Maneesh Jain, PhD

  • 5210 Citations
  • 30 h-Index
20012020

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Article
2020

A phase I study of weekly doxorubicin and oral topotecan for patients with relapsed or refractory small cell lung cancer (SCLC): A Fred and Pamela Buffet Cancer Center Clinical Trials Network study

Ernani, V., Jahan, R., Smith, L. M., Marr, A. S., Kimbrough, S. E., Kos, M. E., Tijerina, J., Pivovar, S., Lakshmanan, I., Ketcham, M., Rauth, S., Mallya, K., Nasser, M. W., Jain, M., Kessinger, A., Batra, S. K. & Ganti, A. K., 2020, In : Cancer Treatment and Research Communications. 22, 100162.

Research output: Contribution to journalArticle

Open Access

CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Awaji, M., Saxena, S., Wu, L., Prajapati, D. R., Purohit, A., Varney, M. L., Kumar, S., Rachagani, S., Ly, Q. P., Jain, M., Batra, S. K. & Singh, R. K., Jul 1 2020, In : FASEB Journal. 34, 7, p. 9405-9418 14 p.

Research output: Contribution to journalArticle

Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer

Gupta, S., Prajapati, A., Gulati, M., Gautam, S. K., Kumar, S., Dalal, V., Talmon, G. A., Rachagani, S. & Jain, M., Feb 2020, In : Neoplasia (United States). 22, 2, p. 98-110 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells

Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., 2019, In : Genes and Cancer. 10, 3-4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer

Carmicheal, J., Hayashi, C., Huang, X., Liu, L., Lu, Y., Krasnoslobodtsev, A., Lushnikov, A., Kshirsagar, P. G., Patel, A., Jain, M., Lyubchenko, Y. L., Lu, Y., Batra, S. K. & Kaur, S., Feb 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 88-96 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2018

Desmoplasia in pancreatic ductal adenocarcinoma: Insight into pathological function and therapeutic potential

Cannon, A., Thompson, C., Hall, B. R., Jain, M., Kumar, S. & Batra, S. K., Mar 2018, In : Genes and Cancer. 9, 3-4, p. 78-86 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

Aithal, A., Junker, W. M., Kshirsagar, P., Das, S., Kaur, S., Orzechowski, C., Gautam, S. K., Jahan, R., Sheinin, Y. M., Lakshmanan, I., Ponnusamy, M. P., Batra, S. K. & Jain, M., Apr 2018, In : PloS one. 13, 4, e0193907.

Research output: Contribution to journalArticle

3 Scopus citations
2017

A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study

Kaur, S., Smith, L. M., Patel, A., Menning, M., Watley, D. C., Malik, S. S., Krishn, S. R., Mallya, K., Aithal, A., Sasson, A. R., Johansson, S. L., Jain, M., Singh, S., Guha, S., Are, C., Raimondo, M., Hollingsworth, M. A., Brand, R. E. & Batra, S. K., Jan 1 2017, In : American Journal of Gastroenterology. 112, 1, p. 172-183 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

Macha, M. A., Rachagani, S., Qazi, A. K., Jahan, R., Gupta, S., Patel, A. A., Seshacharyulu, P., Lin, C., Li, S., Wang, S., Verma, V., Kishida, S., Kishida, M., Nakamura, N., Kibe, T., Lydiatt, W. M., Smith, R. B., Ganti, A. K., Jones, D. T., Batra, S. K. & 1 others, Jain, M., 2017, In : Oncotarget. 8, 13, p. 20961-20973 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: Clinical implication for improved colon surveillance

Krishn, S. R., Kaur, S., Sheinin, Y. M., Smith, L. M., Gautam, S. K., Patel, A., Jain, M., Juvvigunta, V., Pai, P., Lazenby, A. J., Roy, H. K. & Batra, S. K., 2017, In : Oncotarget. 8, 4, p. 7025-7038 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

Krishn, S. R., Kaur, S., Smith, L. M., Johansson, S. L., Jain, M., Patel, A., Gautam, S. K., Hollingsworth, M. A., Mandel, U., Clausen, H., Lo, W. C., Fan, W. T. L., Manne, U. & Batra, S. K., May 1 2016, In : Cancer Letters. 374, 2, p. 304-314 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

Wang, Y., Kumar, S., Rachagani, S., Sajja, B. R., Xie, Y., Hang, Y., Jain, M., Li, J., Boska, M. D., Batra, S. K. & Oupický, D., Sep 1 2016, In : Biomaterials. 101, p. 108-120 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway

Macha, M. A., Rachagani, S., Pai, P., Gupta, S., Lydiatt, W. M., Smith, R. B., Johansson, S. L., Lele, S. M., Kakar, S. S., Lee, J. H., Meza, J., Ganti, A. K., Jain, M. & Batra, S. K., Mar 26 2015, In : Oncogene. 34, 13, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mucin Expression in Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimens Is a Useful Prognostic Factor in Pancreatic Ductal Adenocarcinoma

Higashi, M., Yokoyama, S., Yamamoto, T., Goto, Y., Kitazono, I., Hiraki, T., Taguchi, H., Hashimoto, S., Fukukura, Y., Koriyama, C., Mataki, Y., Maemura, K., Shinchi, H., Jain, M., Batra, S. K. & Yonezawa, S., Jul 25 2015, In : Pancreas. 44, 5, p. 728-734 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nano-immunoassay with improved performance for detection of cancer biomarkers

Krasnoslobodtsev, A. V., Torres, M. P., Kaur, S., Vlassiouk, I. V., Lipert, R. J., Jain, M., Batra, S. K. & Lyubchenko, Y. L., Jan 1 2015, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 1, p. 167-173 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
14 Scopus citations

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Lakshmanan, I., Seshacharyulu, P., Haridas, D., Rachagani, S., Gupta, S., Joshi, S., Guda, C., Yan, Y., Jain, M., Ganti, A. K., Ponnusamy, M. P. & Batra, S. K., 2015, In : Oncotarget. 6, 25, p. 21085-21099 15 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., Xiang, J., Zhang, T., Theilen, T. M., García-Santos, G., Williams, C., Ararso, Y., Huang, Y., Rodrigues, G., Shen, T. L., Labori, K. J. & 17 others, Lothe, I. M. B., Kure, E. H., Hernandez, J., Doussot, A., Ebbesen, S. H., Grandgenett, P. M., Hollingsworth, M. A., Jain, M., Mallya, K., Batra, S. K., Jarnagin, W. R., Schwartz, R. E., Matei, I., Peinado, H., Stanger, B. Z., Bromberg, J. & Lyden, D., Jun 1 2015, In : Nature Cell Biology. 17, 6, p. 816-826 11 p.

Research output: Contribution to journalArticle

923 Scopus citations

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T. L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., Singh, S., Williams, C., Soplop, N., Uryu, K., Pharmer, L., King, T., Bojmar, L., Davies, A. E., Ararso, Y., Zhang, T. & 34 others, Zhang, H., Hernandez, J., Weiss, J. M., Dumont-Cole, V. D., Kramer, K., Wexler, L. H., Narendran, A., Schwartz, G. K., Healey, J. H., Sandstrom, P., Jørgen Labori, K., Kure, E. H., Grandgenett, P. M., Hollingsworth, M. A., De Sousa, M., Kaur, S., Jain, M., Mallya, K., Batra, S. K., Jarnagin, W. R., Brady, M. S., Fodstad, O., Muller, V., Pantel, K., Minn, A. J., Bissell, M. J., Garcia, B. A., Kang, Y., Rajasekhar, V. K., Ghajar, C. M., Matei, I., Peinado, H., Bromberg, J. & Lyden, D., Nov 19 2015, In : Nature. 527, 7578, p. 329-335 7 p.

Research output: Contribution to journalArticle

1489 Scopus citations
2014

MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers

Macha, M. A., Seshacharyulu, P., Krishn, S. R., Pai, P., Rachagani, S., Jain, M. & Batra, S. K., 2014, In : Current Pharmaceutical Design. 20, 33, p. 5287-5297 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages

Kumar, S., Torres, M. P., Kaur, S., Rachagani, S., Joshi, S., Johansson, S. L., Momi, N., Baine, M. J., Gilling, C. E., Smith, L. M., Wyatt, T. A., Jain, M., Joshi, S. S. & Batra, S. K., Jun 9 2014, In : Oncogene. 34, 16, p. 2052-2060 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Unbiased analysis of pancreatic cancer radiation resistance reveals cholesterol biosynthesis as a novel target for radiosensitisation.

Souchek, J. J., Baine, M. J., Lin, C., Rachagani, S., Gupta, S., Kaur, S., Lester, K., Zheng, D., Chen, S., Smith, L. M., Lazenby, A. J., Johansson, S. L., Jain, M. & Batra, S. K., Sep 9 2014, In : British journal of cancer. 111, 6, p. 1139-1149 11 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling

Macha, M. A., Rachagani, S., Gupta, S., Pai, P., Ponnusamy, M. P., Batra, S. K. & Jain, M., Dec 1 2013, In : Cancer Letters. 341, 2, p. 166-177 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells

Mukhopadhyay, P., Lakshmanan, I., Ponnusamy, M. P., Chakraborty, S., Jain, M., Pai, P., Smith, L. M., Lele, S. M. & Batra, S. K., Feb 11 2013, In : PloS one. 8, 2, e54455.

Research output: Contribution to journalArticle

41 Scopus citations

Neutrophil gelatinase-associated lipocalin, macrophage inhibitory cytokine 1, and carbohydrate antigen 19-9 in pancreatic juice: Pathobiologic implications in diagnosing benign and malignant disease of the pancreas

Kaur, S., Baine, M. J., Guha, S., Ochi, N., Chakraborty, S., Mallya, K., Thomas, C., Crook, J., Wallace, M. B., Woodward, T. A., Jain, M., Singh, S., Sasson, A. R., Skinner, V., Raimondo, M. & Batra, S. K., Apr 2013, In : Pancreas. 42, 3, p. 494-501 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pathobiological implications of MUC4 in non-small-cell lung cancer

Majhi, P. D., Lakshmanan, I., Ponnusamy, M. P., Jain, M., Das, S., Kaur, S., Shimizu, S. T., West, W. W., Johansson, S. L., Smith, L. M., Yu, F., Rolle, C. E., Sharma, P., Carey, G. B., Batra, S. K. & Ganti, A. K., Apr 2013, In : Journal of Thoracic Oncology. 8, 4, p. 398-407 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Potentials of Plasma NGAL and MIC-1 as Biomarker(s) in the Diagnosis of Lethal Pancreatic Cancer

Kaur, S., Chakraborty, S., Baine, M. J., Mallya, K., Smith, L. M., Sasson, A., Brand, R., Guha, S., Jain, M., Wittel, U., Singh, S. K. & Batra, S. K., Feb 1 2013, In : PloS one. 8, 2, e55171.

Research output: Contribution to journalArticle

37 Scopus citations
2012
49 Scopus citations

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: Potential implications for diagnosis and therapy

Rachagani, S., Torres, M. P., Kumar, S., Haridas, D., Baine, M., Macha, M. A., Kaur, S., Ponnusamy, M. P., Dey, P., Seshacharyulu, P., Johansson, S. L., Jain, M., Wagner, K. U. & Batra, S. K., 2012, In : Journal of Hematology and Oncology. 5, 68.

Research output: Contribution to journalArticle

40 Scopus citations
2011
54 Scopus citations

Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering

Wang, G., Lipert, R. J., Jain, M., Kaur, S., Chakraboty, S., Torres, M. P., Batra, S. K., Brand, R. E. & Porter, M. D., Apr 1 2011, In : Analytical chemistry. 83, 7, p. 2554-2561 8 p.

Research output: Contribution to journalArticle

156 Scopus citations

Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer

Jain, M., Venkatraman, G., Moniaux, N., Kaur, S., Kumar, S., Chakraborty, S., Varshney, G. C. & Batra, S. K., Aug 23 2011, In : PloS one. 6, 8, e23344.

Research output: Contribution to journalArticle

11 Scopus citations
2010

MUC4 mucin-induced epithelial to mesenchymal transition: A novel mechanism for metastasis of human ovarian cancer cells

Ponnusamy, M. P., Lakshmanan, I., Jain, M., Das, S., Chakraborty, S., Dey, P. & Batra, S. K., Oct 21 2010, In : Oncogene. 29, 42, p. 5741-5754 14 p.

Research output: Contribution to journalArticle

111 Scopus citations
2009

Upregulation of MUC4 in cervical squamous cell carcinoma: Pathologic significance

Munro, E. G., Jain, M., Oliva, E., Kamal, N., Lele, S. M., Lynch, M. P., Guo, L., Fu, K., Sharma, P., Remmenga, S., Growdon, W. B., Davis, J. S., Rueda, B. R. & Batra, S. K., Mar 2009, In : International Journal of Gynecological Pathology. 28, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2008
76 Scopus citations

Early diagnosis of pancreatic cancer: Neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia

Moniaux, N., Chakraborty, S., Yalniz, M., Gonzalez, J., Shostrom, V. K., Standop, J., Lele, S. M., Ouellette, M., Pour, P. M., Sasson, A. R., Brand, R. E., Hollingsworth, M. A., Jain, M. & Batra, S. K., May 6 2008, In : British journal of cancer. 98, 9, p. 1540-1547 8 p.

Research output: Contribution to journalArticle

120 Scopus citations

MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells

Ponnusamy, M. P., Singh, A. P., Jain, M., Chakraborty, S., Moniaux, N. & Batra, S. K., Aug 5 2008, In : British journal of cancer. 99, 3, p. 520-526 7 p.

Research output: Contribution to journalArticle

55 Scopus citations
2007

Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis

Ponnusamy, M. P., Venkatraman, G., Singh, A. P., Chauhan, S. C., Johansson, S. L., Jain, M., Smith, L., Davis, J. S., Remmenga, S. W. & Batra, S. K., Jun 28 2007, In : Cancer Letters. 251, 2, p. 247-257 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2006

Aberrant expression of MUC4 in ovarian carcinoma: Diagnostic significance alone and in combination with MUC1 and MUC16 (CA125)

Chauhan, S. C., Singh, A. P., Ruiz, F., Johansson, S. L., Jain, M., Smith, L. M., Moniaux, N. & Batra, S. K., Oct 21 2006, In : Modern Pathology. 19, 10, p. 1386-1394 9 p.

Research output: Contribution to journalArticle

101 Scopus citations
2005

Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of the monoclonal antibody CC49

Wittel, U. A., Jain, M., Goel, A., Baranowska-Kortylewicz, J., Kurizaki, T., Chauhan, S. C., Agrawal, D. K., Colcher, D. & Batra, S. K., Apr 1 2005, In : Biochemical and Biophysical Research Communications. 329, 1, p. 168-176 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Penetratin improves tumor retention of single-chain antibodies: A novel step toward optimization of radioimmunotherapy of solid tumors

Jain, M., Chauhan, S. C., Singh, A. P., Venkatraman, G., Colcher, D. & Batra, S. K., Sep 1 2005, In : Cancer Research. 65, 17, p. 7840-7846 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Pharmacokinetics and biodistribution of 177Lu-labeled multivalent single-chain Fv construct of the pancarcinoma monoclonal antibody CC49

Chauhan, S. C., Jain, M., Moore, E. D., Wittel, U. A., Li, J., Gwilt, P. R., Colcher, D. & Batra, S. K., Mar 2005, In : European Journal of Nuclear Medicine and Molecular Imaging. 32, 3, p. 264-273 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs

Wittel, U. A., Jain, M., Goel, A., Chauhan, S. C., Colcher, D. & Batra, S. K., Feb 2005, In : Nuclear Medicine and Biology. 32, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

33 Scopus citations
2004

Generation and Characterization of Anti-MUC4 Monoclonal Antibodies Reactive with Normal and Cancer Cells in Humans

Moniaux, N., Varshney, G. C., Chauhan, S. C., Copin, M. C., Jain, M., Wittel, U. A., Andrianifahanana, M., Aubert, J. P. & Batra, S. K., Feb 2004, In : Journal of Histochemistry and Cytochemistry. 52, 2, p. 253-261 9 p.

Research output: Contribution to journalArticle

Open Access
68 Scopus citations