptake in human peripheral blood mononuclear cells

Daberkow, R. L., White, B. R., Cederberg, R. A., Griffin, J. B. & Zempleni, J., Sep 1 2003, In : Journal of Nutrition. 133, 9, p. 2703-2706 4 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations
Open Access
34 Scopus citations

Regulation of gene expression by biotin (review)

Rodriguez-Melendez, R. & Zempleni, J., Dec 2003, In : Journal of Nutritional Biochemistry. 14, 12, p. 680-690 11 p.

Research output: Contribution to journalReview article

101 Scopus citations

The Nuclear Abundance of Transcription Factors Sp1 and Sp3 Depends on Biotin in Jurkat Cells

Griffin, J. B., Rodriguez-Melendez, R. & Zempleni, J., Nov 2003, In : Journal of Nutrition. 133, 11, p. 3409-3415 7 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations
2002

Biotin dependency due to a defect in biotin transport

Mardach, R., Zempleni, J., Wolf, B., Cannon, M. J., Jennings, M. L., Cress, S., Boylan, J., Roth, S., Cederbaum, S. & Mock, D. M., 2002, In : Journal of Clinical Investigation. 109, 12, p. 1617-1623 7 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Biotinidase catalyzes debiotinylation of histones

Ballard, T. D., Wolff, J., Griffin, J. B., Stanley, J. S., Van Calcar, S. & Zempleni, J., 2002, In : European Journal of Nutrition. 41, 2, p. 78-84 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Biotin supply affects expression of biotin transporters, biotinylation of carboxylases and metabolism of interleukin-2 in Jurkat cells

Manthey, K. C., Griffin, J. B. & Zempleni, J., 2002, In : Journal of Nutrition. 132, 5, p. 887-892 6 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

Biotin uptake into human peripheral blood mononuclear cells increases early in the cell cycle, increasing carboxylase activities

Steven Stanley, J., Mock, D. M., Griffin, J. B. & Zempleni, J., 2002, In : Journal of Nutrition. 132, 7, p. 1854-1859 6 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Exposure to UV light causes increased biotinylation of histones in Jurkat cells

Peters, D. M., Griffin, J. B., Steven Stanley, J., Beck, M. M. & Zempleni, J., Sep 2002, In : American Journal of Physiology - Cell Physiology. 283, 3 52-3, p. C878-C884

Research output: Contribution to journalArticle

53 Scopus citations

Synthesis of a rabbit polyclonal antibody to the human sodium-dependent multivitamin transporter

Griffin, J. B., Stanley, J. S. & Zempleni, J., 2002, In : International Journal for Vitamin and Nutrition Research. 72, 4, p. 195-198 4 p.

Research output: Contribution to journalArticle

20 Scopus citations
2001

Biotin homeostasis during the cell cycle

Zempleni, J. & Mock, D. M., 2001, In : Nutrition Research Reviews. 14, 1, p. 45-63 19 p.

Research output: Contribution to journalReview article

7 Scopus citations

Biotinylation of histones in human cells: Effects of cell proliferation

Steven Stanley, J., Griffin, J. B. & Zempleni, J., 2001, In : European Journal of Biochemistry. 268, 20, p. 5424-5429 6 p.

Research output: Contribution to journalArticle

136 Scopus citations
Open Access
53 Scopus citations
22 Scopus citations
2000

Marginal biotin deficiency is teratogenic

Zempleni, J. & Mock, D. M., Jan 2000, In : Proceedings of the Society for Experimental Biology and Medicine. 223, 1, p. 14-21 8 p.

Research output: Contribution to journalReview article

78 Scopus citations

Proliferation of peripheral blood mononuclear cells increases riboflavin influx (44554)

Zempleni, J. & Mock, D. M., 2000, In : Experimental Biology and Medicine. 225, 1, p. 72-79 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Utilization of biotin in proliferating human lymphocytes

Zempleni, J. & Mock, D. M., 2000, In : Journal of Nutrition. 130, 2 SUPPL., p. 335S-337S

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
1999
Open Access
19 Scopus citations

Bioavailability of biotin given orally to humans in pharmacologic doses

Zempleni, J. & Mock, D. M., Mar 1999, In : American Journal of Clinical Nutrition. 69, 3, p. 504-508 5 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Biotin biochemistry and human requirements

Zempleni, J. & Mock, D. M., Mar 1999, In : Journal of Nutritional Biochemistry. 10, 3, p. 128-138 11 p.

Research output: Contribution to journalReview article

91 Scopus citations
16 Scopus citations
18 Scopus citations

Mitogen-induced proliferation increases biotin uptake into human peripheral blood mononuclear cells

Zempleni, J. & Mock, D. M., 1999, In : American Journal of Physiology - Cell Physiology. 276, 5 45-5, p. C1079-C1084

Research output: Contribution to journalArticle

30 Scopus citations

The efflux of biotin from human peripheral blood mononuclear cells

Zempleni, J. & Mock, D. M., Feb 1999, In : Journal of Nutritional Biochemistry. 10, 2, p. 105-109 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
1998

The intrauterine turnover of thiamin in preterm and full-term infants

Link, G., Zempleni, J. & Bitsch, I., 1998, In : International Journal for Vitamin and Nutrition Research. 68, 4, p. 242-248 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Uptake and metabolism of biotin by human peripheral blood mononuclear cells

Zempleni, J. & Mock, D. M., Aug 1998, In : American Journal of Physiology - Cell Physiology. 275, 2 44-2, p. C382-C388

Research output: Contribution to journalArticle

77 Scopus citations
1997

Biliary excretion of biotin and biotin metabolites is quantitatively minor in rats and pigs

Zempleni, J., Green, G. M., Spannagel, A. W. & Mock, D. M., 1997, In : Journal of Nutrition. 127, 8, p. 1496-1500 5 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Biokinetic analysis of vitamin absorption and disposition in humans

Zempleni, J., 1997, In : Methods in enzymology. 281, p. 405-425 21 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of biotin sulfone, bisnorbiotin methyl ketone, and tetranorbiotin-/-sulfoxide in human urine

Zempleni, J., McCormick, D. B. & Mock, D. M., 1997, In : American Journal of Clinical Nutrition. 65, 2, p. 508-511 4 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Lipoic acid reduces the activities of biotin-dependent carboxylases in rat liver

Zempleni, J., Trusty, T. A. & Mock, D. M., Sep 1997, In : Journal of Nutrition. 127, 9, p. 1776-1781 6 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Pyridoxal 5'-phosphate transfer in human placenta [3]

Schenker, S., Coburn, S. P., Zempleni, J. & Link, G., 1997, In : American Journal of Clinical Nutrition. 65, 5, p. 1571-1572 2 p.

Research output: Contribution to journalLetter

Open Access

The biliary excretion of biotin and biotin metabolites is a quantitatively minor route of excretion in rats

Zempleni, J., Green, G. M., Spannagel, A. U. & Mock, D. M., 1997, In : FASEB Journal. 11, 3, p. A233

Research output: Contribution to journalArticle