Jean L Grem, MD

  • 8131 Citations
  • 50 h-Index
1985 …2020

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Review article
2019

Small bowel adenocarcinoma, version 1.2020

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Arain, M. A., Chen, Y. J., Ciombor, K. K., Cohen, S. A., Cooper, H. S., Deming, D. A., Garrido-Laguna, I., Grem, J. L., Hoffe, S. E., Hubbard, J., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J., Miller, E. D. & 17 others, Mulcahy, M. F., Steven Nurkin, Md, Ms, N. M. M., Overman, M. J., Parikh, A., Patel, H., Pedersen, K. S., Saltz, L. B., Schneider, C., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Johnson-Chilla, A., Gregory, K. M. & Gurski, L. A., Jan 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 9, p. 1109-1133 25 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations
2018

Anal Carcinoma, version 2.2018 clinical practice guidelines in Oncology

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Cederquist, L., Chen, Y. J., Ciombor, K. K., Cohen, S., Cooper, H. S., Deming, D., Engstrom, P. F., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J. & 14 others, Mulcahy, M. F., Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wuthrick, E., Gregory, K. M. & Freedman-Cass, D. A., Jul 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 7, p. 852-871 20 p.

Research output: Contribution to journalReview article

61 Scopus citations

Rectal cancer, version 2.2018 clinical practice guidelines in Oncology

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Cederquist, L., Chen, Y. J., Ciombor, K. K., Cohen, S., Cooper, H. S., Deming, D., Engstrom, P. F., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J. & 15 others, Mulcahy, M. F., Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wuthrick, E., Freedman-Cass, D. A., Gregory, K. M. & Gurski, L., Jul 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 7, p. 874-901 28 p.

Research output: Contribution to journalReview article

76 Scopus citations
2017

Colon cancer, version 1.2017: Clinical practice guidelines in oncology

Benson, A. B., Venook, A. P., Cederquist, L., Chan, E., Chen, Y. J., Cooper, H. S., Deming, D., Engstrom, P. F., Enzinger, P. C., Fichera, A., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Mulcahy, M. F. & 13 others, Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wu, C. S., Gregory, K. M. & Freedman-Cass, D., Mar 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 3, p. 370-398 29 p.

Research output: Contribution to journalReview article

Open Access
278 Scopus citations
2016

Biochemistry and Clinical Activity of N-(Phosphonacety1)-L-aspartate: A Review

Grem, J. L., King, S. A., O'Dwyer, P. J. & Leyland-Jones, B., Jan 1 2016, In : Cancer Research. 48, 16, p. 4441-4454 14 p.

Research output: Contribution to journalReview article

8 Scopus citations
2012

Anal carcinoma, version 2.2012: Featured updates to the NCCN guidelines

Benson, A. B., Arnoletti, J. P., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Engstrom, P. F., Enzinger, P. C., Fakih, M. G., Fleshman, J. W., Fuchs, C. S., Grem, J. L., Leong, L. A., Lin, E., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E. & 10 others, Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C. T., Venook, A. P., Willett, C. & Freedman-Cass, D. A., Apr 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 4, p. 449-454 6 p.

Research output: Contribution to journalReview article

Open Access
58 Scopus citations

Rectal cancer

Benson, A. B., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Engstrom, P. F., Enzinger, P. C., Fakih, M. G., Fuchs, C. S., Grem, J. L., Hunt, S., Leong, L. A., Lin, E., Martin, M. G., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E., Ryan, D. P. & 10 others, Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C. T., Venook, A. P., Willett, C. G., Freedman-Cass, D. A. & Gregory, K. M., Dec 1 2012, In : JNCCN Journal of the National Comprehensive Cancer Network. 10, 12, p. 1528-1564 37 p.

Research output: Contribution to journalReview article

115 Scopus citations
2011

Clinical practice guidelines in oncology

Benson, A. B., Arnoletti, J. P., Bekaii-Saab, T., Chan, E., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Engstrom, P. F., Enzinger, P. C., Fleshman, J. W., Fuchs, C. S., Grem, J. L., Knol, J. A., Leong, L. A., Lin, E., May, K. S., Mulcahy, M. F., Murphy, K., Rohren, E. & 9 others, Ryan, D. P., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Small, W., Sofocleous, C. T., Venook, A. P. & Willett, C., Nov 1 2011, In : JNCCN Journal of the National Comprehensive Cancer Network. 9, 11, p. 1238-1289 52 p.

Research output: Contribution to journalReview article

11 Scopus citations
2009

Colon cancer

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y. J., Choti, M. A., Cooper, H. S., Covey, A., Dilawari, R. A., Early, D. S., Enzinger, P. C., Fakih, M. G., Fleshman, J., Fuchs, C., Grem, J. L., Kiel, K., Knol, J. A., Leong, L. A., Lin, E., Mulcahy, M. F., Rao, S. & 8 others, Ryan, D. P., Saltz, L., Shibata, D., Skibber, J. M., Sofocleous, C., Thomas, J., Venook, A. P. & Willett, C., Sep 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 8, p. 778-831 54 p.

Research output: Contribution to journalReview article

Open Access
245 Scopus citations

Rectal cancer

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y. J., Choti, M. A., Cooper, H. S., Covey, A., Dilawari, R. A., Early, D. S., Enzinger, P. C., Fakih, M. G., Fleshman, J., Fuchs, C., Grem, J. L., Kiel, K., Knol, J. A., Leong, L. A., Lin, E., Mulcahy, M. F., Rao, S. & 8 others, Ryan, D. P., Saltz, L., Shibata, D., Skibber, J. M., Sofocleous, C., Thomas, J., Venook, A. P. & Willett, C., Sep 2009, In : JNCCN Journal of the National Comprehensive Cancer Network. 7, 8, p. 838-881 44 p.

Research output: Contribution to journalReview article

Open Access
189 Scopus citations
2007

Colon cancer

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Early, D. S., Fakih, M. G., Fuchs, C., Grem, J. L., Kiel, K., Knol, J. A., Leong, L. A., Ludwig, K. A., Martin, E. W., Rao, S., Saltz, L., Shibata, D., Skibber, J. M. & 1 others, Venook, A. P., Oct 2007, In : JNCCN Journal of the National Comprehensive Cancer Network. 5, 9, p. 884-925 42 p.

Research output: Contribution to journalReview article

9 Scopus citations

Rectal cancer

Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y. J., Choti, M. A., Cooper, H. S., Dilawari, R. A., Early, D. S., Fakih, M. G., Fuchs, C., Grem, J. L., Kiel, K., Knol, J. A., Leong, L. A., Ludwig, K. A., Martin, E. W., Rao, S., Saltz, L., Shibata, D., Skibber, J. M. & 1 others, Venook, A. P., Oct 2007, In : JNCCN Journal of the National Comprehensive Cancer Network. 5, 9, p. 940-981 42 p.

Research output: Contribution to journalReview article

8 Scopus citations
2004

The Gowda/Goel/Berdzik et al article reviewed

Grem, J., Nov 1 2004, In : ONCOLOGY. 18, 13, p. 1676+1680

Research output: Contribution to journalReview article

2003

Mistletoe and Gemcitabine in Patients with Advanced Cancer: A Model for the Phase I Study of Botanicals and Botanical-Drug Interactions in Cancer Therapy

Mansky, P. J., Grem, J., Wallerstedt, D. B., Monahan, B. P. & Blackman, M. R., Dec 1 2003, In : Integrative Cancer Therapies. 2, 4, p. 345-352 8 p.

Research output: Contribution to journalReview article

15 Scopus citations
2002

Oxaliplatin beim kolorektal-karzinom: Neue daten zu first-line-und adjuvanter therapie

Translated title of the contribution: Oxaliplatin in colorectal cancer: New data in first-line and adjuvant therapyGoldberg, R. M., Saltz, L., Grem, J. L., Lenz, H. J., Ajani, J. A., Blackstock, A. W., Tempero, M. A., Plunkett, W., Overmoyer, B. & Weiner, G. J., Oct 9 2002, In : Onkologie. 25, SUPPL. 3, p. 1-11 11 p.

Research output: Contribution to journalReview article

1 Scopus citations

Relative gene expression in normal and tumor tissue by quantitative RT-PCR.

Salonga, D. S., Danenberg, K. D., Grem, J., Park, J. M. & Danenberg, P. V., 2002, In : Methods in molecular biology (Clifton, N.J.). 191, p. 83-98 16 p.

Research output: Contribution to journalReview article

7 Scopus citations
2001

Thymidylate synthase inhibitors.

Ismail, A. S. & Grem, J. L., 2001, In : Cancer chemotherapy and biological response modifiers. 19, p. 1-19 19 p.

Research output: Contribution to journalReview article

2000

5-Fluorouracil: Forty-plus and still ticking. A review of its preclinical and clinical development

Grem, J. L., Oct 28 2000, In : Investigational New Drugs. 18, 4, p. 299-313 15 p.

Research output: Contribution to journalReview article

245 Scopus citations
1999

Antimetabolites.

Grem, J. L., Takimoto, C. H., Multani, P., Chu, E., Ryan, D., Chabner, B. A., Allegra, C. J. & Johnston, P. G., 1999, In : Cancer chemotherapy and biological response modifiers. 18, p. 1-38 38 p.

Research output: Contribution to journalReview article

17 Scopus citations
1997

Antimetabolites.

Johnston, P. G., Takimoto, C. H., Grem, J. L., Fidias, P., Grossbard, M. L., Chabner, B. A., Allegra, C. J. & Chu, E., 1997, In : Cancer chemotherapy and biological response modifiers. 17, p. 1-39 39 p.

Research output: Contribution to journalReview article

10 Scopus citations

Systemic treatment options in advanced colorectal cancer: Perspectives on combination 5-fluorouracil plus leucovorin

Grem, J. L., Dec 1 1997, In : Seminars in Oncology. 24, 5 SUPPL. 18, p. S18-8-S18-18

Research output: Contribution to journalReview article

33 Scopus citations

The prognostic importance of tumor markers in adenocarcinomas of the gastrointestinal tract

Grem, J., Jan 1 1997, In : Current Opinion in Oncology. 9, 4, p. 380-387 8 p.

Research output: Contribution to journalReview article

47 Scopus citations
1996

Antimetabolites.

Johnston, P. G., Takimoto, C. H., Grem, J. L., Chabner, B. A., Allegra, C. J. & Chu, E., 1996, In : Cancer chemotherapy and biological response modifiers. 16, p. 1-27 27 p.

Research output: Contribution to journalReview article

10 Scopus citations

New concepts for the development and use of antifolates

Chu, E., Grem, J. L., Johnston, P. G. & Allegra, C. J., Jan 1 1996, In : STEM CELLS. 14, 1, p. 41-46 6 p.

Research output: Contribution to journalReview article

Open Access
24 Scopus citations
1994

Antimetabolites.

Chu, E., Johnston, P. G., Grem, J. L., Takimoto, C. H., Van Groeningen, C., Chabner, B. A. & Allegra, C. J., 1994, In : Cancer chemotherapy and biological response modifiers. 15, p. 1-31 31 p.

Research output: Contribution to journalReview article

4 Scopus citations

Chemotherapy of advanced gastrointestinal cancer

Geoffroy, F. & Grem, J. L., Jan 1 1994, In : Current Opinion in Oncology. 6, 4, p. 427-434 8 p.

Research output: Contribution to journalReview article

8 Scopus citations
1993

Antimetabolites.

Chu, E., Johnston, P. G., Takimoto, C. H., Politi, P. M., Grem, J. L., Chabner, B. A. & Allegra, C. J., 1993, In : Cancer chemotherapy and biological response modifiers. 14, p. 1-25 25 p.

Research output: Contribution to journalReview article

2 Scopus citations

Doxorubicin: role in the treatment of osteosarcoma.

Blaney, S. M., Smith, M. A. & Grem, J. L., 1993, In : Cancer treatment and research. 62, p. 55-73 19 p.

Research output: Contribution to journalReview article

18 Scopus citations

Neoadjuvant chemotherapy for locally advanced gastric adenocarcinoma

Alexander, H. R., Grem, J. L., Pass, H. I., Hamilton, M., McAtee, N., Fraker, D. L. & Allegra, C. J., Jan 1 1993, In : ONCOLOGY. 7, 5, p. 37-41 5 p.

Research output: Contribution to journalReview article

13 Scopus citations
1992

Antimetabolites

Chen, A. P. & Grem, J. L., Jan 1 1992, In : Current Opinion in Oncology. 4, 6, p. 1089-1098 10 p.

Research output: Contribution to journalReview article

5 Scopus citations

Antimetabolites.

Chu, E., Grem, J. L., Johnston, P. G., Politi, P. M., Chabner, B. A. & Allegra, C. J., Jan 1 1992, In : Cancer chemotherapy and biological response modifiers. 13, p. 1-30 30 p.

Research output: Contribution to journalReview article

1 Scopus citations
1991

Adjuvant treatment of node-positive colon carcinoma with levamisole and 5-fluorouracil

Grem, J. L., Jan 1 1991, In : ONCOLOGY. 5, 3, p. 63-74 12 p.

Research output: Contribution to journalReview article

3 Scopus citations

Antimetabolites.

Grem, J. L., Chabner, B. A., Chu, E., Johnson, P., Yeh, G. C. & Allegra, C. J., Jan 1 1991, In : Cancer chemotherapy and biological response modifiers. 12, p. 1-25 25 p.

Research output: Contribution to journalReview article

1 Scopus citations

Clinical use of thymidine as a rescue agent from methotrexate toxicity

Grem, J. L., King, S. A., Sorensen, J. M. & Christian, M. C., Aug 1 1991, In : Investigational New Drugs. 9, 3, p. 281-290 10 p.

Research output: Contribution to journalReview article

20 Scopus citations

Modulation of cytosine arabinoside toxicity by 3-deazauridine in a murine leukemia model

Grem, J. L., Plowman, J., Rubinstein, L., Hawkins, M. J. & Harrison, S. D., 1991, In : Leukemia Research. 15, 4, p. 229-236 8 p.

Research output: Contribution to journalReview article

9 Scopus citations
1990

Antimetabolites.

Allegra, C. J., Grem, J. L., Chu, E., Johnston, P., Yeh, G. C. & Chabner, B. A., Jan 1 1990, In : Cancer chemotherapy and biological response modifiers. 11, p. 1-28 28 p.

Research output: Contribution to journalReview article

3 Scopus citations

Levamisole as a therapeutic agent for colorectal carcinoma

Grem, J. L., Jan 1 1990, In : Cancer Cells. 2, 5, p. 131-137 7 p.

Research output: Contribution to journalReview article

15 Scopus citations

Metabolism and action of amino acid analog anti-cancer agents

Ahluwalia, G. S., Grem, J. L., Hao, Z. & Cooney, D. A., 1990, In : Pharmacology and Therapeutics. 46, 2, p. 243-271 29 p.

Research output: Contribution to journalReview article

150 Scopus citations
1988

Cephalotaxine esters: Antileukemic advance or therapeutic failure?

Grem, J. L., Cheson, B. D., King, S. A., Leyland-jones, B. & Suffness, M., Sep 21 1988, In : Journal of the National Cancer Institute. 80, 14, p. 1095-1103 9 p.

Research output: Contribution to journalReview article

38 Scopus citations

Teniposide in the treatment of leukemia: A case study of conflicting priorities in the development of drugs for fatal diseases

Grem, J. L., Hoth, D. F., Leyland-Jones, B., King, S. A., Ungerleider, R. S. & Wittes, R. E., Jan 1 1988, In : Journal of Clinical Oncology. 6, 2, p. 351-379 29 p.

Research output: Contribution to journalReview article

14 Scopus citations

The role of methotrexate in osteosarcoma

Grem, J. L., King, S. A., Wittes, R. E. & Leyland-jones, B., Jul 6 1988, In : Journal of the National Cancer Institute. 80, 9, p. 626-655 30 p.

Research output: Contribution to journalReview article

37 Scopus citations
1987

Arabinosyl-5-azacytosine: A novel nucleoside entering clinical trials

Grem, J. L., Shoemaker, D. D., Hoth, D. F., King, S. A., Plowman, J., Zaharko, D., Grieshaber, C. K., Harrison, S. D., Cradock, J. C. & Leyland-Jones, B., Dec 1 1987, In : Investigational New Drugs. 5, 4, p. 315-328 14 p.

Research output: Contribution to journalReview article

22 Scopus citations

Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.

Grem, J. L., Hoth, D. F., Hamilton, J. M., King, S. A. & Leyland-Jones, B., Dec 1987, In : Cancer treatment reports. 71, 12, p. 1249-1264 16 p.

Research output: Contribution to journalReview article

105 Scopus citations