Janos Zempleni, PhD

  • 4464 Citations
  • 38 h-Index
1974 …2020

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Research Output

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Article
2020
Open Access
1 Scopus citations
2019
8 Scopus citations

Bovine milk extracellular vesicles (EVs) modification elicits skeletal muscle growth in rats

Parry, H. A., Brooks Mobley, C., Mumford, P. W., Romero, M. A., Haun, C. T., Zhang, Y., Roberson, P. A., Zempleni, J., Ferrando, A. A., Vechetti, I. J., McCarthy, J. J., Young, K. C., Roberts, M. D. & Kavazis, A. N., 2019, In : Frontiers in Physiology. 10, MAR, 436.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
9 Scopus citations

NIH workshop on human milk composition: Summary and visions

Casavale, K. O., Ahuja, J. K. C., Wu, X., Li, Y., Quam, J., Olson, R., Pehrsson, P., Allen, L., Balentine, D., Hanspal, M., Hayward, D., Hines, E. P., McClung, J. P., Perrine, C. G., Belfort, M. B., Dallas, D., German, B., Kim, J., McGuire, M., McGuire, M. & 6 others, Morrow, A. L., Neville, M., Nommsen-Rivers, L., Rasmussen, K. M., Zempleni, J. & Lynch, C. J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 769-779 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

A cell death assay for assessing the mitochondrial targeting of proteins

Camara Teixeira, D., Cordonier, E. L., Wijeratne, S. S. K., Huebbe, P., Jamin, A., Jarecke, S., Wiebe, M. & Zempleni, J., Jun 2018, In : Journal of Nutritional Biochemistry. 56, p. 48-54 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Concentrations of purine metabolites are elevated in fluids from adults and infants and in livers from mice fed diets depleted of bovine milk exosomes and their RNA cargos

Aguilar-Lozano, A., Baier, S., Grove, R., Shu, J., Giraud, D., Leiferman, A., Mercer, K. E., Cui, J., Badger, T. M., Adamec, J., Andres, A. & Zempleni, J., 2018, In : Journal of Nutrition. 148, 12, p. 1886-1894 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

Manca, S., Upadhyaya, B., Mutai, E., Desaulniers, A. T., Cederberg, R. A., White, B. R. & Zempleni, J., Dec 1 2018, In : Scientific reports. 8, 1, 11321.

Research output: Contribution to journalArticle

39 Scopus citations
2017

Biological activities of extracellular vesicles and their cargos from bovine and human milk in humans and implications for infants

Zempleni, J., Aguilar-Lozano, A., Sadri, M., Sukreet, S., Manca, S., Wu, D., Zhou, F. & Mutai, E., 2017, In : Journal of Nutrition. 147, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
2016

Glucocorticoid cell priming enhances transfection outcomes in adult human mesenchymal stem cells

Kelly, A. M., Plautz, S. A., Zempleni, J. & Pannier, A. K., Feb 1 2016, In : Molecular Therapy. 24, 2, p. 331-341 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human vascular endothelial cells transport foreign exosomes from cow’s milk by endocytosis

Kusuma, R. J., Manca, S., Frieme, T., Sukreet, S., Nguyen, C. & Zempleni, J., May 15 2016, In : American Journal of Physiology - Cell Physiology. 310, 10, p. C800-C807

Research output: Contribution to journalArticle

61 Scopus citations

Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells

Cordonier, E. L., Jarecke, S. K., Hollinger, F. E. & Zempleni, J., Jun 5 2016, In : European Journal of Pharmacology. 780, p. 202-208 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Riboflavin

Pinto, J. T. & Zempleni, J., 2016, In : Advances in Nutrition. 7, 5, p. 973-975 3 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Computational characterization of exogenous microRNAs that can be transferred into human circulation

Shu, J., Chiang, K., Zempleni, J. & Cui, J., Nov 3 2015, In : PloS one. 10, 11, e0140587.

Research output: Contribution to journalArticle

32 Scopus citations

Dietary microRNA database (DMD): An archive database and analytic tool for food-borne microRNAs

Chiang, K., Shu, J., Zempleni, J. & Cui, J., Jun 1 2015, In : PloS one. 10, 6, e0128089.

Research output: Contribution to journalArticle

21 Scopus citations

Loss of miRNAs during processing and storage of cow's (Bos taurus) milk

Howard, K. M., Jati Kusuma, R., Baier, S. R., Friemel, T., Markham, L., Vanamala, J. & Zempleni, J., Jan 21 2015, In : Journal of Agricultural and Food Chemistry. 63, 2, p. 588-592 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster

Cordonier, E. L., Adjam, R., Teixeira, D. C., Onur, S., Zbasnik, R., Read, P. E., Döring, F., Schlegel, V. L. & Zempleni, J., Nov 2015, In : Journal of Nutritional Biochemistry. 26, 11, p. 1379-1384 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
99 Scopus citations
2014
8 Scopus citations
16 Scopus citations
9 Scopus citations
185 Scopus citations

Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism

Zempleni, J., Liu, D., Teixeira Camara, D. & Cordonier, E. L., Jun 2014, In : Nutrition Reviews. 72, 6, p. 369-376 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Off-target effects of sulforaphane include the derepression of long terminal repeats through histone acetylation events

Baier, S. R., Zbasnik, R., Schlegel, V. & Zempleni, J., Jun 2014, In : Journal of Nutritional Biochemistry. 25, 6, p. 665-668 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Reply to witwer

Baier, S. R., Nguyen, C., Xie, F., Wood, J. R. & Zempleni, J., 2014, In : Journal of Nutrition. 144, 11, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

Reply to Witwer

Baier, S. R., Xie, F. & Zempleni, J., Nov 1 2014, In : The Journal of nutrition. 144, 11, p. 1882 1 p.

Research output: Contribution to journalArticle

6 Scopus citations

β-Keto and β-hydroxyphosphonate analogs of biotin-5′-AMP are inhibitors of holocarboxylase synthetase

Sittiwong, W., Cordonier, E. L., Zempleni, J. & Dussault, P. H., Dec 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 24, p. 5568-5571 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Biotinylation of lysine 16 in histone H4 contributes toward nucleosome condensation

Singh, M. P., Wijeratne, S. S. K. & Zempleni, J., Jan 15 2013, In : Archives of Biochemistry and Biophysics. 529, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enrichment of meiotic recombination hotspot sequences by avidin capture technology

Camara Teixeira, D., Malkaram, S. A. & Zempleni, J., Mar 1 2013, In : Gene. 516, 1, p. 101-106 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Epigenetic Synergies Between Biotin and Folate in the Regulation of Pro-Inflammatory Cytokines and Repeats

Xue, J. & Zempleni, J., Nov 2013, In : Scandinavian Journal of Immunology. 78, 5, p. 419-425 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
6 Scopus citations
15 Scopus citations

Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats

Xue, J., Wijeratne, S. S. K. & Zempleni, J., May 2013, In : Epigenetics. 8, 5, p. 504-511 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Identification and assessment of markers of biotin status in healthy adults

Eng, W. K., Giraud, D., Schlegel, V. L., Wang, D., Lee, B. H. & Zempleni, J., Jul 28 2013, In : British Journal of Nutrition. 110, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Three promoters regulate the transcriptional activity of the human holocarboxylase synthetase gene

Xia, M., Malkaram, S. A. & Zempleni, J., Nov 2013, In : Journal of Nutritional Biochemistry. 24, 11, p. 1963-1969 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012
8 Scopus citations

Effects of single-nucleotide polymorphisms in the human holocarboxylase synthetase gene on enzyme catalysis

Esaki, S., Malkaram, S. A. & Zempleni, J., Apr 2012, In : European Journal of Human Genetics. 20, 4, p. 428-433 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
9 Scopus citations
2011

A 96-well plate assay for high-throughput analysis of holocarboxylase synthetase activity

Rios-Avila, L., Prince, S. A., Wijeratne, S. S. K. & Zempleni, J., Apr 11 2011, In : Clinica Chimica Acta. 412, 9-10, p. 735-739 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Biotinylation is a natural, albeit rare, modification of human histones

Kuroishi, T., Rios-Avila, L., Pestinger, V., Wijeratne, S. S. K. & Zempleni, J., Dec 2011, In : Molecular Genetics and Metabolism. 104, 4, p. 537-545 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Development of an internet based system for modeling biotin metabolism using Bayesian networks

Zhou, J., Wang, D., Schlegel, V. & Zempleni, J., Nov 2011, In : Computer Methods and Programs in Biomedicine. 104, 2, p. 254-259 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18

Bao, B., Pestinger, V., Hassan, Y. I., Borgstahl, G. E. O., Kolar, C. & Zempleni, J., May 2011, In : Journal of Nutritional Biochemistry. 22, 5, p. 470-475 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Human holocarboxylase synthetase with a start site at methionine-58 is the predominant nuclear variant of this protein and has catalytic activity

Bao, B., Wijeratne, S. S. K., Rodriguez-Melendez, R. & Zempleni, J., Aug 19 2011, In : Biochemical and Biophysical Research Communications. 412, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
9 Scopus citations

Novel histone biotinylation marks are enriched in repeat regions and participate in repression of transcriptionally competent genes

Pestinger, V., Wijeratne, S. S. K., Rodriguez-Melendez, R. & Zempleni, J., Apr 2011, In : Journal of Nutritional Biochemistry. 22, 4, p. 328-333 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

The role of histone H4 biotinylation in the structure of nucleosomes

Filenko, N. A., Kolar, C., West, J. T., Abbie Smith, S., Hassan, Y. I., Borgstahl, G. E. O., Zempleni, J. & Lyubchenko, Y. L., 2011, In : PloS one. 6, 1, e16299.

Research output: Contribution to journalArticle

26 Scopus citations

The role of holocarboxylase synthetase in genome stability is mediated partly by epigenomic synergies between methylation and biotinylation events

Zempleni, J., Li, Y., Xue, J. & Cordonier, E. L., Jul 2011, In : Epigenetics. 6, 7, p. 892-894 3 p.

Research output: Contribution to journalArticle

6 Scopus citations
2010

Biotin regulates the expression of holocarboxylase synthetase in the miR-539 pathway in HEK-293 cells

Bao, B., Rodriguez-Melendez, R., Wijeratne, S. S. K. & Zempleni, J., Sep 2010, In : Journal of Nutrition. 140, 9, p. 1546-1551 6 p.

Research output: Contribution to journalArticle

22 Scopus citations