• 2593 Citations
  • 33 h-Index
19952020

Research output per year

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Research Output

  • 2593 Citations
  • 33 h-Index
  • 85 Article
  • 8 Review article
  • 2 Chapter
  • 1 Comment/debate
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Article
2020

A long-acting 3TC ProTide nanoformulation suppresses HBV replication in humanized mice

Wang, W., Smith, N., Makarov, E., Sun, Y., Gebhart, C. L., Ganesan, M., Osna, N. A., Gendelman, H. E., Edagwa, B. J. & Poluektova, L. Y., Aug 2020, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 28, 102185.

Research output: Contribution to journalArticle

Open Access

Amplification of Replication Competent HIV-1 by Adoptive Transfer of Human Cells From Infected Humanized Mice

Su, H., Sravanam, S., Gorantla, S., Kaminski, R., Khalili, K., Poluektova, L., Gendelman, H. E. & Dash, P. K., Feb 11 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 38.

Research output: Contribution to journalArticle

Open Access

HIV-1-Associated Left Ventricular Cardiac Dysfunction in Humanized Mice

Dash, P. K., Alomar, F. A., Hackfort, B. T., Su, H., Conaway, A., Poluektova, L. Y., Gendelman, H. E., Gorantla, S. & Bidasee, K. R., Dec 1 2020, In : Scientific reports. 10, 1, 9746.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma

Chava, S., Reynolds, C. P., Pathania, A. S., Gorantla, S., Poluektova, L. Y., Coulter, D. W., Gupta, S. C., Pandey, M. K. & Challagundla, K. B., Jan 1 2020, In : Molecular Oncology. 14, 1, p. 180-196 17 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Small animal models for human immunodeficiency virus (HIV), hepatitis b, and tuberculosis: Proceedings of an NIAID workshop

Akkina, R., Barber, D. L., Bility, M. T., Bissig, K. D., Burwitz, B. J., Eichelberg, K., Endsley, J. J., Garcia, J. V., Hafner, R., Karakousis, P. C., Korba, B. E., Koshy, R., Lambros, C., Menne, S., Nuermberger, E. L., Ploss, A., Podell, B. K., Poluektova, L. Y., Sanders-Beer, B. E., Subbian, S. & 1 others, Wahl, A., 2020, In : Current HIV research. 18, 1, p. 19-28 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

4 Scopus citations

Alcohol metabolism potentiates HIV-induced hepatotoxicity: Contribution to end-stage liver disease

Ganesan, M., New-Aaron, M., Dagur, R. S., Makarov, E., Wang, W., Kharbanda, K. K., Kidambi, S., Poluektova, L. Y. & Osna, N. A., Dec 2019, In : Biomolecules. 9, 12, 851.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
3 Scopus citations

Establishment of the dual humanized TK-NOG mouse model for HIV-associated liver pathogenesis

Dagur, R. S., Wang, W., Makarov, E., Sun, Y. & Poluektova, L. Y., 2019, In : Journal of Visualized Experiments. 2019, 151, e58645.

Research output: Contribution to journalArticle

1 Scopus citations
6 Scopus citations

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice

Mathews, S., Branch Woods, A., Katano, I., Makarov, E., Thomas, M. B., Gendelman, H. E., Poluektova, L. Y., Ito, M. & Gorantla, S., Mar 5 2019, In : Molecular neurodegeneration. 14, 1, 12.

Research output: Contribution to journalArticle

10 Scopus citations

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection 11 Medical and Health Sciences 1107 Immunology

Dagur, R. S., Branch-Woods, A., Mathews, S., Joshi, P. S., Quadros, R. M., Harms, D. W., Cheng, Y., Miles, S. M., Pirruccello, S. J., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., Jan 7 2019, In : BMC Immunology. 20, 1, 2.

Research output: Contribution to journalArticle

1 Scopus citations

Immune activations and viral tissue compartmentalization during progressive HIV-1 infection of humanized mice

Su, H., Cheng, Y., Sravanam, S., Mathews, S., Gorantla, S., Poluektova, L. Y., Dash, P. K. & Gendelman, H. E., 2019, In : Frontiers in immunology. 10, FEB, 340.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Dash, P. K., Kaminski, R., Bella, R., Su, H., Mathews, S., Ahooyi, T. M., Chen, C., Mancuso, P., Sariyer, R., Ferrante, P., Donadoni, M., Robinson, J. A., Sillman, B., Lin, Z., Hilaire, J. R., Banoub, M., Elango, M., Gautam, N., Mosley, R. L., Poluektova, L. Y. & 12 others, McMillan, J. E., Bade, A. N., Gorantla, S., Sariyer, I. K., Burdo, T. H., Young, W. B., Amini, S., Gordon, J., Jacobson, J. M., Edagwa, B., Khalili, K. & Gendelman, H. E., Dec 1 2019, In : Nature communications. 10, 1, 2753.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

Small molecule ONC201 inhibits HIV-1 replication in macrophages via FOXO3a and TRAIL

Zhao, R., Li, Y., Gorantla, S., Poluektova, L. Y., Lin, H., Gao, F., Wang, H., Zhao, J., Zheng, J. C. & Huang, Y., Aug 2019, In : Antiviral Research. 168, p. 134-145 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Antiretroviral drug metabolism in humanized PXR-CAR-CYP3A-NOG mice

McMillan, J. E. M., Cobb, D. A., Lin, Z., Banoub, M. G., Dagur, R. S., Branch Woods, A. A., Wang, W., Makarov, E., Kocher, T., Joshi, P. S., Quadros, R. M., Harms, D. W., Cohen, S. M., Gendelman, H. E., Gurumurthy, C. B., Gorantla, S. & Poluektova, L. Y., May 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 2, p. 272-280 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Creation of a long-acting nanoformulated dolutegravir

Sillman, B., Bade, A. N., Dash, P. K., Bhargavan, B., Kocher, T., Mathews, S., Su, H., Kanmogne, G. D., Poluektova, L. Y., Gorantla, S., McMillan, J., Gautam, N., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Dec 1 2018, In : Nature communications. 9, 1, 443.

Research output: Contribution to journalArticle

38 Scopus citations

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

Zhou, T., Su, H., Dash, P., Lin, Z., Dyavar Shetty, B. L., Kocher, T., Szlachetka, A., Lamberty, B., Fox, H. S., Poluektova, L., Gorantla, S., McMillan, J. E., Gautam, N., Mosley, R. L., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Jan 2018, In : Biomaterials. 151, p. 53-65 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism

Ganesan, M., Tikhanovich, I., Vangimalla, S. S., Dagur, R. S., Wang, W., Poluektova, L. I., Sun, Y., Mercer, D. F., Tuma, D., Weinman, S. A., Kharbanda, K. K. & Osna, N. A., 2018, In : CMGH. 5, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2 Scopus citations

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice

Dagur, R. S., Wang, W., Cheng, Y., Makarov, E., Ganesan, M., Suemizu, H., Gebhart, C. L., Gorantla, S., Osna, N. & Poluektova, L. Y., 2018, In : Biology Open. 7, 2, bio029785.

Research output: Contribution to journalArticle

8 Scopus citations
3 Scopus citations

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

Olson, K. E., Bade, A. N., Namminga, K. L., Potash, M. J., Mosley, R. L., Poluektova, L. Y., Volsky, D. J. & Gendelman, H. E., Aug 1 2018, In : Journal of neurovirology. 24, 4, p. 398-410 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017
50 Scopus citations

Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection

Singh, V. B., Singh, M. V., Piekna-Przybylska, D., Gorantla, S., Poluektova, L. Y. & Maggirwar, S. B., Dec 1 2017, In : Scientific reports. 7, 1, 9578.

Research output: Contribution to journalArticle

7 Scopus citations

Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains

Li, W., Gorantla, S., Gendelman, H. E. & Poluektova, L. Y., Dec 1 2017, In : DMM Disease Models and Mechanisms. 10, 12, p. 1489-1502 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016
17 Scopus citations

HIV-1 cellular and tissue replication patterns in infected humanized mice

Araínga, M., Su, H., Poluektova, L. Y., Gorantla, S. & Gendelman, H. E., Mar 21 2016, In : Scientific reports. 6, 23513.

Research output: Contribution to journalArticle

37 Scopus citations

Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "meet the Experts" 2015 Workshop Summary

Akkina, R., Allam, A., Balazs, A. B., Blankson, J. N., Burnett, J. C., Casares, S., Garcia, J. V., Hasenkrug, K. J., Kashanchi, F., Kitchen, S. G., Klein, F., Kumar, P., Luster, A. D., Poluektova, L. Y., Rao, M., Sanders-Beer, B. E., Shultz, L. D. & Zack, J. A., Feb 2016, In : AIDS Research and Human Retroviruses. 32, 2, p. 109-119 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice

Bade, A. N., Gorantla, S., Dash, P. K., Makarov, E., Sajja, B. R., Poluektova, L. Y., Luo, J., Gendelman, H. E., Boska, M. D. & Liu, Y., Jul 1 2016, In : Molecular Neurobiology. 53, 5, p. 3286-3297 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
13 Scopus citations

Simple and reliable genotyping protocol for mouse PrkdcSCID mutation

Quadros, R. M., Poluektova, L. Y. & Gurumurthy, C. B., Apr 1 2016, In : Journal of Immunological Methods. 431, p. 60-62 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Smoothened agonist reduces human immunodeficiency virus type-1-induced blood-brain barrier breakdown in humanized mice

Singh, V. B., Singh, M. V., Gorantla, S., Poluektova, L. Y. & Maggirwar, S. B., May 31 2016, In : Scientific reports. 6, 26876.

Research output: Contribution to journalArticle

23 Scopus citations

The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy

Zhang, G., Guo, D., Dash, P. K., Araínga, M., Wiederin, J. L., Haverland, N. A., Knibbe-Hollinger, J., Martinez-Skinner, A., Ciborowski, P., Goodfellow, V. S., Wysocki, T. A., Wysocki, B. J., Poluektova, L. Y., Liu, X. M., McMillan, J. E. M., Gorantla, S., Gelbard, H. A. & Gendelman, H. E., Jan 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015
25 Scopus citations

Amphiphilic Cationic Nanogels as Brain-Targeted Carriers for Activated Nucleoside Reverse Transcriptase Inhibitors

Warren, G., Makarov, E., Lu, Y., Senanayake, T., Rivera, K., Gorantla, S., Poluektova, L. Y. & Vinogradov, S. V., Feb 20 2015, In : Journal of Neuroimmune Pharmacology. 10, 1, p. 88-101 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol

Ganesan, M., Hindman, J., Tillman, B., Jaramillo, L., Poluektova, L. Y., French, B. A., Kharbanda, K., French, S. W. & Osna, N. A., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 506-516 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Influence of age, irradiation and humanization on NSG mouse phenotypes

Knibbe-Hollinger, J. S., Fields, N. R., Chaudoin, T. R., Epstein, A. A., Makarov, E., Akhter, S. P., Gorantla, S., Bonasera, S. J., Gendelman, H. E. & Poluektova, L. Y., 2015, In : Biology Open. 4, 10, p. 1243-1252 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics

Zhang, J., Garrison, J. C., Poluektova, L. Y., Bronich, T. K. & Osna, N. A., Nov 1 2015, In : Biomaterials. 70, p. 37-47 11 p., 17009.

Research output: Contribution to journalArticle

12 Scopus citations

Pharmacodynamics of folic acid receptor targeted antiretroviral nanotherapy in HIV-1-infected humanized mice

Puligujja, P., Araínga, M., Dash, P., Palandri, D., Mosley, R. L., Gorantla, S., Poluektova, L., McMillan, J. E. & Gendelman, H. E., 2015, In : Antiviral Research. 120, 1, p. 85-88 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations

Puligujja, P., Balkundi, S. S., Kendrick, L. M., Baldridge, H. M., Hilaire, J. R., Bade, A. N., Dash, P. K., Zhang, G., Poluektova, L. Y., Gorantla, S., Liu, X. M., Ying, T., Feng, Y., Wang, Y., Dimitrov, D. S., McMillan, J. E. M. & Gendelman, H. E., Feb 1 2015, In : Biomaterials. 41, p. 141-150 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
2014

Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice

Boska, M. D., Dash, P. K., Knibbe, J., Epstein, A. A., Akhter, S. P., Fields, N., High, R., Makarov, E., Bonasera, S. J., Gelbard, H. A., Poluektova, L. Y., Gendelman, H. E. & Gorantla, S., 2014, In : Molecular neurodegeneration. 9, p. 58 1 p.

Research output: Contribution to journalArticle

32 Scopus citations

Deficient synthesis of class-switched, HIVneutralizing antibodies to the CD4 binding site and correction by electrophilic gp120 immunogen

Planque, S. A., Mitsuda, Y., Chitsazzadeh, V., Gorantla, S., Poluektova, L., Nishiyama, Y., Ochsenbauer, C., Morris, M. K., Sapparapu, G., Hanson, C. V., Massey, R. J. & Paul, S., 2014, In : AIDS. 28, 15, p. 2201-2211 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ethanol affects hepatitis C pathogenesis: Humanized SCID Alb-uPA mouse model

Osna, N. A., Kharbanda, K. K., Sun, Y., Simpson, R. L., Poluektova, L. E., Ganesan, M., Wisecarver, J. L. & Mercer, D. F., Jul 18 2014, In : Biochemical and Biophysical Research Communications. 450, 1, p. 773-776 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice

Gutti, T. L., Knibbe, J. S., Makarov, E., Zhang, J., Yannam, G. R., Gorantla, S., Sun, Y., Mercer, D. F., Suemizu, H., Wisecarver, J. L., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., Jan 2014, In : American Journal of Pathology. 184, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain

Gerson, T., Makarov, E., Senanayake, T. H., Gorantla, S., Poluektova, L. Y. & Vinogradov, S. V., Jan 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 1, p. 177-185 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2013

Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection

Zhang, J., Mulvenon, A., Makarov, E., Wagoner, J., Knibbe, J., Kim, J. O., Osna, N., Bronich, T. K. & Poluektova, L. Y., May 2013, In : Biomaterials. 34, 15, p. 3846-3857 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection

Epstein, A. A., Narayanasamy, P., Dash, P. K., High, R., Bathena, S. P. R., Gorantla, S., Poluektova, L. Y., Alnouti, Y., Gendelman, H. E. & Boska, M. D., Dec 2013, In : Journal of Neuroimmune Pharmacology. 8, 5, p. 1224-1238 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Improved visualization of neuronal injury following glial activation by manganese enhanced MRI

Bade, A. N., Zhou, B., Epstein, A. A., Gorantla, S., Poluektova, L. Y., Luo, J., Gendelman, H. E., Boska, M. D. & Liu, Y., Sep 2013, In : Journal of Neuroimmune Pharmacology. 8, 4, p. 1027-1036 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Cisplatin-loaded core cross-linked micelles: Comparative pharmacokinetics, antitumor activity, and toxicity in mice

Oberoi, H. S., Nukolova, N. V., Laquer, F. C., Poluektova, L. Y., Huang, J., Alnouti, Y., Yokohira, M., Arnold, L. L., Kabanov, A. V., Cohen, S. M. & Bronich, T. K., 2012, In : International journal of nanomedicine. 7, p. 2557-2571 15 p.

Research output: Contribution to journalArticle

40 Scopus citations