Kaustubh Datta, PhD

  • 1895 Citations
  • 26 h-Index
20002020

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2020

Linking NRP2 With EMT and Chemoradioresistance in Bladder Cancer

Schulz, A., Gorodetska, I., Behrendt, R., Fuessel, S., Erdmann, K., Foerster, S., Datta, K., Mayr, T., Dubrovska, A. & Muders, M. H., Jan 21 2020, In : Frontiers in Oncology. 9, 1461.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Neuropilin-2 is an independent prognostic factor for shorter cancer-specific survival in patients with acinar adenocarcinoma of the prostate

Borkowetz, A., Froehner, M., Rauner, M., Conrad, S., Erdmann, K., Mayr, T., Datta, K., Hofbauer, L. C., Baretton, G. B., Wirth, M., Fuessel, S., Toma, M. & Muders, M. H., May 1 2020, In : International Journal of Cancer. 146, 9, p. 2619-2627 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
4 Scopus citations
2019

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Ponnusamy, M. P., Datta, K. & Batra, S. K., Jun 27 2019, In : Oncogene. 38, 26, p. 5265-5280 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects

Borchardt, H., Schulz, A., Datta, K., Muders, M. H. & Aigner, A., Dec 1 2019, In : Scientific reports. 9, 1, 15471.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Hyaluronic acid formulation of near infrared fluorophores optimizes surgical imaging in a prostate tumor xenograft

Souchek, J. J., Wojtynek, N. E., Payne, W. M., Holmes, M. B., Dutta, S., Qi, B., Datta, K., LaGrange, C. A. & Mohs, A. M., Jul 15 2018, In : Acta Biomaterialia. 75, p. 323-333 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Macrophage-derived neuropilin-2 exhibits novel tumor-promoting functions

Roy, S., Bag, A. K., Dutta, S., Polavaram, N. S., Islam, R., Schellenburg, S., Banwait, J., Guda, C., Ran, S., Hollingsworth, M. A., Singh, R. K., Talmadge, J. E., Muders, M. H., Batra, S. K. & Datta, K., Oct 1 2018, In : Cancer Research. 78, 19, p. 5600-5617 18 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma

Haney, S. L., Upchurch, G. M., Opavska, J., Klinkebiel, D., Hlady, R. A., Roy, S., Dutta, S., Datta, K. & Opavsky, R., Sep 2016, In : PLoS genetics. 12, 9, e1006334.

Research output: Contribution to journalArticle

11 Scopus citations

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development

Bhattacharyya, S., Rainey, M. A., Arya, P., Dutta, S., George, M., Storck, M. D., McComb, R. D., Muirhead, D., Todd, G. L., Gould, K., Datta, K., Waes, J. G. V., Band, V. & Band, H., Feb 17 2016, In : Scientific reports. 6, 20727.

Research output: Contribution to journalArticle

22 Scopus citations

Neuropilin-2 regulates endosome maturation and EGFR trafficking to support cancer cell pathobiology

Dutta, S., Roy, S., Polavaram, N. S., Stanton, M. J., Zhang, H., Bhola, T., Hönscheid, P., Donohue, T. M., Band, H., Batra, S. K., Muders, M. H. & Datta, K., Jan 15 2016, In : Cancer Research. 76, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

NRP2 transcriptionally regulates its downstream effector WDFY1

Dutta, S., Roy, S., Polavaram, N. S., Baretton, G. B., Muders, M. H., Batra, S. & Datta, K., Mar 30 2016, In : Scientific reports. 6, 23588.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

Mimeault, M., Rachagani, S., Muniyan, S., Seshacharyulu, P., Johansson, S. L., Datta, K., Lin, M. F. & Batra, S. K., 2015, In : Oncotarget. 6, 6, p. 3887-3903 17 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis

Haney, S. L., Hlady, R. A., Opavska, J., Klinkebiel, D., Pirruccello, S. J., Dutta, S., Datta, K., Simpson, M. A., Wu, L. & Opavsky, R., Oct 1 2015, In : Oncogene. 34, 43, p. 5436-5446 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Neuropilin-2 and its ligand VEGF-C predict treatment response after transurethral resection and radiochemotherapy in bladder cancer patients

Keck, B., Wach, S., Taubert, H., Zeiler, S., Ott, O. J., Kunath, F., Hartmann, A., Bertz, S., Weiss, C., Hönscheid, P., Schellenburg, S., Rödel, C., Baretton, G. B., Sauer, R., Fietkau, R., Wullich, B., Krause, F. S., Datta, K. & Muders, M. H., Jan 15 2015, In : International Journal of Cancer. 136, 2, p. 443-451 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells

Zhang, L., Yang, S., Chen, X., Stauffer, S., Yu, F., Lele, S. M., Fu, K., Datta, K., Palermo, N., Chen, Y. & Dong, J., 2015, In : Molecular and cellular biology. 35, 8, p. 1350-1362 13 p.

Research output: Contribution to journalArticle

71 Scopus citations
2014

Autophagy: Detection, regulation and its role in cancer and therapy response

Hönscheid, P., Datta, K. & Muders, M. H., Aug 2014, In : International Journal of Radiation Biology. 90, 8, p. 628-635 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

The role of Factor Inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme

Wang, E., Zhang, C., Polavaram, N., Liu, F., Wu, G., Schroeder, M. A., Lau, J. S., Mukhopadhyay, D., Jiang, S. W., O'Neill, B. P., Datta, K. & Li, J., Jan 23 2014, In : PloS one. 9, 1, e86102.

Research output: Contribution to journalArticle

19 Scopus citations
2013

Angiogenic growth factor axis in autophagy regulation

Stanton, M. J., Dutta, S., Polavaram, N. S., Roy, S., Muders, M. H. & Datta, K., May 2013, In : Autophagy. 9, 5, p. 789-790 2 p.

Research output: Contribution to journalArticle

14 Scopus citations

Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance

Stanton, M. J., Dutta, S., Zhang, H., Polavaram, N. S., Leontovich, A. A., Hönscheid, P., Sinicrope, F. A., Tindall, D. J., Muders, M. H. & Datta, K., Jan 1 2013, In : Cancer Research. 73, 1, p. 160-171 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway

Pandey, P., Seshacharyulu, P., Das, S., Rachagani, S., Ponnusamy, M. P., Yan, Y., Johansson, S. L., Datta, K., Lin, M. F. & Batra, S. K., Jun 25 2013, In : British journal of cancer. 108, 12, p. 2590-2600 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo

Mandal, C., Sarkar, S., Dutta, D., Samanta, S. K., Bhattacharya, K., Pal, B. C., Li, J., Datta, K. & Mandal, C., Feb 1 2013, In : International Journal of Cancer. 132, 3, p. 695-706 12 p.

Research output: Contribution to journalArticle

47 Scopus citations
2011

HSulf-1 modulates FGF2- and hypoxia-mediated migration and invasion of breast cancer cells

Khurana, A., Liu, P., Mellone, P., Lorenzon, L., Vincenzi, B., Datta, K., Yang, B., Linhardt, R. J., Lingle, W., Chien, J., Baldi, A. & Shridhar, V., Mar 15 2011, In : Cancer Research. 71, 6, p. 2152-2161 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Lymphangiogenesis in regional lymph nodes is an independent prognostic marker in rectal cancer patients after neoadjuvant treatment

Jakob, C., Aust, D. E., Liebscher, B., Baretton, G. B., Datta, K. & Muders, M. H., Nov 7 2011, In : PloS one. 6, 11, e27402.

Research output: Contribution to journalArticle

21 Scopus citations
2009

Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth

Muders, M. H., Vohra, P. K., Dutta, S. K., Wang, E., Ikeda, Y., Wang, L., Udugamasooriya, D. G., Memic, A., Rupashinghe, C. N., Baretton, G. B., Aust, D. E., Langer, S., Datta, K., Simons, M., Spaller, M. R. & Mukhopadhyay, D., Jun 15 2009, In : Clinical Cancer Research. 15, 12, p. 4095-4103 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of rapamycin complex-2 and AKT-1

Muders, M. H., Zhang, H., Wang, E., Tindall, D. J. & Datta, K., Aug 1 2009, In : Cancer Research. 69, 15, p. 6042-6048 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: Impact on vascular endothelial growth factor expression in hypoxia

Sinha, S., Dutta, S., Datta, K., Ghosh, A. K. & Mukhopadhyay, D., Nov 20 2009, In : Journal of Biological Chemistry. 284, 47, p. 32610-32618 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2008

Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer

Zhang, H., Muders, M. H., Li, J., Rinaldo, F., Tindall, D. J. & Datta, K., Nov 1 2008, In : Cancer Research. 68, 21, p. 8770-8778 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2007

Ist GIPC ein neuer Kandidat für die Therapie des Pankreaskarzinoms?

Translated title of the contribution: GIPC: a new target for therapy in pancreatic adenocarcinoma?Muders, M. H., Baretton, G. B., Aust, D. E., Dutta, S. K., Wang, E., Ikeda, Y., Spaller, M. R., Datta, K. & Mukhopadhyay, D., 2007, In : Verhandlungen der Deutschen Gesellschaft für Pathologie. 91, p. 286-293 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux

Li, J., Wang, E., Dutta, S., Lau, J. S., Jiang, S. W., Datta, K. & Mukhopadhyay, D., Oct 2007, In : Molecular and cellular biology. 27, 20, p. 7345-7353 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation

Rinaldo, F., Li, J., Wang, E., Muders, M. & Datta, K., Mar 15 2007, In : Oncogene. 26, 12, p. 1731-1738 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2006

Expression and regulatory role of GAIP-interacting protein GIPC in pancreatic adenocarcinoma

Muders, M. H., Dutta, S. K., Wang, L., Lau, J. S., Bhattacharya, R., Smyrk, T. C., Chari, S. T., Datta, K. & Mukhopadhyay, D., Nov 1 2006, In : Cancer Research. 66, 21, p. 10264-10268 5 p.

Research output: Contribution to journalArticle

37 Scopus citations
2005

Role of elongin-binding domain of von hippel lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma

Datta, K., Mondal, S., Sinha, S., Li, J., Wang, E., Knebelmann, B., Karumanchi, S. A. & Mukhopadhyay, D., Nov 24 2005, In : Oncogene. 24, 53, p. 7850-7858 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Upregulation of VEGF-C by androgen depletion: The involvement of IGF-IR-FOXO pathway

Li, J., Wang, E., Rinaldo, F. & Datta, K., Aug 18 2005, In : Oncogene. 24, 35, p. 5510-5520 11 p.

Research output: Contribution to journalArticle

50 Scopus citations
2004

Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer

Stephan, S., Datta, K., Wang, E., Li, J., Brekken, R. A., Parangi, S., Thorpe, P. E. & Mukhopadhyay, D., Oct 15 2004, In : Clinical Cancer Research. 10, 20, p. 6993-7000 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on α6β1 integrin in breast carcinoma cells

Chung, J., Yoon, S., Datta, K., Bachelder, R. E. & Mercurio, A. M., Jul 15 2004, In : Cancer Research. 64, 14, p. 4711-4716 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Protein Kinase C ζ Transactivates Hypoxia-Inducible Factor α by Promoting Its Association with p300 in Renal Cancer

Datta, K., Li, J., Bhattacharya, R., Gasparian, L., Wang, E. & Mukhopadhyay, D., Jan 15 2004, In : Cancer Research. 64, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes

Datta, K., Li, J., Ananth Karumanchi, S., Wang, E., Rondeau, E. & Mukhopadhyay, D., Oct 2004, In : Kidney International. 66, 4, p. 1471-1478 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells

Neid, M., Datta, K., Stephan, S., Khanna, I., Pal, S., Shaw, L., White, M. & Mukhopadhyay, D., Feb 6 2004, In : Journal of Biological Chemistry. 279, 6, p. 3941-3948 8 p.

Research output: Contribution to journalArticle

43 Scopus citations
2003

Heterotrimeric Gαq/Gα11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling

Zeng, H., Zhao, D., Yang, S., Datta, K. & Mukhopadhyay, D., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 20738-20745 8 p.

Research output: Contribution to journalArticle

61 Scopus citations
59 Scopus citations
2001

A comparative study of the winged bean protease inhibitors and their interaction with proteases

Datta, K., Usha, R., Dutta, S. K. & Singh, M., 2001, In : Plant Physiology and Biochemistry. 39, 11, p. 949-959 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma

Pal, S., Datta, K. & Mukhopadhyay, D., Sep 15 2001, In : Cancer Research. 61, 18, p. 6952-6957 6 p.

Research output: Contribution to journalArticle

168 Scopus citations

Role of Protein Kinase Cζ in Ras-mediated Transcriptional Activation of Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression

Pal, S., Datta, K., Khosravi-Far, R. & Mukhopadhyay, D., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2395-2403 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

The 104-123 amino acid sequence of the β-domain of von Hippel-Lindau gene product is sufficient to inhibit renal tumor growth and invasion

Datta, K., Sundberg, C., Karumanchi, S. A. & Mukhopadhyay, D., Mar 1 2001, In : Cancer Research. 61, 5, p. 1768-1775 8 p.

Research output: Contribution to journalArticle

80 Scopus citations
2000

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

Datta, K., Nambudripad, R., Pal, S., Zhou, M., Cohen, H. T. & Mukhopadhyay, D., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20700-20706 7 p.

Research output: Contribution to journalArticle

76 Scopus citations