Kenneth H Cowan, MD, PhD

  • 26817 Citations
  • 70 h-Index
1981 …2020

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2020

Association of SOD3 promoter DNA methylation with its down-regulation in breast carcinomas

Griess, B., Klinkebiel, D., Kueh, A., Desler, M., Cowan, K., Fitzgerald, M. & Teoh-Fitzgerald, M., 2020, (Accepted/In press) In : Epigenetics.

Research output: Contribution to journalArticle

Twenty-five-Year Follow-up of a Prospective Randomized Trial Comparing Preoperative Versus Postoperative FLAC/Granulocyte Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer

Malekzadeh, P., Cowan, K., Steinberg, S. M., Camphausen, K. A., Shriver, C., Merino, M. J., Good, M. L., Berman, A. & Danforth, D. N., May 1 2020, In : American journal of clinical oncology. 43, 5, p. 334-339 6 p.

Research output: Contribution to journalArticle

2019

Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality

Berger, A. M., Kupzyk, K. A., Djalilova, D. M. & Cowan, K. H., Apr 1 2019, In : Supportive Care in Cancer. 27, 4, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

The impact of the affordable care act on breast cancer care in the USA: A multi-institutional analysis

Maxwell, J., Shats, O., Aldridge, J., Lyden, E., Krie, A., Conklin, R., Manning, K., Fahed, R., Vaziri, I., Deveras, R. A. E., Mateen, Z., Crow, K., Bjorling, V., Meschi, J. T., Makoni, S., Kruter, F. & Cowan, K., Sep 1 2019, In : Breast Journal. 25, 5, p. 948-952 5 p.

Research output: Contribution to journalArticle

2015

A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation

Yan, Y., Hein, A. L., Greer, P. M., Wang, Z., Kolb, R. H., Batra, S. K. & Cowan, K. H., Apr 23 2015, In : Oncogene. 34, 17, p. 2215-2226 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers

Li, Y., Wang, X., Vural, S., Mishra, N. K., Cowan, K. H. & Guda, C., Mar 24 2015, In : PloS one. 10, 3, e0119383.

Research output: Contribution to journalArticle

8 Scopus citations

Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer

Downs, B., Kim, Y. C., Xiao, F., Snyder, C., Chen, P., Fleissner, E. A., Becirovic, D., Wen, H., Sherman, S., Cowan, K. H., Lynch, H. T. & Wang, S. M., May 1 2015, In : Breast Cancer Research and Treatment. 151, 1, p. 219-224 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer

Wen, H., Kim, Y. C., Snyder, C., Xiao, F., Fleissner, E. A., Becirovic, D., Luo, J., Downs, B., Sherman, S., Cowan, K. H., Lynch, H. T. & Wang, S. M., Jun 26 2014, In : BMC cancer. 14, 1, 470.

Research output: Contribution to journalArticle

11 Scopus citations

Genome instability in blood cells of a BRCA1+ breast cancer family

Xiao, F., Kim, Y. C., Snyder, C., Wen, H., Chen, P. X., Luo, J., Becirovic, D., Downs, B., Cowan, K. H., Lynch, H. & Wang, S. M., May 19 2014, In : BMC cancer. 14, 1, 342.

Research output: Contribution to journalArticle

5 Scopus citations

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation

Yan, Y., Hein, A. L., Etekpo, A., Burchett, K. M., Lin, C., Enke, C. A., Batra, S. K., Cowan, K. H. & Ouellette, M. M., 2014, In : Oncotarget. 5, 21, p. 10251-10270 20 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2013

Can unknown predisposition in familial breast cancer be family-specific?

Lynch, H., Wen, H., Kim, Y. C., Snyder, C., Kinarsky, Y., Chen, P. X., Xiao, F., Goldgar, D., Cowan, K. H. & Wang, S. M., 2013, In : Breast Journal. 19, 5, p. 520-528 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The genome of polymorphonuclear neutrophils maintains normal coding sequences

Xiao, F., Kim, Y. C., Wen, H., Luo, J., Chen, P., Cowan, K. & Wang, S. M., Nov 8 2013, In : PloS one. 8, 11, e78685.

Research output: Contribution to journalArticle

1 Scopus citations
2012

ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation

Kolb, R. H., Greer, P. M., Cao, P. T., Cowan, K. H. & Yan, Y., Nov 16 2012, In : PloS one. 7, 11, e50281.

Research output: Contribution to journalArticle

20 Scopus citations

RAC1 GTPase plays an important role in γ-irradiation induced G 2/M checkpoint activation

Yan, Y., Greer, P. M., Cao, P. T., Kolb, R. H. & Cowan, K. H., Apr 11 2012, In : Breast Cancer Research. 14, 2, R60.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Multicenter Breast Cancer Collaborative Registry

Sherman, S., Shats, O., Fleissner, E., Bascom, G., Yiee, K., Copur, M., Crow, K., Rooney, J., Mateen, Z., Ketcham, M. A., Feng, J., Sherman, A., Gleason, M., Kinarsky, L., Silva-Lopez, E., Edney, J., Reed, E., Berger, A. & Cowan, K., 2011, In : Cancer Informatics. 10, p. 217-226 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials

Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Aug 27 2011, In : The Lancet. 378, 9793, p. 771-784 14 p.

Research output: Contribution to journalArticle

1365 Scopus citations
2010

Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast

Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), 2010, In : Journal of the National Cancer Institute - Monographs. 41, p. 162-177 16 p.

Research output: Contribution to journalArticle

371 Scopus citations

Protein phosphatase 2A has an essential role in the activation of γ-irradiation-induced G2/M checkpoint response

Yan, Y., Cao, P. T., Greer, P. M., Nagengast, E. S., Kolb, R. H., Mumby, M. C. & Cowan, K. H., Jul 29 2010, In : Oncogene. 29, 30, p. 4317-4329 13 p.

Research output: Contribution to journalArticle

42 Scopus citations
2009

Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines

Stoeger, S. M. & Cowan, K. H., Apr 2009, In : Cancer Chemotherapy and Pharmacology. 63, 5, p. 807-818 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

KSR1 is required for cell cycle reinitiation following DNA Damage

Razidlo, G. L., Johnson, H. J., Stoeger, S. M., Cowan, K. H., Bessho, T. & Lewis, R. E., Mar 13 2009, In : Journal of Biological Chemistry. 284, 11, p. 6705-6715 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2008

Closing the manufacturing process of dendritic cell vaccines transduced with adenovirus vectors

Gulen, D., Abe, F., Maas, S., Reed, E., Cowan, K., Pirruccello, S., Wisecarver, J., Warkentin, P., Northam, M., Turken, O., Coskun, U., Senesac, J. & Talmadge, J. E., Dec 20 2008, In : International Immunopharmacology. 8, 13-14, p. 1728-1736 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

γ-Irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated Kinase 1/2 and BRCA1

Yan, Y., Black, C. P., Cao, P. T., Haferbier, J. L., Kolb, R. H., Spieker, R. S., Ristow, A. M. & Cowan, K. H., Jul 1 2008, In : Cancer Research. 68, 13, p. 5113-5121 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Breast cancer risk reduction: Clinical Practice Guidelines in Oncology™

Bevers, T. B., Armstrong, D. K., Arun, B., Carlson, R. W., Cowan, K. H., Daly, M. B., Fleming, I., Garber, J. E., Gemignani, M., Gradishar, W. J., Krontiras, H., Kulkarni, S., Laronga, C., Lawton, T., Loftus, L., MacDonald, D. J., Mahoney, M. C., Merajver, S. D., Seewaldt, V., Sellin, R. V. & 3 others, Shapiro, C. L., Singletary, E. & Ward, J. H., Sep 2007, In : JNCCN Journal of the National Comprehensive Cancer Network. 5, 8, p. 676-701 26 p.

Research output: Contribution to journalArticle

10 Scopus citations

Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

Yan, Y., Black, C. P. & Cowan, K. H., Jul 12 2007, In : Oncogene. 26, 32, p. 4689-4698 10 p.

Research output: Contribution to journalArticle

71 Scopus citations

Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells

Yaar, M., Eller, M. S., Panova, I., Kubera, J., Wee, L. H., Cowan, K. H. & Gilchrest, B. A., Jan 26 2007, In : Breast Cancer Research. 9, 1, R13.

Research output: Contribution to journalArticle

49 Scopus citations
2006

Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1

Muraoka-Cook, R. S., Caskey, L. S., Sandahl, M. A., Hunter, D. M., Husted, C., Strunk, K. E., Sartor, C. I., Rearick, W. A., McCall, W., Sgagias, M. K., Cowan, K. H. & Earp, H. S., Sep 2006, In : Molecular and cellular biology. 26, 17, p. 6412-6424 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Neural stem cells in the adult ciliary epithelium express GFAP and are regulated by Wnt signaling

Das, A. V., Zhao, X., James, J., Kim, M., Cowan, K. H. & Ahmad, I., Jan 13 2006, In : Biochemical and Biophysical Research Communications. 339, 2, p. 708-716 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2005

BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53

Basma, H., El-Refaey, H., Sgagias, M. K., Cowan, K. H., Luo, X. & Cheng, P. W., Dec 2005, In : Journal of Biomedical Science. 12, 6, p. 999-1011 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation

Yan, Y., Spieker, R. S., Kim, M., Stoeger, S. M. & Cowan, K. H., May 5 2005, In : Oncogene. 24, 20, p. 3285-3296 12 p.

Research output: Contribution to journalArticle

48 Scopus citations
120 Scopus citations

Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials

Early Breast Cancer Trialists' Collaborative Group (EBCTCG), May 14 2005, In : Lancet. 365, 9472, p. 1687-1717 31 p.

Research output: Contribution to journalArticle

5570 Scopus citations

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials

Abe, O., Abe, R., Enomoto, K., Kikuchi, K., Koyama, H., Masuda, H., Nomura, Y., Sakai, K., Sugimachi, K., Tominaga, T., Uchino, J., Yoshida, M., Haybittle, J. L., Davies, C., Harvey, V. J., Holdaway, T. M., Kay, R. G., Mason, B. H., Forbes, J. F., Wilcken, N. & 420 others, Gnant, M., Jakesz, R., Ploner, M., Yosef, H. M. A., Focan, C., Lobelle, J. P., Peek, U., Oates, G. D., Powell, J., Durand, M., Mauriac, L., Di Leo, A., Dolci, S., Piccart, M. J., Masood, M. B., Parker, D., Price, J. J., Hupperets, P. S. G. J., Jackson, S., Ragaz, J., Berry, D., Broadwater, G., Cirrincione, C., Muss, H., Norton, L., Weiss, R. B., Abu-Zahra, H. T., Portnoj, S. M., Baum, M., Cuzick, J., Houghton, J., Riley, D., Mansel, R. E., Gordon, N. H., Davis, H. L., Beatrice, A., Mihura, J., Naja, A., Lehingue, Y., Romestaing, P., Dubois, J. B., Delozier, T., Mace Lesec'h, J., Rambert, P., Petruzelka, L., Pribylova, O., Owen, J. R., Harbeck, N., Jänicke, F., Meisner, C., Meier, P., Howell, A., Ribeiro, G. C., Swindell, R., Burrett, J., Clarke, M., Collins, R., Darby, S., Davies, C., Elphinstone, P., Evans, V., Godwin, J., Gray, R., Harwood, C., Hicks, C., Jackson, D., James, S., MacKinnon, E., McGale, P., McHugh, T., Mead, G., Morris, P., Oulds, J., Peto, R., Taylor, C., Wang, Y., Albano, J., De Oliveira, C. F., Gervásio, H., Gordilho, J., Johansen, H., Mouridsen, H. T., Gelman, R. S., Harris, J. R., Henderson, I. C., Shapiro, C. L., Christiansen, P., Ejlertsen, B., Mouridsen, H. T., Møller, S., Overgaard, M., Carstensen, B., Palshof, T., Trampisch, H. J., Dalesio, O., De Vries, E. G. E., Rodenhuis, S., Van Tinteren, H., Comis, R. L., Davidson, N. E., Gray, R., Robert, N., Sledge, G., Tormey, D. C., Wood, W., Cameron, D., Chetty, U., Forrest, P., Jack, W., Rossbach, J., Klijn, J. G. M., Treurniet-Donker, A. D., Van Putten, W. L. J., Costa, A., Veronesi, U., Bartelink, H., Duchateau, L., Legrand, C., Sylvester, R., Van Der Hage, J. A., Van De Velde, C. J. H., Cunningham, M. P., Catalano, R., Creech, R. H., Bonneterre, J., Fargeot, P., Fumoleau, P., Kerbrat, P., Namer, M., Jonat, W., Kaufmann, M., Schumacher, M., Von Minckwitz, G., Bastert, G., Rauschecker, H., Sauer, R., Sauerbrei, W., Schauer, A., Schumacher, M., De Schryver, A., Vakaet, L., Belfiglio, M., Nicolucci, A., Pellegrini, F., Sacco, M., Valentini, M., McArdle, C. S., Smith, D. C., Galligioni, E., Boccardo, F., Rubagotti, A., Dent, D. M., Gudgeon, C. A., Hacking, A., Erazo, A., Medina, J. Y., Izuo, M., Morishita, Y., Takei, H., Fentiman, I. S., Hayward, J. L., Rubens, R. D., Skilton, D., Scheurlen, H., Kaufmann, M., Von Fournier, D., Dafni, U., Fountzilas, G., Klefstrom, P., Blomqvist, C., Saarto, T., Margreiter, R., Asselain, B., Salmon, R. J., Vilcoq, J. R., Arriagada, R., Hill, C., Laplanche, A., Lê, M. G., Spielmann, M., Bruzzi, P., Montanaro, E., Rosso, R., Sertoli, M. R., Venturini, M., Amadori, D., Benraadt, J., Kooi, M., Van De Velde, A. O., Van Dongen, J. A., Vermorken, J. B., Castiglione, M., Cavalli, F., Coates, A., Collins, J., Forbes, J., Gelber, R. D., Goldhirsch, A., Lindtner, J., Price, K. N., Rudenstam, C. M., Senn, H. J., Bliss, J. M., Chilvers, C. E. D., Coombes, R. C., Hall, E., Marty, M., Borovik, R., Brufman, G., Hayat, H., Robinson, E., Wigler, N., Bonadonna, G., Camerini, T., De Palo, G., Del Vecchio, M., Formelli, F., Valagussa, P., Martoni, A., Pannuti, F., Cocconi, G., Colozza, A., Camisa, R., Aogi, K., Takashima, S., Abe, O., Ikeda, T., Inokuchi, K., Kikuchi, K., Sawa, K., Sonoo, H., Korzeniowski, S., Skolyszewski, J., Ogawa, M., Yamashita, J., Bonte, J., Christiaens, R., Paridaens, R., Van Den Bogaert, W., Martin, P., Romain, S., Hakes, T., Hudis, C. A., Norton, L., Wittes, R., Giokas, G., Kondylis, D., Lissaios, B., De La Huerta, R., Sainz, M. G., Altemus, R., Cowan, K., Danforth, D., Lichter, A., Lippman, M., O'Shaughnessy, J., Pierce, L. J., Steinberg, S., Venzon, D., Zujewski, J. A., Paradiso, A., De Lena, M., Schittulli, F., Myles, J. D., Pater, J. L., Pritchard, K. I., Whelan, T., Nomura, Y., Anderson, S., Bass, G., Brown, A., Bryant, J., Costantino, J., Dignam, J., Fisher, B., Redmond, C., Wieand, S., Wolmark, N., Baum, M., Jackson, I. M., Palmer, M. K., Ingle, J. N., Suman, V. J., Bengtsson, N. O., Jonsson, H., Larsson, L. G., Lythgoe, J. P., Swindell, R., Kissin, M., Erikstein, B., Hannisdal, E., Jacobsen, A. B., Varhaug, J. E., Erikstein, B., Gundersen, S., Hauer-Jensen, M., Høst, H., Jacobsen, A. B., Nissen-Meyer, R., Blamey, R. W., Mitchell, A. K., Morgan, D. A. L., Robertson, J. F. R., Di Palma, M., Mathé, G., Misset, J. L., Clark, R. M., Levine, M., Pritchard, K. I., Whelan, T., Morimoto, K., Sawa, K., Takatsuka, Y., Crossley, E., Harris, A., Talbot, D., Taylor, M., Cocconi, G., Di Blasio, B., Ivanov, V., Semiglazov, V., Brockschmidt, J., Cooper, M. R., Ueo, H., Falkson, C. I., A'Hern, R., Ashley, S., Powles, T. J., Smith, I. E., Yarnold, J. R., Gazet, J. C., Corcoran, N., Deshpande, N., Di Martino, L., Douglas, P., Hacking, A., Høst, H., Lindtner, A., Notter, G., Bryant, A. J. S., Ewing, G. H., Firth, L. A., Krushen-Kosloski, J. L., Nissen-Meyer, R., Foster, L., George, W. D., Stewart, H. J., Stroner, P., Malmström, P., Möller, T. R., Rydén, S., Tengrup, I., Tennvall-Nittby, L., Carstenssen, J., Dufmats, M., Hatschek, T., Nordenskjöld, B., Söderberg, M., Carpenter, J. T., Albain, K., Crowley, J., Green, S., Martino, S., Osborne, C. K., Ravdin, P. M., Glas, U., Johansson, U., Rutqvist, L. E., Singnomklao, T., Wallgren, A., Castiglione, M., Goldhirsch, A., Maibach, R., Senn, H. J., Thürlimann, B., Brenner, H., Hercbergs, A., Yoshimoto, M., DeBoer, G., Paterson, A. H. G., Pritchard, K. I., Meakin, J. W., Panzarella, T., Pritchard, K. I., Shan, Y., Shao, Y. F., Wang, X., Zhao, D. B., Chen, Z. M., Pan, H. C., Bahi, J., Reid, M., Spittle, M., Deutsch, G. P., Senanayake, F., Kwong, D. L. W., Bianco, A. R., Carlomagno, C., De Laurentiis, M., De Placido, S., Buzdar, A. U., Smith, T., Bergh, J., Holmberg, L., Liljegren, G., Nilsson, J., Seifert, M., Sevelda, P., Zielinsky, C. C., Buchanan, R. B., Cross, M., Royle, G. T., Dunn, J. A., Hills, R. K., Lee, M., Morrison, J. M., Spooner, D., Litton, A., Chlebowski, R. T. & Caffier, H., Dec 17 2005, In : Lancet. 366, 9503, p. 2087-2106 20 p.

Research output: Contribution to journalArticle

3412 Scopus citations

Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity

Kim, M., Yan, Y., Kortum, R. L., Stoeger, S. M., Sgagias, M. K., Lee, K., Lewis, R. E. & Cowan, K. H., May 15 2005, In : Cancer Research. 65, 10, p. 3986-3992 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
2004

Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression

Kim, M., Sgagias, M., Deng, X., Jung, Y. J., Rikiyama, T., Lee, K., Ouellette, M. & Cowan, K., Jul 16 2004, In : Biochemical and Biophysical Research Communications. 320, 1, p. 138-144 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS

Sgagias, M. K., Wagner, K. U., Hamik, B., Stoeger, S., Spieker, R., Huber, L. J., Chodosh, L. A. & Cowan, K. H., Nov 2004, In : Cell Cycle. 3, 11, p. 1451-1456 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
21 Scopus citations

The combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) and genistein is effective in inhibiting pancreatic cancer growth

Nozawa, F., Itami, A., Saruc, M., Kim, M., Standop, J., Picha, K. S., Cowan, K. H. & Pour, P. M., Jul 2004, In : Pancreas. 29, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Thromboembolism following removal of femoral venous apheresis catheters in patients with breast cancer

Saif, M. W., Leitman, S. F., Cusack, G., Horne, M., Freifeld, A., Venzon, D., PremKumar, A., Cowan, K. H., Gress, R. E., Zujewski, J. & Kasten-Sportes, C., Sep 2004, In : Annals of Oncology. 15, 9, p. 1366-1372 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
2003

Adenovirus Expressing p27KIP1 Induces Apoptosis Against Cholangiocarcinoma Cells by Triggering Fas Ligand on the Cell Surface

Yamamoto, K., Katayose, Y., Suzuki, M., Unno, M., Sasaki, T., Mizuma, M., Shiraso, S., Ohtuka, H., Cowan, K. H., Seth, P. & Matsuno, S., Nov 2003, In : Hepato-Gastroenterology. 50, 54, p. 1847-1853 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

A pilot study of dose intense doxorubicin and cyclophosphamide followed by infusional paclitaxel in high-risk primary breast cancer

Zujewski, J. A., Eng-Wong, J., O'Shaughnessy, J., Venzon, D., Chow, C., Danforth, D., Kohler, D. R., Cusack, G., Riseberg, D. & Cowan, K. H., Sep 2003, In : Breast Cancer Research and Treatment. 81, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Preoperative FLAC/granulocyte-colony-stimulating factor chemotherapy for stage II breast cancer: A prospective randomized trial

Danforth, D. N., Cowan, K., Altemus, R., Merino, M., Chow, C., Berman, A., Chaudhry, U., Shriver, C., Steinberg, S. M. & Zujewski, J. A., 2003, In : Annals of Surgical Oncology. 10, 6, p. 635-644 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2002

BRCA1-induced apoptosis involves inactivation of ERK1/2 activities

Yan, Y., Haas, J. P., Kim, M., Sgagias, M. K. & Cowan, K. H., Sep 6 2002, In : Journal of Biological Chemistry. 277, 36, p. 33422-33430 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Yarden, R. I., Pardo-Reoyo, S., Sgagias, M., Cowan, K. H. & Brody, L. C., Mar 2002, In : Nature Genetics. 30, 3, p. 285-289 5 p.

Research output: Contribution to journalArticle

364 Scopus citations

Recombinant adenovirus-mediated p14ARF overexpression sensitizes human breast cancer cells to cisplatin

Deng, X., Kim, M., Vandier, D., Jung, Y. J., Rikiyama, T., Sgagias, M. K., Goldsmith, M. & Cowan, K. H., 2002, In : Biochemical and Biophysical Research Communications. 296, 4, p. 792-798 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells

Kim, M., Turnquist, H., Sgagias, M., Yan, Y., Cowan, K., Jackson, J., Sharp, J. G., Gong, M. & Dean, M., 2002, In : Clinical Cancer Research. 8, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

342 Scopus citations
2001

Phase I clinical trial of alitretinoin and tamoxifen in breast cancer patients: Toxicity, pharmacokinetic, and biomarker evaluations

Lawrence, J. A., Adamson, P. C., Caruso, R., Chow, C., Kleiner, D., Murphy, R. F., Venzon, D. J., Shovlin, M., Noone, M., Merino, M., Cowan, K. H., Kaiser, M., O'Shaughnessy, J. & Zujewski, J. A., May 15 2001, In : Journal of Clinical Oncology. 19, 10, p. 2754-2763 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2000

Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines

Knutsen, T., Koneti Rao, V., Ried, T., Mickley, L., Schneider, E., Miyake, K., Michael Ghadimi, B., Padilla-Nash, H., Pack, S., Greenberger, L., Cowan, K., Dean, M., Fojo, T. & Bates, S., Jan 2000, In : Genes Chromosomes and Cancer. 27, 1, p. 110-116 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression

MacLachlan, T. K., Somasundaram, K., Sgagias, M., Shifman, Y., Muschel, R. J., Cowan, K. H. & El-Deiry, W. S., Jan 28 2000, In : Journal of Biological Chemistry. 275, 4, p. 2777-2785 9 p.

Research output: Contribution to journalArticle

187 Scopus citations

Construction of a recombinant adeno-associated virus (rAAV) vector expressing murine interleukin-12 (IL-12)

Paul, D., Qazilbash, M. H., Song, K., Xu, H., Sinha, B. K., Liu, J. & Cowan, K. H., 2000, In : Cancer Gene Therapy. 7, 2, p. 308-315 8 p.

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Detection of circulating tumor cells and micrometastases in stage II, III, and IV breast cancer patients utilizing cytology and immunocytochemistry

Fetsch, P. A., Cowan, K. H., Weng, D. E., Freifield, A., Filie, A. C. & Abati, A., May 2000, In : Diagnostic cytopathology. 22, 5, p. 323-328 6 p.

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28 Scopus citations