Maneesh Jain, PhD

  • 5210 Citations
  • 30 h-Index
20012020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions

Siddiqui, J. A., Pothuraju, R., Jain, M., Batra, S. K. & Nasser, M. W., Apr 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 2, 188359.

Research output: Contribution to journalReview article

A phase I study of weekly doxorubicin and oral topotecan for patients with relapsed or refractory small cell lung cancer (SCLC): A Fred and Pamela Buffet Cancer Center Clinical Trials Network study

Ernani, V., Jahan, R., Smith, L. M., Marr, A. S., Kimbrough, S. E., Kos, M. E., Tijerina, J., Pivovar, S., Lakshmanan, I., Ketcham, M., Rauth, S., Mallya, K., Nasser, M. W., Jain, M., Kessinger, A., Batra, S. K. & Ganti, A. K., 2020, In : Cancer Treatment and Research Communications. 22, 100162.

Research output: Contribution to journalArticle

Open Access

CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Awaji, M., Saxena, S., Wu, L., Prajapati, D. R., Purohit, A., Varney, M. L., Kumar, S., Rachagani, S., Ly, Q. P., Jain, M., Batra, S. K. & Singh, R. K., Jul 1 2020, In : FASEB Journal. 34, 7, p. 9405-9418 14 p.

Research output: Contribution to journalArticle

Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s)

Carmicheal, J., Patel, A., Dalal, V., Atri, P., Dhaliwal, A. S., Wittel, U. A., Malafa, M. P., Talmon, G., Swanson, B. J., Singh, S., Jain, M., Kaur, S. & Batra, S. K., Jan 2020, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1873, 1, 188318.

Research output: Contribution to journalReview article

Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer

Gupta, S., Prajapati, A., Gulati, M., Gautam, S. K., Kumar, S., Dalal, V., Talmon, G. A., Rachagani, S. & Jain, M., Feb 2020, In : Neoplasia (United States). 22, 2, p. 98-110 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MUCIN-4 (MUC4) is a novel tumor antigen in pancreatic cancer immunotherapy

Gautam, S. K., Kumar, S., Dam, V., Ghersi, D., Jain, M. & Batra, S. K., Feb 2020, In : Seminars in Immunology. 47, 101391.

Research output: Contribution to journalReview article

Radiomics in stratification of pancreatic cystic lesions: Machine learning in action

Dalal, V., Carmicheal, J., Dhaliwal, A., Jain, M., Kaur, S. & Batra, S. K., Jan 28 2020, In : Cancer Letters. 469, p. 228-237 10 p.

Research output: Contribution to journalShort survey

2019

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells

Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., 2019, In : Genes and Cancer. 10, 3-4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Cancer-associated mucins: role in immune modulation and metastasis

Bhatia, R., Gautam, S. K., Cannon, A., Thompson, C., Hall, B. R., Aithal, A., Banerjee, K., Jain, M., Solheim, J. C., Kumar, S. & Batra, S. K., Jun 15 2019, In : Cancer and Metastasis Reviews. 38, 1-2, p. 223-236 14 p.

Research output: Contribution to journalReview article

18 Scopus citations

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

Carmicheal, J., Hayashi, C., Huang, X., Liu, L., Lu, Y., Krasnoslobodtsev, A., Lushnikov, A., Kshirsagar, P. G., Patel, A., Jain, M., Lyubchenko, Y. L., Lu, Y., Batra, S. K. & Kaur, S., Feb 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 88-96 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2018

Desmoplasia in pancreatic ductal adenocarcinoma: Insight into pathological function and therapeutic potential

Cannon, A., Thompson, C., Hall, B. R., Jain, M., Kumar, S. & Batra, S. K., Mar 2018, In : Genes and Cancer. 9, 3-4, p. 78-86 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

Aithal, A., Junker, W. M., Kshirsagar, P., Das, S., Kaur, S., Orzechowski, C., Gautam, S. K., Jahan, R., Sheinin, Y. M., Lakshmanan, I., Ponnusamy, M. P., Batra, S. K. & Jain, M., Apr 2018, In : PloS one. 13, 4, e0193907.

Research output: Contribution to journalArticle

3 Scopus citations

Emerging trends in the immunotherapy of pancreatic cancer

Banerjee, K., Kumar, S., Ross, K. A., Gautam, S., Poelaert, B., Nasser, M. W., Aithal, A., Bhatia, R., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Batra, S. K. & Jain, M., Mar 28 2018, In : Cancer Letters. 417, p. 35-46 12 p.

Research output: Contribution to journalShort survey

24 Scopus citations

MUC16 as a novel target for cancer therapy

Aithal, A., Rauth, S., Kshirsagar, P., Shah, A., Lakshmanan, I., Junker, W. M., Jain, M., Ponnusamy, M. P. & Batra, S. K., Aug 3 2018, In : Expert Opinion on Therapeutic Targets. 22, 8, p. 675-686 12 p.

Research output: Contribution to journalReview article

14 Scopus citations
2017

A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study

Kaur, S., Smith, L. M., Patel, A., Menning, M., Watley, D. C., Malik, S. S., Krishn, S. R., Mallya, K., Aithal, A., Sasson, A. R., Johansson, S. L., Jain, M., Singh, S., Guha, S., Are, C., Raimondo, M., Hollingsworth, M. A., Brand, R. E. & Batra, S. K., Jan 1 2017, In : American Journal of Gastroenterology. 112, 1, p. 172-183 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

Macha, M. A., Rachagani, S., Qazi, A. K., Jahan, R., Gupta, S., Patel, A. A., Seshacharyulu, P., Lin, C., Li, S., Wang, S., Verma, V., Kishida, S., Kishida, M., Nakamura, N., Kibe, T., Lydiatt, W. M., Smith, R. B., Ganti, A. K., Jones, D. T., Batra, S. K. & 1 others, Jain, M., 2017, In : Oncotarget. 8, 13, p. 20961-20973 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Biological determinants of radioresistance and their remediation in pancreatic cancer

Seshacharyulu, P., Baine, M. J., Souchek, J. J., Menning, M., Kaur, S., Yan, Y., Ouellette, M. M., Jain, M., Lin, C. & Batra, S. K., Aug 1 2017, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1868, 1, p. 69-92 24 p.

Research output: Contribution to journalReview article

19 Scopus citations

Genetic variants of mucins: Unexplored conundrum

Kumar, S., Cruz, E., Joshi, S., Patel, A., Jahan, R., KBatra, S. & Jain, M., Jul 1 2017, In : Carcinogenesis. 38, 7, p. 671-679 9 p., bgw120.

Research output: Contribution to journalReview article

10 Scopus citations

MUC4 mucin- a therapeutic target for pancreatic ductal adenocarcinoma

Gautam, S. K., Kumar, S., Cannon, A., Hall, B., Bhatia, R., Nasser, M. W., Mahapatra, S., Batra, S. K. & Jain, M., Jul 3 2017, In : Expert Opinion on Therapeutic Targets. 21, 7, p. 657-669 13 p.

Research output: Contribution to journalReview article

22 Scopus citations

Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: Clinical implication for improved colon surveillance

Krishn, S. R., Kaur, S., Sheinin, Y. M., Smith, L. M., Gautam, S. K., Patel, A., Jain, M., Juvvigunta, V., Pai, P., Lazenby, A. J., Roy, H. K. & Batra, S. K., 2017, In : Oncotarget. 8, 4, p. 7025-7038 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

Krishn, S. R., Kaur, S., Smith, L. M., Johansson, S. L., Jain, M., Patel, A., Gautam, S. K., Hollingsworth, M. A., Mandel, U., Clausen, H., Lo, W. C., Fan, W. T. L., Manne, U. & Batra, S. K., May 1 2016, In : Cancer Letters. 374, 2, p. 304-314 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

Wang, Y., Kumar, S., Rachagani, S., Sajja, B. R., Xie, Y., Hang, Y., Jain, M., Li, J., Boska, M. D., Batra, S. K. & Oupický, D., Sep 1 2016, In : Biomaterials. 101, p. 108-120 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer

Macha, M. A., Krishn, S. R., Jahan, R., Banerjee, K., Batra, S. K. & Jain, M., Mar 1 2015, In : Cancer Treatment Reviews. 41, 3, p. 277-288 12 p.

Research output: Contribution to journalReview article

14 Scopus citations

Erratum: MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway (Oncogene (2015) 34:2814 DOI:10.1038/onc.2015.116)

Macha, M. A., Rachagani, S., Pai, P., Gupta, S., Lydiatt, W. M., Smith, R. B., Johansson, S. L., Lele, S. M., Kakar, S. S., Farghaly, H., Lee, J. H., Meza, J., Ganti, A. K., Jain, M. & Batra, S. K., May 21 2015, In : Oncogene. 34, 21, 1 p.

Research output: Contribution to journalComment/debate

Genetically engineered mucin mouse models for inflammation and cancer

Joshi, S., Kumar, S., Bafna, S., Rachagani, S., Wagner, K. U., Jain, M. & Batra, S. K., Dec 1 2015, In : Cancer and Metastasis Reviews. 34, 4, p. 593-609 17 p.

Research output: Contribution to journalReview article

9 Scopus citations

MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway

Macha, M. A., Rachagani, S., Pai, P., Gupta, S., Lydiatt, W. M., Smith, R. B., Johansson, S. L., Lele, S. M., Kakar, S. S., Lee, J. H., Meza, J., Ganti, A. K., Jain, M. & Batra, S. K., Mar 26 2015, In : Oncogene. 34, 13, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mucin Expression in Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimens Is a Useful Prognostic Factor in Pancreatic Ductal Adenocarcinoma

Higashi, M., Yokoyama, S., Yamamoto, T., Goto, Y., Kitazono, I., Hiraki, T., Taguchi, H., Hashimoto, S., Fukukura, Y., Koriyama, C., Mataki, Y., Maemura, K., Shinchi, H., Jain, M., Batra, S. K. & Yonezawa, S., Jul 25 2015, In : Pancreas. 44, 5, p. 728-734 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mucins in lung cancer: Diagnostic, prognostic, and therapeutic implications

Lakshmanan, I., Ponnusamy, M. P., Macha, M. A., Haridas, D., Majhi, P. D., Kaur, S., Jain, M., Batra, S. K. & Ganti, A. K., Jan 1 2015, In : Journal of Thoracic Oncology. 10, 1, p. 19-27 9 p.

Research output: Contribution to journalReview article

43 Scopus citations

Nano-immunoassay with improved performance for detection of cancer biomarkers

Krasnoslobodtsev, A. V., Torres, M. P., Kaur, S., Vlassiouk, I. V., Lipert, R. J., Jain, M., Batra, S. K. & Lyubchenko, Y. L., Jan 1 2015, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 1, p. 167-173 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
14 Scopus citations

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Lakshmanan, I., Seshacharyulu, P., Haridas, D., Rachagani, S., Gupta, S., Joshi, S., Guda, C., Yan, Y., Jain, M., Ganti, A. K., Ponnusamy, M. P. & Batra, S. K., 2015, In : Oncotarget. 6, 25, p. 21085-21099 15 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., Xiang, J., Zhang, T., Theilen, T. M., García-Santos, G., Williams, C., Ararso, Y., Huang, Y., Rodrigues, G., Shen, T. L., Labori, K. J. & 17 others, Lothe, I. M. B., Kure, E. H., Hernandez, J., Doussot, A., Ebbesen, S. H., Grandgenett, P. M., Hollingsworth, M. A., Jain, M., Mallya, K., Batra, S. K., Jarnagin, W. R., Schwartz, R. E., Matei, I., Peinado, H., Stanger, B. Z., Bromberg, J. & Lyden, D., Jun 1 2015, In : Nature Cell Biology. 17, 6, p. 816-826 11 p.

Research output: Contribution to journalArticle

923 Scopus citations

Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets

Chugh, S., Gnanapragassam, V. S., Jain, M., Rachagani, S., Ponnusamy, M. P. & Batra, S. K., Dec 1 2015, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1856, 2, p. 211-225 15 p.

Research output: Contribution to journalReview article

34 Scopus citations

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T. L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., Singh, S., Williams, C., Soplop, N., Uryu, K., Pharmer, L., King, T., Bojmar, L., Davies, A. E., Ararso, Y., Zhang, T. & 34 others, Zhang, H., Hernandez, J., Weiss, J. M., Dumont-Cole, V. D., Kramer, K., Wexler, L. H., Narendran, A., Schwartz, G. K., Healey, J. H., Sandstrom, P., Jørgen Labori, K., Kure, E. H., Grandgenett, P. M., Hollingsworth, M. A., De Sousa, M., Kaur, S., Jain, M., Mallya, K., Batra, S. K., Jarnagin, W. R., Brady, M. S., Fodstad, O., Muller, V., Pantel, K., Minn, A. J., Bissell, M. J., Garcia, B. A., Kang, Y., Rajasekhar, V. K., Ghajar, C. M., Matei, I., Peinado, H., Bromberg, J. & Lyden, D., Nov 19 2015, In : Nature. 527, 7578, p. 329-335 7 p.

Research output: Contribution to journalArticle

1489 Scopus citations
2014

Antibody labeling with radioiodine and radiometals

Gupta, S., Batra, S. K. & Jain, M., 2014, Methods in Molecular Biology. Humana Press Inc., Vol. 1141. p. 147-157 11 p. (Methods in Molecular Biology; vol. 1141).

Research output: Chapter in Book/Report/Conference proceedingChapter

Antibody labeling with radioiodine and radiometals

Gupta, S., Batra, S. & Jain, M., 2014, Drug Delivery System. Humana Press Inc., p. 147-157 11 p. (Methods in Molecular Biology; vol. 1141).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers

Macha, M. A., Seshacharyulu, P., Krishn, S. R., Pai, P., Rachagani, S., Jain, M. & Batra, S. K., 2014, In : Current Pharmaceutical Design. 20, 33, p. 5287-5297 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages

Kumar, S., Torres, M. P., Kaur, S., Rachagani, S., Joshi, S., Johansson, S. L., Momi, N., Baine, M. J., Gilling, C. E., Smith, L. M., Wyatt, T. A., Jain, M., Joshi, S. S. & Batra, S. K., Jun 9 2014, In : Oncogene. 34, 16, p. 2052-2060 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Unbiased analysis of pancreatic cancer radiation resistance reveals cholesterol biosynthesis as a novel target for radiosensitisation.

Souchek, J. J., Baine, M. J., Lin, C., Rachagani, S., Gupta, S., Kaur, S., Lester, K., Zheng, D., Chen, S., Smith, L. M., Lazenby, A. J., Johansson, S. L., Jain, M. & Batra, S. K., Sep 9 2014, In : British journal of cancer. 111, 6, p. 1139-1149 11 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Analysis of tumor-associated mucin glycotopes by western transfer methods

Gnanapragassam, V. S., Jain, M. & Batra, S. K., 2013, Pancreatic Cancer: Methods and Protocols. Humana Press Inc., p. 331-340 10 p. (Methods in Molecular Biology; vol. 980).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Emerging trends for radioimmunotherapy in solid tumors

Jain, M., Gupta, S., Kaur, S., Ponnusamy, M. P. & Batra, S. K., Nov 1 2013, In : Cancer Biotherapy and Radiopharmaceuticals. 28, 9, p. 639-650 12 p.

Research output: Contribution to journalReview article

12 Scopus citations

Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling

Macha, M. A., Rachagani, S., Gupta, S., Pai, P., Ponnusamy, M. P., Batra, S. K. & Jain, M., Dec 1 2013, In : Cancer Letters. 341, 2, p. 166-177 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells

Mukhopadhyay, P., Lakshmanan, I., Ponnusamy, M. P., Chakraborty, S., Jain, M., Pai, P., Smith, L. M., Lele, S. M. & Batra, S. K., Feb 11 2013, In : PloS one. 8, 2, e54455.

Research output: Contribution to journalArticle

41 Scopus citations

Neutrophil gelatinase-associated lipocalin, macrophage inhibitory cytokine 1, and carbohydrate antigen 19-9 in pancreatic juice: Pathobiologic implications in diagnosing benign and malignant disease of the pancreas

Kaur, S., Baine, M. J., Guha, S., Ochi, N., Chakraborty, S., Mallya, K., Thomas, C., Crook, J., Wallace, M. B., Woodward, T. A., Jain, M., Singh, S., Sasson, A. R., Skinner, V., Raimondo, M. & Batra, S. K., Apr 2013, In : Pancreas. 42, 3, p. 494-501 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pathobiological implications of MUC4 in non-small-cell lung cancer

Majhi, P. D., Lakshmanan, I., Ponnusamy, M. P., Jain, M., Das, S., Kaur, S., Shimizu, S. T., West, W. W., Johansson, S. L., Smith, L. M., Yu, F., Rolle, C. E., Sharma, P., Carey, G. B., Batra, S. K. & Ganti, A. K., Apr 2013, In : Journal of Thoracic Oncology. 8, 4, p. 398-407 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Potentials of Plasma NGAL and MIC-1 as Biomarker(s) in the Diagnosis of Lethal Pancreatic Cancer

Kaur, S., Chakraborty, S., Baine, M. J., Mallya, K., Smith, L. M., Sasson, A., Brand, R., Guha, S., Jain, M., Wittel, U., Singh, S. K. & Batra, S. K., Feb 1 2013, In : PloS one. 8, 2, e55171.

Research output: Contribution to journalArticle

37 Scopus citations
2012

Early diagnosis of pancreatic cancer: Challenges and new developments

Kaur, S., Baine, M. J., Jain, M., Sasson, A. R. & Batra, S. K., Oct 2012, In : Biomarkers in Medicine. 6, 5, p. 597-612 16 p.

Research output: Contribution to journalReview article

99 Scopus citations
49 Scopus citations

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: Potential implications for diagnosis and therapy

Rachagani, S., Torres, M. P., Kumar, S., Haridas, D., Baine, M., Macha, M. A., Kaur, S., Ponnusamy, M. P., Dey, P., Seshacharyulu, P., Johansson, S. L., Jain, M., Wagner, K. U. & Batra, S. K., 2012, In : Journal of Hematology and Oncology. 5, 68.

Research output: Contribution to journalArticle

40 Scopus citations