• 9342 Citations
  • 43 h-Index
1980 …2020

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Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients

Dutta, R., McDonough, J., Chang, A., Swamy, L., Siu, A., Kidd, G. J., Rudick, R., Mirnics, K. & Trapp, B. D., Oct 2007, In : Brain. 130, 10, p. 2566-2576 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia

Hashimoto, T., Arion, D., Unger, T., Maldonado-Avilés, J. G., Morris, H. M., Volk, D. W., Mirnics, K. & Lewis, D. A., Feb 2008, In : Molecular Psychiatry. 13, 2, p. 147-161 15 p.

Research output: Contribution to journalArticle

337 Scopus citations

Altered expression of 14-3-3 in the prefrontal cortex of subjects with schizophrenia

Middleton, F. A., Peng, L., Lewis, D. A., Levitt, P. & Mirnics, K., May 2005, In : Neuropsychopharmacology. 30, 5, p. 974-983 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

Shelton, R. C., Claiborne, J., Sidoryk-Wegrzynowicz, M., Reddy, R., Aschner, M., Lewis, D. A. & Mirnics, K., Jul 2011, In : Molecular Psychiatry. 16, 7, p. 751-762 12 p.

Research output: Contribution to journalArticle

299 Scopus citations

Amiodarone Alters Cholesterol Biosynthesis through Tissue-Dependent Inhibition of Emopamil Binding Protein and Dehydrocholesterol Reductase 24

Allen, L. B., Genaro-Mattos, T. C., Anderson, A., Porter, N. A., Mirnics, K. & Korade, Z., May 20 2020, In : ACS Chemical Neuroscience. 11, 10, p. 1413-1423 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation

Sabatini, M. J., Ebert, P., Lewis, D. A., Levitt, P., Cameron, J. L. & Mirnics, K., Mar 21 2007, In : Journal of Neuroscience. 27, 12, p. 3295-3304 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

An altered peripheral IL6 response in major depressive disorder

Money, K. M., Olah, Z., Korade, Z., Garbett, K. A., Shelton, R. C. & Mirnics, K., May 1 2016, In : Neurobiology of Disease. 89, p. 46-54 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Antioxidant supplementation ameliorates molecular deficits in smith-lemli-opitz syndrome

Korade, Z., Xu, L., Harrison, F. E., Ahsen, R., Hart, S. E., Folkes, O. M., Mirnics, K. & Porter, N. A., Feb 1 2014, In : Biological Psychiatry. 75, 3, p. 215-222 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

A role for presenilins in autophagy revisited: Normal acidification of lysosomes in cells lacking PSEN1 and PSEN2

Zhang, X., Garbett, K., Veeraraghavalu, K., Wilburn, B., Gilmore, R., Mirnics, K. & Sisodia, S. S., Jun 20 2012, In : Journal of Neuroscience. 32, 25, p. 8633-8648 16 p.

Research output: Contribution to journalArticle

68 Scopus citations

Central sprouting and functional plasticity of regenerated primary afferents

Koerber, H. R., Mirnics, K., Brown, P. B. & Mendell, L. M., Jun 1994, In : Journal of Neuroscience. 14, 6, p. 3655-3671 17 p.

Research output: Contribution to journalArticle

Open Access
133 Scopus citations

Cholesterol Biosynthesis and Uptake in Developing Neurons

Genaro-Mattos, T. C., Anderson, A., Allen, L. B., Korade, Z. & Mirnics, K., Aug 21 2019, In : ACS Chemical Neuroscience. 10, 8, p. 3671-3681 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia

Bharadwa, R., Jiang, Y., Mao, W., Jakovcevski, M., Dincer, A., Krueger, W., Garbett, K., Whittle, C., Tushir, J. S., Liu, J., Sequeira, A., Vawter, M. P., Gardner, P. D., Casaccia, P., Rasmussen, T., Bunney, W. E., Mirnics, K., Futai, K. & Akbarian, S., 2013, In : Journal of Neuroscience. 33, 29, p. 11839-11851 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia

Hashimoto, T., Bazmi, H. H., Mirnics, K., Wu, Q., Sampson, A. R. & Lewis, D. A., Apr 2008, In : American Journal of Psychiatry. 165, 4, p. 479-489 11 p.

Research output: Contribution to journalArticle

279 Scopus citations

Coordinated messenger RNA/microRNA changes in fibroblasts of patients with major depression

Garbett, K. A., Vereczkei, A., Kálmán, S., Brown, J. A., Taylor, W. D., Faludi, G., Korade, Ž., Shelton, R. C. & Mirnics, K., Feb 1 2015, In : Biological Psychiatry. 77, 3, p. 256-265 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy

Arion, D., Sabatini, M., Unger, T., Pastor, J., Alonso-Nanclares, L., Ballesteros-Yáñez, I., García Sola, R., Muñoz, A., Mirnics, K. & DeFelipe, J., May 2006, In : Neurobiology of Disease. 22, 2, p. 374-387 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

Desmosterolosis and desmosterol homeostasis in the developing mouse brain

Allen, L. B., Genaro-Mattos, T. C., Porter, N. A., Mirnics, K. & Korade, Z., Sep 1 2019, In : Journal of Inherited Metabolic Disease. 42, 5, p. 934-943 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model

Xu, L., Mirnics, K., Bowman, A. B., Liu, W., Da, J., Porter, N. A. & Korade, Z., Mar 2012, In : Neurobiology of Disease. 45, 3, p. 923-929 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
8 Scopus citations

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

Mirnics, K., Middleton, F. A., Stanwood, G. D., Lewis, D. A. & Levitt, P., 2001, In : Molecular Psychiatry. 6, 3, p. 293-301 9 p.

Research output: Contribution to journalArticle

374 Scopus citations

Disruption of cerebral cortex MET signaling in autism spectrum disorder

Campbell, D. B., D'Oronzio, R., Garbett, K., Ebert, P. J., Mirnics, K., Levitt, P. & Persico, A. M., Sep 2007, In : Annals of Neurology. 62, 3, p. 243-250 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

DNA microarray analysis of postmortem brain tissue

Mirnics, K., Levitt, P. & Lewis, D. A., 2004, In : International Review of Neurobiology. 60, p. 153-181 29 p.

Research output: Contribution to journalArticle

24 Scopus citations

DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes

Mirnics, Z. K., Mirnics, K., Terrano, D., Lewis, D. A., Sisodia, S. S. & Schor, N. F., 2003, In : Molecular Psychiatry. 8, 10, p. 863-878 16 p.

Research output: Contribution to journalArticle

26 Scopus citations

DNA pooling: A comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia

Chowdari, K. V., Northup, A., Pless, L., Wood, J., Joo, Y. H., Mirnics, K., Lewis, D. A., Levitt, P. R., Bacanu, S. A. & Nimgaonkar, V. L., Apr 2007, In : Genes, Brain and Behavior. 6, 3, p. 229-239 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

DNA self-polymers as microarray probes improve assay sensitivity

Hollingshead, D., Korade, Ž., Lewis, D. A., Levitt, P. & Mirnics, K., Mar 15 2006, In : Journal of Neuroscience Methods. 151, 2, p. 216-223 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Effects of maternal immune activation on gene expression patterns in the fetal brain

Garbett, K. A., Hsiao, E. Y., Kálmán, S., Patterson, P. H. & Mirnics, K., 2012, In : Translational Psychiatry. 2, e98.

Research output: Contribution to journalArticle

95 Scopus citations

Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice

Lazarov, O., Robinson, J., Tang, Y. P., Hairston, I. S., Korade-Mirnics, Z., Lee, V. M. Y., Hersh, L. B., Sapolsky, R. M., Mirnics, K. & Sisodia, S. S., Mar 11 2005, In : Cell. 120, 5, p. 701-713 13 p.

Research output: Contribution to journalArticle

674 Scopus citations

Evaluation of a Susceptibility Gene for Schizophrenia: Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen Independent Samples

Talkowski, M. E., Seltman, H., Bassett, A. S., Brzustowicz, L. M., Chen, X., Chowdari, K. V., Collier, D. A., Cordeiro, Q., Corvin, A. P., Deshpande, S. N., Egan, M. F., Gill, M., Kendler, K. S., Kirov, G., Heston, L. L., Levitt, P., Lewis, D. A., Li, T., Mirnics, K., Morris, D. W. & 16 others, Norton, N., O'Donovan, M. C., Owen, M. J., Richard, C., Semwal, P., Sobell, J. L., St Clair, D., Straub, R. E., Thelma, B. K., Vallada, H., Weinberger, D. R., Williams, N. M., Wood, J., Zhang, F., Devlin, B. & Nimgaonkar, V. L., Jul 15 2006, In : Biological Psychiatry. 60, 2, p. 152-162 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia

Ingason, A., Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Friedl, M., Ripke, S., Sullivan, P. F., St Clair, D., Collier, D. A., O'Donovan, M. C., Mirnics, K. & Rujescu, D., Oct 27 2015, In : Translational Psychiatry. 5, 10, A151.

Research output: Contribution to journalArticle

17 Scopus citations

Fibroblasts from patients with major depressive disorder show distinct transcriptional response to metabolic stressors

Garbett, K. A., Vereczkei, A., Kálmán, S., Wang, L., Korade, Z., Shelton, R. C. & Mirnics, K., 2015, In : Translational Psychiatry. 5, 3, A523.

Research output: Contribution to journalArticle

14 Scopus citations

Gene expression changes in schizophrenia: How do they arise and what do they mean?

Lewis, D. A., Mirnics, K. & Levitt, P., Sep 2005, In : Clinical Neuroscience Research. 5, 1 SPEC. ISS., p. 15-21 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia

Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R. & Lewis, D. A., Jul 16 2003, In : Journal of Neuroscience. 23, 15, p. 6315-6326 12 p.

Research output: Contribution to journalArticle

Open Access
648 Scopus citations

Gene Expression Profiling Reveals Alterations of Specific Metabolic Pathways in Schizophrenia

Middleton, F. A., Mirnics, K., Pierri, J. N., Lewis, D. A. & Levitt, P., Apr 1 2002, In : Journal of Neuroscience. 22, 7, p. 2718-2729 12 p.

Research output: Contribution to journalArticle

Open Access
343 Scopus citations

Gene expression profiling with DNA microarrays: Advancing our understanding of psychiatric disorders

Pongrac, J., Middleton, F. A., Lewis, D. A., Levitt, P. & Mirnics, K., Oct 1 2002, In : Neurochemical Research. 27, 10, p. 1049-1063 15 p.

Research output: Contribution to journalArticle

97 Scopus citations

Gene transcripts associated with BMI in the motor cortex and caudate nucleus of calorie restricted rhesus monkeys

Mitchell, A. C., Leak, R. K., Zigmond, M. J., Cameron, J. L. & Mirnics, K., Mar 2012, In : Genomics. 99, 3, p. 144-151 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Gestational diabetes exacerbates maternal immune activation effects in the developing brain

Money, K. M., Barke, T. L., Serezani, A., Gannon, M., Garbett, K. A., Aronoff, D. M. & Mirnics, K., Sep 1 2018, In : Molecular Psychiatry. 23, 9

Research output: Contribution to journalArticle

5 Scopus citations

Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia

Pongrac, J. L., Middleton, F. A., Peng, L., Lewis, D. A., Levitt, P. & Mirnics, K., Dec 15 2004, In : Biological Psychiatry. 56, 12, p. 943-950 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Immune system gene dysregulation in autism and schizophrenia

Michel, M., Schmidt, M. J. & Mirnics, K., Oct 2012, In : Developmental Neurobiology. 72, 10, p. 1277-1287 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Immune transcriptome alterations in the temporal cortex of subjects with autism

Garbett, K., Ebert, P. J., Mitchell, A., Lintas, C., Manzi, B., Mirnics, K. & Persico, A. M., Jun 2008, In : Neurobiology of Disease. 30, 3, p. 303-311 9 p.

Research output: Contribution to journalArticle

250 Scopus citations

Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: Signature of altered neural development?

Arion, D., Horváth, S., Lewis, D. A. & Mirnics, K., Mar 2010, In : Neurobiology of Disease. 37, 3, p. 738-746 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes

Brown, J. A., Ramikie, T. S., Schmidt, M. J., Báldi, R., Garbett, K., Everheart, M. G., Warren, L. E., Gellért, L., Horváth, S., Patel, S. & Mirnics, K., Dec 1 2015, In : Molecular Psychiatry. 20, 12, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells

Kim, H. Y. H., Korade, Z., Tallman, K. A., Liu, W., Weaver, C. D., Mirnics, K. & Porter, N. A., May 16 2016, In : Chemical Research in Toxicology. 29, 5, p. 892-900 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Involvement of the PRKCB1 gene in autistic disorder: Significant genetic association and reduced neocortical gene expression

Lintas, C., Sacco, R., Garbett, K., Mirnics, K., Militerni, R., Bravaccio, C., Curatolo, P., Manzi, B., Schneider, C., Melmed, R., Elia, M., Pascucci, T., Puglisi-Allegra, S., Reichelt, K. L. & Persico, A. M., Jul 2009, In : Molecular Psychiatry. 14, 7, p. 705-718 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Linkage disequilibrium patterns and functional analysis of RGS4 polymorphisms in relation to schizophrenia

Chowdari, K. V., Bamne, M., Wood, J., Talkowski, M. E., Mirnics, K., Levitt, P., Lewis, D. A. & Nimgaonkar, V. L., Jan 2008, In : Schizophrenia bulletin. 34, 1, p. 118-126 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome

Korade, Z., Xu, L., Mirnics, K. & Porter, N. A., Jan 2013, In : Journal of Inherited Metabolic Disease. 36, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex

Mitchell, A. C., Javidfar, B., Bicks, L. K., Neve, R., Garbett, K., Lander, S. S., Mirnics, K., Morishita, H., Wood, M. A., Jiang, Y., Gaisler-Salomon, I. & Akbarian, S., Sep 6 2016, In : Nature communications. 7, 12743.

Research output: Contribution to journalArticle

9 Scopus citations

Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment

Genaro-Mattos, T. C., Allen, L. B., Anderson, A., Tallman, K. A., Porter, N. A., Korade, Z. & Mirnics, K., Apr 1 2019, In : Molecular Psychiatry. 24, 4, p. 491-500 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis

Genaro-Mattos, T. C., Anderson, A., Allen, L. B., Tallman, K. A., Porter, N. A., Korade, Z. & Mirnics, K., 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access

Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques

de Campo, D. M., Cameron, J. L., Miano, J. M., Lewis, D. A., Mirnics, K. & Fudge, J. L., Mar 1 2017, In : Developmental Psychobiology. 59, 2, p. 235-249 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Maternal immune activation alters fetal brain development through interleukin-6

Smith, S. E. P., Li, J., Garbett, K., Mirnics, K. & Patterson, P. H., Oct 3 2007, In : Journal of Neuroscience. 27, 40, p. 10695-10702 8 p.

Research output: Contribution to journalArticle

847 Scopus citations

Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia

Brown, J. A., Sherrod, S. D., Goodwin, C. R., Brewer, B., Yang, L., Garbett, K. A., Li, D., McLean, J. A., Wikswo, J. P. & Mirnics, K., Nov 6 2014, In : Journal of Neuroinflammation. 11, 1, 183.

Research output: Contribution to journalArticle

18 Scopus citations