Lawrence M Schopfer, PhD

  • 4333 Citations
  • 37 h-Index
1975 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 4333 Citations
  • 37 h-Index
  • 140 Article
  • 3 Chapter
  • 3 Review article
  • 1 Comment/debate

(20) Identification of organophosphate-reactive proteins by tandem mass spectrometry

Li, H., Schopfer, L., Spaulding, R., Thompson, C. M. & Lockridge, O., Dec 15 2005, In : Chemico-Biological Interactions. 157-158, p. 383-384 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

19F NMR Studies on 8-Fluoroflavins and 8-Fluoro Flavoproteins

Macheroux, P., Kojiro, C. L., Schopfer, L. M., Chakraborty, S. & Massey, V., Mar 1 1990, In : Biochemistry. 29, 11, p. 2670-2679 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

2-Thioflavins as active site probes of flavoproteins.

Claiborne, A., Massey, V., Fitzpatrick, P. F. & Schopfer, L. M., Jan 10 1982, In : Journal of Biological Chemistry. 257, 1, p. 174-182 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Absolute Stereochemistry of Flavins in Enzyme-Catalyzed Reactions

Manstein, D. J., Pai, E. F., Schopfer, L. M. & Massey, V., Nov 1986, In : Biochemistry. 25, 22, p. 6807-6816 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse

Li, B., Stribley, J. A., Ticu, A., Xie, W., Schopfer, L. M., Hammond, P., Brimijoin, S., Hinrichs, S. H. & Lockridge, O., Sep 11 2000, In : Journal of Neurochemistry. 75, 3, p. 1320-1331 12 p.

Research output: Contribution to journalArticle

277 Scopus citations

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters

Masson, P., Nachon, F., Broomfield, C. A., Lenz, D. E., Verdier, L., Schopfer, L. M. & Lockridge, O., Sep 25 2008, In : Chemico-Biological Interactions. 175, 1-3, p. 273-280 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Active site probes of flavoproteins. Determination of the solvent accessibility of the flavin position 8 for a series of flavoproteins.

Schopfer, L. M., Massey, V. & Claiborne, A., Jul 25 1981, In : Journal of Biological Chemistry. 256, 14, p. 7329-7337 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation

Carletti, E., Li, H., Li, B., Ekström, F., Nicolet, Y., Loiodice, M., Gillon, E., Froment, M. T., Lockridge, O., Schopfer, L. M., Masson, P. & Nachon, F., Nov 26 2008, In : Journal of the American Chemical Society. 130, 47, p. 16011-16020 10 p.

Research output: Contribution to journalArticle

84 Scopus citations

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

Li, H., Schopfer, L. M., Nachon, F., Froment, M. T., Masson, P. & Lockridge, O., Nov 1 2007, In : Toxicological Sciences. 100, 1, p. 136-145 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry

Peeples, E. S., Schopfer, L. M., Duysen, E. G., Spaulding, R., Voelker, T., Thompson, C. M. & Lockridge, O., Feb 1 2005, In : Toxicological Sciences. 83, 2, p. 303-312 10 p.

Research output: Contribution to journalArticle

112 Scopus citations
14 Scopus citations

Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate

Masson, P., Froment, M. T., Darvesh, S., Schopfer, L. M. & Lockridge, O., Aug 1 2007, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 22, 4, p. 463-469 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Binding and hydrolysis of soman by human serum albumin

Li, B., Nachon, F., Froment, M. T., Verdier, L., Debouzy, J. C., Brasme, B., Gillon, E., Schopfer, L. M., Lockridge, O. & Masson, P., Feb 1 2008, In : Chemical Research in Toxicology. 21, 2, p. 421-431 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Biomarkers of exposure to organophosphorus poisons: A new motif for covalent binding to tyrosine in proteins that have no active site serine

Lockridge, O., Schopfer, L. M. & Masson, P., Dec 1 2009, Handbook of Toxicology of Chemical Warfare Agents. Elsevier Inc., p. 847-858 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Biomarkers of Exposure to Organophosphorus Poisons: A New Motif for Covalent Binding to Tyrosine in Proteins That Have No Active Site Serine. A New Motif for Covalent Binding to Tyrosine in Proteins That Have No Active Site Serine

Lockridge, O., Schopfer, L. M. & Masson, P., Jan 21 2015, Handbook of Toxicology of Chemical Warfare Agents: Second Edition. Elsevier Inc., p. 953-965 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biomarkers of organophosphate exposure

Lockridge, O. & Schopfer, L. M., Dec 1 2006, Toxicology of Organophosphate & Carbamate Compounds. Elsevier Inc., p. 703-711 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations

Biomarkers of organophosphorus (OP) exposures in humans

Marsillach, J., Richter, R. J., Kim, J. H., Stevens, R. C., MacCoss, M. J., Tomazela, D., Suzuki, S. M., Schopfer, L. M., Lockridge, O. & Furlong, C. E., Oct 1 2011, In : NeuroToxicology. 32, 5, p. 656-660 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: Analysis of volume changes upon reaction and hysteretic behavior

Masson, P., Froment, M. T., Fort, S., Ribes, F., Bec, N., Balny, C. & Schopfer, L. M., Jun 3 2002, In : Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology. 1597, 2, p. 229-243 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

Calorimetric evidence for allosteric subunit interactions associated with inhibitor binding to band 3 transporter

Van Dort, H. M., Low, P. S., Cordes, K. A., Schopfer, L. M. & Salhany, J. M., Jan 7 1994, In : Journal of Biological Chemistry. 269, 1, p. 59-61 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum

Li, H., Ricordel, I., Tong, L., Schopfer, L. M., Baud, F., Mégarbane, B., Maury, E., Masson, P. & Lockridge, O., Mar 1 2009, In : Journal of Applied Toxicology. 29, 2, p. 149-155 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine

Biberoglu, K., Schopfer, L. M., Tacal, O. & Lockridge, O., Jul 1 2020, In : Analytical Biochemistry. 600, 113718.

Research output: Contribution to journalArticle

Open Access

Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410)

Schopfer, L. M., Champion, M. M., Tamblyn, N., Thompson, C. M. & Lockridge, O., Oct 1 2005, In : Analytical Biochemistry. 345, 1, p. 122-132 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Characterization of a novel BCHE "silent" allele: Point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium

Delacour, H., Lushchekina, S., Mabboux, I., Bousquet, A., Ceppa, F., Schopfer, L. M., Lockridge, O. & Masson, P., Jul 23 2014, In : PloS one. 9, 7, e101552.

Research output: Contribution to journalArticle

22 Scopus citations

Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium

Delacour, H., Lushchekina, S., Mabboux, I., Ceppa, F., Masson, P., Schopfer, L. M. & Lockridge, O., Dec 1 2014, In : Biochemical Pharmacology. 92, 3, p. 476-483 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Characterization of butyrylcholinesterase from porcine milk

Saxena, A., Belinskaya, T., Schopfer, L. M. & Lockridge, O., Aug 15 2018, In : Archives of Biochemistry and Biophysics. 652, p. 38-49 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Characterization of butyrylcholinesterase in bovine serum

Dafferner, A. J., Lushchekina, S., Masson, P., Xiao, G., Schopfer, L. M. & Lockridge, O., Mar 25 2017, In : Chemico-Biological Interactions. 266, p. 17-27 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Characterization of the flavin–protein interaction in L‐Lactate oxidase and old yellow enzyme by resonance inverse Raman spectroscopy

Bienstock, R. J., Schopfer, L. M. & Morris, M. D., Jun 1987, In : Journal of Raman Spectroscopy. 18, 4, p. 241-245 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Characterization of the Stilbenedisulfonate Binding Site on Band 3

Schopfer, L. M. & Salhany, J. M., Jul 1995, In : Biochemistry. 34, 26, p. 8320-8329 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Characterization of the stilbenedisulphonate binding site on band 3 Memphis variant II (Pro-854 → Leu)

Salhany, J. M., Sloan, R. L. & Schopfer, L. M., Jul 15 1996, In : Biochemical Journal. 317, 2, p. 509-514 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Chlorpyrifos oxon-induced isopeptide bond formation in human butyrylcholinesterase

Biberoglu, K., Tacal, O., Schopfer, L. M. & Lockridge, O., Jan 25 2020, In : Molecules. 25, 3, 533.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad

Grigorenko, B. L., Novichkova, D. A., Lushchekina, S. V., Zueva, I. V., Schopfer, L. M., Nemukhin, A. V., Varfolomeev, S. D., Lockridge, O. & Masson, P., Jun 1 2019, In : Chemico-Biological Interactions. 306, p. 138-146 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine

Grigoryan, H., Li, B., Anderson, E. K., Xue, W., Nachon, F., Lockridge, O. & Schopfer, L. M., Aug 14 2009, In : Chemico-Biological Interactions. 180, 3, p. 492-498 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
13 Scopus citations
1 Scopus citations

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly

Leung, M. R., van Bezouwen, L. S., Schopfer, L. M., Sussman, J. L., Silman, I., Lockridge, O. & Zeev-Ben-Mordehai, T., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13270-13275 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate

Masson, P., Goldstein, B. N., Debouzy, J. C., Froment, M. T., Lockridge, O. & Schopfer, L. M., Jan 1 2004, In : European Journal of Biochemistry. 271, 1, p. 220-234 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos

Li, B., Ricordel, I., Schopfer, L. M., Baud, F., Mégarbane, B., Nachon, F., Masson, P. & Lockridge, O., Apr 15 2010, In : Toxicological Sciences. 116, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome

Schopfer, L. M., Masson, P., Lamourette, P., Simon, S. & Lockridge, O., Sep 15 2014, In : Analytical Biochemistry. 461, p. 17-26 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Determination of glucose oxidase oxidation-reduction potentials and the oxygen reactivity of fully reduced and semiquinoid forms

Stankovich, M. T., Schopfer, L. M. & Massay, V., Jan 1 1978, In : Journal of Biological Chemistry. 253, 14, p. 4971-4979 9 p.

Research output: Contribution to journalArticle

140 Scopus citations

Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma

Bartels, C. F., Xie, W., Miller-Lindholm, A. K., Schopfer, L. M. & Lockridge, O., Aug 15 2000, In : Biochemical Pharmacology. 60, 4, p. 479-487 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Development of diagnostics in the search for an explanation of aerotoxic syndrome

Schopfer, L. M., Furlong, C. E. & Lockridge, O., Sep 2010, In : Analytical Biochemistry. 404, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose

Li, B., Ricordel, I., Schopfer, L. M., Baud, F., Mégarbane, B., Massond, P. & Lockridgea, O., Aug 1 2010, In : Journal of Applied Toxicology. 30, 6, p. 559-565 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Differences in protein structure of xanthine dehydrogenase and xanthine oxidase revealed by reconstitution with flavin active site probes

Massey, V., Schopfer, L. M., Nishino, T. & Nishino, T., Jan 1 1989, In : Journal of Biological Chemistry. 264, 18, p. 10567-10573 7 p.

Research output: Contribution to journalArticle

39 Scopus citations
18 Scopus citations

Differential sensitivity of stilbenedisulfonates in their reaction with band 3 HT (Pro-868 → Leu)

Salhany, J. M., Schopfer, L. M., Kay, M. M. B., Gamble, D. N. & Lawrence, C., Dec 5 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 25, p. 11844-11848 5 p.

Research output: Contribution to journalArticle

19 Scopus citations
32 Scopus citations
29 Scopus citations

Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: Supersensitivity of acetylcholinesterase knockout mouse to VX lethality

Duysen, E. G., Li, B., Xie, W., Schopfer, L. M., Anderson, R. S., Broomfield, C. A. & Lockridge, O., Oct 30 2001, In : Journal of Pharmacology and Experimental Therapeutics. 299, 2, p. 528-535 8 p.

Research output: Contribution to journalArticle

120 Scopus citations

Exposure to tri-o-cresyl phosphate detected in jet airplane passengers

Liyasova, M., Li, B., Schopfer, L. M., Nachon, F., Masson, P., Furlong, C. E. & Lockridge, O., Nov 1 2011, In : Toxicology and Applied Pharmacology. 256, 3, p. 337-347 11 p.

Research output: Contribution to journalArticle

44 Scopus citations