Lawrence M Schopfer, PhD

  • 4404 Citations
  • 37 h-Index
1975 …2020

Research output per year

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Research Output

  • 4404 Citations
  • 37 h-Index
  • 141 Article
  • 3 Chapter
  • 3 Review article
  • 1 Comment/debate
2020

Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine

Biberoglu, K., Schopfer, L. M., Tacal, O. & Lockridge, O., Jul 1 2020, In : Analytical Biochemistry. 600, 113718.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Chlorpyrifos oxon-induced isopeptide bond formation in human butyrylcholinesterase

Biberoglu, K., Tacal, O., Schopfer, L. M. & Lockridge, O., Jan 25 2020, In : Molecules. 25, 3, 533.

Research output: Contribution to journalArticle

Open Access

Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers

Toker, L., Silman, I., Zeev-Ben-Mordehai, T., Sussman, J. L., Schopfer, L. M. & Lockridge, O., Mar 1 2020, In : Chemico-Biological Interactions. 319, 109007.

Research output: Contribution to journalArticle

Open Access

Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine

Schopfer, L. M. & Lockridge, O., Jun 8 2020, In : Molecules. 25, 11

Research output: Contribution to journalArticle

Open Access
2019

Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko, B. L., Novichkova, D. A., Lushchekina, S. V., Zueva, I. V., Schopfer, L. M., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Jun 1 2019, In : Chemico-Biological Interactions. 306, p. 138-146 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution

Lockridge, O., Verdier, L. & Schopfer, L. M., Sep 25 2019, In : Chemico-Biological Interactions. 311, 108788.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
5 Scopus citations
7 Scopus citations
2018

Characterization of butyrylcholinesterase from porcine milk

Saxena, A., Belinskaya, T., Schopfer, L. M. & Lockridge, O., Aug 15 2018, In : Archives of Biochemistry and Biophysics. 652, p. 38-49 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
6 Scopus citations

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly

Leung, M. R., van Bezouwen, L. S., Schopfer, L. M., Sussman, J. L., Silman, I., Lockridge, O. & Zeev-Ben-Mordehai, T., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13270-13275 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mass Spectral Detection of Diethoxyphospho-Tyrosine Adducts on Proteins from HEK293 Cells Using Monoclonal Antibody depY for Enrichment

Onder, S., Schopfer, L. M., Tacal, O., Blake, T. A., Johnson, R. C. & Lockridge, O., Jun 18 2018, In : Chemical Research in Toxicology. 31, 6, p. 520-530 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Optimization of cholinesterase-based catalytic bioscavengers against organophosphorus agents

Lushchekina, S. V., Schopfer, L. M., Grigorenko, B. L., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 211.

Research output: Contribution to journalArticle

15 Scopus citations

Purification of recombinant human butyrylcholinesterase on Hupresin®

Lockridge, O., David, E., Schopfer, L. M., Masson, P., Brazzolotto, X. & Nachon, F., Dec 1 2018, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1102-1103, p. 109-115 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Use of Hupresin to Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure

Onder, S., Schopfer, L. M., Cashman, J. R., Tacal, O., Johnson, R. C., Blake, T. A. & Lockridge, O., Jan 2 2018, In : Analytical chemistry. 90, 1, p. 974-979 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Characterization of butyrylcholinesterase in bovine serum

Dafferner, A. J., Lushchekina, S., Masson, P., Xiao, G., Schopfer, L. M. & Lockridge, O., Mar 25 2017, In : Chemico-Biological Interactions. 266, p. 17-27 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hupresin retains binding capacity for butyrylcholinesterase and acetylcholinesterase after sanitation with sodium hydroxide

Onder, S., David, E., Tacal, O., Schopfer, L. M. & Lockridge, O., Oct 10 2017, In : Frontiers in Pharmacology. 8, OCT, 713.

Research output: Contribution to journalArticle

9 Scopus citations

Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure

Dafferner, A. J., Schopfer, L. M., Xiao, G., Cashman, J. R., Yerramalla, U., Johnson, R. C., Blake, T. A. & Lockridge, O., Oct 16 2017, In : Chemical Research in Toxicology. 30, 10, p. 1897-1910 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids

Onder, S., Dafferner, A. J., Schopfer, L. M., Xiao, G., Yerramalla, U., Tacal, O., Blake, T. A., Johnson, R. C. & Lockridge, O., Dec 18 2017, In : Chemical Research in Toxicology. 30, 12, p. 2218-2228 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

The C5 variant of the butyrylcholinesterase tetramer includes a noncovalently bound 60 kDa lamellipodin fragment

Schopfer, L. M., Delacour, H., Masson, P., Leroy, J., Krejci, E. & Lockridge, O., Jul 2017, In : Molecules. 22, 7, 1083.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers

Peng, H., Schopfer, L. M. & Lockridge, O., Nov 25 2016, In : Chemico-Biological Interactions. 259, p. 63-69 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
8 Scopus citations
2015

Biomarkers of Exposure to Organophosphorus Poisons: A New Motif for Covalent Binding to Tyrosine in Proteins That Have No Active Site Serine. A New Motif for Covalent Binding to Tyrosine in Proteins That Have No Active Site Serine

Lockridge, O., Schopfer, L. M. & Masson, P., Jan 21 2015, Handbook of Toxicology of Chemical Warfare Agents: Second Edition. Elsevier Inc., p. 953-965 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin

Schopfer, L. M., Lockridge, O. & Brimijoin, S., Dec 1 2015, In : General and Comparative Endocrinology. 224, p. 61-68 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

Characterization of a novel BCHE "silent" allele: Point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium

Delacour, H., Lushchekina, S., Mabboux, I., Bousquet, A., Ceppa, F., Schopfer, L. M., Lockridge, O. & Masson, P., Jul 23 2014, In : PloS one. 9, 7, e101552.

Research output: Contribution to journalArticle

23 Scopus citations

Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium

Delacour, H., Lushchekina, S., Mabboux, I., Ceppa, F., Masson, P., Schopfer, L. M. & Lockridge, O., Dec 1 2014, In : Biochemical Pharmacology. 92, 3, p. 476-483 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome

Schopfer, L. M., Masson, P., Lamourette, P., Simon, S. & Lockridge, O., Sep 15 2014, In : Analytical Biochemistry. 461, p. 17-26 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
4 Scopus citations
2013
1 Scopus citations
32 Scopus citations

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

Carletti, E., Colletier, J. P., Schopfer, L. M., Santoni, G., Masson, P., Lockridge, O., Nachon, F. & Weik, M., Feb 18 2013, In : Chemical Research in Toxicology. 26, 2, p. 280-289 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mass Spectrometry Method to Identify Aging Pathways of Sp- and Rp-Tabun Adducts on Human Butyrylcholinesterase Based on the Acid Labile P-N Bond

Jiang, W., Cashman, J. R., Nachon, F., Masson, P., Schopfer, L. M. & Lockridge, O., Apr 2013, In : Toxicological Sciences. 132, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase

Jiang, W., Murashko, E. A., Dubrovskii, Y. A., Podolskaya, E. P., Babakov, V. N., Mikler, J., Nachon, F., Masson, P., Schopfer, L. M. & Lockridge, O., 2013, In : Analytical Biochemistry. 439, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor

Liyasova, M. S., Schopfer, L. M., Kodani, S., Lantz, S. R., Casida, J. E. & Lockridge, O., Mar 18 2013, In : Chemical Research in Toxicology. 26, 3, p. 422-431 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

PHOS-select iron affinity beads enrich peptides for the detection of organophosphorus adducts on albumin

Jiang, W., Dubrovskii, Y. A., Podolskaya, E. P., Murashko, E. A., Babakov, V., Nachon, F., Masson, P., Schopfer, L. M. & Lockridge, O., Dec 16 2013, In : Chemical Research in Toxicology. 26, 12, p. 1917-1925 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Polyclonal antibody to soman-tyrosine

Li, B., Duysen, E. G., Froment, M. T., Masson, P., Nachon, F., Jiang, W., Schopfer, L. M., Thiele, G. M., Klassen, L. W., Cashman, J., Williams, G. R. & Lockridge, O., Apr 15 2013, In : Chemical Research in Toxicology. 26, 4, p. 584-592 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase

Biberoglu, K., Schopfer, L. M., Saxena, A., Tacal, O. & Lockridge, O., Apr 2013, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 4, p. 745-753 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Protein tyrosine adduct in humans self-poisoned by chlorpyrifos

Li, B., Eyer, P., Eddleston, M., Jiang, W., Schopfer, L. M. & Lockridge, O., Jun 15 2013, In : Toxicology and Applied Pharmacology. 269, 3, p. 215-225 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
1 Scopus citations
2012
14 Scopus citations
13 Scopus citations
18 Scopus citations

The proline-rich tetramerization peptides in equine serum butyrylcholinesterase

Biberoglu, K., Schopfer, L. M., Tacal, O. & Lockridge, O., Oct 2012, In : FEBS Journal. 279, 20, p. 3844-3858 15 p.

Research output: Contribution to journalArticle

22 Scopus citations
2011

Biomarkers of organophosphorus (OP) exposures in humans

Marsillach, J., Richter, R. J., Kim, J. H., Stevens, R. C., MacCoss, M. J., Tomazela, D., Suzuki, S. M., Schopfer, L. M., Lockridge, O. & Furlong, C. E., Oct 2011, In : NeuroToxicology. 32, 5, p. 656-660 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Exposure to tri-o-cresyl phosphate detected in jet airplane passengers

Liyasova, M., Li, B., Schopfer, L. M., Nachon, F., Masson, P., Furlong, C. E. & Lockridge, O., Nov 1 2011, In : Toxicology and Applied Pharmacology. 256, 3, p. 337-347 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Production of ES1 plasma carboxylesterase knockout mice for toxicity studies

Duysen, E. G., Koentgen, F., Williams, G. R., Timperley, C. M., Schopfer, L. M., Cerasoli, D. M. & Lockridge, O., Nov 21 2011, In : Chemical Research in Toxicology. 24, 11, p. 1891-1898 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
41 Scopus citations

X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L. M., Masson, P. & Lockridge, O., Feb 15 2011, In : Biochemical Journal. 434, 1, p. 73-82 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2010

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos

Li, B., Ricordel, I., Schopfer, L. M., Baud, F., Mégarbane, B., Nachon, F., Masson, P. & Lockridge, O., Apr 15 2010, In : Toxicological Sciences. 116, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

35 Scopus citations