• 2556 Citations
  • 27 h-Index
1994 …2020

Research output per year

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Research Output

  • 2556 Citations
  • 27 h-Index
  • 44 Article
  • 2 Review article
  • 1 Chapter
2020

Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome

Roychoudhury, S., Pramanik, S., Harris, H. L., Tarpley, M., Sarkar, A., Spagnol, G., Sorgen, P. L., Chowdhury, D., Band, V., Klinkebiel, D. & Bhakat, K. K., May 26 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 21, A44.

Research output: Contribution to journalArticle

Open Access

Pan-Cancer Analysis Reveals the Diverse Landscape of Novel Sense and Antisense Fusion Transcripts

Vellichirammal, N. N., Albahrani, A., Banwait, J. K., Mishra, N. K., Li, Y., Roychoudhury, S., Kling, M. J., Mirza, S., Bhakat, K. K., Band, V., Joshi, S. S. & Guda, C., Mar 6 2020, In : Molecular Therapy - Nucleic Acids. 19, p. 1379-1398 20 p.

Research output: Contribution to journalArticle

Open Access

Targeting histone chaperone FACT complex overcomes 5-fluorouracil resistance in colon cancer

Song, H., Zeng, J., Roychoudhury, S., Biswas, P., Mohapatra, B., Ray, S., Dowlatshahi, K., Wang, J., Band, V., Talmon, G. & Bhakat, K. K., 2020, In : Molecular cancer therapeutics. 19, 1, p. 258-269 12 p.

Research output: Contribution to journalArticle

2019

Biochemical and cellular assays to assess the effects of acetylation on base excision repair enzymes

Roychoudhury, S., Pramanik, S., Harris, H. L. & Bhakat, K. K., 2019, Methods in Molecular Biology. Humana Press Inc., p. 191-206 16 p. (Methods in Molecular Biology; vol. 1983).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress

Sengupta, S., Yang, C., Hegde, M. L., Hegde, P. M., Mitra, J., Pandey, A., Dutta, A., Datarwala, A. T., Bhakat, K. K. & Mitra, S., Jun 1 2018, In : DNA Repair. 66-67, p. 1-10 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
4 Scopus citations
2017

Human apurinic/apyrimidinic endonuclease (APE1) is acetylated at DNA damage sites in chromatin, and acetylation modulates its DNA repair activity

Roychoudhury, S., Nath, S., Song, H., Hegde, M. L., Bellot, L. J., Mantha, A. K., Sengupta, S., Ray, S., Natarajan, A. & Bhakat, K. K., 2017, In : Molecular and cellular biology. 37, 6, e00401-16.

Research output: Contribution to journalArticle

22 Scopus citations

The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression

Nath, S., Roychoudhury, S., Kling, M. J., Song, H., Biswas, P., Shukla, A., Band, H., Joshi, S. & Bhakat, K. K., Nov 2017, In : Cellular Signalling. 39, p. 18-31 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair

Sengupta, S., Mantha, A. K., Song, H., Roychoudhury, S., Nath, S., Ray, S. & Bhakat, K. K., 2016, In : Oncotarget. 7, 46, p. 75197-75209 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation

Bhakat, K. K., Sengupta, S., Adeniyi, V. F., Roychoudhury, S., Nath, S., Bellot, L. J., Feng, D., Mantha, A. K., Sinha, M., Qiu, S. & Luxon, B. A., Apr 19 2016, In : Oncotarget. 7, 16, p. 22590-22604 15 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Dual Regulatory Roles of Human AP-Endonuclease (APE1/Ref-1) in CDKN1A/p21 Expression

Sengupta, S., Mitra, S. & Bhakat, K. K., Jul 16 2013, In : PloS one. 8, 7, e68467.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

Lirussi, L., Antoniali, G., Vascotto, C., D'Ambrosio, C., Poletto, M., Romanello, M., Marasco, D., Leone, M., Quadrifoglio, F., Bhakat, K. K., Scaloni, A. & Tell, G., Oct 15 2012, In : Molecular biology of the cell. 23, 20, p. 4079-4096 18 p.

Research output: Contribution to journalArticle

60 Scopus citations

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

Hegde, M. L., Mantha, A. K., Hazra, T. K., Bhakat, K. K., Mitra, S. & Szczesny, B., Apr 2012, In : Mechanisms of Ageing and Development. 133, 4, p. 157-168 12 p.

Research output: Contribution to journalArticle

93 Scopus citations

Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex

Sengupta, S., Chattopadhyay, R., Mantha, A. K., Mitra, S. & Bhakat, K. K., May 2012, In : Journal of Hypertension. 30, 5, p. 917-925 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1

Sengupta, S., Mantha, A. K., Mitra, S. & Bhakat, K. K., Jan 27 2011, In : Oncogene. 30, 4, p. 482-493 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P. S., Mitra, S. & Hazra, T. K., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

Research output: Contribution to journalArticle

88 Scopus citations
2010
20 Scopus citations
2009

Acetylation of Apurinic/Apyrimidinic Endonuclease-1 Regulates Helicobacter pylori-Mediated Gastric Epithelial Cell Apoptosis

Bhattacharyya, A., Chattopadhyay, R., Burnette, B. R., Cross, J. V., Mitra, S., Ernst, P. B., Bhakat, K. K. & Crowe, S. E., Jun 2009, In : Gastroenterology. 136, 7, p. 2258-2269 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis

Konduri, S. D., Ticku, J., Bobustuc, G. C., Sutphin, R. M., Colon, J., Isley, B., Bhakat, K. K., Kalkunte, S. S. & Baker, C. H., Oct 1 2009, In : Clinical Cancer Research. 15, 19, p. 6087-6095 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

p53-mediated down-regulation of the human DNA repair gene O 6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor

Bocangel, D., Sengupta, S., Mitra, S. & Bhakat, K. K., Oct 2009, In : Anticancer Research. 29, 10, p. 3741-3750 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein

Bhakat, K. K., Mantha, A. K. & Mitra, S., Mar 1 2009, In : Antioxidants and Redox Signaling. 11, 3, p. 621-637 17 p.

Research output: Contribution to journalReview article

158 Scopus citations
2008

APE1/Ref-1 regulates PTEN expression mediated by Egr-1

Fantini, D., Vascotto, C., Deganuto, M., Bivi, N., Gustincich, S., Marcon, G., Quadrifoglio, F., Damante, G., Bhakat, K. K., Mitra, S. & Tell, G., Jan 2008, In : Free Radical Research. 42, 1, p. 20-29 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen: The potential for replication-associated repair of oxidized bases in mammalian genomes

Dou, H., Theriot, C. A., Das, A., Hegde, M. L., Matsumoto, Y., Boldogh, I., Hazra, T. K., Bhakat, K. K. & Mitra, S., Feb 8 2008, In : Journal of Biological Chemistry. 283, 6, p. 3130-3140 11 p.

Research output: Contribution to journalArticle

110 Scopus citations

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

Zaky, A., Busso, C., Izumi, T., Chattopadhyay, R., Bassiouny, A., Mitra, S. & Bhakat, K. K., Mar 2008, In : Nucleic acids research. 36, 5, p. 1555-1566 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1

Chattopadhyay, R., Das, S., Maiti, A. K., Boldogh, I., Xie, J., Hazra, T. K., Kohno, K., Mitra, S. & Bhakat, K. K., Dec 2008, In : Molecular and cellular biology. 28, 23, p. 7066-7080 15 p.

Research output: Contribution to journalArticle

89 Scopus citations

Unusual Role of a Cysteine Residue in Substrate Binding and Activity of Human AP-Endonuclease 1

Mantha, A. K., Oezguen, N., Bhakat, K. K., Izumi, T., Braun, W. & Mitra, S., May 23 2008, In : Journal of Molecular Biology. 379, 1, p. 28-37 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2007

Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein

Mitra, S., Izumi, T., Boldogh, I., Bhakat, K. K., Chattopadhyay, R. & Szczesny, B., Apr 1 2007, In : DNA Repair. 6, 4, p. 461-469 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Krüppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation

Evans, P. M., Zhang, W., Chen, X., Yang, J., Bhakat, K. K. & Liu, C., Nov 23 2007, In : Journal of Biological Chemistry. 282, 47, p. 33994-34002 9 p.

Research output: Contribution to journalArticle

148 Scopus citations

O6-Methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor-induced resistance against temozolomide in human melanoma cells

Fontijn, D., Adema, A. D., Bhakat, K. K., Pinedo, H. M., Peters, G. J. & Boven, E., Oct 1 2007, In : Molecular cancer therapeutics. 6, 10, p. 2807-2815 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress

Das, S., Chattopadhyay, R., Bhakat, K. K., Boldogh, I., Kohno, K., Prasad, R., Wilson, S. H. & Hazra, T. K., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28474-28484 11 p.

Research output: Contribution to journalArticle

86 Scopus citations
2006

Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo

Bhakat, K. K., Mokkapati, S. K., Boldogh, I., Hazra, T. K. & Mitra, S., Mar 2006, In : Molecular and cellular biology. 26, 5, p. 1654-1665 12 p.

Research output: Contribution to journalArticle

126 Scopus citations

LVMH Recherche Symposium on mitochondria October 6th, 2005 Paris

Bonté, F., Scheffler, I. E., Roubertoux, P. L., De Grey, A. D. N. J., Krutmann, J., Szczesny, B., Chattopadhyay, R., Hazra, T. K., Bhakat, K. K., Izumi, T., Wiederhold, L. R., Boldogh, I., Mitra, S., Friguet, B., Zuliani, T., Dumas, M., Ratinaud, M. H., Salvioli, S., Capri, M., Monti, D. & 3 others, Santoro, A., Barbi, C. & Claudio Franceschi, F., Jun 2006, In : Bioscience Reports. 26, 3, p. 183-201 19 p.

Research output: Contribution to journalArticle

2005

Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species

Das, A., Hazra, T. K., Boldogh, I., Mitra, S. & Bhakat, K. K., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35272-35280 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Two essential but distinct functions of the mammalian abasic endonuclease

Izumi, T., Brown, D. B., Naidu, C. V., Bhakat, K. K., MacInnes, M. A., Saito, H., Chen, D. J. & Mitra, S., Apr 19 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 16, p. 5739-5743 5 p.

Research output: Contribution to journalArticle

172 Scopus citations
2004

Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity

Bhakat, K. K., Hazra, T. K. & Mitra, S., 2004, In : Nucleic acids research. 32, 10, p. 3033-3039 7 p.

Research output: Contribution to journalArticle

63 Scopus citations

Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution

Szczesny, B., Bhakat, K. K., Mitra, S. & Boldogh, I., Oct 2004, In : Mechanisms of Ageing and Development. 125, 10-11 SPEC. ISS., p. 755-765 11 p.

Research output: Contribution to journalArticle

51 Scopus citations
2003

Acetylation of Human AP-Endonuclease 1, A Critical Enzyme in DNA Repair and Transcription Regulation

Bhakat, K. K., Yang, S. H. & Mitra, S., 2003, In : Methods in enzymology. 371, p. 292-300 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration

Bhakat, K. K. & Mitra, S., Aug 1 2003, In : Carcinogenesis. 24, 8, p. 1337-1345 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea

Shimada, Y., Nishimura, M., Kakinuma, S., Ogiu, T., Fujimoto, H., Kubo, A., Nagai, J., Kobayash, K., Tano, K., Yoshinaga, S. & Bhakat, K. K., Jun 1 2003, In : International Journal of Radiation Biology. 79, 6, p. 423-430 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mammalian DNA base excision repair proteins: Their interactions and role in repair of oxidative DNA damage

Izumi, T., Wiederhold, L. R., Roy, G., Roy, R., Jaiswal, A., Bhakat, K. K., Mitra, S. & Hazra, T. K., Nov 15 2003, In : Toxicology. 193, 1-2, p. 43-65 23 p.

Research output: Contribution to journalReview article

165 Scopus citations

Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress

Boldogh, I., Roy, G., Lee, M. S., Bacsi, A., Hazra, T. K., Bhakat, K. K., Das, G. C. & Mitra, S., Nov 15 2003, In : Toxicology. 193, 1-2, p. 137-152 16 p.

Research output: Contribution to journalArticle

52 Scopus citations

Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene

Bhakat, K. K., Izumi, T., Yang, S. H., Hazra, T. K. & Mitra, S., Dec 1 2003, In : EMBO Journal. 22, 23, p. 6299-6309 11 p.

Research output: Contribution to journalArticle

142 Scopus citations
2002

Choreography of oxidative damage repair in mammalian genomes

Mitra, S., Izumi, T., Boldogh, I., Bhakat, K. K., Hill, J. W. & Hazra, T. K., Jul 1 2002, In : Free Radical Biology and Medicine. 33, 1, p. 15-28 14 p.

Research output: Contribution to journalArticle

115 Scopus citations

Multifaceted resistance of gliomas to temozolomide

Bocangel, D. B., Finkelstein, S., Clifford Schold, S., Bhakat, K. K., Mitra, S. & Kokkinakis, D. M., 2002, In : Clinical Cancer Research. 8, 8, p. 2725-2734 10 p.

Research output: Contribution to journalArticle

95 Scopus citations
2000
Open Access
50 Scopus citations
1999

The murK gene of Vibrio cholerae: A new gene involved in DNA mismatch repair

Bhakat, K. K., Sharma M., S. & Das, J., Feb 1999, In : Journal of bacteriology. 181, 3, p. 879-883 5 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
1994

Methyl directed DNA mismatch repair in Vibrio cholerae

Bandyopadhyay, R., Sengupta, A., Bera, T. K., Bhakat, K. K., Dutta, C. & Das, J., Dec 1994, In : J Biosci. 19, 5, p. 557-564 8 p.

Research output: Contribution to journalArticle