Kurt H Piepenbrink, PhD

  • 673 Citations
  • 16 h-Index
20082019

Research output per year

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Research Output

  • 673 Citations
  • 16 h-Index
  • 23 Article
  • 2 Review article
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Article
2019

Candida albicans quorum-sensing molecule farnesol modulates staphyloxanthin production and activates the thiol-based oxidative-stress response in Staphylococcus aureus

Vila, T., Kong, E. F., Ibrahim, A., Piepenbrink, K., Shetty, A. C., McCracken, C., Bruno, V. & Jabra-Rizk, M. A., Jan 1 2019, In : Virulence. 10, 1, p. 625-642 18 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The structure of PilA from Acinetobacter baumannii AB5075 suggests a mechanism for functional specialization in Acinetobacter type IV pili

Ronish, L. A., Lillehoj, E., Fields, J. K., Sundberg, E. J. & Piepenbrink, K. H., Jan 4 2019, In : Journal of Biological Chemistry. 294, 1, p. 218-230 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

How an alloreactive T-cell receptor achieves peptide and MHC specificity

Wang, Y., Singh, N. K., Spear, T. T., Hellman, L. M., Piepenbrink, K. H., McMahan, R. H., Rosen, H. R., Vander Kooi, C. W., Nishimura, M. I. & Baker, B. M., Jun 13 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 24, p. E4792-E4801

Research output: Contribution to journalArticle

11 Scopus citations

Structurebased design of hepatitis C virus vaccines that elicit neutralizing antibody responses to a conserved epitope

Pierce, B. G., Boucher, E. N., Piepenbrink, K. H., Ejemel, M., Rapp, C. A., Thomas, W. D., Sundberg, E. J., Weng, Z. & Wang, Y., Oct 1 2017, In : Journal of virology. 91, 20, e01032-17.

Research output: Contribution to journalArticle

26 Scopus citations
2016

A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces

Riley, T. P., Ayres, C. M., Hellman, L. M., Singh, N. K., Cosiano, M., Cimons, J. M., Anderson, M. J., Piepenbrink, K. H., Pierce, B. G., Weng, Z. & Baker, B. M., 2016, In : Protein Engineering, Design and Selection. 29, 12, p. 595-606 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Motility and adhesion through type IV pili in Gram-positive bacteria

Piepenbrink, K. H. & Sundberg, E. J., Dec 15 2016, In : Biochemical Society Transactions. 44, 6, p. 1659-1666 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Some of the most interesting CASP11 targets through the eyes of their authors

Kryshtafovych, A., Moult, J., Baslé, A., Burgin, A., Craig, T. K., Edwards, R. A., Fass, D., Hartmann, M. D., Korycinski, M., Lewis, R. J., Lorimer, D., Lupas, A. N., Newman, J., Peat, T. S., Piepenbrink, K. H., Prahlad, J., van Raaij, M. J., Rohwer, F., Segall, A. M., Seguritan, V. & 4 others, Sundberg, E. J., Singh, A. K., Wilson, M. A. & Schwede, T., Sep 1 2016, In : Proteins. 84, p. 34-50 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

Structural diversity in the type IV Pili of multidrug-resistant acinetobacter

Piepenbrink, K. H., Lillehoj, E., Harding, C. M., Labonte, J. W., Zuo, X., Rapp, C. A., Munson, R. S., Goldblum, S. E., Feldman, M. F., Gray, J. J. & Sundberg, E. J., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 22924-22935 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo

Hyun, S. W., Liu, A., Liu, Z., Cross, A. S., Verceles, A. C., Magesh, S., Kommagalla, Y., Kona, C., Ando, H., Luzina, I. G., Atamas, S. P., Piepenbrink, K. H., Sundberg, E. J., Guang, W., Ishida, H., Lillehoj, E. P. & Goldblum, S. E., Aug 1 2016, In : Glycobiology. 26, 8, p. 834-849 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Type IV pili promote early biofilm formation by Clostridium difficile

Maldarelli, G. A., Piepenbrink, K. H., Scott, A. J., Freiberg, J. A., Song, Y., Achermann, Y., Ernst, R. K., Shirtliff, M. E., Sundberg, E. J., Donnenberg, M. S. & von Rosenvinge, E. C., Aug 1 2016, In : Pathogens and disease. 74, 6, ftw061.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Structural and evolutionary analyses show unique stabilization strategies in the type IV Pili of clostridium difficile

Piepenbrink, K. H., Maldarelli, G. A., Martinez De La Peña, C. F., Dingle, T. C., Mulvey, G. L., Lee, A., Von Rosenvinge, E., Armstrong, G. D., Donnenberg, M. S. & Sundberg, E. J., Feb 3 2015, In : Structure. 23, 2, p. 385-396 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
2014

A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant clostridium difficile infection in mice

Yang, Z., Schmidt, D., Liu, W., Li, S., Shi, L., Sheng, J., Chen, K., Yu, H., Tremblay, J. M., Chen, X., Piepenbrink, K. H., Sundberg, E. J., Kelly, C. P., Bai, G., Shoemaker, C. B. & Feng, H., 2014, In : Journal of Infectious Diseases. 210, 6, p. 964-972 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Structure of clostridium difficile pilj exhibits unprecedented divergence from known type iv pilins

Piepenbrink, K. H., Maldarelli, G. A., De La Peña, C. F. M., Mulvey, G. L., Snyder, G. A., De Masi, L., Von Rosenvinge, E. C., Günther, S., Armstrong, G. D., Donnenberg, M. S. & Sundberg, E. J., Feb 14 2014, In : Journal of Biological Chemistry. 289, 7, p. 4334-4345 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes

Smith, S. N., Sommermeyer, D., Piepenbrink, K. H., Blevins, S. J., Bernhard, H., Uckert, W., Baker, B. M. & Kranz, D. M., Nov 15 2013, In : Journal of Molecular Biology. 425, 22, p. 4496-4507 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain

Piao, W., Ru, L. W., Piepenbrink, K. H., Sundberg, E. J., Vogel, S. N. & Toshchakov, V. Y., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 19036-19041 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

The basis for limited specificity and MHC restriction in a T cell receptor interface

Piepenbrink, K. H., Blevins, S. J., Scott, D. R. & Baker, B. M., Jun 5 2013, In : Nature communications. 4, 1948.

Research output: Contribution to journalArticle

22 Scopus citations
2012

Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains

Aggen, D. H., Chervin, A. S., Schmitt, T. M., Engels, B., Stone, J. D., Richman, S. A., Piepenbrink, K. H., Baker, B. M., Greenberg, P. D., Schreiber, H. & Kranz, D. M., Apr 2012, In : Gene Therapy. 19, 4, p. 365-374 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics

Borbulevych, O. Y., Piepenbrink, K. H. & Baker, B. M., Mar 1 2011, In : Journal of Immunology. 186, 5, p. 2950-2958 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism

Scott, D. R., Borbulevych, O. Y., Piepenbrink, K. H., Corcelli, S. A. & Baker, B. M., Dec 2 2011, In : Journal of Molecular Biology. 414, 3, p. 385-400 16 p.

Research output: Contribution to journalArticle

46 Scopus citations

Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

Aggen, D. H., Chervin, A. S., Insaidoo, F. K., Piepenbrink, K. H., Baker, B. M. & Kranz, D. M., Apr 2011, In : Protein Engineering, Design and Selection. 24, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

25 Scopus citations
2009

Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner

Piepenbrink, K. H., Borbulevych, O. Y., Sommese, R. F., Clemens, J., Armstrong, K. M., Desmond, C., Do, P. & Baker, B. M., Nov 1 2009, In : Biochemical Journal. 423, 3, p. 353-361 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Methods for quantifying T cell receptor binding affinities and thermodynamics.

Piepenbrink, K. H., Gloor, B. E., Armstrong, K. M. & Baker, B. M., 2009, In : Methods in enzymology. 466, p. 359-381 23 p.

Research output: Contribution to journalArticle

10 Scopus citations

T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility

Borbulevych, O. Y., Piepenbrink, K. H., Gloor, B. E., Scott, D. R., Sommese, R. F., Cole, D. K., Sewell, A. K. & Baker, B. M., Dec 18 2009, In : Immunity. 31, 6, p. 885-896 12 p.

Research output: Contribution to journalArticle

113 Scopus citations