• 1446 Citations
  • 22 h-Index
1984 …2020

Research output per year

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Research Output

  • 1446 Citations
  • 22 h-Index
  • 65 Article
  • 20 Review article
  • 6 Editorial
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Article
2020

A long-acting 3TC ProTide nanoformulation suppresses HBV replication in humanized mice

Wang, W., Smith, N., Makarov, E., Sun, Y., Gebhart, C. L., Ganesan, M., Osna, N. A., Gendelman, H. E., Edagwa, B. J. & Poluektova, L. Y., Aug 2020, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 28, 102185.

Research output: Contribution to journalArticle

Open Access

Role of Elevated Intracellular S-Adenosylhomocysteine in the Pathogenesis of Alcohol-Related Liver Disease

Arumugam, M. K., Talawar, S., Listenberger, L., Donohue, T. M., Osna, N. A. & Kharbanda, K. K., Jun 23 2020, In : Cells. 9, 6

Research output: Contribution to journalArticle

Open Access
2019

Acetaldehyde suppresses the display of HBV-MHC class I complexes on HBV-expressing hepatocytes

Ganesan, M., Krutik, V. M., Makarov, E., Mathews, S., Kharbanda, K. K., Poluektova, L. Y., Casey, C. A. & Osna, N. A., Aug 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 317, 2, p. G127-G140

Research output: Contribution to journalArticle

4 Scopus citations

Alcohol metabolism potentiates HIV-induced hepatotoxicity: Contribution to end-stage liver disease

Ganesan, M., New-Aaron, M., Dagur, R. S., Makarov, E., Wang, W., Kharbanda, K. K., Kidambi, S., Poluektova, L. Y. & Osna, N. A., Dec 2019, In : Biomolecules. 9, 12, 851.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
6 Scopus citations

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism

Ganesan, M., Tikhanovich, I., Vangimalla, S. S., Dagur, R. S., Wang, W., Poluektova, L. I., Sun, Y., Mercer, D. F., Tuma, D., Weinman, S. A., Kharbanda, K. K. & Osna, N. A., 2018, In : CMGH. 5, 2, p. 101-112 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2 Scopus citations

Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice

Dagur, R. S., Wang, W., Cheng, Y., Makarov, E., Ganesan, M., Suemizu, H., Gebhart, C. L., Gorantla, S., Osna, N. & Poluektova, L. Y., 2018, In : Biology Open. 7, 2, bio029785.

Research output: Contribution to journalArticle

8 Scopus citations
3 Scopus citations

The loss of α-and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing

Labisso, W. L., Raulin, A. C., Nwidu, L. L., Kocon, A., Wayne, D., Erdozain, A. M., Morentin, B., Schwendener, D., Allen, G., Enticott, J., Gerdes, H. K., Johnson, L., Grzeskowiak, J., Drizou, F., Tarbox, R., Osna, N. A., Kharbanda, K. K., Callado, L. F. & Carter, W. G., Sep 11 2018, In : Brain Sciences. 8, 9, 175.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Alcoholic liver disease: Pathogenesis and current management

Osna, N. A., Donohue, T. M. & Kharbanda, K. K., 2017, In : Alcohol Research: Current Reviews. 38, 2, p. 7-21 15 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

Osna, N. A., Carter, W. G., Ganesan, M., Kirpich, I. A., McClain, C. J., Petersen, D. R., Shearn, C. T., Tomasi, M. L. & Kharbanda, K. K., Jul 21 2016, In : World Journal of Gastroenterology. 22, 27, p. 6192-6200 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
17 Scopus citations

Creatine Supplementation Does Not Prevent the Development of Alcoholic Steatosis

Ganesan, M., Feng, D., Barton, R. W., Thomes, P. G., McVicker, B. L., Tuma, D. J., Osna, N. A. & Kharbanda, K. K., Nov 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 11, p. 2312-2319 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury

Osna, N. A., Feng, D., Ganesan, M., Maillacheruvu, P. F., Orlicky, D. J., French, S. W., Tuma, D. J. & Kharbanda, K. K., Oct 14 2016, In : World Journal of Gastroenterology. 22, 38, p. 8497-8508 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
13 Scopus citations
2015
25 Scopus citations

FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol

Ganesan, M., Hindman, J., Tillman, B., Jaramillo, L., Poluektova, L. Y., French, B. A., Kharbanda, K., French, S. W. & Osna, N. A., Dec 1 2015, In : Experimental and Molecular Pathology. 99, 3, p. 506-516 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury

Carter, W. G., Vigneswara, V., Newlaczyl, A., Wayne, D., Ahmed, B., Saddington, S., Brewer, C., Raut, N., Gerdes, H. K., Erdozain, A. M., Tooth, D., Bolt, E. L., Osna, N. A., Tuma, D. J. & Kharbanda, K. K., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 626-631 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics

Zhang, J., Garrison, J. C., Poluektova, L. Y., Bronich, T. K. & Osna, N. A., Nov 1 2015, In : Biomaterials. 70, p. 37-47 11 p., 17009.

Research output: Contribution to journalArticle

12 Scopus citations
10 Scopus citations
2014

Alcohol consumption decreases rat hepatic creatine biosynthesis via altered guanidinoacetate methyltransferase activity

Kharbanda, K. K., Todero, S. L., Moats, J. C., Harris, R. M., Osna, N. A., Thomes, P. G. & Tuma, D. J., Mar 2014, In : Alcoholism: Clinical and Experimental Research. 38, 3, p. 641-648 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Ethanol affects hepatitis C pathogenesis: Humanized SCID Alb-uPA mouse model

Osna, N. A., Kharbanda, K. K., Sun, Y., Simpson, R. L., Poluektova, L. E., Ganesan, M., Wisecarver, J. L. & Mercer, D. F., Jul 18 2014, In : Biochemical and Biophysical Research Communications. 450, 1, p. 773-776 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice

Gutti, T. L., Knibbe, J. S., Makarov, E., Zhang, J., Yannam, G. R., Gorantla, S., Sun, Y., Mercer, D. F., Suemizu, H., Wisecarver, J. L., Osna, N. A., Bronich, T. K. & Poluektova, L. Y., Jan 2014, In : American Journal of Pathology. 184, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Increased methylation demand exacerbates ethanol-induced liver injury

Kharbanda, K. K., Todero, S. L., Thomes, P. G., Orlicky, D. J., Osna, N. A., French, S. W. & Tuma, D. J., Aug 2014, In : Experimental and Molecular Pathology. 97, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection

Zhang, J., Mulvenon, A., Makarov, E., Wagoner, J., Knibbe, J., Kim, J. O., Osna, N., Bronich, T. K. & Poluektova, L. Y., May 2013, In : Biomaterials. 34, 15, p. 3846-3857 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
16 Scopus citations
11 Scopus citations
7 Scopus citations
2012

Early Growth Response-1 Contributes to Steatosis Development After Acute Ethanol Administration

Donohue, T. M., Osna, N. A., Trambly, C. S., Whitaker, N. P., Thomes, P. G., Todero, S. L. & Davis, J. S., May 2012, In : Alcoholism: Clinical and Experimental Research. 36, 5, p. 759-767 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ethanol and Hepatitis C Virus Suppress Peptide-MHC Class I Presentation in Hepatocytes by Altering Proteasome Function

Osna, N. A., Bardag-Gorce, F., White, R. L., Weinman, S. A., Donohue, T. M. & Kharbanda, K. K., Dec 2012, In : Alcoholism: Clinical and Experimental Research. 36, 12, p. 2028-2035 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2010

Chronic Ethanol Consumption Results in Atypical Liver Injury in Copper/Zinc Superoxide Dismutase Deficient Mice

Curry-Mccoy, T. V., Osna, N. A., Nanji, A. A. & Donohue, T. M., Feb 2010, In : Alcoholism: Clinical and Experimental Research. 34, 2, p. 251-261 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Impaired methylation as a novel mechanism for proteasome suppression in liver cells

Osna, N. A., White, R. L., Donohue, T. M., Beard, M. R., Tuma, D. J. & Kharbanda, K. K., Jan 8 2010, In : Biochemical and Biophysical Research Communications. 391, 2, p. 1291-1296 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells

Osna, N. A., White, R. L., Thiele, G. M. & Donohue, T. M., 2009, In : Hepatology. 49, 4, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Modulation of lysozyme function and degradation after nitration with peroxynitrite

Curry-McCoy, T. V., Osna, N. A. & Donohue, T. M., Aug 2009, In : Biochimica et Biophysica Acta - General Subjects. 1790, 8, p. 778-786 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Proteasome Activation by Hepatitis C Core Protein Is Reversed by Ethanol-Induced Oxidative Stress

Osna, N. A., White, R. L., Krutik, V. M., Wang, T., Weinman, S. A. & Donohue, T. M., Jun 2008, In : Gastroenterology. 134, 7, p. 2144-2152 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2007

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells

Osna, N. A., White, R. L., Todero, S., Mc Vicker, B. L., Thiele, G. M., Clemens, D. L., Tuma, D. J. & Donohue, T. M., Jan 2007, In : Hepatology. 45, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Implication of altered proteasome function in alcoholic liver injury

Osna, N. A. & Donohue, T. M., Oct 7 2007, In : World Journal of Gastroenterology. 13, 37, p. 4931-4937 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury

Donohue, T. M., Curry-McCoy, T. V., Todero, S. L., White, R. L., Kharbanda, K. K., Nanji, A. A. & Osna, N. A., Jun 2007, In : Alcoholism: Clinical and Experimental Research. 31, 6, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
24 Scopus citations
2006
92 Scopus citations
2005

Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells

Osna, N. A., Clemens, D. L. & Donohue, T. M., Nov 2005, In : Hepatology. 42, 5, p. 1109-1117 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2004

Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: Implications for impaired immune function during disease

Haorah, J., Heilman, D., Diekmann, C., Osna, N., Donohue, T. M., Ghorpade, A. & Persidsky, Y., Jun 2004, In : Cellular Immunology. 229, 2, p. 139-148 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo

Osna, N. A., Haorah, J., Krutik, V. M. & Donohue, T. M., Sep 2004, In : Hepatology. 40, 3, p. 574-582 9 p.

Research output: Contribution to journalArticle

46 Scopus citations
2003
48 Scopus citations
2001

Alcohol consumption is associated with alterations in macrophage responses to interferon-γ and infection by Salmonella typhimurium

Sibley, D. A., Osna, N., Kusynski, C., Wilkie, L. & Jerrells, T. R., 2001, In : FEMS Immunology and Medical Microbiology. 32, 1, p. 73-83 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Histamine utilizes JAK-STAT pathway in regulating cytokine production

Osna, N., Elliott, K., Chaika, O., Patterson, E., Lewis, R. E. & Khan, M. M., 2001, In : International Immunopharmacology. 1, 4, p. 759-762 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells

Elliott, K. A., Osna, N. A., Scofield, M. A. & Khan, M. M., 2001, In : International Immunopharmacology. 1, 11, p. 1923-1937 15 p.

Research output: Contribution to journalArticle

38 Scopus citations

Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes

Osna, N., Elliott, K. & Khan, M. M., 2001, In : International Immunopharmacology. 1, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

85 Scopus citations