• 9342 Citations
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1980 …2020

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2020

Amiodarone Alters Cholesterol Biosynthesis through Tissue-Dependent Inhibition of Emopamil Binding Protein and Dehydrocholesterol Reductase 24

Allen, L. B., Genaro-Mattos, T. C., Anderson, A., Porter, N. A., Mirnics, K. & Korade, Z., May 20 2020, In : ACS Chemical Neuroscience. 11, 10, p. 1413-1423 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis

Genaro-Mattos, T. C., Anderson, A., Allen, L. B., Tallman, K. A., Porter, N. A., Korade, Z. & Mirnics, K., 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
2019

Cholesterol Biosynthesis and Uptake in Developing Neurons

Genaro-Mattos, T. C., Anderson, A., Allen, L. B., Korade, Z. & Mirnics, K., Aug 21 2019, In : ACS Chemical Neuroscience. 10, 8, p. 3671-3681 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Desmosterolosis and desmosterol homeostasis in the developing mouse brain

Allen, L. B., Genaro-Mattos, T. C., Porter, N. A., Mirnics, K. & Korade, Z., Sep 1 2019, In : Journal of Inherited Metabolic Disease. 42, 5, p. 934-943 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment

Genaro-Mattos, T. C., Allen, L. B., Anderson, A., Tallman, K. A., Porter, N. A., Korade, Z. & Mirnics, K., Apr 1 2019, In : Molecular Psychiatry. 24, 4, p. 491-500 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sex modifies placental gene expression in response to metabolic and inflammatory stress

Barke, T. L., Money, K. M., Du, L., Serezani, A., Gannon, M., Mirnics, K. & Aronoff, D. M., Mar 2019, In : Placenta. 78, p. 1-9 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Subcellular localization of sterol biosynthesis enzymes

Koczok, K., Gurumurthy, C. B., Balogh, I., Korade, Z. & Mirnics, K., Feb 15 2019, In : Journal of Molecular Histology. 50, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018
8 Scopus citations

Gestational diabetes exacerbates maternal immune activation effects in the developing brain

Money, K. M., Barke, T. L., Serezani, A., Gannon, M., Garbett, K. A., Aronoff, D. M. & Mirnics, K., Sep 1 2018, In : Molecular Psychiatry. 23, 9

Research output: Contribution to journalArticle

5 Scopus citations

Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex

Schwede, M., Nagpal, S., Gandal, M. J., Parikshak, N. N., Mirnics, K., Geschwind, D. H. & Morrow, E. M., Jun 1 2018, In : Journal of Neurodevelopmental Disorders. 10, 1, 18.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques

de Campo, D. M., Cameron, J. L., Miano, J. M., Lewis, D. A., Mirnics, K. & Fudge, J. L., Mar 1 2017, In : Developmental Psychobiology. 59, 2, p. 235-249 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Vulnerability of DHCR7 +/- mutation carriers to aripiprazole and trazodone exposure

Korade, Z., Genaro-Mattos, T. C., Tallman, K. A., Liu, W., Garbett, K. A., Koczok, K., Balogh, I., Mirnics, K. & Porter, N. A., 2017, In : Journal of Lipid Research. 58, 11, p. 2139-2146 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

An altered peripheral IL6 response in major depressive disorder

Money, K. M., Olah, Z., Korade, Z., Garbett, K. A., Shelton, R. C. & Mirnics, K., May 1 2016, In : Neurobiology of Disease. 89, p. 46-54 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells

Kim, H. Y. H., Korade, Z., Tallman, K. A., Liu, W., Weaver, C. D., Mirnics, K. & Porter, N. A., May 16 2016, In : Chemical Research in Toxicology. 29, 5, p. 892-900 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex

Mitchell, A. C., Javidfar, B., Bicks, L. K., Neve, R., Garbett, K., Lander, S. S., Mirnics, K., Morishita, H., Wood, M. A., Jiang, Y., Gaisler-Salomon, I. & Akbarian, S., Sep 6 2016, In : Nature communications. 7, 12743.

Research output: Contribution to journalArticle

9 Scopus citations

The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts

Korade, Z., Kim, H. Y. H., Tallman, K. A., Liu, W., Koczok, K., Balogh, I., Xu, L., Mirnics, K. & Porter, N. A., Feb 11 2016, In : Journal of Medicinal Chemistry. 59, 3, p. 1102-1115 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Coordinated messenger RNA/microRNA changes in fibroblasts of patients with major depression

Garbett, K. A., Vereczkei, A., Kálmán, S., Brown, J. A., Taylor, W. D., Faludi, G., Korade, Ž., Shelton, R. C. & Mirnics, K., Feb 1 2015, In : Biological Psychiatry. 77, 3, p. 256-265 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia

Ingason, A., Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Friedl, M., Ripke, S., Sullivan, P. F., St Clair, D., Collier, D. A., O'Donovan, M. C., Mirnics, K. & Rujescu, D., Oct 27 2015, In : Translational Psychiatry. 5, 10, A151.

Research output: Contribution to journalArticle

17 Scopus citations

Fibroblasts from patients with major depressive disorder show distinct transcriptional response to metabolic stressors

Garbett, K. A., Vereczkei, A., Kálmán, S., Wang, L., Korade, Z., Shelton, R. C. & Mirnics, K., 2015, In : Translational Psychiatry. 5, 3, A523.

Research output: Contribution to journalArticle

14 Scopus citations

Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes

Brown, J. A., Ramikie, T. S., Schmidt, M. J., Báldi, R., Garbett, K., Everheart, M. G., Warren, L. E., Gellért, L., Horváth, S., Patel, S. & Mirnics, K., Dec 1 2015, In : Molecular Psychiatry. 20, 12, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Transcriptional maturation of the mouse auditory forebrain

Hackett, T. A., Guo, Y., Clause, A., Hackett, N. J., Garbett, K., Zhang, P., Polley, D. B. & Mirnics, K., Aug 14 2015, In : BMC genomics. 16, 1, 606.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Antioxidant supplementation ameliorates molecular deficits in smith-lemli-opitz syndrome

Korade, Z., Xu, L., Harrison, F. E., Ahsen, R., Hart, S. E., Folkes, O. M., Mirnics, K. & Porter, N. A., Feb 1 2014, In : Biological Psychiatry. 75, 3, p. 215-222 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia

Brown, J. A., Sherrod, S. D., Goodwin, C. R., Brewer, B., Yang, L., Garbett, K. A., Li, D., McLean, J. A., Wikswo, J. P. & Mirnics, K., Nov 6 2014, In : Journal of Neuroinflammation. 11, 1, 183.

Research output: Contribution to journalArticle

18 Scopus citations

Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts

Kálmán, S., Garbett, K. A., Vereczkei, A., Shelton, R. C., Korade, Ž. & Mirnics, K., Jan 15 2014, In : Experimental Cell Research. 320, 2, p. 343-353 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Modulation of behavioral networks by selective interneuronal inactivation

Schmidt, M. J., Horvath, S., Ebert, P., Norris, J. L., Seeley, E. H., Brown, J., Gellert, L., Everheart, M., Garbett, K. A., Grice, T. W., Caprioli, R. M. & Mirnics, K., May 2014, In : Molecular Psychiatry. 19, 5, p. 580-587 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

The role of cannabinoid 1 receptor expressing interneurons in behavior

Brown, J. A., Horváth, S., Garbett, K. A., Schmidt, M. J., Everheart, M., Gellért, L., Ebert, P. & Mirnics, K., Mar 2014, In : Neurobiology of Disease. 63, p. 210-221 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia

Bharadwa, R., Jiang, Y., Mao, W., Jakovcevski, M., Dincer, A., Krueger, W., Garbett, K., Whittle, C., Tushir, J. S., Liu, J., Sequeira, A., Vawter, M. P., Gardner, P. D., Casaccia, P., Rasmussen, T., Bunney, W. E., Mirnics, K., Futai, K. & Akbarian, S., 2013, In : Journal of Neuroscience. 33, 29, p. 11839-11851 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome

Korade, Z., Xu, L., Mirnics, K. & Porter, N. A., Jan 2013, In : Journal of Inherited Metabolic Disease. 36, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells

Xu, L., Korade, Z., Rosado, D. A., Mirnics, K. & Porter, N. A., Apr 2013, In : Journal of Lipid Research. 54, 4, p. 1135-1143 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2012

A role for presenilins in autophagy revisited: Normal acidification of lysosomes in cells lacking PSEN1 and PSEN2

Zhang, X., Garbett, K., Veeraraghavalu, K., Wilburn, B., Gilmore, R., Mirnics, K. & Sisodia, S. S., Jun 20 2012, In : Journal of Neuroscience. 32, 25, p. 8633-8648 16 p.

Research output: Contribution to journalArticle

68 Scopus citations

DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model

Xu, L., Mirnics, K., Bowman, A. B., Liu, W., Da, J., Porter, N. A. & Korade, Z., Mar 2012, In : Neurobiology of Disease. 45, 3, p. 923-929 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Effects of maternal immune activation on gene expression patterns in the fetal brain

Garbett, K. A., Hsiao, E. Y., Kálmán, S., Patterson, P. H. & Mirnics, K., 2012, In : Translational Psychiatry. 2, e98.

Research output: Contribution to journalArticle

95 Scopus citations

Gene transcripts associated with BMI in the motor cortex and caudate nucleus of calorie restricted rhesus monkeys

Mitchell, A. C., Leak, R. K., Zigmond, M. J., Cameron, J. L. & Mirnics, K., Mar 2012, In : Genomics. 99, 3, p. 144-151 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Immune system gene dysregulation in autism and schizophrenia

Michel, M., Schmidt, M. J. & Mirnics, K., Oct 2012, In : Developmental Neurobiology. 72, 10, p. 1277-1287 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Modeling interneuron dysfunction in Schizophrenia

Schmidt, M. J. & Mirnics, K., Sep 2012, In : Developmental Neuroscience. 34, 2-3, p. 152-158 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Physical activity-associated gene expression signature in nonhuman primate motor cortex

Mitchell, A. C., Leak, R. K., Garbett, K., Zigmond, M. J., Cameron, J. L. & Mirnics, K., Mar 2012, In : Obesity. 20, 3, p. 692-698 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates

Leak, R. K., Garbett, K. A., Dettmer, A. M., Zhang, Z., Mirnics, K. & Cameron, J. L., Dec 2012, In : Cell and Tissue Research. 350, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

Shelton, R. C., Claiborne, J., Sidoryk-Wegrzynowicz, M., Reddy, R., Aschner, M., Lewis, D. A. & Mirnics, K., Jul 2011, In : Molecular Psychiatry. 16, 7, p. 751-762 12 p.

Research output: Contribution to journalArticle

299 Scopus citations

Synaptic changes in the brain of subjects with schizophrenia

Faludi, G. & Mirnics, K., May 2011, In : International Journal of Developmental Neuroscience. 29, 3, p. 305-309 5 p.

Research output: Contribution to journalArticle

82 Scopus citations
2010

Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: Signature of altered neural development?

Arion, D., Horváth, S., Lewis, D. A. & Mirnics, K., Mar 2010, In : Neurobiology of Disease. 37, 3, p. 738-746 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Molecular correlates of spontaneous activity in non-human primates

Mitchell, A. C., Aldridge, G., Kohler, S., Stanton, G., Sullivan, E., Garbett, K., Faludi, G., Mirnics, K., Cameron, J. L. & Greenough, W., Dec 2010, In : Journal of Neural Transmission. 117, 12, p. 1353-1358 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Novel animal models for studying complex brain disorders: BAC-driven miRNA-mediated in vivo silencing of gene expression

Garbett, K. A., Horváth, S., Ebert, P. J., Schmidt, M. J., Lwin, K., Mitchell, A., Levitt, P. & Mirnics, K., Oct 2010, In : Molecular Psychiatry. 15, 10, p. 987-995 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2009

Involvement of the PRKCB1 gene in autistic disorder: Significant genetic association and reduced neocortical gene expression

Lintas, C., Sacco, R., Garbett, K., Mirnics, K., Militerni, R., Bravaccio, C., Curatolo, P., Manzi, B., Schneider, C., Melmed, R., Elia, M., Pascucci, T., Puglisi-Allegra, S., Reichelt, K. L. & Persico, A. M., Jul 2009, In : Molecular Psychiatry. 14, 7, p. 705-718 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Molecular consequences of altered neuronal cholesterol biosynthesis

Korade, Ž., Kenworthy, A. K. & Mirnics, K., 2009, In : Journal of Neuroscience Research. 87, 4, p. 866-875 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

NRIF is a regulator of neuronal cholesterol biosynthesis genes

Korade, Z., Kenchappa, R. S., Mirnics, K. & Carter, B. D., Jun 2009, In : Journal of Molecular Neuroscience. 38, 2, p. 152-158 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

The organization of the transcriptional network in specific neuronal classes

Winden, K. D., Oldham, M. C., Mirnics, K., Ebert, P. J., Swan, C. H., Levitt, P., Rubenstein, J. L., Horvath, S. & Geschwind, D. H., Jan 20 2009, In : Molecular Systems Biology. 5, 291.

Research output: Contribution to journalArticle

87 Scopus citations

Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency

Zigmond, M. J., Cameron, J. L., Leak, R. K., Mirnics, K., Russell, V. A., Smeyne, R. J. & Smith, A. D., Dec 2009, In : Parkinsonism and Related Disorders. 15, SUPPL. 3, p. S42-S45

Research output: Contribution to journalArticle

68 Scopus citations
2008

Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia

Hashimoto, T., Arion, D., Unger, T., Maldonado-Avilés, J. G., Morris, H. M., Volk, D. W., Mirnics, K. & Lewis, D. A., Feb 2008, In : Molecular Psychiatry. 13, 2, p. 147-161 15 p.

Research output: Contribution to journalArticle

337 Scopus citations

Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia

Hashimoto, T., Bazmi, H. H., Mirnics, K., Wu, Q., Sampson, A. R. & Lewis, D. A., Apr 2008, In : American Journal of Psychiatry. 165, 4, p. 479-489 11 p.

Research output: Contribution to journalArticle

279 Scopus citations

Immune transcriptome alterations in the temporal cortex of subjects with autism

Garbett, K., Ebert, P. J., Mitchell, A., Lintas, C., Manzi, B., Mirnics, K. & Persico, A. M., Jun 2008, In : Neurobiology of Disease. 30, 3, p. 303-311 9 p.

Research output: Contribution to journalArticle

250 Scopus citations