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Matrix metalloproteinase roles in cardiac remodeling Macrophage, neutrophil, and fibroblast polarization after myocardial infarction

  • 8302 Citations
  • 49 h-Index
19972020

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2020

Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI

Daseke, M. J., Tenkorang, M. A. A., Chalise, U., Konfrst, S. R. & Lindsey, M. L., 2020, (Accepted/In press) In : Matrix Biology.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction

Daseke, M. J., Tenkorang-Impraim, M. A. A., Ma, Y., Chalise, U., Konfrst, S. R., Garrett, M. R., DeLeon-Pennell, K. Y. & Lindsey, M. L., Aug 2020, In : Journal of Molecular and Cellular Cardiology. 145, p. 112-121 10 p.

Research output: Contribution to journalArticle

Open Access

Loss of ARHGEF11 in the Dahl salt-sensitive rat protects against hypertension-induced renal injury

Johnson, A. C., Wu, W., Attipoe, E. M., Sasser, J. M., Taylor, E. B., Showmaker, K. C., Kyle, P. B., Lindsey, M. L. & Garrett, M. R., Apr 1 2020, In : Hypertension. p. 1012-1024 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

The compendium of matrix metalloproteinase expression in the left ventricle of mice following myocardial infarction

Kaminski, A. R., Moore, E. T., Daseke, M. J., Valerio, F. M., Flynn, E. R. & Lindsey, M. L., Mar 1 2020, In : American journal of physiology. Heart and circulatory physiology. 318, 3, p. H706-H714

Research output: Contribution to journalArticle

2019

Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality

Lindsey, M. L., Jung, M., Yabluchanskiy, A., Cannon, P. L., Iyer, R. P., Flynn, E. R., Deleon-Pennell, K. Y., Valerio, F. M., Harrison, C. L., Ripplinger, C. M., Hall, M. E. & Ma, Y., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 395-408 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis

Mouton, A. J., Ma, Y., Rivera Gonzalez, O. J., Daseke, M. J., Flynn, E. R., Freeman, T. C., Garrett, M. R., DeLeon-Pennell, K. Y. & Lindsey, M. L., Mar 1 2019, In : Basic research in cardiology. 114, 2, 6.

Research output: Contribution to journalArticle

22 Scopus citations

Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure

Deleon-Pennell, K. Y., Ero, O. K., Ma, Y., Padmanabhan Iyer, R., Flynn, E. R., Espinoza, I., Musani, S. K., Vasan, R. S., Hall, M. E., Fox, E. R. & Lindsey, M. L., Jan 15 2019, In : ACS Omega. 4, 1, p. 1272-1280 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identifying the molecular and cellular signature of cardiac dilation following myocardial infarction

Lindsey, M. L., Ma, Y., Flynn, E. R., Winniford, M. D., Hall, M. E. & DeLeon-Pennell, K. Y., Jul 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 7, p. 1845-1852 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

RELISH Consortium, 2019, In : Database. 2019, p. 1-67 67 p.

Research output: Contribution to journalArticle

Open Access

Menopause and foxp3 treg cell depletion eliminate female protection against t cell-mediated angiotensin ii hypertension

Pollow, D. P., Uhlorn, J. A., Sylvester, M. A., Romero-Aleshire, M. J., Uhrlaub, J. L., Lindsey, M. L., Nikolich-Zugich, J. & Brooks, H. L., Aug 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 2, p. H415-H423

Research output: Contribution to journalArticle

6 Scopus citations

Neutrophil proteome shifts over the myocardial infarction time continuum

Daseke, M. J., Valerio, F. M., Kalusche, W. J., Ma, Y., DeLeon-Pennell, K. Y. & Lindsey, M. L., Sep 1 2019, In : Basic research in cardiology. 114, 5, 37.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2018

Extracellular matrix in cardiovascular pathophysiology

Bloksgaard, M., Lindsey, M. & Martinez-Lemus, L. A., Dec 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 6, p. H1687-H1690

Research output: Contribution to journalArticle

2 Scopus citations

LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling

DeLeon-Pennell, K. Y., Mouton, A. J., Ero, O. K., Ma, Y., Padmanabhan Iyer, R., Flynn, E. R., Espinoza, I., Musani, S. K., Vasan, R. S., Hall, M. E., Fox, E. R. & Lindsey, M. L., Sep 1 2018, In : Basic research in cardiology. 113, 5, 40.

Research output: Contribution to journalArticle

41 Scopus citations

Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction

Meschiari, C. A., Jung, M., Iyer, R. P., Yabluchanskiy, A., Toba, H., Garrett, M. R. & Lindsey, M. L., Feb 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 2, p. H224-H235

Research output: Contribution to journalArticle

19 Scopus citations

Mapping macrophage polarization over the myocardial infarction time continuum

Mouton, A. J., DeLeon-Pennell, K. Y., Rivera Gonzalez, O. J., Flynn, E. R., Freeman, T. C., Saucerman, J. J., Garrett, M. R., Ma, Y., Harmancey, R. & Lindsey, M. L., Jul 1 2018, In : Basic research in cardiology. 113, 4, 26.

Research output: Contribution to journalArticle

47 Scopus citations

The mouse heart attack research tool 1.0 database

Deleon-Pennell, K. Y., Iyer, R. P., Ma, Y., Yabluchanskiy, A., Zamilpa, R., Chiao, Y. A., Cannon, P. L., Kaplan, A., Cates, C. A., Flynn, E. R., Halade, G. V., de Castro Brás, L. E. & Lindsey, M. L., Sep 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 3, p. H522-H530

Research output: Contribution to journalArticle

4 Scopus citations
2017

Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction

De Jesus, N. M., Wang, L., Lai, J., Rigor, R. R., Francis Stuart, S. D., Bers, D. M., Lindsey, M. L. & Ripplinger, C. M., May 2017, In : Heart Rhythm. 14, 5, p. 727-736 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Dentin sialoprotein is a novel substrate of matrix metalloproteinase 9 in vitro and in vivo

Yuan, G., Chen, L., Feng, J., Yang, G., Ni, Q., Xu, X., Wan, C., Lindsey, M., Donly, K. J., MacDougall, M., Chen, Z. & Chen, S., Feb 14 2017, In : Scientific reports. 7, 42449.

Research output: Contribution to journalArticle

4 Scopus citations

Elevated serum osteoprotegerin is associated with increased left ventricular mass index and myocardial stiffness

Kamimura, D., Suzuki, T., Furniss, A. L., Griswold, M. E., Kullo, I. J., Lindsey, M. L., Winniford, M. D., Butler, K. R., Mosley, T. H. & Hall, M. E., Dec 1 2017, In : Journal of Cardiovascular Medicine. 18, 12, p. 954-961 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Glucose regulates the intrinsic inflammatory response of the heart to surgically induced hypothermic ischemic arrest and reperfusion

Bux, A. S., Lindsey, M. L., Vasquez, H. G., Taegtmeyer, H. & Harmancey, R., Jan 1 2017, In : Physiological genomics. 49, 1, p. 37-52 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation

Jung, M., Ma, Y., Iyer, R. P., DeLeon-Pennell, K. Y., Yabluchanskiy, A., Garrett, M. R. & Lindsey, M. L., May 1 2017, In : Basic research in cardiology. 112, 3, 33.

Research output: Contribution to journalArticle

72 Scopus citations

Periodontal-induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast-mediated cardiac wound healing

DeLeon-Pennell, K. Y., Iyer, R. P., Ero, O. K., Cates, C. A., Flynn, E. R., Cannon, P. L., Jung, M., Shannon, DA., Garrett, M. R., Buchanan, W., Hall, M. E., Ma, Y. & Lindsey, M. L., Sep 21 2017, In : JCI insight. 2, 18

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis

Toba, H., Cannon, P. L., Yabluchanskiy, A., Iyer, R. P., D’Armiento, J. & Lindsey, M. L., Mar 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 3, p. H375-H383

Research output: Contribution to journalArticle

22 Scopus citations
2016

CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal during Cardiac Remodeling

Deleon-Pennell, K. Y., Tian, Y., Zhang, B., Cates, C. A., Iyer, R. P., Cannon, P., Shah, P., Aiyetan, P., Halade, G. V., Ma, Y., Flynn, E., Zhang, Z., Jin, Y. F., Zhang, H. & Lindsey, M. L., Feb 1 2016, In : Circulation: Cardiovascular Genetics. 9, 1, p. 14-25 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Defining the sham environment for post-myocardial infarction studies in mice

Iyer, R. P., de Castro Brás, L. E., Cannon, P. L., Ma, Y., DeLeon-Pennell, K. Y., Jung, M., Flynn, E. R., Henry, J. B., Bratton, D. R., White, J. A., Fulton, L. K., Grady, A. W. & Lindsey, M. L., Sep 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 3, p. H822-H836

Research output: Contribution to journalArticle

15 Scopus citations

Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution

Iyer, R. P., de Castro Brás, L. E., Patterson, N. L., Bhowmick, M., Flynn, E. R., Asher, M., Cannon, P. L., Deleon-Pennell, K. Y., Fields, G. B. & Lindsey, M. L., Nov 1 2016, In : Journal of Molecular and Cellular Cardiology. 100, p. 109-117 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium

Toba, H., de Castro Brás, L. E., Baicu, C. F., Zile, M. R., Lindsey, M. L. & Bradshaw, A. D., Jun 1 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 310, 11, p. E1027-E1035

Research output: Contribution to journalArticle

22 Scopus citations

Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction

Lindsey, M. L., Saucerman, J. J. & DeLeon-Pennell, K. Y., Dec 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 12, p. 2288-2292 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Myocardial infarction superimposed on aging: MMP-9 deletion promotes M2 macrophage polarization

Yabluchanskiy, A., Ma, Y., Deleon-Pennell, K. Y., Altara, R., Halade, G. V., Voorhees, A. P., Nguyen, N. T., Jin, Y. F., Winniford, M. D., Hall, M. E., Han, H. C. & Lindsey, M. L., Apr 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 4, p. 475-483 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Temporal neutrophil polarization following myocardial infarction

Ma, Y., Yabluchanskiy, A., Iyer, R. P., Cannon, P. L., Flynn, E. R., Jung, M., Henry, J., Cates, C. A., Deleon-Pennell, K. Y. & Lindsey, M. L., May 1 2016, In : Cardiovascular research. 110, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

91 Scopus citations
2015

A Novel Collagen Matricryptin Reduces Left Ventricular Dilation Post-Myocardial Infarction by Promoting Scar Formation and Angiogenesis

Lindsey, M. L., Iyer, R. P., Zamilpa, R., Yabluchanskiy, A., DeLeon-Pennell, K. Y., Hall, M. E., Kaplan, A., Zouein, F. A., Bratton, D., Flynn, E. R., Cannon, P. L., Tian, Y., Jin, Y. F., Lange, R. A., Tokmina-Roszyk, D., Fields, G. B. & De Castro Brás, L. E., Sep 22 2015, In : Journal of the American College of Cardiology. 66, 12, p. 1364-1374 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation

De Jesus, N. M., Wang, L., Herren, A. W., Wang, J., Shenasa, F., Bers, D. M., Lindsey, M. L. & Ripplinger, C. M., Jan 1 2015, In : Heart Rhythm. 12, 1, p. 169-178 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Building a better infarct: Modulation of collagen cross-linking to increase infarct stiffness and reduce left ventricular dilation post-myocardial infarction

Voorhees, A. P., DeLeon-Pennell, K. Y., Ma, Y., Halade, G. V., Yabluchanskiy, A., Iyer, R. P., Flynn, E., Cates, C. A., Lindsey, M. L. & Han, H. C., Aug 1 2015, In : Journal of Molecular and Cellular Cardiology. 85, p. 229-239 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Cardiac aging: Send in the vinculin reinforcements

DeLeon-Pennell, K. Y. & Lindsey, M. L., Jun 17 2015, In : Science translational medicine. 7, 292, 292fs26.

Research output: Contribution to journalArticle

3 Scopus citations

Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence

Ma, Y., Chiao, Y. A., Clark, R., Flynn, E. R., Yabluchanskiy, A., Ghasemi, O., Zouein, F., Lindsey, M. L. & Jin, Y. F., Jun 1 2015, In : Cardiovascular research. 106, 3, p. 421-431 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution

Iyer, R. P., Patterson, N. L., Zouein, F. A., Ma, Y., Dive, V., De Castro Brás, L. E. & Lindsey, M. L., Apr 15 2015, In : International Journal of Cardiology. 185, p. 198-208 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Obesity superimposed on aging magnifies inflammation and delays the resolving response after myocardial infarction

Lopez, E. F., Kabarowski, J. H., Ingle, K. A., Kain, V., Barnes, S., Crossman, D. K., Lindsey, M. L. & Halade, G. V., 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 4, p. H269-H280

Research output: Contribution to journalArticle

51 Scopus citations

Osteopontin is proteolytically processed by matrix metalloproteinase 9

Lindsey, M. L., Zouein, F. A., Tian, Y., Iyer, R. P. & de Castro Brás, L. E., Jan 19 2015, In : Canadian journal of physiology and pharmacology. 93, 10, p. 879-886 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Plasma glycoproteomics reveals sepsis outcomes linked to distinct proteins in common pathways

De Coux, A., Tian, Y., Deleon-Pennell, K. Y., Nguyen, N. T., De Castro Brás, L. E., Flynn, E. R., Cannon, P. L., Griswold, M. E., Jin, Y. F., Puskarich, M. A., Jones, A. E. & Lindsey, M. L., Oct 1 2015, In : Critical care medicine. 43, 10, p. 2049-2058 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization

Toba, H., de Castro Brás, L. E., Baicu, C. F., Lindsey, M. L. & Bradshaw, A. D., Jun 15 2015, In : American Journal of Physiology - Cell Physiology. 308, 12, p. C972-C982

Research output: Contribution to journalArticle

19 Scopus citations

Systems analysis of gene ontology and biological pathways involved in post-myocardial infarction responses

Nguyen, N. T., Lindsey, M. L. & Jin, Y. F., Jun 11 2015, In : BMC genomics. 16, 7, S18.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Age and SPARC change the extracellular matrix composition of the left ventricle

De Castro Brás, L. E., Toba, H., Baicu, C. F., Zile, M. R., Weintraub, S. T., Lindsey, M. L. & Bradshaw, A. D., 2014, In : BioMed research international. 2014, 810562.

Research output: Contribution to journalArticle

23 Scopus citations

Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects

Ramirez, T. A., Iyer, R. P., Ghasemi, O., Lopez, E. F., Levin, D. B., Zhang, J., Zamilpa, R., Chou, Y. M., Jin, Y. F. & Lindsey, M. L., Jul 2014, In : Journal of Molecular and Cellular Cardiology. 72, p. 326-335 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

And the beat goes on: Maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat

Grimes, K. M., Reddy, A. K., Lindsey, M. L. & Buffenstein, R., 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 307, 3, p. H284-H291

Research output: Contribution to journalArticle

24 Scopus citations

Artery buckling stimulates cell proliferation and NF-κB signaling

Xiao, Y., Hayman, D., Khalafvand, S. S., Lindsey, M. L. & Han, H. C., Aug 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 307, 4, p. H542-H551

Research output: Contribution to journalArticle

9 Scopus citations

Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction

Yabluchanskiy, A., Ma, Y., Chiao, Y. A., Lopez, E. F., Voorhees, A. P., Toba, H., Hall, M. E., Han, H. C., Lindsey, M. L. & Jin, Y. F., May 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 10, p. H1398-H1407

Research output: Contribution to journalArticle

37 Scopus citations

Cardiac assessment in pediatric mice: Strain analysis as a diagnostic measurement

Andrews, T. G., Lindsey, M. L., Lange, R. A. & Aune, G. J., Mar 2014, In : Echocardiography. 31, 3, p. 375-384 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cardiac extracellular proteome profiling and membrane topology analysis using glycoproteomics

Tian, Y., Koganti, T., Yao, Z., Cannon, P., Shah, P., Pietrovito, L., Modesti, A., Aiyetan, P., Deleon-Pennell, K., Ma, Y., Halade, G. V., Hicks, C., Zhang, H. & Lindsey, M. L., Aug 2014, In : Proteomics - Clinical Applications. 8, 7-8, p. 595-602 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cardiac function of the naked mole-rat: Ecophysiological responses to working underground

Grimes, K. M., Voorhees, A., Chiao, Y. A., Han, H. C., Lindsey, M. L. & Buffenstein, R., Mar 1 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 5, p. H730-H737

Research output: Contribution to journalArticle

17 Scopus citations