Karen A Gould

Bhattacharyya, S., Rainey, M. A., Arya, P., Dutta, S., George, M., Storck, M. D., McComb, R. D., Muirhead, D., Todd, G. L., Gould, K., Datta, K., Waes, J. G. V., Band, V. & Band, H., Feb 17 2016, In: Scientific reports. 6, 20727.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2015

Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice

Yoachim, S. D., Nuxoll, J. S., Bynoté, K. K. & Gould, K. A., Jun 1 2015, In: Clinical Immunology. 158, 2, p. 153-166 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Genetic dissection of the Mom5 modifier locus and evaluation of Mom5 candidate genes

Otterpohl, K. L. & Gould, K. A., Jun 2 2015, In: Mammalian Genome. 26, 5-6, p. 235-247 13 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2013

Accelerated development of chronic lymphocytic leukemia in New Zealand black mice expressing a low level of interferon regulatory factor 4

Ma, S., Shukla, V., Fang, L., Gould, K. A., Joshi, S. S. & Lu, R., Sep 13 2013, In: Journal of Biological Chemistry. 288, 37, p. 26430-26440 11 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis

Yuan, F., Tabor, D. E., Nelson, R. K., Yuan, H., Zhang, Y., Nuxoll, J., Bynoté, K. K., Lele, S. M., Wang, D. & Gould, K. A., Nov 28 2013, In: PloS one. 8, 11, e81483.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2012

Dexamethasone prodrug treatment prevents nephritis in lupus-prone (NZB × NZW)F1 mice without causing systemic side effects

Yuan, F., Nelson, R. K., Tabor, D. E., Zhang, Y., Akhter, M. P., Gould, K. A. & Wang, D., Dec 2012, In: Arthritis and rheumatism. 64, 12, p. 4029-4039 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans

Mikuls, T. R., Levan, T., Gould, K. A., Yu, F., Thiele, G. M., Bynote, K. K., Conn, D., Jonas, B. L., Callahan, L. F., Smith, E., Brasington, R., Moreland, L. W., Reynolds, R., Gaffo, A. & Bridges, S. L., Mar 2012, In: Arthritis and rheumatism. 64, 3, p. 655-664 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2010

Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: Influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a cross-sectional study

Mikuls, T. R., Gould, K. A., Bynoté, K. K., Yu, F., LeVan, T. D., Thiele, G. M., Michaud, K. D., O'Dell, J. R., Reimold, A. M., Hooker, R., Caplan, L., Johnson, D. S., Kerr, G., Richards, J. S., Cannon, G. W., Criswell, L. A., Noble, J. A., Bridges, L. S., Hughes, L. & Gregersen, P. K., Nov 18 2010, In: Arthritis Research and Therapy. 12, 6, R213.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Associations of cigarette smoking with rheumatoid arthritis in African Americans

Mikuls, T. R., Sayles, H., Yu, F., Levan, T., Gould, K. A., Thiele, G. M., Conn, D. L., Jonas, B. L., Callahan, L. F., Smith, E., Brasington, R., Moreland, L. W., Reynolds, R. J. & Bridges, S. L., Dec 2010, In: Arthritis Care and Research. 62, 12, p. 3560-3568 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Gender-dependent expression of murine Irf5 gene: Implications for sex bias in autoimmunity

Shen, H., Panchanathan, R., Rajavelu, P., Duan, X., Gould, K. A. & Choubey, D., 2010, In: Journal of Molecular Cell Biology. 2, 5, p. 284-290 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

2009

Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc^Min/+ mice

Cleveland, A. G., Oikarinen, S. I., Bynoté, K. K., Marttinen, M., Rafter, J. J., Gustafsson, J. Å., Roy, S. K., Pitot, H. C., Korach, K. S., Lubahn, D. B., Mutanen, M. & Gould, K. A., 2009, In: Carcinogenesis. 30, 9, p. 1581-1590 10 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval

Panchanathan, R., Shen, H., Bupp, M. G., Gould, K. A. & Choubey, D., Dec 1 2009, In: Journal of Immunology. 183, 11, p. 7031-7038 8 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Genetic mapping of Mom5, a novel modifier of Apc^Min-induced intestinal tumorigenesis

Oikarinen, S. I., Cleveland, A. G., Cork, K. M., Bynoté, K. K., Rafter, J. J., Gustafsson, J. Å., Mutanen, M. & Gould, K. A., 2009, In: Carcinogenesis. 30, 9, p. 1591-1596 6 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2008

Estrogen receptor-α deficiency attenuates autoimmune disease in (NZB × NZW)F₁ mice

Bynoté, K. K., Hackenberg, J. M., Korach, K. S., Lubahn, D. B., Lane, P. H. & Gould, K. A., Mar 2008, In: Genes and Immunity. 9, 2, p. 137-152 16 p.

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat

Kurz, S. G., Hansen, K. K., McLaughlin, M. T., Shivaswamy, V., Schaffer, B. S., Gould, K. A., McComb, R. D., Meza, J. L. & Shull, J. D., Aug 2008, In: Endocrinology. 149, 8, p. 3850-3859 10 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2007

Genetic control of estrogen action in the rat: Mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross

Shull, J. D., Lachel, C. M., Murrin, C. R., Pennington, K. L., Schaffer, B. S., Strecker, T. E. & Gould, K. A., Sep 2007, In: Mammalian Genome. 18, 9, p. 657-669 13 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2006

Genetic bases of estrogen-induced tumorigenesis in the rat: Mapping of loci controlling susceptibility to mammary cancer in a Brown Norway × ACI intercross

Schaffer, B. S., Lachel, C. M., Pennington, K. L., Murrin, C. R., Strecker, T. E., Tochacek, M., Gould, K. A., Meza, J. L., McComb, R. D. & Shull, J. D., Aug 1 2006, In: Cancer Research. 66, 15, p. 7793-7800 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Genetic bases of renal agenesis in the ACI rat: Mapping of Renag1 to chromosome 14

Shull, J. D., Lachel, C. M., Strecker, T. E., Spady, T. J., Tochacek, M., Pennington, K. L., Murrin, C. R., Meza, J. L., Schaffer, B. S., Flood, L. A. & Gould, K. A., Jul 2006, In: Mammalian Genome. 17, 7, p. 751-759 9 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat

Gould, K. A., Strecker, T. E., Hansen, K. K., Bynoté, K. K., Peterson, K. A. & Shull, J. D., May 2006, In: Mammalian Genome. 17, 5, p. 451-464 14 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

2005

Genetic bases of estrogen-induced pituitary tumorigenesis: Identification of genetic loci determining estrogen-induced pituitary growth in reciprocal crosses between the ACI and Copenhagen rat strains

Strecker, T. E., Spady, T. J., Schaffer, B. S., Gould, K. A., Kaufman, A. E., Shen, F., McLaughlin, M. T., Pennington, K. L., Meza, J. L. & Shull, J. D., Apr 2005, In: Genetics. 169, 4, p. 2189-2197 9 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5

Gould, K. A., Pandey, J., Lachel, C. M., Murrin, C. R., Flood, L. A., Pennington, K. L., Schaffer, B. S., Tochacek, M., McComb, R. D., Meza, J. L., Wendell, D. L. & Shull, J. D., Nov 2005, In: Mammalian Genome. 16, 11, p. 854-864 11 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Localization of Eutr2, a locus controlling susceptibility to DES-induced uterine inflammation and pyometritis, to RNO5 using a congenic rat strain

Pandey, J., Gould, K. A., McComb, R. D., Shull, J. D. & Wendell, D. L., Nov 2005, In: Mammalian Genome. 16, 11, p. 865-872 8 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2004

Estrogen receptor α-mediated events promote sex-specific diabetic glomerular hypertrophy

Lovegrove, A. S., Sun, J., Gould, K. A., Lubahn, D. B., Korach, K. S. & Lane, P. H., Sep 2004, In: American Journal of Physiology - Renal Physiology. 287, 3 56-3, p. F586-F591

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: Mapping of Emca1 and Emca2 to chromosomes 5 and 18

Gould, K. A., Tochacek, M., Schaffer, B. S., Reindl, T. M., Murrin, C. R., Lachel, C. M., VanderWoude, E. A., Pennington, K. L., Flood, L. A., Bynote, K. K., Meza, J. L., Newton, M. A. & Shull, J. D., Dec 2004, In: Genetics. 168, 4, p. 2113-2125 13 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

2003

Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction

Harvell, D. M. E., Buckles, L. K., Gould, K. A., Pennington, K. L., McComb, R. D. & Shull, J. D., Jul 2003, In: Endocrine. 21, 2, p. 175-183 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2000

DES action in the thymus: inhibition of cell proliferation and genetic variation

Gould, K. A., Shull, J. D. & Gorski, J., Dec 22 2000, In: Molecular and Cellular Endocrinology. 170, 1-2, p. 31-39 9 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

The Mom1(AKR) intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64

Cormier, R. T., Bilger, A., Lillich, A. J., Halberg, R. B., Hong, K. H., Gould, K. A., Borenstein, N., Lander, E. S. & Dove, W. F., Jun 29 2000, In: Oncogene. 19, 28, p. 3182-3192 11 p.

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

1998

Analysis of the mom1 modifier of intestinal neoplasia in mice

Gould, K. A. & Dove, W. F., 1998, In: Experimental Lung Research. 24, 4, p. 437-453 17 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Sequence determinants of DNA binding by the hematopoietic helix-loop- helix transcription factor TAL1: Importance of sequences flanking the E-box core

Gould, K. A. & Bresnick, E. H., 1998, In: Gene Expression. 7, 2, p. 87-101 15 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

The intestinal epithelium and its neoplasms: Genetic, cellular and tissue interactions

Dove, W. F., Cormier, R. T., Gould, K. A., Halberg, R. B., Merritt, A. J., Newton, M. A. & Shoemaker, A. R., Jun 29 1998, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 353, 1370, p. 915-923 9 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

1997

Intestinal neoplasia in the Apc(Min) mouse: Independence from the microbial and natural killer (beige locus) status

Dove, W. F., Clipson, L., Gould, K. A., Luongo, C., Marshall, D. J., Moser, A. R., Newton, M. A. & Jacoby, R. F., 1997, In: Cancer Research. 57, 5, p. 812-814 3 p.

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Localized gene action controlling intestinal neoplasia in mice

Gould, K. A. & Dove, W. F., May 27 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 11, p. 5848-5853 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Polyclonal structure of intestinal adenomas in Apc^Min/+ mice with concomitant loss of Apc⁺ from all tumor lineages

Merritt, A. J., Gould, K. A. & Dove, W. F., Dec 9 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 25, p. 13927-13931 5 p.

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

1996

Action of Min and Mom1 on neoplasia in ectopic intestinal grafts

Gould, K. A. & Dove, W. F., 1996, In: Cell Growth and Differentiation. 7, 10, p. 1361-1368 8 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice

Gould, K. A., Luongo, C., Moser, A. R., McNeley, M. K., Borenstein, N., Shedlovsky, A., Dove, W. F., Hong, K., Dietrich, W. F. & Lander, E. S., Dec 1996, In: Genetics. 144, 4, p. 1777-1785 9 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice

Gould, K. A., Dietrich, W. F., Borenstein, N., Lander, E. S. & Dove, W. F., Dec 1996, In: Genetics. 144, 4, p. 1769-1776 8 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

1995

Apc^Min: A mouse model for intestinal and mammary tumorigenesis

Moser, A. R., Luongo, C., Gould, K. A., McNeley, M. K., Shoemaker, A. R. & Dove, W. F., 1995, In: European Journal of Cancer. 31, 7-8, p. 1061-1064 4 p.

Research output: Contribution to journal › Article › peer-review

252 Scopus citations

Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation

Moser, A. R., Shoemaker, A. R., Connelly, C. S., Clipson, L., Gould, K. A., Luongo, C., Dove, W. F., Siggers, P. H. & Gardner, R. L., Aug 1995, In: Developmental Dynamics. 203, 4, p. 422-433 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

135 Scopus citations

1994

The adenomatous polyposis coli gene of the mouse in development and neoplasia

Dove, W. F., Luongo, C., Connelly, C. S., Gould, K. A., Shoemaker, A. R., Moser, A. R. & Gardner, R. L., 1994, In: Cold Spring Harbor Symposia on Quantitative Biology. 59, p. 501-508 8 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

1993

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

Dietrich, W. F., Lander, E. S., Smith, J. S., Moser, A. R., Gould, K. A., Luongo, C., Borenstein, N. & Dove, W., Nov 19 1993, In: Cell. 75, 4, p. 631-639 9 p.

Research output: Contribution to journal › Article › peer-review

624 Scopus citations

Immunolocalization of ras oncogene p21 in human liver diseases

Radosevich, J. A., Gould, K. A., Koukoulis, G. K., Haines, G. K., Rosen, S. T., Lee, I. & Gould, V. E., Jan 1 1993, In: Ultrastructural Pathology. 17, 1, p. 1-8 8 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Mapping of multiple intestinal neoplasia (Min) to proximal chromosome 18 of the mouse

Luongo, C., Gould, K. A., Su, L. K., Kinzler, K. W., Vogelstein, B., Dietrich, W., Lander, E. S. & Moser, A. R., Jan 1993, In: Genomics. 15, 1, p. 3-8 6 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

1992

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

Su, L. K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A. & Dove, W. F., 1992, In: Science. 256, 5057, p. 668-670 3 p.

Research output: Contribution to journal › Article › peer-review

1395 Scopus citations

Karen A Gould, PhD

Research output

Search results