• 2576 Citations
  • 29 h-Index
1985 …2020

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Article
2020

Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis

Rasineni, K., Kubik, J. L., Knight, K. L., Hall, L., Casey, C. A. & Kharbanda, K. K., May 1 2020, In : Chemico-Biological Interactions. 322, 109059.

Research output: Contribution to journalArticle

1 Scopus citations

Role of Elevated Intracellular S-Adenosylhomocysteine in the Pathogenesis of Alcohol-Related Liver Disease

Arumugam, M. K., Talawar, S., Listenberger, L., Donohue, T. M., Osna, N. A. & Kharbanda, K. K., Jun 23 2020, In : Cells. 9, 6

Research output: Contribution to journalArticle

Open Access
2019

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

4 Scopus citations

Alcohol metabolism potentiates HIV-induced hepatotoxicity: Contribution to end-stage liver disease

Ganesan, M., New-Aaron, M., Dagur, R. S., Makarov, E., Wang, W., Kharbanda, K. K., Kidambi, S., Poluektova, L. Y. & Osna, N. A., Dec 2019, In : Biomolecules. 9, 12, 851.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
4 Scopus citations
4 Scopus citations
Open Access
2 Scopus citations
2018

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism

Ganesan, M., Tikhanovich, I., Vangimalla, S. S., Dagur, R. S., Wang, W., Poluektova, L. I., Sun, Y., Mercer, D. F., Tuma, D., Weinman, S. A., Kharbanda, K. K. & Osna, N. A., 2018, In : CMGH. 5, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2 Scopus citations

N-Acetyl Cysteine Treatment Restores Early Phase Fracture Healing in Ethanol-Fed Rats

Duryee, M. J., Dusad, A., Hunter, C. D., Kharbanda, K., Bruenjes, J. D., Easterling, K. C., Siebler, J. C., Thiele, G. M. & Chakkalakal, D. A., Jul 2018, In : Alcoholism: Clinical and Experimental Research. 42, 7, p. 1206-1216 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
3 Scopus citations

Role of nutrition in alcoholic liver disease: Summary of the symposium at the ESBRA 2017 congress

Kharbanda, K. K., Ronis, M. J. J., Shearn, C. T., Petersen, D. R., Zakhari, S., Warner, D. R., Feldstein, A. E., McClain, C. J. & Kirpich, I. A., Jun 2018, In : Biomolecules. 8, 2, 16.

Research output: Contribution to journalArticle

3 Scopus citations

The loss of α-and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing

Labisso, W. L., Raulin, A. C., Nwidu, L. L., Kocon, A., Wayne, D., Erdozain, A. M., Morentin, B., Schwendener, D., Allen, G., Enticott, J., Gerdes, H. K., Johnson, L., Grzeskowiak, J., Drizou, F., Tarbox, R., Osna, N. A., Kharbanda, K. K., Callado, L. F. & Carter, W. G., Sep 11 2018, In : Brain Sciences. 8, 9, 175.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress

Akhtar, F., Rouse, C. A., Catano, G., Montalvo, M., Ullevig, S. L., Asmis, R., Kharbanda, K. & Maffi, S. K., Sep 30 2017, In : Journal of Neuroinflammation. 14, 1, 195.

Research output: Contribution to journalArticle

11 Scopus citations

Alcoholic liver disease: Pathogenesis and current management

Osna, N. A., Donohue, T. M. & Kharbanda, K. K., 2017, In : Alcohol Research: Current Reviews. 38, 2, p. 7-21 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cigarette Smoke Impairs A 2A Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 Expression

Tian, Z., Zhang, H., DIxon, J., Traphagen, N., Wyatt, T. A., Kharbanda, K., Simet Chadwick, S., Kolliputi, N. & Allen-Gipson, DI. S., Mar 24 2017, In : Scientific reports. 7, 44405.

Research output: Contribution to journalArticle

4 Scopus citations
2 Scopus citations
3 Scopus citations
2016

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

Osna, N. A., Carter, W. G., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., Shearn, C. T., Tomasi, M. L. & Kharbanda, K. K., Jul 21 2016, In : World Journal of Gastroenterology. 22, 27, p. 6192-6200 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
15 Scopus citations
8 Scopus citations

Ceramide induces human hepcidin gene transcription through JAK/STAT3 pathway

Lu, S., Natarajan, S. K., Mott, J. L., Kharbanda, K. K. & Harrison-Findik, D. D., Jan 2016, In : PloS one. 11, 1, e0147474.

Research output: Contribution to journalArticle

9 Scopus citations

Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis

Ganesan, M., Feng, D., Barton, R. W., Thomes, P. G., McVicker, B. L., Tuma, D. J., Osna, N. A. & Kharbanda, K. K., Nov 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 11, p. 2312-2319 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Effects of nonpurified and choline supplemented or nonsupplemented purified diets on hepatic steatosis and methionine metabolism in C3H Mice

Syed, R., Shibata, N. M., Kharbanda, K. K., Su, R. J., Olson, K., Yokoyama, A., Rutledge, J. C., Chmiel, K. J., Kim, K., Halsted, C. H. & Medici, V., May 1 2016, In : Metabolic Syndrome and Related Disorders. 14, 4, p. 202-209 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
5 Scopus citations

Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury

Osna, N. A., Feng, D., Ganesan, M., Maillacheruvu, P. F., Orlicky, D. J., French, S. W., Tuma, D. J. & Kharbanda, K. K., Oct 14 2016, In : World Journal of Gastroenterology. 22, 38, p. 8497-8508 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
13 Scopus citations

Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT−/− mice

Stockebrand, M., Nejad, A. S., Neu, A., Kharbanda, K. K., Sauter, K., Schillemeit, S., Isbrandt, D. & Choe, C. U., Aug 1 2016, In : Amino Acids. 48, 8, p. 2025-2039 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model

Medici, V., Kieffer, D. A., Shibata, N. M., Chima, H., Kim, K., Canovas, A., Medrano, J. F., Islas-Trejo, A. D., Kharbanda, K. K., Olson, K., Su, R. J., Islam, M. S., Syed, R., Keen, C. L., Miller, A. Y., Rutledge, J. C., Halsted, C. H. & LaSalle, J. M., Nov 1 2016, In : Epigenetics. 11, 11, p. 804-818 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015
25 Scopus citations

FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol

Ganesan, M., Hindman, J., Tillman, B., Jaramillo, L., Poluektova, L. Y., French, B. A., Kharbanda, K., French, S. W. & Osna, N. A., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 506-516 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

In vivo acute on chronic ethanol effects in liver: A mouse model exhibiting exacerbated injury, altered metabolic and epigenetic responses

Shukla, S. D., Aroor, A. R., Restrepo, R., Kharbanda, K. K. & Ibdah, J. A., Nov 20 2015, In : Biomolecules. 5, 4, p. 3280-3294 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury

Carter, W. G., Vigneswara, V., Newlaczyl, A., Wayne, D., Ahmed, B., Saddington, S., Brewer, C., Raut, N., Gerdes, H. K., Erdozain, A. M., Tooth, D., Bolt, E. L., Osna, N. A., Tuma, D. J. & Kharbanda, K. K., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 626-631 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Multiple roles of betaine in protecting against alcohol-induced liver injury

Thomes, P. G., Bligh, S. M. & Kharbanda, K. K., Jan 1 2015, In : Food and Nutritional Components in Focus. 2015-January, 7, p. 285-310 26 p.

Research output: Contribution to journalArticle

1 Scopus citations
10 Scopus citations
2014

Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity

Kharbanda, K. K., Todero, S. L., Moats, J. C., Harris, R. M., Osna, N. A., Thomes, P. G. & Tuma, D. J., Mar 2014, In : Alcoholism: Clinical and Experimental Research. 38, 3, p. 641-648 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Characterization of timed changes in hepatic copper concentrations, Methionine metabolism, gene expression, and global DNA Methylation in the Jackson toxic milk mouse model of Wilson disease

Le, A., Shibata, N. M., French, S. W., Kim, K., Kharbanda, K. K., Islam, M. S., Lasalle, J. M., Halsted, C. H., Keen, C. L. & Medici, V., May 7 2014, In : International journal of molecular sciences. 15, 5, p. 8004-8023 20 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ethanol affects hepatitis C pathogenesis: Humanized SCID Alb-uPA mouse model

Osna, N. A., Kharbanda, K. K., Sun, Y., Simpson, R. L., Poluektova, L. E., Ganesan, M., Wisecarver, J. L. & Mercer, D. F., Jul 18 2014, In : Biochemical and Biophysical Research Communications. 450, 1, p. 773-776 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Increased methylation demand exacerbates ethanol-induced liver injury

Kharbanda, K. K., Todero, S. L., Thomes, P. G., Orlicky, D. J., Osna, N. A., French, S. W. & Tuma, D. J., Aug 2014, In : Experimental and Molecular Pathology. 97, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Malondialdehyde-acetaldehyde (MAA) adducted proteins bind to scavenger receptor A in airway epithelial cells

Berger, J. P., Simet, S. M., DeVasure, J. M., Boten, J. A., Sweeter, J. M., Kharbanda, K. K., Sisson, J. H. & Wyatt, T. A., Aug 2014, In : Alcohol. 48, 5, p. 493-500 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease

Medici, V., Shibata, N. M., Kharbanda, K. K., Islam, M. S., Keen, C. L., Kim, K., Tillman, B., French, S. W., Halsted, C. H. & LaSalle, J. M., 2014, In : Epigenetics. 9, 2

Research output: Contribution to journalArticle

32 Scopus citations

Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse

Medici, V., Schroeder, D. I., Woods, R., Lasalle, J. M., Geng, Y., Shibata, N. M., Peerson, J., Hodzic, E., Dayal, S., Tsukamoto, H., Kharbanda, K. K., Tillman, B., French, S. W. & Halsted, C. H., Jun 2014, In : Alcoholism: Clinical and Experimental Research. 38, 6, p. 1540-1549 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2 Scopus citations

Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure

Tikhanovich, I., Kuravi, S., Campbell, R. V., Kharbanda, K. K., Artigues, A., Villar, M. T. & Weinman, S. A., Jan 1 2014, In : Hepatology. 59, 1, p. 58-70 13 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations
2013

Smoke extract impairs adenosine wound healing: Implications of smoke-generated reactive oxygen species

Allen-Gipson, D. S., Zimmerman, M. C., Zhang, H., Castellanos, G., O'Malley, J. K., Alvarez-Ramirez, H., Kharbanda, K., Sisson, J. H. & Wyatt, T. A., May 2013, In : American journal of respiratory cell and molecular biology. 48, 5, p. 665-673 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Wilson's disease: Changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

Medici, V., Shibata, N. M., Kharbanda, K. K., Lasalle, J. M., Woods, R., Liu, S., Engelberg, J. A., Devaraj, S., Török, N. J., Jiang, J. X., Havel, P. J., Lönnerdal, B., Kim, K. & Halsted, C. H., Feb 2013, In : Hepatology. 57, 2, p. 555-565 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2012

Ethanol and Hepatitis C Virus Suppress Peptide-MHC Class I Presentation in Hepatocytes by Altering Proteasome Function

Osna, N. A., Bardag-Gorce, F., White, R. L., Weinman, S. A., Donohue, T. M. & Kharbanda, K. K., Dec 2012, In : Alcoholism: Clinical and Experimental Research. 36, 12, p. 2028-2035 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Malondialdehyde-acetaldehyde-adducted protein inhalation causes lung injury

Wyatt, T. A., Kharbanda, K. K., McCaskill, M. L., Tuma, D. J., Yanov, D., DeVasure, J. & Sisson, J. H., Feb 2012, In : Alcohol. 46, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

β-Catenin is essential for ethanol metabolism and protection against alcohol-mediated liver steatosis in mice

Liu, S., Yeh, T. H., Singh, V. P., Shiva, S., Krauland, L., Li, H., Zhang, P., Kharbanda, K., Ritov, V., Monga, S. P. S., Scott, D. K., Eagon, P. K. & Behari, J., Mar 2012, In : Hepatology. 55, 3, p. 931-940 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2011
8 Scopus citations