Jialin C Zheng, MD

  • 4877 Citations
  • 39 h-Index
1980 …2020

Research output per year

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Research Output

2020

Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain

Zhang, Y., Lu, P., Liang, F., Liufu, N., Dong, Y., Zheng, J. C. & Xie, Z., Feb 11 2020, In : Frontiers in Cell and Developmental Biology. 7, 396.

Research output: Contribution to journalArticle

Open Access

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release

Gao, G., Li, C., Zhu, J., Wang, Y., Huang, Y., Zhao, S., Sheng, S., Song, Y., Ji, C., Li, C., Yang, X., Ye, L., Qi, X., Zhang, Y., Xia, X. & Zheng, J. C., Feb 7 2020, In : Frontiers in immunology. 11, 161.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Reprogrammed astrocytes display higher neurogenic competence, migration ability and cell death resistance than reprogrammed fibroblasts

Xia, X., Li, C., Wang, Y., Deng, X., Ma, Y., Ding, L. & Zheng, J., Feb 8 2020, In : Translational Neurodegeneration. 9, 1, 6.

Research output: Contribution to journalArticle

Open Access

Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

Chen, X., Guo, J., Huang, Y., Liu, S., Huang, Y., Zhang, Z., Zhang, F., Lu, Z., Li, F., Zheng, J. C. & Ding, W., Sep 2020, In : Environmental Pollution. 264, 114716.

Research output: Contribution to journalArticle

Open Access
2019

Direct and selective lineage conversion of human fibroblasts to dopaminergic precursors

He, M., Zhang, H., Li, Y., Tian, C., Tang, B., Huang, Y. & Zheng, J., Apr 23 2019, In : Neuroscience Letters. 699, p. 16-23 8 p.

Research output: Contribution to journalArticle

Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

Xia, X., Wang, Y., Huang, Y., Zhang, H., Lu, H. & Zheng, J. C., Dec 2019, In : Progress in Neurobiology. 183, 101694.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a

Ma, Y., Li, C., Huang, Y., Wang, Y., Xia, X. & Zheng, J. C., Aug 16 2019, In : Cell Communication and Signaling. 17, 1, 96.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Glutaminase C regulates microglial activation and pro-inflammatory exosome release: Relevance to the pathogenesis of Alzheimer’s disease

Gao, G., Zhao, S., Xia, X., Li, C., Li, C., Ji, C., Sheng, S., Tang, Y., Zhu, J., Wang, Y., Huang, Y. & Zheng, J. C., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 264.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Induced neural progenitor cells abundantly secrete extracellular vesicles and promote the proliferation of neural progenitors via extracellular signal–regulated kinase pathways

Ma, Y., Wang, K., Pan, J., Fan, Z., Tian, C., Deng, X., Ma, K., Xia, X., Huang, Y. & Zheng, J. C., Apr 2019, In : Neurobiology of Disease. 124, p. 322-334 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

MiR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis

Xia, X., Lu, H., Li, C., Huang, Y., Wang, Y., Yang, X. & Zheng, J. C., Sep 23 2019, In : Stem Cell Research and Therapy. 10, 1, 282.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Propofol reduces microglia activation and neurotoxicity through inhibition of extracellular vesicle release

Liu, J., Li, Y., Xia, X., Yang, X., Zhao, R., Peer, J., Wang, H., Tong, Z., Gao, F., Lin, H., Wu, B., Huang, Y. & Zheng, J. C., Aug 15 2019, In : Journal of Neuroimmunology. 333, 476962.

Research output: Contribution to journalArticle

Open Access

Responsibility and Sustainability in Brain Science, Technology, and Neuroethics in China—a Culture-Oriented Perspective

Wang, Y., Yin, J., Wang, G., Li, P., Bi, G., Li, S., Xia, X., Song, J., Pei, G. & Zheng, J. C., Feb 6 2019, In : Neuron. 101, 3, p. 375-379 5 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Small molecule ONC201 inhibits HIV-1 replication in macrophages via FOXO3a and TRAIL

Zhao, R., Li, Y., Gorantla, S., Poluektova, L. Y., Lin, H., Gao, F., Wang, H., Zhao, J., Zheng, J. C. & Huang, Y., Aug 2019, In : Antiviral Research. 168, p. 134-145 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Cathelicidin-derived antimicrobial peptides inhibit Zika virus through direct inactivation and interferon pathway

He, M., Zhang, H., Li, Y., Wang, G., Tang, B., Zhao, J., Huang, Y. & Zheng, J., Apr 12 2018, In : Frontiers in immunology. 9, APR, 722.

Research output: Contribution to journalArticle

21 Scopus citations

Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons

Ma, K., Deng, X., Xia, X., Fan, Z., Qi, X., Wang, Y., Li, Y., Ma, Y., Chen, Q., Peng, H., Ding, J., Li, C., Huang, Y., Tian, C. & Zheng, J. C., Nov 5 2018, In : Translational Neurodegeneration. 7, 1, 29.

Research output: Contribution to journalArticle

9 Scopus citations

Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate

Wu, B., Liu, J., Zhao, R., Li, Y., Peer, J., Braun, A. L., Zhao, L., Wang, Y., Tong, Z., Huang, Y. & Zheng, J. C., Mar 14 2018, In : Journal of Neuroinflammation. 15, 1, 79.

Research output: Contribution to journalArticle

11 Scopus citations

Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives

Global Neuroethics Summit Delegates, Oct 10 2018, In : Neuron. 100, 1, p. 19-36 18 p.

Research output: Contribution to journalReview article

19 Scopus citations

Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869

Huang, Y., Li, Y., Zhang, H., Zhao, R., Jing, R., Xu, Y., He, M., Peer, J., Kim, Y. C., Luo, J., Tong, Z. & Zheng, J., Dec 1 2018, In : Cell Discovery. 4, 1, 19.

Research output: Contribution to journalArticle

15 Scopus citations

英美中三国全科医生培养模式对比研究

Translated title of the contribution: Models for training general practitioners in the uk,u.s. and china:a comparative studyZhao, X. X., Sun, X. T., Pan, Z. G. & Zheng, J. L., Aug 5 2018, In : Chinese General Practice. 21, 22, p. 2660-2663 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017
9 Scopus citations

CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells

Zhang, M., Qiu, L., Zhang, Y., Xu, D., Zheng, J. C. & Jiang, L., Dec 1 2017, In : Scientific reports. 7, 1, 8289.

Research output: Contribution to journalArticle

23 Scopus citations

Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice

Wang, Y., Li, Y., Zhao, R., Wu, B., Lanoha, B., Tong, Z., Peer, J., Liu, J., Xiong, H., Huang, Y. & Zheng, J., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 135-145 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
5 Scopus citations

The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders

Smith, D. K., He, M., Zhang, C. L. & Zheng, J. C., Oct 2017, In : Progress in Neurobiology. 157, p. 212-229 18 p.

Research output: Contribution to journalReview article

13 Scopus citations

TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase

Wang, K., Ye, L., Lu, H., Chen, H., Zhang, Y., Huang, Y. & Zheng, J. C., Apr 20 2017, In : Journal of Neuroinflammation. 14, 1, 87.

Research output: Contribution to journalArticle

21 Scopus citations
2016

CXCR7 participates in CXCL12-mediated cell cycle and proliferation regulation in mouse neural progenitor cells

Wang, Y., Xu, P., Qiu, L., Zhang, M., Huang, Y. & Zheng, J. C., Sep 1 2016, In : Current Molecular Medicine. 16, 8, p. 738-746 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cytokines and chemokines

Huang, Y. & Zheng, J., Jan 1 2016, Neuroimmune Pharmacology. Springer International Publishing, p. 261-283 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Novel fluorinated pyrrolomycins as potent anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities

Yang, Z., Liu, Y., Ahn, J., Qiao, Z., Endres, J. L., Gautam, N., Huang, Y., Li, J., Zheng, J. C., Alnouti, Y., Bayles, K. W. & Li, R., 2016, In : European Journal of Medicinal Chemistry. 124, p. 129-137 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Stem cells and neurogenesis for brain development, degeneration and therapy

Peer, J., Zhang, H., Peng, H., Vance, K., Huang, Y. & Zheng, J. C., Jan 1 2016, Neuroimmune Pharmacology. Springer International Publishing, p. 217-243 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Applications of stripe assay in the study of CXCL12-mediated neural progenitor cell migration and polarization

Zhang, M., Song, A., Lai, S., Qiu, L., Huang, Y., Chen, Q., Zhu, B., Xu, D. & Zheng, J. C., Dec 2015, In : Biomaterials. 72, p. 163-171 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4

Chen, Q., Zhang, M., Li, Y., Xu, D., Wang, Y., Song, A., Zhu, B., Huang, Y. & Zheng, J. C., Aug 1 2015, In : STEM CELLS. 33, 8, p. 2574-2585 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Direct reprogramming of induced neural progenitors: A new promising strategy for AD treatment

Lai, S., Zhang, M., Xu, D., Zhang, Y., Qiu, L., Tian, C. & Zheng, J. C., Apr 18 2015, In : Translational Neurodegeneration. 4, 1, 7.

Research output: Contribution to journalReview article

8 Scopus citations

Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity

Wu, B., Huang, Y., Braun, A. L., Tong, Z., Zhao, R., Li, Y., Liu, F. & Zheng, J. C., Nov 6 2015, In : Molecular neurodegeneration. 10, 1, 61.

Research output: Contribution to journalArticle

16 Scopus citations

Living cell imaging and Rac1-GTP levels of CXCL12-treated migrating neural progenitor cells in stripe assay

Zhang, M., Song, A., Lai, S., Qiu, L., Huang, Y., Chen, Q., Zhu, B., Xu, D. & Zheng, J. C., Dec 1 2015, In : Data in Brief. 5, p. 712-716 5 p.

Research output: Contribution to journalArticle

Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation

Liu, F., Huang, Y., Zhang, F., Chen, Q., Wu, B., Rui, W., Zheng, J. C. & Ding, W., Jul 1 2015, In : Journal of Neurochemistry. 134, 2, p. 315-326 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

RIG-I detects HIV-1 infection and mediates type i interferon response in human macrophages from patients with HIV-1-associated neurocognitive disorders

Wang, M. Q., Huang, Y. L., Huang, J., Zheng, J. L. & Qian, G. X., Oct 28 2015, In : Genetics and Molecular Research. 14, 4, p. 13799-13811 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion

Tian, C., Li, Y., Huang, Y., Wang, Y., Chen, D., Liu, J., Deng, X., Sun, L., Anderson, K., Qi, X., Li, Y., Lee Mosley, R., Chen, X., Huang, J. & Zheng, J. C., Jul 30 2015, In : Scientific reports. 5, 12622.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Cellular interactions and signaling in neuroAIDS: Emerging issues colloquium

Al-Harthi, L., Buch, S., Geiger, J. D., Gendelman, H. E., He, J. J., Jordan-Sciutto, K. L., Kolson, D. L., Rappaport, J., Roy, S., Zheng, J. & Fox, H. S., Jun 2014, In : Journal of Neuroimmune Pharmacology. 9, 3, p. 269-276 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Glutaminase 1 is essential for the differentiation, proliferation, and survival of human neural progenitor cells

Wang, Y., Huang, Y., Zhao, L., Li, Y. & Zheng, J., Nov 15 2014, In : Stem Cells and Development. 23, 22, p. 2782-2790 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Secretory Carrier Membrane Protein (SCAMP) deficiency influences behavior of adult flies

Zheng, J. L. C., Tham, C. T., Keatings, K., Fan, S., Liou, A. Y. C., Numata, Y., Allan, D. & Numata, M., Nov 18 2014, In : Frontiers in Cell and Developmental Biology. 2, NOV, 64.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2013

A novel role of the STAT3 pathway in brain inflammation-induced human neural progenitor cell differentiation

Chen, E., Xu, D., Lan, X., Jia, B., Sun, L., Zheng, J. C. & Peng, H., 2013, In : Current Molecular Medicine. 13, 9, p. 1474-1484 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Characterization of induced neural progenitors from skin fibroblasts by a novel combination of defined factors

Tian, C., Liu, Q., Ma, K., Wang, Y., Chen, Q., Ambroz, R., Klinkebiel, D. L., Li, Y., Huang, Y., Ding, J., Wu, J. & Zheng, J. C., 2013, In : Scientific reports. 3, 1345.

Research output: Contribution to journalArticle

10 Scopus citations

Exciting progresses in stem cell and neural stem cell research

Zheng, J. C. & Tong, Z., 2013, In : Current Molecular Medicine. 13, 9, p. 1409-1411 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

FoxO3a contributes to the reprogramming process and the differentiation of induced pluripotent stem cells

Wang, Y., Tian, C. & Zheng, J. C., Nov 15 2013, In : Stem Cells and Development. 22, 22, p. 2954-2963 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

IL-1β and TNF-α induce neurotoxicity through glutamate production: A potential role for neuronal glutaminase

Ye, L., Huang, Y., Zhao, L., Li, Y., Sun, L., Zhou, Y., Qian, G. & Zheng, J. C., Jun 2013, In : Journal of Neurochemistry. 125, 6, p. 897-908 12 p.

Research output: Contribution to journalArticle

141 Scopus citations

Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells

Ye, L., Zhao, X., Lu, J., Qian, G., Zheng, J. C. & Ge, S., Jul 26 2013, In : Biochemical and Biophysical Research Communications. 437, 2, p. 300-306 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

STAT1 Regulates Human Glutaminase 1 Promoter Activity through Multiple Binding Sites in HIV-1 Infected Macrophages

Zhao, L., Huang, Y. & Zheng, J., Sep 24 2013, In : PloS one. 8, 9, e76581.

Research output: Contribution to journalArticle

8 Scopus citations

The Genetic Variation of SORCS1 Is Associated with Late-Onset Alzheimer's Disease in Chinese Han Population

Xu, W., Xu, J., Wang, Y., Tang, H., Deng, Y., Ren, R., Wang, G., Niu, W., Ma, J., Wu, Y., Zheng, J., Chen, S. & Ding, J., May 20 2013, In : PloS one. 8, 5, e63621.

Research output: Contribution to journalArticle

13 Scopus citations
2012

CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway

Zhu, B., Xu, D., Deng, X., Chen, Q., Huang, Y., Peng, H., Li, Y., Jia, B., Thoreson, W. B., Ding, W., Ding, J., Zhao, L., Wang, Y., Wavrin, K. L., Duan, S. & Zheng, J., Nov 2012, In : STEM CELLS. 30, 11, p. 2571-2583 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

Direct conversion of dermal fibroblasts into neural progenitor cells by a novel cocktail of defined factors

Tian, C., Ambroz, R. J., Sun, L., Wang, Y., Ma, K., Chen, Q., Zhu, B. & Zheng, J. C., Feb 2012, In : Current Molecular Medicine. 12, 2, p. 126-137 12 p.

Research output: Contribution to journalArticle

38 Scopus citations