Moorthy Palanimuthu Ponnusamy, PhD

  • 2229 Citations
  • 25 h-Index
20052020

Research output per year

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Research Output

  • 2229 Citations
  • 25 h-Index
  • 46 Article
  • 21 Review article
  • 2 Comment/debate
  • 1 Editorial
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Article
2020

Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis

Gupta, R., Leon, F., Thompson, C. M., Nimmakayala, R., Karmakar, S., Nallasamy, P., Chugh, S., Prajapati, D. R., Rachagani, S., Kumar, S. & Ponnusamy, M. P., May 26 2020, In : British journal of cancer. 122, 11, p. 1661-1672 12 p.

Research output: Contribution to journalArticle

2019

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Ponnusamy, M. P., Datta, K. & Batra, S. K., Jun 27 2019, In : Oncogene. 38, 26, p. 5265-5280 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., Aug 26 2019, In : Genome biology. 20, 1, 171.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Nimmakayala, R. K., Seshacharyulu, P., Lakshmanan, I., Rachagani, S., Chugh, S., Karmakar, S., Rauth, S., Vengoji, R., Atri, P., Talmon, G. A., Lele, S. M., Smith, L. M., Thapa, I., Bastola, D., Ouellette, M. M., Batra, S. K. & Ponnusamy, M. P., Sep 2018, In : Gastroenterology. 155, 3, p. 892-908.e6

Research output: Contribution to journalArticle

20 Scopus citations

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

Aithal, A., Junker, W. M., Kshirsagar, P., Das, S., Kaur, S., Orzechowski, C., Gautam, S. K., Jahan, R., Sheinin, Y. M., Lakshmanan, I., Ponnusamy, M. P., Batra, S. K. & Jain, M., Apr 2018, In : PloS one. 13, 4, e0193907.

Research output: Contribution to journalArticle

3 Scopus citations

Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice

Chugh, S., Barkeer, S., Rachagani, S., Nimmakayala, R. K., Perumal, N., Pothuraju, R., Atri, P., Mahapatra, S., Thapa, I., Talmon, G. A., Smith, L. M., Yu, X., Neelamegham, S., Fu, J., Xia, L., Palanimuthu Ponnusamy, M. & Batra, S. K., Nov 2018, In : Gastroenterology. 155, 5, p. 1608-1624 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma

Kanteti, R., Mirzapoiazova, T., Riehm, J. J., Dhanasingh, I., Mambetsariev, B., Wang, J., Kulkarni, P., Kaushik, G., Seshacharyulu, P., Ponnusamy, M. P., Kindler, H. L., Nasser, M. W., Batra, S. K. & Salgia, R., Apr 3 2018, In : Cancer Biology and Therapy. 19, 4, p. 316-327 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells

Barkeer, S., Chugh, S., Karmakar, S., Kaushik, G., Rauth, S., Rachagani, S., Batra, S. K. & Ponnusamy, M. P., Nov 22 2018, In : BMC cancer. 18, 1, 1157.

Research output: Contribution to journalArticle

8 Scopus citations
2017

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells

Karmakar, S., Seshacharyulu, P., Lakshmanan, I., Vaz, A. P., Chugh, S., Sheinin, Y. M., Mahapatra, S., Batra, S. K. & Palanimuthu Ponnusamy, M., 2017, In : Oncotarget. 8, 9, p. 14806-14820 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53

Lakshmanan, I., Salfity, S., Seshacharyulu, P., Rachagani, S., Thomas, A., Das, S., Majhi, P. D., Nimmakayala, R. K., Vengoji, R., Lele, S. M., Ponnusamy, M. P., Batra, S. K. & Ganti, A. K., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer

Joshi, S., Cruz, E., Rachagani, S., Guha, S., Brand, R. E., Ponnusamy, M. P., Kumar, S. & Batra, S. K., Aug 1 2016, In : Molecular Oncology. 10, 7, p. 1063-1077 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
20 Scopus citations
14 Scopus citations

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism

Muniyan, S., Haridas, D., Chugh, S., Rachagani, S., Lakshmanan, I., Gupta, S., Seshacharyulu, P., Smith, L. M., Ponnusamy, M. P. & Batra, S. K., Mar 2016, In : Genes and Cancer. 7, 3-4, p. 110-124 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the notch effector hath1 in colorectal cancer

Pai, P., Rachagani, S., Dhawan, P., Sheinin, Y. M., Macha, M. A., Qazi, A. K., Chugh, S., Ponnusamy, M. P., Mallya, K., Pothuraju, R. & Batra, S. K., May 2016, In : Genes and Cancer. 7, 5-6, p. 154-168 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling

Lakshmanan, I., Rachagani, S., Hauke, R., Krishn, S. R., Paknikar, S., Seshacharyulu, P., Karmakar, S., Nimmakayala, R. K., Kaushik, G., Johansson, S. L., Carey, G. B., Ponnusamy, M. P., Kaur, S., Batra, S. K. & Ganti, A. K., Aug 4 2016, In : Oncogene. 35, 31, p. 4112-4121 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

Vaz, A. P., Deb, S., Rachagani, S., Dey, P., Muniyan, S., Lakshmanan, I., Karmakar, S., Smith, L., Johansson, S., Lele, S., Ouellette, M., Ponnusamy, M. P. & Batra, S. K., 2016, In : Oncotarget. 7, 3, p. 3317-3331 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling

Hein, A. L., Seshacharyulu, P., Rachagani, S., Sheinin, Y. M., Ouellette, M. M., Ponnusamy, M. P., Mumby, M. C., Batra, S. K. & Yan, Y., Apr 15 2016, In : Cancer Research. 76, 8, p. 2243-2253 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma

Pai, P., Rachagani, S., Lakshmanan, I., Macha, M. A., Sheinin, Y., Smith, L. M., Ponnusamy, M. P. & Batra, S. K., Feb 1 2016, In : Molecular Oncology. 10, 2, p. 224-239 16 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015
14 Scopus citations

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Lakshmanan, I., Seshacharyulu, P., Haridas, D., Rachagani, S., Gupta, S., Joshi, S., Guda, C., Yan, Y., Jain, M., Ganti, A. K., Ponnusamy, M. P. & Batra, S. K., 2015, In : Oncotarget. 6, 25, p. 21085-21099 15 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Seshacharyulu, P., Ponnusamy, M. P., Rachagani, S., Lakshmanan, I., Haridas, D., Yan, Y., Ganti, A. K. & Batra, S. K., 2015, In : Oncotarget. 6, 7, p. 5164-5181 18 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations
2014

Altered Mucins (MUC) trafficking in Benign and malignant conditions

Joshi, S., Kumar, S., Choudhury, A., Ponnusamy, M. P. & Batra, S. K., 2014, In : Oncotarget. 5, 17, p. 7272-7284 13 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
21 Scopus citations

PD2/Paf1 depletion in pancreatic acinar cells promotes acinarto-ductal metaplasia

Dey, P., Rachagani, S., Vaz, A. P., Ponnusamy, M. P. & Batra, S. K., 2014, In : Oncotarget. 5, 12, p. 4480-4491 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
2013

Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling

Macha, M. A., Rachagani, S., Gupta, S., Pai, P., Ponnusamy, M. P., Batra, S. K. & Jain, M., Dec 1 2013, In : Cancer Letters. 341, 2, p. 166-177 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway

Pandey, P., Seshacharyulu, P., Das, S., Rachagani, S., Ponnusamy, M. P., Yan, Y., Johansson, S. L., Datta, K., Lin, M. F. & Batra, S. K., Jun 25 2013, In : British journal of cancer. 108, 12, p. 2590-2600 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells

Mukhopadhyay, P., Lakshmanan, I., Ponnusamy, M. P., Chakraborty, S., Jain, M., Pai, P., Smith, L. M., Lele, S. M. & Batra, S. K., Feb 11 2013, In : PloS one. 8, 2, e54455.

Research output: Contribution to journalArticle

41 Scopus citations

Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation

Momi, N., Ponnusamy, M. P., Kaur, S., Rachagani, S., Kunigal, S. S., Chellappan, S., Ouellette, M. M. & Batra, S. K., Mar 14 2013, In : Oncogene. 32, 11, p. 1384-1395 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Pathobiological implications of MUC4 in non-small-cell lung cancer

Majhi, P. D., Lakshmanan, I., Ponnusamy, M. P., Jain, M., Das, S., Kaur, S., Shimizu, S. T., West, W. W., Johansson, S. L., Smith, L. M., Yu, F., Rolle, C. E., Sharma, P., Carey, G. B., Batra, S. K. & Ganti, A. K., Apr 2013, In : Journal of Thoracic Oncology. 8, 4, p. 398-407 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells

Lakshmanan, I., Ponnusamy, M. P., Das, S., Chakraborty, S., Haridas, D., Mukhopadhyay, P., Lele, S. M. & Batra, S. K., Feb 16 2012, In : Oncogene. 31, 7, p. 805-817 13 p.

Research output: Contribution to journalArticle

72 Scopus citations
49 Scopus citations

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: Potential implications for diagnosis and therapy

Rachagani, S., Torres, M. P., Kumar, S., Haridas, D., Baine, M., Macha, M. A., Kaur, S., Ponnusamy, M. P., Dey, P., Seshacharyulu, P., Johansson, S. L., Jain, M., Wagner, K. U. & Batra, S. K., 2012, In : Journal of Hematology and Oncology. 5, 68.

Research output: Contribution to journalArticle

40 Scopus citations
19 Scopus citations
2011
54 Scopus citations
17 Scopus citations

MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells

Ponnusamy, M. P., Seshacharyulu, P., Vaz, A., Dey, P. & Batra, S. K., 2011, In : Journal of Ovarian Research. 4, 1, 7.

Research output: Contribution to journalArticle

30 Scopus citations

Pathobiological implications of MUC16 expression in pancreatic cancer

Haridas, D., Chakraborty, S., Ponnusamy, M. P., Lakshmanan, I., Rachagani, S., Cruz, E., Kumar, S., Das, S., Lele, S. M., Anderson, J. M., Wittel, U. A., Hollingsworth, M. A. & Batra, S. K., Nov 4 2011, In : PloS one. 6, 10, e26839.

Research output: Contribution to journalArticle

72 Scopus citations
2010

Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: Implications for the development of novel cancer therapies

Torres, M. P., Ponnusamy, M. P., Chakraborty, S., Smith, L. M., Das, S., Arafat, H. A. & Batra, S. K., May 2010, In : Molecular cancer therapeutics. 9, 5, p. 1419-1431 13 p.

Research output: Contribution to journalArticle

72 Scopus citations

MUC4 mucin-induced epithelial to mesenchymal transition: A novel mechanism for metastasis of human ovarian cancer cells

Ponnusamy, M. P., Lakshmanan, I., Jain, M., Das, S., Chakraborty, S., Dey, P. & Batra, S. K., Oct 21 2010, In : Oncogene. 29, 42, p. 5741-5754 14 p.

Research output: Contribution to journalArticle

111 Scopus citations
2009

RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells

Ponnusamy, M. P., Deb, S., Dey, P., Chakraborty, S., Rachagani, S., Senapati, S. & Batra, S. K., Dec 2009, In : STEM CELLS. 27, 12, p. 3001-3011 11 p.

Research output: Contribution to journalArticle

36 Scopus citations
2008

MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells

Ponnusamy, M. P., Singh, A. P., Jain, M., Chakraborty, S., Moniaux, N. & Batra, S. K., Aug 5 2008, In : British journal of cancer. 99, 3, p. 520-526 7 p.

Research output: Contribution to journalArticle

55 Scopus citations
2007

Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis

Ponnusamy, M. P., Venkatraman, G., Singh, A. P., Chauhan, S. C., Johansson, S. L., Jain, M., Smith, L., Davis, J. S., Remmenga, S. W. & Batra, S. K., Jun 28 2007, In : Cancer Letters. 251, 2, p. 247-257 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

IFN-γ-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: A novel mechanism for IFN-γ response

Andrianifahanana, M., Singh, A. P., Nemos, C., Ponnusamy, M. P., Moniaux, N., Mehta, P. P., Varshney, G. C. & Batra, S. K., Nov 8 2007, In : Oncogene. 26, 51, p. 7251-7261 11 p.

Research output: Contribution to journalArticle

39 Scopus citations
2005

Expression of the gas7 gene and Oct4 in embryonic stem cells of mice

Moorthy, P. P., Kumar, A. A. & Devaraj, H., Dec 2005, In : Stem Cells and Development. 14, 6, p. 664-670 7 p.

Research output: Contribution to journalArticle

16 Scopus citations