Lora L Arnold, MS

Assistant Professor

  • 2618 Citations
  • 30 h-Index
1987 …2020

Research output per year

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Research Output

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Article
2020

Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo

Suzuki, S., Cohen, S. M., Arnold, L. L., Pennington, K. L., Kato, H., Naiki, T., Naiki-Ito, A., Yamashita, Y. & Takahashi, S., Jan 15 2020, In : Toxicology. 429, 152325.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Evaluation of immunologic and intestinal effects in rats administered an E 171-containing diet, a food grade titanium dioxide (TiO2)

Blevins, L. K., Crawford, R. B., Bach, A., Rizzo, M. D., Zhou, J., Henriquez, J. E., Khan, D. M. I. O., Sermet, S., Arnold, L. L., Pennington, K. L., Souza, N. P., Cohen, S. M. & Kaminski, N. E., Nov 2019, In : Food and Chemical Toxicology. 133, 110793.

Research output: Contribution to journalArticle

4 Scopus citations

Experimental cryptorchidism enhances testicular susceptibility to dibutyl phthalate or acrylamide in Sprague-Dawley rats

de Souza, N. P., Cardoso, AP. F., Gomide, L. M. M., Lima, T. R. R., Miot, H. A., Martino-Andrade, A. J., Arnold, L. L., Pennington, K. L., Cohen, S. M., de Camargo, J. L. V. & Nascimento e Pontes, M. G., Aug 1 2019, In : Human and Experimental Toxicology. 38, 8, p. 899-913 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Isolation and molecular characterization of spermatogonia from male Sprague-Dawley rats exposed in utero and postnatally to dibutyl phthalate or acrylamide

Souza, N. P., Arnold, L. L., Pennington, K. L., Nascimento e Pontes, M. G., Miot, H. A., de Camargo, J. L. V. & Cohen, S. M., Sep 2 2019, In : Toxicology Mechanisms and Methods. 29, 7, p. 488-498 11 p.

Research output: Contribution to journalArticle

Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes

Liao, Y., Tham, D. K. L., Liang, F. X., Chang, J., Wei, Y., Sudhir, P. R., Sall, J., Ren, S. J., Chicote, J. U., Arnold, L. L., Hu, C. C. A., Romih, R., Andrade, L. R., Rindler, M. J., Cohen, S. M., DeSalle, R., Garcia-España, A., Ding, M., Wu, X. R. & Sun, T. T., Nov 15 2019, In : Molecular biology of the cell. 30, 24, p. 2969-2984 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Effect of polyhexamethylene biguanide on rat liver

Chowdhury, A., Arnold, L. L., Wang, Z., Pennington, K. L., Dodmane, P., Farragut-Cardoso, A. P., Klaunig, J. E., Cros, D., Creppy, E. E. & Cohen, S. M., Mar 15 2018, In : Toxicology Letters. 285, p. 94-103 10 p.

Research output: Contribution to journalArticle

Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN)

Souza, N. P., Hard, G. C., Arnold, L. L., Foster, K. W., Pennington, K. L. & Cohen, S. M., Apr 1 2018, In : Toxicologic Pathology. 46, 3, p. 266-272 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Orally administered nicotine effects on rat urinary bladder proliferation and carcinogenesis

Suzuki, S., Cohen, S. M., Arnold, L. L., Kato, H., Fuji, S., Pennington, K. L., Nagayasu, Y., Naiki-Ito, A., Yamashita, Y. & Takahashi, S., Apr 1 2018, In : Toxicology. 398-399, p. 31-40 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Low-dose dose-response for reduced cell viability after exposure of human keratinocyte (HEK001) cells to arsenite

Bogen, K. T., Arnold, L. L., Chowdhury, A., Pennington, K. L. & Cohen, S. M., Jan 1 2017, In : Toxicology Reports. 4, p. 32-38 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Identification of Methylated Dithioarsenicals in the Urine of Rats Fed with Sodium Arsenite

Chen, B., Lu, X., Arnold, L. L., Cohen, S. M. & Le, X. C., Sep 19 2016, In : Chemical Research in Toxicology. 29, 9, p. 1480-1487 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells

Dodmane, P. R., Arnold, L. L., Pennington, K. L., Singh, R. K., Cardoso, A. P. F. & Cohen, S. M., May 1 2015, In : Toxicology Reports. 2, p. 833-837 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic

Dodmane, P. R., Arnold, L. L., Muirhead, D. E., Suzuki, S., Yokohira, M., Pennington, K. L., Dave, B. J., Lu, X., Le, X. C. & Cohen, S. M., Jan 2014, In : Toxicological Sciences. 137, 1, p. 36-46 11 p., kft227.

Research output: Contribution to journalArticle

13 Scopus citations

Mode of action for inorganic arsenic toxicity and carcinogenesis

Dodmane, P. R., Arnold, L. L. & Cohen, S. M., Nov 1 2014, In : Chinese Science Bulletin. 59, 11, p. 1078-1082 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Orally administered nicotine induces urothelial hyperplasia in rats and mice

Dodmane, P. R., Arnold, L. L., Pennington, K. L. & Cohen, S. M., Jan 6 2014, In : Toxicology. 315, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Time Course of Urothelial Changes in Rats and Mice Orally Administered Arsenite

Arnold, L. L., Suzuki, S., Yokohira, M., Kakiuchi-Kiyota, S., Pennington, K. L. & Cohen, S. M., Jul 2014, In : Toxicologic Pathology. 42, 5, p. 855-862 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Arsenic speciation in the blood of arsenite-treated F344 rats

Chen, B., Lu, X., Shen, S., Arnold, L. L., Cohen, S. M. & Le, X. C., Jun 17 2013, In : Chemical Research in Toxicology. 26, 6, p. 952-962 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cytotoxicity and gene expression changes induced by inorganic and organic trivalent arsenicals in human cells

Dodmane, P. R., Arnold, L. L., Kakiuchi-Kiyota, S., Qiu, F., Liu, X., Rennard, S. I. & Cohen, S. M., Aug 27 2013, In : Toxicology. 312, 1, p. 18-29 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Diuron metabolites and urothelial cytotoxicity: In vivo, in vitro and molecular approaches

Da Rocha, M. S., Arnold, L. L., Dodmane, P. R., Pennington, K. L., Qiu, F., De Camargo, J. L. V. & Cohen, S. M., Dec 15 2013, In : Toxicology. 314, 2-3, p. 238-246 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
14 Scopus citations

Evaluation of Expression Profiles of Hematopoietic Stem Cell, Endothelial Cell, and Myeloid Cell Antigens in Spontaneous and Chemically Induced Hemangiosarcomas and Hemangiomas in Mice

Kakiuchi-Kiyota, S., Crabbs, T. A., Arnold, L. L., Pennington, K. L., Cook, J. C., Malarkey, D. E. & Cohen, S. M., Jul 2013, In : Toxicologic Pathology. 41, 5, p. 709-721 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evaluation of gene expression changes in human primary uroepithelial cells following 24-Hr exposures to inorganic arsenic and its methylated metabolites

Yager, J. W., Gentry, P. R., Thomas, R. S., Pluta, L., Efremenko, A., Black, M., Arnold, L. L., McKim, J. M., Wilga, P., Gill, G., Choe, K. Y. & Clewell, H. J., Mar 2013, In : Environmental and Molecular Mutagenesis. 54, 2, p. 82-98 17 p.

Research output: Contribution to journalArticle

24 Scopus citations

Pathogenesis of human hemangiosarcomas and hemangiomas

Liu, L., Kakiuchi-Kiyota, S., Arnold, L. L., Johansson, S. L., Wert, D. & Cohen, S. M., Oct 1 2013, In : Human Pathology. 44, 10, p. 2302-2311 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Urothelial cell intracytoplasmic inclusions after treatment of promyelocytic leukemia with arsenic trioxide

Wedel, W. R., Muirhead, D. E., Arnold, L. L., Dodmane, P. R., Lele, S. M., Maness-Harris, L., Hoyt, R. & Cohen, S. M., Aug 1 2013, In : Toxicological Sciences. 134, 2, p. 271-275 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Cisplatin-loaded core cross-linked micelles: Comparative pharmacokinetics, antitumor activity, and toxicity in mice

Oberoi, H. S., Nukolova, N. V., Laquer, F. C., Poluektova, L. Y., Huang, J., Alnouti, Y., Yokohira, M., Arnold, L. L., Kabanov, A. V., Cohen, S. M. & Bronich, T. K., Dec 5 2012, In : International journal of nanomedicine. 7, p. 2557-2571 15 p.

Research output: Contribution to journalArticle

40 Scopus citations

Diuron-induced rat bladder epithelial cytotoxicity

Da rocha, M. S., Arnold, L. L., Pennington, K. L., Muirhead, D., Dodmane, P. R., Anwar, M. M., Battalora, M., De camargo, J. L. V. & Cohen, S. M., Dec 1 2012, In : Toxicological Sciences. 130, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium

Suzuki, S., Arnold, L. L., Pennington, K. L., Kakiuchi-Kiyota, S., Chen, B., Lu, X., Le, X. C. & Cohen, S. M., Sep 28 2012, In : Toxicology. 299, 2-3, p. 155-159 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mode of action of pulegone on the urinary bladder of F344 rats

Da rocha, M. S., Dodmane, P. R., Arnold, L. L., Pennington, K. L., Anwar, M. M., Adams, B. R., Taylor, S. V., Wermes, C., Adams, T. B. & Cohen, S. M., Jul 1 2012, In : Toxicological Sciences. 128, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011

Chemical carcinogenesis

Cohen, S. M. & Arnold, L. L., Mar 4 2011, In : Toxicological Sciences. 120, SUPPL.1, p. S76-S92

Research output: Contribution to journalArticle

81 Scopus citations

Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice

Yokohira, M., Arnold, L. L., Pennington, K. L., Suzuki, S., Kakiuchi-Kiyota, S., Herbin-Davis, K., Thomas, D. J. & Cohen, S. M., Jun 6 2011, In : Toxicological Sciences. 121, 2, p. 257-266 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Evaluation of direct and indirect effects of the PPARγ agonist troglitazone on mouse endothelial cell proliferation

Kakiuchi-Kiyota, S., Arnold, L. L., Yokohira, M., Koza-Taylor, P., Suzuki, S., Varney, M., Pennington, K. L. & Cohen, S. M., Dec 1 2011, In : Toxicologic Pathology. 39, 7, p. 1032-1045 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Evaluation of PPARγ agonists on rodent endothelial cell proliferation

Kakiuchi-Kiyota, S., Arnold, L. L., Yokohira, M., Suzuki, S., Pennington, K. L. & Cohen, S. M., Sep 5 2011, In : Toxicology. 287, 1-3, p. 91-98 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
40 Scopus citations

The effects of oral treatment with transfluthrin on the urothelium of rats and its metabolite, tetrafluorobenzoic acid on urothelial cells in vitro

Yokohira, M., Arnold, L. L., Lautraite, S., Sheets, L., Wason, S., Stahl, B., Eigenberg, D., Pennington, K. L., Kakiuchi-Kiyota, S. & Cohen, S. M., Jun 1 2011, In : Food and Chemical Toxicology. 49, 6, p. 1215-1223 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2010

Dietary administration of sodium arsenite to rats: Relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary bladder epithelium

Suzuki, S., Arnold, L. L., Pennington, K. L., Chen, B., Naranmandura, H., Le, X. C. & Cohen, S. M., Apr 1 2010, In : Toxicology and Applied Pharmacology. 244, 2, p. 99-105 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report

Yokohira, M., Arnold, L. L., Pennington, K. L., Suzuki, S., Kakiuchi-Kiyota, S., Herbin-Davis, K., Thomas, D. J. & Cohen, S. M., Jul 1 2010, In : Toxicology and Applied Pharmacology. 246, 1-2, p. 1-7 7 p.

Research output: Contribution to journalArticle

37 Scopus citations
2009

Effects of an epidermal growth factor receptor inhibitor on arsenic associated toxicity in the rat bladder epithelium

Suzuki, S., Arnold, L. L., Pennington, K. L., Chen, B., Le, X. C. & Cohen, S. M., Jun 1 2009, In : Toxicology Letters. 187, 2, p. 124-129 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Effects of co-administration of dietary sodium arsenite and an NADPH oxidase inhibitor on the rat bladder epithelium

Suzuki, S., Arnold, L. L., Pennington, K. L., Kakiuchi-Kiyota, S. & Cohen, S. M., Jun 30 2009, In : Toxicology. 261, 1-2, p. 41-46 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effects of pioglitazone, a peroxisome proliferator-Activated receptor gamma agonist, on the urine and urothelium of the rat

Suzuki, S., Arnold, L. L., Pennington, K. L., Kakiuchi-Kiyota, S., Wei, M., Wanibuchi, H. & Cohen, S. M., Oct 25 2009, In : Toxicological Sciences. 113, 2, p. 349-357 9 p., kfp256.

Research output: Contribution to journalArticle

63 Scopus citations

Effects of the PPARγ agonist troglitazone on endothelial cells in vivo and in vitro: Differences between human and mouse

Kakiuchi-Kiyota, S., Vetro, J. A., Suzuki, S., Varney, M. L., Han, H. Y., Nascimento, M., Pennington, K. L., Arnold, L. L., Singh, R. K. & Cohen, S. M., May 15 2009, In : Toxicology and Applied Pharmacology. 237, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Strain-related Differences in Urine Composition of Male Rats of Potential Relevance to Urolithiasis

Tannehill-Gregg, S. H., Dominick, M. A., Reisinger, A. J., Moehlenkamp, J. D., Waites, C. R., Stock, D. A., Sanderson, T. P., Cohen, S. M., Arnold, L. L. & Schilling, B. E., Apr 2009, In : Toxicologic Pathology. 37, 3, p. 293-305 13 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

Cytotoxicity of combinations of arsenicals on rat urinary bladder urothelial cells in vitro

Nascimento, M. G., Suzuki, S., Wei, M., Tiwari, A., Arnold, L. L., Lu, X., Le, X. C. & Cohen, S. M., Jul 10 2008, In : Toxicology. 249, 1, p. 69-74 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Effects of inorganic arsenic on the rat and mouse urinary bladder

Suzuki, S., Arnold, L. L., Ohnishi, T. & Cohen, S. M., Jan 1 2008, In : Toxicological Sciences. 106, 2, p. 350-363 14 p.

Research output: Contribution to journalArticle

34 Scopus citations

Inorganic arsenic-induced intramitochondrial granules in mouse urothelium

Suzuki, S., Arnold, L. L., Muirhead, D., Xiufen Lu, L., Le, X. C., Bjork, J. A., Wallace, K. B., Ohnishi, T., Kakiuchi-Kiyota, S., Pennington, K. L. & Cohen, S. M., Dec 1 2008, In : Toxicologic Pathology. 36, 7, p. 999-1005 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Safety of saccharin

Cohen, S. M., Arnold, L. L. & Emerson, J. L., Nov 1 2008, In : Agro Food Industry Hi-Tech. 19, 6, p. 24-28 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2007

Arsenic-induced bladder cancer in an animal model

Cohen, S. M., Ohnishi, T., Arnold, L. L. & Le, X. C., Aug 1 2007, In : Toxicology and Applied Pharmacology. 222, 3, p. 258-263 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Binding of dimethylarsinous acid to Cys-13α of rat hemoglobin is responsible for the retention of arsenic in rat blood

Lu, M., Wang, H., Li, X. F., Arnold, L. L., Cohen, S. M. & Le, X. C., Jan 1 2007, In : Chemical Research in Toxicology. 20, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

Comparison of endothelial cell proliferation in normal liver and adipose tissue in B6C3F1 mice, F344 rats, and humans

Ohnishi, T., Arnold, L. L., Clark, N. M., Wisecarver, J. L. & Cohen, S. M., Dec 1 2007, In : Toxicologic Pathology. 35, 7, p. 904-909 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Inhalation of tobacco smoke induces increased proliferation of urinary bladder epithelium and endothelium in female C57BL/6 mice

Ohnishi, T., Arnold, L. L., He, J., Clark, N. M., Kawasaki, S., Rennard, S. I., Boyer, C. W. & Cohen, S. M., Nov 20 2007, In : Toxicology. 241, 1-2, p. 58-65 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Investigations of Rodent Urinary Bladder Carcinogens: Collection, Processing, and Evaluation of Urine and Bladders

Cohen, S. M., Ohnishi, T., Clark, N. M., he, J. & Arnold, L. L., Apr 2007, In : Toxicologic Pathology. 35, 3, p. 337-347 11 p.

Research output: Contribution to journalArticle

65 Scopus citations