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Matrix metalloproteinase roles in cardiac remodeling Macrophage, neutrophil, and fibroblast polarization after myocardial infarction

  • 8302 Citations
  • 49 h-Index
19972020

Research output per year

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Research Output

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Review article
2020

Fibroblasts: The arbiters of extracellular matrix remodeling

DeLeon-Pennell, K. Y., Barker, T. H. & Lindsey, M. L., 2020, (Accepted/In press) In : Matrix Biology.

Research output: Contribution to journalReview article

2019

Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure

Wilson, M. A., Liberzon, I., Lindsey, M. L., Lokshina, Y., Risbrough, V. B., Sah, R., Wood, S. K., Williamson, J. B. & Spinale, F. G., 2019, In : Stress. 22, 5, p. 530-547 18 p.

Research output: Contribution to journalReview article

2 Scopus citations

Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly

Toba, H. & Lindsey, M. L., Jan 2019, In : Pharmacology and Therapeutics. 193, p. 99-120 22 p.

Research output: Contribution to journalReview article

6 Scopus citations

Somewhere over the sex differences rainbow of myocardial infarction remodeling: hormones, chromosomes, inflammasome, oh my

DeLeon-Pennell, K. Y. & Lindsey, M. L., Dec 2 2019, In : Expert Review of Proteomics. 16, 11-12, p. 933-940 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology

de Boer, R. A., De Keulenaer, G., Bauersachs, J., Brutsaert, D., Cleland, J. G., Diez, J., Du, X. J., Ford, P., Heinzel, F. R., Lipson, K. E., McDonagh, T., Lopez-Andres, N., Lunde, I. G., Lyon, A. R., Pollesello, P., Prasad, S. K., Tocchetti, C. G., Mayr, M., Sluijter, J. P. G., Thum, T. & 8 others, Tschöpe, C., Zannad, F., Zimmermann, W. H., Ruschitzka, F., Filippatos, G., Lindsey, M. L., Maack, C. & Heymans, S., Mar 2019, In : European Journal of Heart Failure. 21, 3, p. 272-285 14 p.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations

Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes

Nielsen, S. H., Mouton, A. J., DeLeon-Pennell, K. Y., Genovese, F., Karsdal, M. & Lindsey, M. L., Jan 2019, In : Matrix Biology. 75-76, p. 43-57 15 p.

Research output: Contribution to journalReview article

32 Scopus citations

Understanding the mechanisms that determine extracellular matrix remodeling in the infarcted myocardium

Tenkorang, M. A. A., Chalise, U., Daseke, M. J., Konfrst, S. R. & Lindsey, M. L., Nov 14 2019, In : Biochemical Society Transactions. 47, 6, p. 1679-1687 9 p.

Research output: Contribution to journalReview article

2018

Assigning matrix metalloproteinase roles in ischaemic cardiac remodelling

Lindsey, M. L., Aug 1 2018, In : Nature Reviews Cardiology. 15, 8, p. 471-479 9 p.

Research output: Contribution to journalReview article

25 Scopus citations

Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

Ma, Y., Mouton, A. J. & Lindsey, M. L., Jan 2018, In : Translational Research. 191, p. 15-28 14 p.

Research output: Contribution to journalReview article

64 Scopus citations

Guidelines for authors and reviewers on antibody use in physiology studies

Brooks, H. L. & Lindsey, M. L., Apr 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 4, p. H724-H732

Research output: Contribution to journalReview article

32 Scopus citations

Guidelines for experimental models of myocardial ischemia and infarction

Lindsey, M. L., Bolli, R., Canty, J. M., Du, X. J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., Lefer, D. J., Liao, R., Murphy, E., Ping, P., Przyklenk, K., Recchia, F. A., Longacre, L. S., Ripplinger, C. M., Van Eyk, J. E. & Heusch, G., Apr 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 4, p. H812-H838

Research output: Contribution to journalReview article

116 Scopus citations

Guidelines for measuring cardiac physiology in mice

Lindsey, M. L., Kassiri, Z., Virag, J. A. I., De Castro Brás, L. E. & Scherrer-Crosbie, M., Apr 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 4, p. H733-H752

Research output: Contribution to journalReview article

63 Scopus citations

Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction

Mouton, A. J., Rivera Gonzalez, O. J., Kaminski, A. R., Moore, E. T. & Lindsey, M. L., Nov 2018, In : Pharmacological Research. 137, p. 252-258 7 p.

Research output: Contribution to journalReview article

2 Scopus citations

Myocardial infarction remodeling that progresses to heart failure: A signaling misunderstanding

Mouton, A. J., Rivera, O. J. & Lindsey, M. L., Jul 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 1, p. H71-H79

Research output: Contribution to journalReview article

13 Scopus citations

Physiological proteomics of heart failure

O'Reilly, J., Lindsey, M. L. & Baugh, J. A., Feb 2018, In : Current Opinion in Physiology. 1, p. 185-197 13 p.

Research output: Contribution to journalReview article

Proteomic analysis of the cardiac extracellular matrix: clinical research applications

Lindsey, M. L., Jung, M., Hall, M. E. & DeLeon-Pennell, K. Y., Feb 1 2018, In : Expert Review of Proteomics. 15, 2, p. 105-112 8 p.

Research output: Contribution to journalReview article

9 Scopus citations

Statistical considerations in reporting cardiovascular research

Lindsey, M. L., Gray, G. A., Wood, S. K. & Curran-Everett, D., Aug 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 2, p. H303-H313

Research output: Contribution to journalReview article

30 Scopus citations
2017

Cardiac Fibroblast Activation Post-Myocardial Infarction: Current Knowledge Gaps

Ma, Y., Iyer, R. P., Jung, M., Czubryt, M. P. & Lindsey, M. L., May 1 2017, In : Trends in Pharmacological Sciences. 38, 5, p. 448-458 11 p.

Research output: Contribution to journalReview article

52 Scopus citations

The impact of aging on cardiac extracellular matrix

Meschiari, C. A., Ero, O. K., Pan, H., Finkel, T. & Lindsey, M. L., Feb 1 2017, In : GeroScience. 39, 1, p. 7-18 12 p.

Research output: Contribution to journalReview article

58 Scopus citations
2016

Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction

Lindsey, M. L., Hall, M. E., Harmancey, R. & Ma, Y., Sep 15 2016, In : Clinical Proteomics. 13, 1, 19.

Research output: Contribution to journalReview article

15 Scopus citations

Crossing into the Next Frontier of Cardiac Extracellular Matrix Research

Spinale, F. G., Frangogiannis, N. G., Hinz, B., Holmes, J. W., Kassiri, Z. & Lindsey, M. L., Oct 28 2016, In : Circulation Research. 119, 10, p. 1040-1045 6 p.

Research output: Contribution to journalReview article

27 Scopus citations

Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling

Lindsey, M. L., Iyer, R. P., Jung, M., DeLeon-Pennell, K. Y. & Ma, Y., Feb 1 2016, In : Journal of Molecular and Cellular Cardiology. 91, p. 134-140 7 p.

Research output: Contribution to journalReview article

48 Scopus citations

MMP-9 signaling in the left ventricle following myocardial infarction

Iyer, R. P., Jung, M. & Lindsey, M. L., Jul 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 1, p. H190-H198

Research output: Contribution to journalReview article

35 Scopus citations

The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction

Francis Stuart, S. D., De Jesus, N. M., Lindsey, M. L. & Ripplinger, C. M., Feb 1 2016, In : Journal of Molecular and Cellular Cardiology. 91, p. 114-122 9 p.

Research output: Contribution to journalReview article

83 Scopus citations
2015

Harnessing the heart of big data

Scruggs, S. B., Watson, K., Su, A. I., Hermjakob, H., Yates, J. R., Lindsey, M. L. & Ping, P., Mar 27 2015, In : Circulation Research. 116, 7, p. 1115-1119 5 p.

Research output: Contribution to journalReview article

31 Scopus citations

The circular relationship between matrix metalloproteinase-9 and inflammation following myocardial infarction

DeLeon-Pennell, K. Y., Altara, R., Yabluchanskiy, A., Modesti, A. & Lindsey, M. L., Aug 1 2015, In : IUBMB Life. 67, 8, p. 611-618 8 p.

Research output: Contribution to journalReview article

16 Scopus citations

Transformative impact of proteomics on cardiovascular health and disease: A scientific statement from the American Heart Association

Lindsey, M. L., Mayr, M., Gomes, A. V., Delles, C., Arrell, D. K., Murphy, A. M., Lange, R. A., Costello, C. E., Jin, Y. F., Laskowitz, D. T., Sam, F., Terzic, A., Van Eyk, J. & Srinivas, P. R., Sep 1 2015, In : Circulation. 132, 9, p. 852-872 21 p.

Research output: Contribution to journalReview article

70 Scopus citations
2014

Applications of miRNA technology for atherosclerosis

Toba, H., Cortez, D., Lindsey, M. L. & Chilton, R. J., Feb 2014, In : Current atherosclerosis reports. 16, 2, 386.

Research output: Contribution to journalReview article

24 Scopus citations

Myocardial matrix metalloproteinase-2: Inside out and upside down

DeCoux, A., Lindsey, M. L., Villarreal, F., Garcia, R. A. & Schulz, R., Dec 1 2014, In : Journal of Molecular and Cellular Cardiology. 77, p. 64-72 9 p.

Research output: Contribution to journalReview article

53 Scopus citations

Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling

Ma, Y., De Castro Brás, L. E., Toba, H., Iyer, R. P., Hall, M. E., Winniford, M. D., Lange, R. A., Tyagi, S. C. & Lindsey, M. L., Jun 2014, In : Pflugers Archiv European Journal of Physiology. 466, 6, p. 1113-1127 15 p.

Research output: Contribution to journalReview article

74 Scopus citations

The tell-tale heart: Molecular and cellular responses to childhood anthracycline exposure

Lindsey, M. L., Lange, R. A., Parsons, H., Andrews, T. & Aune, G. J., Nov 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 307, 10, p. H1379-H1389

Research output: Contribution to journalReview article

9 Scopus citations

Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: Cardiac metalloproteinase actions (carMA) postulates

Iyer, R. P., De Castro Brás, L. E., Jin, Y. F. & Lindsey, M. L., Feb 28 2014, In : Circulation Research. 114, 5, p. 860-871 12 p.

Research output: Contribution to journalReview article

26 Scopus citations
11 Scopus citations
2013

Matrix metalloproteinase (MMP)-9: A proximal biomarker for cardiac remodeling and a distal biomarker for inflammation

Halade, G. V., Jin, Y. F. & Lindsey, M. L., Jul 2013, In : Pharmacology and Therapeutics. 139, 1, p. 32-40 9 p.

Research output: Contribution to journalReview article

112 Scopus citations

Matrix metalloproteinase-9: Many shades of function in cardiovascular disease

Yabluchanskiy, A., Ma, Y., Iyer, R. P., Hall, M. E. & Lindsey, M. L., Nov 1 2013, In : Physiology. 28, 6, p. 391-403 13 p.

Research output: Contribution to journalReview article

173 Scopus citations

Matrix metalloproteinases: Drug targets for myocardial infarction

Yabluchanskiy, A., Li, Y., Chilton, R. J. & Lindsey, M. L., 2013, In : Current drug targets. 14, 3, p. 276-286 11 p.

Research output: Contribution to journalReview article

31 Scopus citations

Neutrophil roles in left ventricular remodeling following myocardial infarction

Ma, Y., Yabluchanskiy, A. & Lindsey, M. L., Jun 3 2013, In : Fibrogenesis and Tissue Repair. 6, 1, 11.

Research output: Contribution to journalReview article

71 Scopus citations

Using proteomics to uncover extracellular matrix interactions during cardiac remodeling

Patterson, N. L., Iyer, R. P., de Castro Brás, L. E., Li, Y., Andrews, T. G., Aune, G. J., Lange, R. A. & Lindsey, M. L., Aug 2013, In : Proteomics - Clinical Applications. 7, 7-8, p. 516-527 12 p.

Research output: Contribution to journalReview article

18 Scopus citations
2012
10 Scopus citations

Extracellular matrix proteomics in cardiac Ischemia/Reperfusion: The Search Is on

DeLeon, K. Y., De Castro Brás, L. E., Lange, R. A. & Lindsey, M. L., Feb 14 2012, In : Circulation. 125, 6, p. 746-748 3 p.

Research output: Contribution to journalReview article

3 Scopus citations
102 Scopus citations

The history of matrix metalloproteinases: Milestones, myths, and misperceptions

Iyer, R. P., Patterson, N. L., Fields, G. B. & Lindsey, M. L., Oct 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 8, p. H919-H930

Research output: Contribution to journalReview article

101 Scopus citations
2011

Walking the oxidative stress tightrope: A perspective from the naked mole-rat, the longest-living rodent

Rodriguez, K. A., Wywial, E., Perez, V. I., Lambert, A. J., Edrey, Y. H., Lewis, K. N., Grimes, K., Lindsey, M. L., Brand, M. D. & Buffenstein, R., Jul 2011, In : Current Pharmaceutical Design. 17, 22, p. 2290-2307 18 p.

Research output: Contribution to journalReview article

29 Scopus citations
2010

Extracellular matrix roles during cardiac repair

Jourdan-LeSaux, C., Zhang, J. & Lindsey, M. L., Sep 2010, In : Life Sciences. 87, 13-14, p. 391-400 10 p.

Research output: Contribution to journalReview article

66 Scopus citations

Extracellular matrix turnover and signaling during cardiac remodeling following MI: Causes and consequences

Zamilpa, R. & Lindsey, M. L., Mar 2010, In : Journal of Molecular and Cellular Cardiology. 48, 3, p. 558-563 6 p.

Research output: Contribution to journalReview article

81 Scopus citations
2008

Inhibiting metalloproteases with PD 166793 in heart failure: Impact on cardiac remodeling and beyond

Kaludercic, N., Lindsey, M. L., Tavazzi, B., Lazzarino, G. & Paolocci, N., Mar 2008, In : Cardiovascular Therapeutics. 26, 1, p. 24-37 14 p.

Research output: Contribution to journalReview article

25 Scopus citations

Macrophage roles following myocardial infarction

Lambert, J. M., Lopez, E. F. & Lindsey, M. L., Nov 12 2008, In : International Journal of Cardiology. 130, 2, p. 147-158 12 p.

Research output: Contribution to journalReview article

224 Scopus citations
2007

Mechanisms to inhibit matrix metalloproteinase activity: Where are we in the development of clinically relevant inhibitors?

Corbitt, C. A., Lin, J. & Lindsey, M. L., Jun 2007, In : Recent Patents on Anti-Cancer Drug Discovery. 2, 2, p. 135-142 8 p.

Research output: Contribution to journalReview article

29 Scopus citations
2006
12 Scopus citations
2005

Age-dependent changes in myocardial matrix metalloproteinase/tissue inhibitor of metalloproteinase profiles and fibroblast function

Lindsey, M. L., Goshorn, D. K., Squires, C. E., Escobar, G. P., Hendrick, J. W., Mingoia, J. T., Sweterlitsch, S. E. & Spinale, F. G., May 1 2005, In : Cardiovascular research. 66, 2, p. 410-419 10 p.

Research output: Contribution to journalReview article

116 Scopus citations