Mark A Wilson

  • 3487 Citations
  • 22 h-Index
1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020
Open Access

Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli

Patterson, J. A., He, H., Folz, J. S., Li, Q., Wilson, M. A., Fiehn, O., Bruner, S. D., Bar-Even, A. & Hanson, A. D., May 15 2020, In : The Biochemical journal. 477, 9, p. 1745-1757 13 p.

Research output: Contribution to journalArticle

Open Access
2019

Engineering and characterization of hybrid carboxylic acid reductases

Kramer, L., Le, X., Hankore, E. D., Wilson, M. A., Guo, J. & Niu, W., Oct 10 2019, In : Journal of Biotechnology. 304, p. 52-56 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Methylation deficiency of chromatin proteins is a non-mutational and epigenetic-like trait in evolved lines of the archaeon Sulfolobus solfataricus

Johnson, T., Payne, S., Grove, R., McCarthy, S., Oeltjen, E., Mach, C., Adamec, J., Wilson, M. A., Cott, K. V. & Blum, P., May 10 2019, In : Journal of Biological Chemistry. 294, 19, p. 7821-7832 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis

Dasgupta, M., Budday, D., de Oliveira, S. H. P., Madzelan, P., Marchany-Rivera, D., Seravalli, J., Hayes, B., Sierra, R. G., Boutet, S., Hunter, M. S., Alonso-Mori, R., Batyuk, A., Wierman, J., Lyubimov, A., Brewster, A. S., Sauter, N. K., Applegate, G. A., Tiwari, V. K., Berkowitz, D. B., Thompson, M. C. & 5 others, Cohen, A. E., Fraser, J. S., Wall, M. E., van den Bedem, H. & Wilson, M. A., Dec 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 25634-25640 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Shining light on cysteine modification: connecting protein conformational dynamics to catalysis and regulation

Van Den Bedem, H. & Wilson, M. A., Jul 1 2019, In : Journal of Synchrotron Radiation. 26, p. 958-966 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells

Bahmed, K., Boukhenouna, S., Karim, L., Andrews, T., Lin, J., Powers, R., Wilson, M. A., Lin, C. R., Messier, E., Reisdorph, N., Powell, R. L., Tang, H. Y., Mason, R. J., Criner, G. J. & Kosmider, B., Sep 1 2019, In : Cell Death and Disease. 10, 9, 638.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema

Lin, C. R., Bahmed, K., Tomar, D., Marchetti, N., Criner, G. J., Bolla, S., Wilson, M. A., Madesh, M. & Kosmider, B., 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 6, p. L791-L804

Research output: Contribution to journalArticle

2018

15N CEST data and traditional model-free analysis capture fast internal dynamics of DJ-1

Catazaro, J., Andrews, T., Milkovic, N. M., Lin, J., Lowe, A. J., Wilson, M. A. & Powers, R., Feb 1 2018, In : Analytical Biochemistry. 542, p. 24-28 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Characterization of a recurrent missense mutation in the forkhead DNA-binding domain of FOXP1

Johnson, T. B., Mechels, K., Anderson, R. E., Cain, J. T., Sturdevant, D. A., Braddock, S., Pinz, H., Wilson, M. A., Landsverk, M., Roux, K. J. & Weimer, J. M., Dec 1 2018, In : Scientific reports. 8, 1, 16161.

Research output: Contribution to journalArticle

The peroxidative cleavage of kaempferol contributes to the biosynthesis of the benzenoid moiety of ubiquinone in plants

Soubeyrand, E., Johnson, T. S., Latimer, S., Block, A., Kim, J., Colquhoun, T. A., Butelli, E., Martin, C., Wilson, M. A. & Basseta, G. J., Dec 2018, In : Plant Cell. 30, 12, p. 2910-2921 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Short carboxylic acid-carboxylate hydrogen bonds can have fully localized protons

Lin, J., Pozharski, E. & Wilson, M. A., 2017, In : Biochemistry. 56, 2, p. 391-402 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Toxoplasma DJ-1 regulates organelle secretion by a direct interaction with calcium-dependent protein kinase 1

Child, M. A., Garland, M., Foe, I., Madzelan, P., Treeck, M., Van Der Linden, W. A., Bender, K. O., Weerapana, E., Wilson, M. A., Boothroyd, J. C., Reese, M. L. & Bogyo, M., Jan 1 2017, In : mBio. 8, 1, e02189-16.

Research output: Contribution to journalArticle

6 Scopus citations

Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design

Hu, D., Bowder, D., Wei, W., Thompson, J., Wilson, M. A. & Xiang, S. H., May 25 2017, In : Vaccine. 35, 23, p. 3067-3075 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca2+-calmodulin

Lin, J., van den Bedem, H., Brunger, A. T. & Wilson, M. A., 2016, In : Acta Crystallographica Section D: Structural Biology. 72, 1, p. 83-92 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease

Johnson, W. M., Golczak, M., Choe, K., Curran, P. L., Miller, O. G., Yao, C., Wang, W., Lin, J., Milkovic, N. M., Ray, A., Ravindranath, V., Zhu, X., Wilson, M. A., Wilson-Delfosse, A. L., Chen, S. G. & Mieyal, J. J., Aug 16 2016, In : Biochemistry. 55, 32, p. 4519-4532 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Some of the most interesting CASP11 targets through the eyes of their authors

Kryshtafovych, A., Moult, J., Baslé, A., Burgin, A., Craig, T. K., Edwards, R. A., Fass, D., Hartmann, M. D., Korycinski, M., Lewis, R. J., Lorimer, D., Lupas, A. N., Newman, J., Peat, T. S., Piepenbrink, K. H., Prahlad, J., van Raaij, M. J., Rohwer, F., Segall, A. M., Seguritan, V. & 4 others, Sundberg, E. J., Singh, A. K., Wilson, M. A. & Schwede, T., Sep 1 2016, In : Proteins. 84, p. 34-50 17 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

A Chemical Approach for the Detection of Protein Sulfinylation

Lo Conte, M., Lin, J., Wilson, M. A. & Carroll, K. S., Aug 21 2015, In : ACS chemical biology. 10, 8, p. 1825-1830 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature

Milkovic, N. M., Catazaro, J., Lin, J., Halouska, S., Kizziah, J. L., Basiaga, S., Cerny, R. L., Powers, R. & Wilson, M. A., Oct 1 2015, In : Protein Science. 24, 10, p. 1671-1685 15 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014
44 Scopus citations

Crystal cryocooling distorts conformational heterogeneity in a model michaelis complex of DHFR

Keedy, D. A., Van Den Bedem, H., Sivak, D. A., Petsko, G. A., Ringe, D., Wilson, M. A. & Fraser, J. S., Jun 10 2014, In : Structure. 22, 6, p. 899-910 12 p.

Research output: Contribution to journalArticle

57 Scopus citations

Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+

Wan, Q., Kovalevsky, A. Y., Wilson, M. A., Bennett, B. C., Langan, P. & Dealwis, C., Jun 2014, In : Acta Crystallographica Section F:Structural Biology Communications. 70, 6, p. 814-818 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography

Wan, Q., Bennett, B. C., Wilson, M. A., Kovalevsky, A., Langan, P., Howell, E. E. & Dealwis, C., Dec 23 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 51, p. 18225-18230 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers

Prahlad, J., Hauser, D. N., Milkovic, N. M., Cookson, M. R. & Wilson, M. A., Sep 1 2014, In : Journal of Neurochemistry. 130, 6, p. 839-853 15 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Functional convergence of structurally distinct thioesterases from cyanobacteria and plants involved in phylloquinone biosynthesis

Furt, F., Allen, W. J., Widhalm, J. R., Madzelan, P., Rizzo, R. C., Basset, G. & Wilson, M. A., Oct 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 10, p. 1876-1888 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

O-demethylations catalyzed by rieske nonheme iron monooxygenases involve the difficult oxidation of a saturated C-H bond

Jiang, W., Wilson, M. A. & Weeks, D. P., Aug 16 2013, In : ACS chemical biology. 8, 8, p. 1687-1691 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1

Lin, J., Prahlad, J. & Wilson, M. A., May 8 2012, In : Biochemistry. 51, 18, p. 3799-3807 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Influence of peptide dipoles and hydrogen bonds on reactive cysteine pKa values in fission yeast DJ-1

Madzelan, P., Labunska, T. & Wilson, M. A., Nov 2012, In : FEBS Journal. 279, 22, p. 4111-4120 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011

A plant DJ-1 homolog is essential for Arabidopsis thaliana chloroplast development

Lin, J., Nazarenus, T. J., Frey, J. L., Liang, X., Wilson, M. A. & Stone, J. M., Aug 23 2011, In : PloS one. 6, 8, e23731.

Research output: Contribution to journalArticle

17 Scopus citations
5 Scopus citations

The role of cysteine oxidation in DJ-1 function and dysfunction

Wilson, M. A., Jul 1 2011, In : Antioxidants and Redox Signaling. 15, 1, p. 111-122 12 p.

Research output: Contribution to journalArticle

185 Scopus citations
2010

Evolution of new enzymatic function by structural modulation of cysteine reactivity in Pseudomonas fluorescens isocyanide hydratase

Lakshminarasimhan, M., Madzelan, P., Nan, R., Milkovic, N. M. & Wilson, M. A., Sep 17 2010, In : Journal of Biological Chemistry. 285, 38, p. 29651-29661 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
2009

Crystal Structure of Dicamba Monooxygenase: A Rieske Nonheme Oxygenase that Catalyzes Oxidative Demethylation

Dumitru, R., Jiang, W. Z., Weeks, D. P. & Wilson, M. A., Sep 18 2009, In : Journal of Molecular Biology. 392, 2, p. 498-510 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1

Blackinton, J., Lakshminarasimhan, M., Thomas, K. J., Ahmad, R., Greggio, E., Raza, A. S., Cookson, M. R. & Wilson, M. A., Mar 6 2009, In : Journal of Biological Chemistry. 284, 10, p. 6476-6485 10 p.

Research output: Contribution to journalArticle

188 Scopus citations
2008

Cysteine pKa depression by a protonated glutamic acid in human DJ-1

Witt, A. C., Lakshminarasimhan, M., Remington, B. C., Hasim, S., Pozharski, E. & Wilson, M. A., Jul 15 2008, In : Biochemistry. 47, 28, p. 7430-7440 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Structural impact of three Parkinsonism-associated missense mutations on human DJ-1

Lakshminarasimhan, M., Maldonado, M. T., Zhou, W., Fink, A. L. & Wilson, M. A., Feb 5 2008, In : Biochemistry. 47, 5, p. 1381-1392 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
2007

Identification of functional subclasses in the DJ-1 superfamily proteins

Wei, Y., Ringe, D., Wilson, M. A. & Ondrechen, M. J., Jan 2007, In : PLoS computational biology. 3, 1, p. 120-126 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Intrinsic motions along an enzymatic reaction trajectory

Henzler-Wildman, K. A., Thai, V., Lei, M., Ott, M., Wolf-Watz, M., Fenn, T., Pozharski, E., Wilson, M. A., Petsko, G. A., Karplus, M., Hübner, C. G. & Kern, D., Dec 6 2007, In : Nature. 450, 7171, p. 838-844 7 p.

Research output: Contribution to journalArticle

625 Scopus citations
2006

The oxidation state of DJ-1 regulates its chaperone activity toward α-synuclein

Zhou, W., Zhu, M., Wilson, M. A., Petsko, G. A. & Fink, A. L., Mar 3 2006, In : Journal of Molecular Biology. 356, 4, p. 1036-1048 13 p.

Research output: Contribution to journalArticle

274 Scopus citations
2005
51 Scopus citations
2004

Anchoring a Cationic Ligand: The Structure of the Fab Fragment of the Anti-morphine Antibody 9B1 and its Complex with Morphine

Pozharski, E., Wilson, M. A., Hewagama, A., Shanafelt, A. B., Petsko, G. & Ringe, D., Mar 26 2004, In : Journal of Molecular Biology. 337, 3, p. 691-697 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

The 1.8-Å resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamily

Wilson, M. A., St. Amour, C. V., Collins, J. L., Ringe, D. & Petsko, G. A., Feb 10 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 6, p. 1531-1536 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

The Parkinson's disease DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

Canet-Avilés, R. M., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A. & Cookson, M. R., Jun 15 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 24, p. 9103-9108 6 p.

Research output: Contribution to journalArticle

797 Scopus citations
2003

2.4 Å resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor

Holyoak, T., Wilson, M. A., Fenn, T. D., Kettner, C. A., Petsko, G. A., Fuller, R. S. & Ringe, D., Jun 10 2003, In : Biochemistry. 42, 22, p. 6709-6718 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

Domain flexibility in the 1.75 Å resolution structure of Pb 2+-calmodulin

Wilson, M. A. & Brunger, A. T., Oct 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 10, p. 1782-1792 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Malonate: A versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals

Holyoak, T., Fenn, T. D., Wilson, M. A., Moulin, A. G., Ringe, D. & Petsko, G. A., Dec 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 12, p. 2356-2358 3 p.

Research output: Contribution to journalArticle

45 Scopus citations

The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

Wilson, M. A., Collins, J. L., Hod, Y., Ringe, D. & Petsko, G. A., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9256-9261 6 p.

Research output: Contribution to journalArticle

231 Scopus citations
2000
259 Scopus citations