Jay F Storz

  • 5513 Citations
  • 44 h-Index
19952020

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2020

Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope

Signore, A. V. & Storz, J. F., Jun 2020, In : Science Advances. 6, 25, eabb544.

Research output: Contribution to journalArticle

Open Access

Coordinated changes across the O2 transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice

Tate, K. B., Wearing, O. H., Ivy, C. M., Cheviron, Z. A., Storz, J. F., McClelland, G. B. & Scott, G. R., May 27 2020, In : Proceedings. Biological sciences. 287, 1927, 1 p.

Research output: Contribution to journalArticle

Open Access

Darwin's Fancy Revised: An Updated Understanding of the Genomic Constitution of Pigeon Breeds

Pacheco, G., Van Grouw, H., Shapiro, M. D., Gilbert, M. T. P., Vieira, F. G. & Storz, J., Mar 17 2020, In : Genome Biology and Evolution. 12, 3, p. 136-150 15 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Ontogenesis of evolved changes in respiratory physiology in deer mice native to high altitude

Ivy, C. M., Greaves, M. A., Sangster, E. D., Robertson, C. E., Natarajan, C., Storz, J. F., McClelland, G. B. & Scott, G. R., 2020, In : Journal of Experimental Biology. 223, 4, jeb219360.

Research output: Contribution to journalArticle

Open Access

Origin of complexity in haemoglobin evolution

Pillai, A. S., Chandler, S. A., Liu, Y., Signore, A. V., Cortez-Romero, C. R., Benesch, J. L. P., Laganowsky, A., Storz, J. F., Hochberg, G. K. A. & Thornton, J. W., May 28 2020, In : Nature. 581, 7809, p. 480-485 6 p.

Research output: Contribution to journalArticle

Oxygenation properties of hemoglobin and the evolutionary origins of isoform multiplicity in an amphibious air-breathing fish, the blue-spotted mudskipper (Boleophthalmus pectinirostris)

Storz, J. F., Natarajan, C., Grouleff, M. K., Vandewege, M., Hoffmann, F. G., You, X., Venkatesh, B. & Fago, A., 2020, In : Journal of Experimental Biology. 223, 2, jeb217307.

Research output: Contribution to journalArticle

Open Access

Structure and function of crocodilian hemoglobins and allosteric regulation by chloride, ATP, and CO2

Fago, A., Natarajan, C., Pettinati, M., Hoffmann, F. G., Wang, T., Weber, R. E., Drusin, S. I., Issoglio, F., Martí, M. A., Estrin, D. & Storz, J. F., Mar 1 2020, In : American journal of physiology. Regulatory, integrative and comparative physiology. 318, 3, p. R657-R667

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Synthesis of Recombinant Human Hemoglobin With NH2 -Terminal Acetylation in Escherichia coli

Natarajan, C., Signore, A. V., Kumar, V. & Storz, J. F., Sep 1 2020, In : Current Protocols in Protein Science. 101, 1, p. e112

Research output: Contribution to journalArticle

2019

Adaptive Changes in Hemoglobin Function in High-Altitude Tibetan Canids Were Derived via Gene Conversion and Introgression

Signore, A. V., Yang, Y. Z., Yang, Q. Y., Qin, G., Moriyama, H., Ge, R. L., Storz, J. F. & Wilke, C., Oct 1 2019, In : Molecular biology and evolution. 36, 10, p. 2227-2237 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Evolution of physiological performance capacities and environmental adaptation: Insights from high-elevation deer mice (Peromyscus maniculatus)

Storz, J. F., Cheviron, Z. A., McClelland, G. B. & Scott, G. R., 2019, In : Journal of Mammalogy. 100, 3, p. 910-922 13 p., gyy173.

Research output: Contribution to journalArticle

6 Scopus citations

Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice

Schweizer, R. M., Velotta, J. P., Ivy, C. M., Jones, M. R., Muir, S. M., Bradburd, G. S., Storz, J. F., Scott, G. R. & Cheviron, Z. A., 2019, In : PLoS genetics. 15, 11, e1008420.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The role of mutation bias in adaptive molecular evolution: Insights from convergent changes in protein function

Storz, J. F., Natarajan, C., Signore, A. V., Witt, C. C., McCandlish, D. M. & Stoltzfus, A., 2019, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1777, 20180238.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Allosteric mechanisms underlying the adaptive increase in hemoglobin–oxygen affinity of the bar-headed goose

Jendroszek, A., Malte, H., Overgaard, C. B., Beedholm, K., Natarajan, C., Weber, R. E., Storz, J. F. & Fago, A., Sep 2018, In : Journal of Experimental Biology. 221, 18, jeb185470.

Research output: Contribution to journalArticle

9 Scopus citations

Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau

Zhu, X., Guan, Y., Signore, A. V., Natarajan, C., DuBay, S. G., Cheng, Y., Han, N., Song, G., Qu, Y., Moriyama, H., Hoffmann, F. G., Fago, A., Lei, F. & Storz, J. F., Feb 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. 1865-1870 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Gene turnover and diversificationof the α-and β-GlobinGene families in sauropsid vertebrates

Hoffmann, F. G., Vandewege, M. W., Storz, J. F. & Opazo, J. C., Jan 2018, In : Genome Biology and Evolution. 10, 1, p. 344-358 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose

Natarajan, C., Jendroszek, A., Kumar, A., Weber, R. E., Tame, J. R. H., Fago, A. & Storz, J. F., Apr 2018, In : PLoS genetics. 14, 4, e1007331.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Acclimation to hypoxia increases carbohydrate use during exercise in high-altitude deer mice

Lau, D. S., Connaty, A. D., Mahalingam, S., Wall, N., Cheviron, Z. A., Storz, J. F., Scott, G. R. & McClelland, G. B., Mar 10 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 312, 3, p. R400-R411

Research output: Contribution to journalArticle

16 Scopus citations

Alteration of the α1 β22 β1 subunit interface contributes to the increased hemoglobinoxygen affinity of high-altitude deer mice

Inoguchi, N., Mizuno, N., Baba, S., Kumasaka, T., Natarajan, C., Storz, J. F. & Moriyama, H., Mar 2017, In : PloS one. 12, 3, e0174921.

Research output: Contribution to journalArticle

2 Scopus citations

Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice

Tate, K. B., Ivy, C. M., Velotta, J. P., Storz, J. F., McClelland, G. B., Cheviron, Z. A. & Scott, G. R., Oct 15 2017, In : Journal of Experimental Biology. 220, 20, p. 3616-3620 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin

Kumar, A., Natarajan, C., Moriyama, H., Witt, C. C., Weber, R. E., Fago, A. & Storz, J. F., May 1 2017, In : Molecular biology and evolution. 34, 5, p. 1240-1251 12 p.

Research output: Contribution to journalArticle

16 Scopus citations
2016
11 Scopus citations

Predictable convergence in hemoglobin function has unpredictable molecular underpinnings

Natarajan, C., Hoffmann, F. G., Weber, R. E., Fago, A., Witt, C. C. & Storz, J. F., Oct 21 2016, In : Science. 354, 6310, p. 336-339 4 p.

Research output: Contribution to journalArticle

74 Scopus citations
2015

Adaptive Modifications of Muscle Phenotype in High-Altitude Deer Mice Are Associated with Evolved Changes in Gene Regulation

Scott, G. R., Elogio, T. S., Lui, M. A., Storz, J. F. & Cheviron, Z. A., Aug 1 2015, In : Molecular biology and evolution. 32, 8, p. 1962-1976 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

Ancient duplications and expression divergence in the globin gene superfamily of vertebrates: Insights from the elephant shark genome and transcriptome

Opazo, J. C., Lee, A. P., Hoffmann, F. G., Toloza-Villalobos, J., Burmester, T., Venkatesh, B. & Storz, J. F., Jul 1 2015, In : Molecular biology and evolution. 32, 7, p. 1684-1694 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Contribution of a mutational hot spot to hemoglobin adaptation in high-Altitude Andean house wrens

Galen, S. C., Natarajan, C., Moriyama, H., Weber, R. E., Fago, A., Benham, P. M., Chavez, A. N., Cheviron, Z. A., Storz, J. F. & Witt, C. C., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 13958-13963 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Convergent Evolution of Hemoglobin Function in High-Altitude Andean Waterfowl Involves Limited Parallelism at the Molecular Sequence Level

Natarajan, C., Projecto-Garcia, J., Moriyama, H., Weber, R. E., Muñoz-Fuentes, V., Green, A. J., Kopuchian, C., Tubaro, P. L., Alza, L., Bulgarella, M., Smith, M. M., Wilson, R. E., Fago, A., McCracken, K. G. & Storz, J. F., 2015, In : PLoS genetics. 11, 12, e1005681.

Research output: Contribution to journalArticle

47 Scopus citations

Epistasis constrains mutational pathways of hemoglobin adaptation in high-altitude pikas

Tufts, D. M., Natarajan, C., Revsbech, I. G., Projecto-Garcia, J., Hoffmann, F. G., Weber, R. E., Fago, A., Moriyama, H. & Storz, J. F., Feb 1 2015, In : Molecular biology and evolution. 32, 2, p. 287-298 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Genetically based low oxygen affinities of felid hemoglobins: Lack of biochemical adaptation to high-altitude hypoxia in the snow leopard

Janecka, J. E., Nielsen, S. S. E., Andersen, S. D., Hoffmann, F. G., Weber, R. E., Anderson, T., Storz, J. F. & Fago, A., Aug 1 2015, In : Journal of Experimental Biology. 218, 15, p. 2402-2409 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Gene turnover in the avian globin gene families and evolutionary changes in hemoglobin isoform expression

Opazo, J. C., Hoffmann, F. G., Natarajan, C., Witt, C. C., Berenbrink, M. & Storz, J. F., Apr 1 2015, In : Molecular biology and evolution. 32, 4, p. 871-887 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

High-altitude ancestry and hypoxia acclimation have distinct effects on exercise capacity and muscle phenotype in deer mice

Lui, M. A., Mahalingam, S., Patel, P., Connaty, A. D., Ivy, C. M., Cheviron, Z. A., Storz, J. F., McClelland, G. B. & Scott, G. R., 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 308, 9, p. R779-R791

Research output: Contribution to journalArticle

43 Scopus citations

Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin

Natarajan, C., Hoffmann, F. G., Lanier, H. C., Wolf, C. J., Cheviron, Z. A., Spangler, M. L., Weber, R. E., Fago, A. & Storz, J. F., Apr 1 2015, In : Molecular biology and evolution. 32, 4, p. 978-997 20 p.

Research output: Contribution to journalArticle

46 Scopus citations

Oxygenation properties and isoform diversity of snake hemoglobins

Storz, J. F., Natarajan, C., Moriyama, H., Hoffmann, F. G., Wang, T., Fago, A., Malte, H., Overgaard, J. & Weber, R. E., 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309, 9, p. R1178-R1191

Research output: Contribution to journalArticle

17 Scopus citations
2014

Comparative genomics reveals insights into avian genome evolution and adaptation

Avian Genome Consortium, Dec 12 2014, In : Science. 346, 6215, p. 1311-1320 10 p.

Research output: Contribution to journalArticle

417 Scopus citations

Functional genomics of adaptation to hypoxic cold-stress in high-altitude deer mice: Transcriptomic plasticity and thermogenic performance

Cheviron, Z. A., Connaty, A. D., Mcclelland, G. B. & Storz, J. F., Jan 2014, In : Evolution. 68, 1, p. 48-62 15 p.

Research output: Contribution to journalArticle

55 Scopus citations

Integrating evolutionary and functional tests of adaptive hypotheses: A case study of altitudinal differentiation in hemoglobin function in an andean sparrow, zonotrichia capensis

Cheviron, Z. A., Natarajan, C., Projecto-Garcia, J., Eddy, D. K., Jones, J., Carling, M. D., Witt, C. C., Moriyama, H., Weber, R. E., Fago, A. & Storz, J. F., Nov 1 2014, In : Molecular biology and evolution. 31, 11, p. 2948-2962 15 p.

Research output: Contribution to journalArticle

37 Scopus citations

Repeated evolution of chimeric fusion genes in the β-globin gene family of laurasiatherian mammals

Gaudry, M. J., Storz, J. F., Butts, G. T., Campbell, K. L. & Hoffmann, F. G., May 2014, In : Genome Biology and Evolution. 6, 5, p. 1219-1233 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

The globin gene repertoire of lampreys: Convergent evolution of hemoglobin and myoglobin in jawed and jawless vertebrates

Schwarze, K., Campbell, K. L., Hankeln, T., Storz, J. F., Hoffmann, F. G. & Burmester, T., Oct 1 2014, In : Molecular biology and evolution. 31, 10, p. 2708-2721 14 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Contributions of phenotypic plasticity to differences in thermogenic performance between highland and lowland deer mice

Cheviron, Z. A., Bachman, G. C. & Storz, J. F., Apr 2013, In : Journal of Experimental Biology. 216, 7, p. 1160-1166 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Deer mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the e helix

Inoguchi, N., Oshlo, J. R., Natarajan, C., Weber, R. E., Fago, A., Storz, J. F. & Moriyama, H., Apr 2013, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 4, p. 393-398 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Epistasis among adaptive mutations in deer mouse hemoglobin

Natarajan, C., Inoguchi, N., Weber, R. E., Fago, A., Moriyama, H. & Storz, J. F., 2013, In : Science. 340, 6138, p. 1324-1327 4 p.

Research output: Contribution to journalArticle

106 Scopus citations

Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) with different altitudinal ranges

Revsbech, I. G., Tufts, D. M., Projecto-Garcia, J., Moriyama, H., Weber, R. E., Storz, J. F. & Fago, A., Nov 2013, In : Journal of Experimental Biology. 216, 22, p. 4264-4271 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
24 Scopus citations
23 Scopus citations

Phenotypic plasticity in blood-oxygen transport in highland and lowland deer mice

Tufts, D. M., Revsbech, I. G., Cheviron, Z. A., Weber, R. E., Fago, A. & Storz, J. F., Apr 2013, In : Journal of Experimental Biology. 216, 7, p. 1167-1173 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Repeated elevational transitions in hemoglobin function during the evolution of Andean hummingbirds

Projecto-Garcia, J., Natarajan, C., Moriyama, H., Weber, R. E., Fago, A., Cheviron, Z. A., Dudley, R., McGuire, J. A., Witt, C. C. & Storz, J. F., Dec 17 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 51, p. 20669-20674 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Whole-genome duplication and the functional diversification of teleost fish hemoglobins

Opazo, J. C., Butts, G. T., Nery, M. F., Storz, J. F. & Hoffmann, F. G., Jan 2013, In : Molecular biology and evolution. 30, 1, p. 140-153 14 p.

Research output: Contribution to journalArticle

48 Scopus citations
2012

Altitudinal variation at duplicated β-globin genes in deer mice: Effects of selection, recombination, and gene conversion

Storz, J. F., Natarajan, C., Cheviron, Z. A., Hoffmann, F. G. & Kelly, J. K., Jan 2012, In : Genetics. 190, 1, p. 203-216 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Androglobin: A chimeric globin in metazoans that is preferentially expressed in mammalian testes

Hoogewijs, D., Ebner, B., Germani, F., Hoffmann, F. G., Fabrizius, A., Moens, L., Burmester, T., Dewilde, S., Storz, J. F., Vinogradov, S. N. & Hankeln, T., Apr 2012, In : Molecular biology and evolution. 29, 4, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Copy number polymorphism in the α-globin gene cluster of European rabbit (Oryctolagus cuniculus)

Campos, R., Storz, J. F. & Ferrand, N., May 2012, In : Heredity. 108, 5, p. 531-536 6 p.

Research output: Contribution to journalArticle

3 Scopus citations