• 1446 Citations
  • 22 h-Index
1984 …2020

Research output per year

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Research Output

  • 1446 Citations
  • 22 h-Index
  • 65 Article
  • 20 Review article
  • 6 Editorial
2020

A long-acting 3TC ProTide nanoformulation suppresses HBV replication in humanized mice

Wang, W., Smith, N., Makarov, E., Sun, Y., Gebhart, C. L., Ganesan, M., Osna, N. A., Gendelman, H. E., Edagwa, B. J. & Poluektova, L. Y., Aug 2020, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 28, 102185.

Research output: Contribution to journalArticle

Open Access

Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: From Genetics to nutrition: Summary of the ISBRA 2018 symposium

Kirpich, I. A., Warner, D. R., Feng, W., Joshi-Barve, S., McClain, C. J., Seth, D., Zhong, W., Zhou, Z., Osna, N. A. & Kharbanda, K. K., Mar 2020, In : Alcohol. 83, p. 105-114 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Recent advances in understanding the complexity of alcohol-induced pancreatic dysfunction and pancreatitis development

Rasineni, K., Srinivasan, M. P., Balamurugan, A. N., Kaphalia, B. S., Wang, S., Ding, W. X., Pandol, S. J., Lugea, A., Simon, L., Molina, P. E., Gao, P., Casey, C. A., Osna, N. A. & Kharbanda, K. K., May 2020, In : Biomolecules. 10, 5, 669.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Role of alcohol in pathogenesis of hepatitis B virus infection

Ganesan, M., Eikenberry, A., Poluektova, L. Y., Kharbanda, K. K. & Osna, N. A., Mar 7 2020, In : World Journal of Gastroenterology. 26, 9, p. 883-903 21 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Role of Elevated Intracellular S-Adenosylhomocysteine in the Pathogenesis of Alcohol-Related Liver Disease

Arumugam, M. K., Talawar, S., Listenberger, L., Donohue, T. M., Osna, N. A. & Kharbanda, K. K., Jun 23 2020, In : Cells. 9, 6

Research output: Contribution to journalArticle

Open Access

Role of non-Genetic Risk Factors in Exacerbating Alcohol-related organ damage

Osna, N. A., Bhatia, R., Thompson, C., Batra, S. K., Kumar, S., Cho, Y., Szabo, G., Molina, P. E., Weinman, S. A., Ganesan, M. & Kharbanda, K. K., Sep 2020, In : Alcohol. 87, p. 63-72 10 p.

Research output: Contribution to journalReview article

2019

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

4 Scopus citations

Alcohol metabolism potentiates HIV-induced hepatotoxicity: Contribution to end-stage liver disease

Ganesan, M., New-Aaron, M., Dagur, R. S., Makarov, E., Wang, W., Kharbanda, K. K., Kidambi, S., Poluektova, L. Y. & Osna, N. A., Dec 2019, In : Biomolecules. 9, 12, 851.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
6 Scopus citations

Lysosome and proteasome dysfunction in alcohol-induced liver injury

Donohue, T. M., Osna, N. A., Kharbanda, K. K. & Thomes, P. G., Dec 2019, In : Liver Research. 3, 3-4, p. 191-205 15 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism

Ganesan, M., Tikhanovich, I., Vangimalla, S. S., Dagur, R. S., Wang, W., Poluektova, L. I., Sun, Y., Mercer, D. F., Tuma, D., Weinman, S. A., Kharbanda, K. K. & Osna, N. A., 2018, In : CMGH. 5, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2 Scopus citations

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice

Dagur, R. S., Wang, W., Cheng, Y., Makarov, E., Ganesan, M., Suemizu, H., Gebhart, C. L., Gorantla, S., Osna, N. & Poluektova, L. Y., 2018, In : Biology Open. 7, 2, bio029785.

Research output: Contribution to journalArticle

8 Scopus citations

Liver as a target of human immunodeficiency virus infection

Ganesan, M., Poluektova, L. Y., Kharbanda, K. K. & Osna, N. A., Nov 14 2018, In : World Journal of Gastroenterology. 24, 42, p. 4728-4737 10 p.

Research output: Contribution to journalReview article

8 Scopus citations
3 Scopus citations

The loss of α-and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing

Labisso, W. L., Raulin, A. C., Nwidu, L. L., Kocon, A., Wayne, D., Erdozain, A. M., Morentin, B., Schwendener, D., Allen, G., Enticott, J., Gerdes, H. K., Johnson, L., Grzeskowiak, J., Drizou, F., Tarbox, R., Osna, N. A., Kharbanda, K. K., Callado, L. F. & Carter, W. G., Sep 11 2018, In : Brain Sciences. 8, 9, 175.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Alcoholic liver disease: Pathogenesis and current management

Osna, N. A., Donohue, T. M. & Kharbanda, K. K., 2017, In : Alcohol Research: Current Reviews. 38, 2, p. 7-21 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Alcoholic Liver Disease: Pathogenesis and Current Management

Osna, N. A., Donohue, T. M. & Kharbanda, K. K., 2017, In : Alcohol research : current reviews. 38, 2, p. 147-161 15 p.

Research output: Contribution to journalReview article

58 Scopus citations

Bifunctional enzyme JMJD6 contributes to multiple disease pathogenesis: New twist on the old story

Vangimalla, S. S., Ganesan, M., Kharbanda, K. K. & Osna, N. A., Jun 2017, In : Biomolecules. 7, 2, 41.

Research output: Contribution to journalReview article

10 Scopus citations

Structure, function and metabolism of hepatic and adipose tissue lipid droplets: Implications in alcoholic liver disease

Natarajan, S. K., Rasineni, K., Ganesan, M., Feng, D., McVicker, B. L., McNiven, M. A., Osna, N. A., Mott, J. L., Casey, C. A. & Kharbanda, K., Aug 1 2017, In : Current Molecular Pharmacology. 10, 3, p. 237-248 12 p.

Research output: Contribution to journalReview article

4 Scopus citations

Treatment options for alcoholic and non-alcoholic fatty liver disease: A review

Singh, S., Osna, N. A. & Kharbanda, K., Sep 28 2017, In : World Journal of Gastroenterology. 23, 36, p. 6549-6570 22 p.

Research output: Contribution to journalReview article

45 Scopus citations
2016

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

Osna, N. A., Carter, W. G., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., Shearn, C. T., Tomasi, M. L. & Kharbanda, K. K., Jul 21 2016, In : World Journal of Gastroenterology. 22, 27, p. 6192-6200 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
17 Scopus citations

Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis

Ganesan, M., Feng, D., Barton, R. W., Thomes, P. G., McVicker, B. L., Tuma, D. J., Osna, N. A. & Kharbanda, K. K., Nov 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 11, p. 2312-2319 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Multi-organ alcohol-related damage: Mechanisms and treatment

Osna, N. A. & Kharbanda, K. K., Apr 15 2016, In : Biomolecules. 6, 2, 20.

Research output: Contribution to journalEditorial

7 Scopus citations

Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury

Osna, N. A., Feng, D., Ganesan, M., Maillacheruvu, P. F., Orlicky, D. J., French, S. W., Tuma, D. J. & Kharbanda, K. K., Oct 14 2016, In : World Journal of Gastroenterology. 22, 38, p. 8497-8508 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
13 Scopus citations
2015
25 Scopus citations

Alcoholic liver disease: Clinical and translational research

Neuman, M. G., Malnick, S., Maor, Y., Nanau, R. M., Melzer, E., Ferenci, P., Seitz, H. K., Mueller, S., Mell, H., Samuel, D., Cohen, L. B., Kharbanda, K. K., Osna, N. A., Ganesan, M., Thompson, K. J., McKillop, I. H., Bautista, A., Bataller, R. & French, S. W., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 596-610 15 p.

Research output: Contribution to journalReview article

21 Scopus citations

FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol

Ganesan, M., Hindman, J., Tillman, B., Jaramillo, L., Poluektova, L. Y., French, B. A., Kharbanda, K., French, S. W. & Osna, N. A., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 506-516 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hepatitis C, innate immunity and alcohol: Friends or foes?

Osna, N. A., Ganesan, M. & Kharbanda, K. K., 2015, In : Biomolecules. 5, 1, p. 76-94 19 p.

Research output: Contribution to journalReview article

18 Scopus citations

Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury

Carter, W. G., Vigneswara, V., Newlaczyl, A., Wayne, D., Ahmed, B., Saddington, S., Brewer, C., Raut, N., Gerdes, H. K., Erdozain, A. M., Tooth, D., Bolt, E. L., Osna, N. A., Tuma, D. J. & Kharbanda, K. K., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 626-631 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics

Zhang, J., Garrison, J. C., Poluektova, L. Y., Bronich, T. K. & Osna, N. A., Nov 1 2015, In : Biomaterials. 70, p. 37-47 11 p., 17009.

Research output: Contribution to journalArticle

12 Scopus citations
10 Scopus citations
2014

Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity

Kharbanda, K. K., Todero, S. L., Moats, J. C., Harris, R. M., Osna, N. A., Thomes, P. G. & Tuma, D. J., Mar 2014, In : Alcoholism: Clinical and Experimental Research. 38, 3, p. 641-648 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Alcoholic and non-alcoholic steatohepatitis

Neuman, M. G., French, S. W., French, B. A., Seitz, H. K., Cohen, L. B., Mueller, S., Osna, N. A., Kharbanda, K. K., Seth, D., Bautista, A., Thompson, K. J., McKillop, I. H., Kirpich, I. A., McClain, C. J., Bataller, R., Nanau, R. M., Voiculescu, M., Opris, M., Shen, H., Tillman, B. & 5 others, Li, J., Liu, H., Thomes, P. G., Ganesan, M. & Malnick, S., Dec 1 2014, In : Experimental and Molecular Pathology. 97, 3, p. 492-510 19 p.

Research output: Contribution to journalReview article

37 Scopus citations

Ethanol affects hepatitis C pathogenesis: Humanized SCID Alb-uPA mouse model

Osna, N. A., Kharbanda, K. K., Sun, Y., Simpson, R. L., Poluektova, L. E., Ganesan, M., Wisecarver, J. L. & Mercer, D. F., Jul 18 2014, In : Biochemical and Biophysical Research Communications. 450, 1, p. 773-776 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice

Gutti, T. L., Knibbe, J. S., Makarov, E., Zhang, J., Yannam, G. R., Gorantla, S., Sun, Y., Mercer, D. F., Suemizu, H., Wisecarver, J. L., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., Jan 2014, In : American Journal of Pathology. 184, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Increased methylation demand exacerbates ethanol-induced liver injury

Kharbanda, K. K., Todero, S. L., Thomes, P. G., Orlicky, D. J., Osna, N. A., French, S. W. & Tuma, D. J., Aug 2014, In : Experimental and Molecular Pathology. 97, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Proteasome- and ethanol-dependent regulation of HCV-infection pathogenesis

Osna, N. A., Ganesan, M. & Donohue, T. M., Dec 1 2014, In : Biomolecules. 4, 4, p. 885-896 12 p.

Research output: Contribution to journalReview article

6 Scopus citations
2013

Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection

Zhang, J., Mulvenon, A., Makarov, E., Wagoner, J., Knibbe, J., Kim, J. O., Osna, N., Bronich, T. K. & Poluektova, L. Y., May 2013, In : Biomaterials. 34, 15, p. 3846-3857 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
16 Scopus citations
11 Scopus citations

Impact of Altered Methylation in Cytokine Signaling and Proteasome Function in Alcohol and Viral-Mediated Diseases

Kharbanda, K. K., Bardag-Gorce, F., Barve, S., Molina, P. E. & Osna, N. A., Jan 2013, In : Alcoholism: Clinical and Experimental Research. 37, 1, p. 1-7 7 p.

Research output: Contribution to journalReview article

6 Scopus citations
7 Scopus citations
2012

Early Growth Response-1 Contributes to Steatosis Development After Acute Ethanol Administration

Donohue, T. M., Osna, N. A., Trambly, C. S., Whitaker, N. P., Thomes, P. G., Todero, S. L. & Davis, J. S., May 2012, In : Alcoholism: Clinical and Experimental Research. 36, 5, p. 759-767 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ethanol and Hepatitis C Virus Suppress Peptide-MHC Class I Presentation in Hepatocytes by Altering Proteasome Function

Osna, N. A., Bardag-Gorce, F., White, R. L., Weinman, S. A., Donohue, T. M. & Kharbanda, K. K., Dec 2012, In : Alcoholism: Clinical and Experimental Research. 36, 12, p. 2028-2035 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

An annual topic highlight: Alcohol and liver, 2011

Osna, N. A., May 28 2011, In : World Journal of Gastroenterology. 17, 20, p. 2455 1 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis

Osna, N. A., Thomes, P. G. & Donohue, T. M., May 28 2011, In : World Journal of Gastroenterology. 17, 20, p. 2507-2514 8 p.

Research output: Contribution to journalReview article

33 Scopus citations