Kenneth W Bayles, PhD

  • 7256 Citations
  • 49 h-Index
1989 …2020

Research output per year

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Research Output

2020

An integrated computational and experimental study to investigate Staphylococcus aureus metabolism

Mazharul Islam, M., Thomas, V. C., Van Beek, M., Ahn, J. S., Alqarzaee, A. A., Zhou, C., Fey, P. D., Bayles, K. W. & Saha, R., Dec 1 2020, In : npj Systems Biology and Applications. 6, 1, 3.

Research output: Contribution to journalArticle

Open Access

Fluorescent Sensor Arrays Can Predict and Quantify the Composition of Multicomponent Bacterial Samples

Svechkarev, D., Sadykov, M. R., Houser, L. J., Bayles, K. W. & Mohs, A. M., Jan 15 2020, In : Frontiers in Chemistry. 7, 916.

Research output: Contribution to journalArticle

Open Access

Genetic and biochemical analysis of cody-mediated cell aggregation in staphylococcus aureus reveals an interaction between extracellular DNA and polysaccharide in the extracellular matrix

Mlynek, K. D., Bulock, L. L., Stone, C. J., Curran, L. J., Sadykov, M. R., Bayles, K. W. & Brinsmade, S. R., Mar 1 2020, In : Journal of bacteriology. 202, 8, e00593-19.

Research output: Contribution to journalArticle

Stochastic expression of sae-dependent virulence genes during staphylococcus aureus biofilm development is dependent on saes

Delmain, E. A., Moormeier, D. E., Endres, J. L., Hodges, R. E., Sadykov, M. R., Horswill, A. R. & Bayles, K. W., Jan 1 2020, In : mBio. 11, 1, e03081-19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

CidR and CcpA synergistically regulate staphylococcus aureus cidABC expression

Sadykov, M. R., Windham, I. H., Widhelm, T. J., Yajjala, V. K., Watson, S. M., Endres, J. L., Bavari, A. I., Thomas, V. C., Bose, J. L. & Bayles, K. W., Dec 1 2019, In : Journal of bacteriology. 201, 23, e00371-19.

Research output: Contribution to journalArticle

1 Scopus citations

Construction of a Sequence-Defined Transposon Mutant Library in Staphylococcus aureus

Endres, J. L., Yajjala, V. K., Fey, P. D. & Bayles, K. W., 2019, Methods in Molecular Biology. Humana Press Inc., p. 29-37 9 p. (Methods in Molecular Biology; vol. 2016).

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification of extracellular DNA-binding proteins in the biofilm matrix

Kavanaugh, J. S., Flack, C. E., Lister, J., Ricker, E. B., Ibberson, C. B., Jenul, C., Moormeier, D. E., Delmain, E. A., Bayles, K. W. & Horswill, A. R., May 1 2019, In : mBio. 10, 3, e01137-19.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Observations of shear stress effects on Staphylococcus aureus biofilm formation

Sherman, E., Bayles, K., Moormeier, D., Endres, J. & Wei, T., 2019, In : mSphere. 4, 4, e00372-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Guanine limitation results in CodY-dependent and -independent alteration of Staphylococcus aureus physiology and gene expression

King, A. N., Borkar, S. A., Samuels, D. J., Batz, Z., Bulock, L. L., Sadykov, M. R., Bayles, K. W. & Brinsmade, S. R., Jul 1 2018, In : Journal of bacteriology. 200, 14, e00136-18.

Research output: Contribution to journalArticle

4 Scopus citations

Nutritional regulation of the Sae two-component system by CodY in Staphylococcus aureus

Mlynek, K. D., Sause, W. E., Moormeier, D. E., Sadykov, M. R., Hill, K. R., Torres, V. J., Bayles, K. W. & Brinsmade, S. R., Apr 1 2018, In : Journal of bacteriology. 200, 8, e00012-18.

Research output: Contribution to journalArticle

11 Scopus citations

Ratiometric Fluorescent Sensor Array as a Versatile Tool for Bacterial Pathogen Identification and Analysis

Svechkarev, D., Sadykov, M. R., Bayles, K. W. & Mohs, A. M., Mar 23 2018, In : ACS Sensors. 3, 3, p. 700-708 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2017

Poly(3-hydroxybutyrate) fuels the tricarboxylic acid cycle and de novo lipid biosynthesis during Bacillus anthracis sporulation

Sadykov, M. R., Ahn, J. S., Widhelm, T. J., Eckrich, V. M., Endres, J. L., Driks, A., Rutkowski, G. E., Wingerd, K. L. & Bayles, K. W., Jun 2017, In : Molecular Microbiology. 104, 5, p. 793-803 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Simple synthesis of endophenazine G and other phenazines and their evaluation as anti-methicillin-resistant Staphylococcus aureus agents

Conda-Sheridan, M., Udumula, V., Endres, J. L., Harper, C. N., Jaramillo, L., Zhong, H. A. & Bayles, K. W., 2017, In : European Journal of Medicinal Chemistry. 125, p. 710-721 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Staphylococcus aureus biofilm: a complex developmental organism

Moormeier, D. E. & Bayles, K. W., May 2017, In : Molecular Microbiology. 104, 3, p. 365-376 12 p.

Research output: Contribution to journalReview article

70 Scopus citations

Staphylococcus aureus CidC Is a Pyruvate:Menaquinone Oxidoreductase

Zhang, X., Bayles, K. W. & Luca, S., Sep 12 2017, In : Biochemistry. 56, 36, p. 4819-4829 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Allelic exchange

Lehman, M. K., Bose, J. L. & Bayles, K. W., 2016, Methods in Molecular Biology. Humana Press Inc., p. 89-96 8 p. (Methods in Molecular Biology; vol. 1373).

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Effects of low-dose amoxicillin on Staphylococcus aureus USA300 biofilms

Mlynek, K. D., Callahan, M. T., Shimkevitch, A. V., Farmer, J. T., Endres, J. L., Marchand, M., Bayles, K. W., Horswill, A. R. & Kaplan, J. B., May 2016, In : Antimicrobial Agents and Chemotherapy. 60, 5, p. 2639-2651 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Generation of a transposon mutant library in staphylococcus aureus and staphylococcus epidermidis using bursa aurealis

Yajjala, V. K., Widhelm, T. J., Endres, J. L., Fey, P. D. & Bayles, K. W., 2016, Methods in Molecular Biology. Humana Press Inc., p. 103-110 8 p. (Methods in Molecular Biology; vol. 1373).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Identification of inhibitors for single-stranded DNA-binding proteins in eubacteria

Glanzer, J. G., Endres, J. L., Byrne, B. M., Liu, S., Bayles, K. W. & Oakley, G. G., 2016, In : Journal of Antimicrobial Chemotherapy. 71, 12, p. 3432-3440 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Novel fluorinated pyrrolomycins as potent anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities

Yang, Z., Liu, Y., Ahn, J., Qiao, Z., Endres, J. L., Gautam, N., Huang, Y., Li, J., Zheng, J. C., Alnouti, Y., Bayles, K. W. & Li, R., 2016, In : European Journal of Medicinal Chemistry. 124, p. 129-137 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Potassium uptake modulates Staphylococcus aureus metabolism

Gries, C. M., Sadykov, M. R., Bulock, L. L., Chaudhari, S. S., Thomas, V. C., Bose, J. L. & Bayles, K. W., May 1 2016, In : mSphere. 1, 3, e00125-16.

Research output: Contribution to journalArticle

6 Scopus citations

Redox Imbalance Underlies the Fitness Defect Associated with Inactivation of the Pta-AckA Pathway in Staphylococcus aureus

Marshall, D. D., Sadykov, M. R., Thomas, V. C., Bayles, K. W. & Powers, R., Apr 1 2016, In : Journal of proteome research. 15, 4, p. 1205-1212 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Resistance to acute macrophage killing promotes airway fitness of prevalent community-acquired staphylococcus aureus strains

Yajjala, V. K., Thomas, V. C., Bauer, C., Scherr, T. D., Fischer, K. J., Fey, P. D., Bayles, K. W., Kielian, T. & Sun, K., May 15 2016, In : Journal of Immunology. 196, 10, p. 4196-4203 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

SrrAB modulates Staphylococcus aureus cell death through regulation of cidABC transcription

Windham, I. H., Chaudhari, S. S., Bose, J. L., Thomas, V. C. & Bayles, K. W., 2016, In : Journal of bacteriology. 198, 7, p. 1114-1122 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death in Staphylococcus aureus

Chaudhari, S. S., Thomas, V. C., Sadykov, M. R., Bose, J. L., Ahn, D. J., Zimmerman, M. C. & Bayles, K. W., Sep 1 2016, In : Molecular Microbiology. 101, 6, p. 942-953 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model

McCarthy, H., Waters, E. M., Bose, J. L., Foster, S., Bayles, K. W., O'Neill, E., Fey, P. D. & O'Gara, J. P., Apr 3 2016, In : FEMS Microbiology Letters. 363, 9, fnw087.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Examination of the Staphylococcus aureus nitric oxide reductase (saNOR) reveals its contribution to modulating intracellular NO levels and cellular respiration

Lewis, A. M., Matzdorf, S. S., Endres, J. L., Windham, I. H., Bayles, K. W. & Rice, K. C., May 1 2015, In : Molecular Microbiology. 96, 3, p. 651-669 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of the amino acids essential for LytSR-mediated signal transduction in Staphylococcus aureus and their roles in biofilm-specific gene expression

Lehman, M. K., Bose, J. L., Sharma-Kuinkel, B. K., Moormeier, D. E., Endres, J. L., Sadykov, M. R., Biswas, I. & Bayles, K. W., Feb 1 2015, In : Molecular Microbiology. 95, 4, p. 723-737 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Staphylococcus aureus biofilms induce macrophage dysfunction through leukocidin AB and alpha-toxin

Scherr, T. D., Hanke, M. L., Huang, O., James, D. B. A., Horswill, A. R., Bayles, K. W., Fey, P. D., Torres, V. J. & Kielian, T., Aug 25 2015, In : mBio. 6, 4, e01021-15.

Research output: Contribution to journalArticle

59 Scopus citations
2014

A Central Role for Carbon-Overflow Pathways in the Modulation of Bacterial Cell Death

Thomas, V. C., Sadykov, M. R., Chaudhari, S. S., Jones, J., Endres, J. L., Widhelm, T. J., Ahn, J. S., Jawa, R. S., Zimmerman, M. C. & Bayles, K. W., Jun 2014, In : PLoS pathogens. 10, 6, e1004205.

Research output: Contribution to journalArticle

51 Scopus citations

Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis

Lindgren, J. K., Thomas, V. C., Olson, M. E., Chaudhari, S. S., Nuxoll, A. S., Schaeffer, C. R., Lindgren, K. E., Jones, J., Zimmerman, M. C., Dunman, P. M., Bayles, K. W. & Fey, P. D., 2014, In : Journal of bacteriology. 196, 12, p. 2277-2289 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Bacterial programmed cell death: Making sense of a paradox

Bayles, K. W., Jan 2014, In : Nature Reviews Microbiology. 12, 1, p. 63-69 7 p.

Research output: Contribution to journalReview article

120 Scopus citations

Examination of Staphylococcus epidermidis biofilms using flow-cell technology

Moormeier, D. E. & Bayles, K. W., 2014, Staphylococcus Epidermidis: Methods and Protocols. Humana Press Inc., p. 143-155 13 p. (Methods in Molecular Biology; vol. 1106).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Identification of the Staphylococcus aureus vfrAB operon, a novel virulence factor regulatory locus

Bose, J. L., Daly, S. M., Hall, P. R. & Bayles, K. W., May 2014, In : Infection and immunity. 82, 5, p. 1813-1822 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Impact of vancomycin on sarA-mediated biofilm formation: Role in persistent endovascular infections due to methicillin-resistant staphylococcus aureus

Abdelhady, W., Bayer, A. S., Seidl, K., Moormeier, D. E., Bayles, K. W., Cheung, A., Yeaman, M. R. & Xiong, Y. Q., Apr 15 2014, In : Journal of Infectious Diseases. 209, 8, p. 1231-1240 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Methods to generate a sequence-defined transposon mutant library in Staphylococcus epidermidis strain 1457

Widhelm, T. J., Yajjala, V. K., Endres, J. L., Fey, P. D. & Bayles, K. W., 2014, Staphylococcus Epidermidis: Methods and Protocols. Humana Press Inc., p. 135-142 8 p. (Methods in Molecular Biology; vol. 1106).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Predicting the virulence of MRSA from its genome sequence

Laabei, M., Recker, M., Rudkin, J. K., Aldeljawi, M., Gulay, Z., Sloan, T. J., Williams, P., Endres, J. L., Bayles, K. W., Fey, P. D., Yajjala, V. K., Widhelm, T., Hawkins, E., Lewis, K., Parfett, S., Scowen, L., Peacock, S. J., Holden, M., Wilson, D., Read, T. D. & 6 others, Van Den Elsen, J., Priest, N. K., Feil, E. J., Hurst, L. D., Josefsson, E. & Massey, R. C., May 2014, In : Genome Research. 24, 5, p. 839-849 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

Temporal and stochastic control of staphylococcus aureus biofilm development

Moormeier, D. E., Bose, J. L., Horswill, A. R. & Bayles, K. W., Oct 14 2014, In : mBio. 5, 5, e01341-14.

Research output: Contribution to journalArticle

63 Scopus citations

The development of drug-free therapy for prevention of dental caries

Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2014, In : Pharmaceutical Research. 31, 11, p. 3031-3037 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Transformation of human cathelicidin LL-37 into selective, stable, and potent antimicrobial compounds

Wang, G., Hanke, M. L., Mishra, B., Lushnikova, T., Heim, C. E., Thomas, V. C., Bayles, K. W. & Kielian, T., Sep 19 2014, In : ACS chemical biology. 9, 9, p. 1997-2002 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
2013

A dysfunctional tricarboxylic acid cycle enhances fitness of Staphylococcus epidermidis during β-lactam stress

Chittezham Thomas, V., Kinkead, L. C., Janssen, A., Schaeffer, C. R., Woods, K. M., Lindgren, J. K., Peaster, J. M., Chaudhari, S. S., Sadykov, M., Jones, J., Mohamadi AbdelGhani, S. M., Zimmerman, M. C., Bayles, K. W., Somerville, G. A. & Fey, P. D., Aug 20 2013, In : mBio. 4, 4, e00437-13.

Research output: Contribution to journalArticle

28 Scopus citations

A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes

Fey, P. D., Endres, J. L., Yajjala, V. K., Widhelm, T. J., Boissy, R. J., Bose, J. L. & Bayles, K. W., 2013, In : mBio. 4, 1, e00537-12.

Research output: Contribution to journalArticle

318 Scopus citations

Genetic tools to enhance the study of gene function and regulation in Staphylococcus aureus

Bose, J. L., Fey, P. D. & Bayles, K. W., Apr 2013, In : Applied and environmental microbiology. 79, 7, p. 2218-2224 7 p.

Research output: Contribution to journalArticle

94 Scopus citations

Inactivation of the Pta-AckA pathway causes cell death in staphylococcus aureus

Sadykov, M. R., Thomas, V. C., Marshall, D. D., Wenstrom, C. J., Moormeier, D. E., Widhelm, T. J., Nuxoll, A. S., Powers, R. & Bayles, K. W., 2013, In : Journal of bacteriology. 195, 13, p. 3035-3044 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Programmed cell death in plants: Lessons from bacteria?

Wang, J. & Bayles, K. W., Mar 2013, In : Trends in Plant Science. 18, 3, p. 133-139 7 p.

Research output: Contribution to journalReview article

33 Scopus citations

Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in staphylococcus aureus

Yang, S. J., Xiong, Y. Q., Yeaman, M. R., Bayles, K. W., Abdelhady, W. & Bayer, A. S., Aug 2013, In : Antimicrobial Agents and Chemotherapy. 57, 8, p. 3875-3882 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Staphylococcus aureus

Bose, J. L. & Bayles, K. W., Feb 27 2013, Brenner's Encyclopedia of Genetics: Second Edition. Elsevier Inc., p. 553-555 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The development of dentotropic micelles with biodegradable tooth-binding moieties

Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2013, In : Pharmaceutical Research. 30, 11, p. 2808-2817 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
29 Scopus citations

Use of microfluidic technology to analyze gene expression during Staphylococcus aureus biofilm formation reveals distinct physiological niches

Moormeier, D. E., Endres, J. L., Mann, E. E., Sadykov, M. R., Horswill, A. R., Rice, K. C., Fey, P. D. & Bayles, K. W., Jun 2013, In : Applied and environmental microbiology. 79, 11, p. 3413-3424 12 p.

Research output: Contribution to journalArticle

53 Scopus citations