Pankaj Singh, PhD

  • 2457 Citations
  • 25 h-Index
20062020

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2020

EHD1 and RUSC2 control basal epidermal growth factor receptor cell surface expression and recycling

Tom, E. C., Mushtaq, I., Mohapatra, B. C., Luan, H., Bhat, A. M., Zutshi, N., Chakraborty, S., Islam, N., Arya, P., Bielecki, T. A., Iseka, F. M., Bhattacharyya, S., Cypher, L. R., Goetz, B. T., Negi, S. K., Storck, M. D., Rana, S., Barnekow, A., Singh, P. K., Ying, G. & 4 others, Guda, C., Natarajan, A., Band, V. & Banda, H., Apr 1 2020, In : Molecular and cellular biology. 40, 7, e00434.

Research output: Contribution to journalArticle

1 Scopus citations

Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia

Shukla, S. K., Markov, S. D., Attri, K. S., Vernucci, E., King, R. J., Dasgupta, A., Grandgenett, P. M., Hollingsworth, M. A., Singh, P. K., Yu, F. & Mehla, K., Aug 1 2020, In : Cancer Letters. 484, p. 29-39 11 p.

Research output: Contribution to journalArticle

Metabolic alterations in pancreatic cancer progression

Vernucci, E., Abrego, J., Gunda, V., Shukla, S. K., Dasgupta, A., Rai, V., Chaika, N., Buettner, K., Illies, A., Yu, F., Lazenby, A. J., Swanson, B. J. & Singh, P. K., Jan 2020, In : Cancers. 12, 1, 2.

Research output: Contribution to journalArticle

Open Access

Metabolic subtyping for novel personalized therapies against pancreatic cancer

Mehla, K. & Singh, P. K., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 6-8 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

Yamada, K. J., Heim, C. E., Xi, X., Attri, K. S., Wang, D., Zhang, W., Singh, P. K., Bronich, T. K. & Kielian, T., 2020, In : PLoS pathogens. 16, 3, e1008354.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism

Olou, A. A., King, R. J., Yu, F. & Singh, P. K., Apr 16 2020, In : Oncogene. 39, 16, p. 3381-3395 15 p.

Research output: Contribution to journalArticle

Sirt1–nox4 signaling axis regulates cancer cachexia

Dasgupta, A., Shukla, S. K., Vernucci, E., King, R. J., Abrego, J., Mulder, S. E., Mullen, N. J., Graves, G., Buettner, K., Thakur, R., Murthy, D., Attri, K. S., Wang, D., Chaika, N. V., Pacheco, C. G., Rai, I., Engle, D. D., Grandgenett, P. M., Punsoni, M., Reames, B. N. & 10 others, Teoh-Fitzgerald, M., Oberley-Deegan, R., Yu, F., Klute, K. A., Hollingsworth, M. A., Zimmerman, M. C., Mehla, K., Sadoshima, J., Tuveson, D. A. & Singh, P. K., Jul 6 2020, In : Journal of Experimental Medicine. 217, 7, e20190745.

Research output: Contribution to journalArticle

2019

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments

Lin, S., Huang, C., Gunda, V., Sun, J., Chellappan, S. P., Li, Z., Izumi, V., Fang, B., Koomen, J., Singh, P. K., Hao, J. & Yang, S., Sep 10 2019, In : Cell Reports. 28, 11, p. 2824-2836.e8

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes

Moshfegh, C. M., Collins, C. W., Gunda, V., Vasanthakumar, A., Cao, J. Z., Singh, P. K., Godley, L. A. & Case, A. J., Oct 2019, In : Redox Biology. 27, 101141.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Mar 19 2019, In : Immunity. 50, 3, p. 576-590.e6

Research output: Contribution to journalArticle

13 Scopus citations

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Hsieh, M. H., Choe, J. H., Gadhvi, J., Kim, Y. J., Arguez, M. A., Palmer, M., Gerold, H., Nowak, C., Do, H., Mazambani, S., Knighton, J. K., Cha, M., Goodwin, J., Kang, M. K., Jeong, J. Y., Lee, S. Y., Faubert, B., Xuan, Z., Abel, E. D., Scafoglio, C. & 11 others, Shackelford, D. B., Minna, J. D., Singh, P. K., Shulaev, V., Bleris, L., Hoyt, K., Kim, J., Inoue, M., DeBerardinis, R. J., Kim, T. H. & Kim, J. W., Aug 13 2019, In : Cell Reports. 28, 7, p. 1860-1878.e9

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A. & Bronich, T. K., Jul 28 2019, In : Journal of Controlled Release. 306, p. 149-164 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

RNA-binding protein hur regulates both mutant and wild-type IDH1 in IDH1-mutated cancer

Zarei, M., Lal, S., Vaziri-Gohar, A., O'Hayer, K., Gunda, V., Singh, P. K., Brody, J. R. & Winter, J. M., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 508-520 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selective inhibition of histone deacetylases 1/2/6 in combination with gemcitabine: A promising combination for pancreatic cancer therapy

Laschanzky, R. S., Humphrey, L. E., Ma, J., Smith, L. M., Enke, T. J., Shukla, S. K., Dasgupta, A., Singh, P. K., Howell, G. M., Brattain, M. G., Ly, Q. P., Black, A. R. & Black, J. D., Sep 2019, In : Cancers. 11, 9, 1327.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Lin, S., Huang, C., Sun, J., Bollt, O., Wang, X., Martine, E., Kang, J., Taylor, M. D., Fang, B., Singh, P. K., Koomen, J., Hao, J. & Yang, S., Dec 1 2019, In : EMBO Molecular Medicine. 11, 12, e10849.

Research output: Contribution to journalArticle

Open Access
2018

Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors

Mehla, K., Tremayne, J., Grunkemeyer, J. A., O’Connell, K. A., Steele, M. M., Caffrey, T. C., Zhu, X., Yu, F., Singh, P. K., Schultes, B. C., Madiyalakan, R., Nicodemus, C. F. & Hollingsworth, M. A., Mar 1 2018, In : Cancer Immunology, Immunotherapy. 67, 3, p. 445-457 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Insights into gemcitabine resistance and the potential for therapeutic monitoring

Gebregiworgis, T., Bhinderwala, F., Purohit, V., Chaika, N. V., Singh, P. K. & Powers, R., Dec 1 2018, In : Metabolomics. 14, 12, 156.

Research output: Contribution to journalArticle

5 Scopus citations

Microscale Gene Expression Analysis of Tumor-Associated Macrophages

Attri, K. S., Mehla, K., Shukla, S. K. & Singh, P. K., Dec 1 2018, In : Scientific reports. 8, 1, 2408.

Research output: Contribution to journalArticle

3 Scopus citations

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

Li, T., Li, X., Attri, K. S., Liu, C., Li, L., Herring, L. E., Asara, J. M., Lei, Y. L., Singh, P. K., Gao, C. & Wen, H., Dec 12 2018, In : Cell Host and Microbe. 24, 6, p. 791-803.e6

Research output: Contribution to journalArticle

13 Scopus citations
2017

Combination treatment with orlistat-containing nanoparticles and taxanes is synergistic and enhances microtubule stability in taxane-resistant prostate cancer cells

Souchek, J. J., Davis, A. L., Hill, T. K., Holmes, M. B., Qi, B., Singh, P. K., Kridel, S. J. & Mohs, A. M., Sep 2017, In : Molecular cancer therapeutics. 16, 9, p. 1819-1830 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

De Novo lipid synthesis facilitates gemcitabine resistance through endoplasmic reticulum stress in pancreatic cancer

Tadros, S., Shukla, S. K., King, R. J., Gunda, V., Vernucci, E., Abrego, J., Chaika, N. V., Yu, F., Lazenby, A. J., Berim, L., Grem, J., Sasson, A. R. & Singh, P. K., Oct 15 2017, In : Cancer Research. 77, 20, p. 5503-5517 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Glucose limitation alters glutamine metabolism in MUC1- overexpressing pancreatic cancer cells

Gebregiworgis, T., Purohit, V., Shukla, S. K., Tadros, S., Chaika, N. V., Abrego, J., Mulder, S. E., Gunda, V., Singh, P. K. & Powers, R., Oct 6 2017, In : Journal of proteome research. 16, 10, p. 3536-3546 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells

Abrego, J., Gunda, V., Vernucci, E., Shukla, S. K., King, R. J., Dasgupta, A., Goode, G., Murthy, D., Yu, F. & Singh, P. K., Aug 1 2017, In : Cancer Letters. 400, p. 37-46 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., Illies, A. L., Gebregiworgis, T., Dai, B., Augustine, J. J., Murthy, D., Attri, K. S., Mashadova, O., Grandgenett, P. M., Powers, R., Ly, Q. P. & 17 others, Lazenby, A. J., Grem, J. L., Yu, F., Matés, J. M., Asara, J. M., Kim, J. W., Hankins, J. H., Weekes, C., Hollingsworth, M. A., Serkova, N. J., Sasson, A. R., Fleming, J. B., Oliveto, J. M., Lyssiotis, C. A., Cantley, L. C., Berim, L. & Singh, P. K., Jul 10 2017, In : Cancer Cell. 32, 1, p. 71-87.e7

Research output: Contribution to journalArticle

109 Scopus citations

MUC1 facilitates metabolomic reprogramming in triple-negative breast cancer

Goode, G., Gunda, V., Chaika, N. V., Purohit, V., Yu, F. & Singh, P. K., May 2017, In : PloS one. 12, 5, e0176820.

Research output: Contribution to journalArticle

15 Scopus citations

MUC1-mediated metabolic alterations regulate response to radiotherapy in pancreatic cancer

Gunda, V., Souchek, J., Abrego, J., Shukla, S. K., Goode, G. D., Vernucci, E., Dasgupta, A., Chaika, N. V., King, R. J., Li, S., Wang, S., Yu, F., Bessho, T., Lin, C. & Singh, P. K., Oct 1 2017, In : Clinical Cancer Research. 23, 19, p. 5881-5891 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Goodwin, J., Neugent, M. L., Lee, S. Y., Choe, J. H., Choi, H., Enkins, D. M. R. J., Ruthenborg, R. J., Robinson, M. W., Jeong, J. Y., Wake, M., Abe, H., Takeda, N., Endo, H., Inoue, M., Xuan, Z., Yoo, H., Chen, M., Ahn, J. M., Minna, J. D., Helke, K. L. & 3 others, Singh, P. K., Shackelford, D. B. & Kim, J. W., May 26 2017, In : Nature communications. 8, 15503.

Research output: Contribution to journalArticle

50 Scopus citations
2016

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

Coothankandaswamy, V., Cao, S., Xu, Y., Prasad, P. D., Singh, P. K., Reynolds, C. P., Yang, S., Ogura, J., Ganapathy, V. & Bhutia, Y. D., 2016, In : British Journal of Pharmacology. 173, 23, p. 3292-3306 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer

Mondal, G., Kumar, V., Shukla, S. K., Singh, P. K. & Mahato, R. I., Jan 11 2016, In : Biomacromolecules. 17, 1, p. 301-313 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
15 Scopus citations
2015

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

Yang, S., Zhang, L., Purohit, V., Shukla, S. K., Chen, X., Yu, F., Fu, K., Chen, Y., Solheim, J., Singh, P. K., Song, W. & Dong, J., 2015, In : Oncotarget. 6, 34, p. 36019-36031 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism

Shukla, S. K., Gunda, V., Abrego, J., Haridas, D., Mishra, A., Souchek, J., Chaika, N. V., Yu, F., Sasson, A. R., Lazenby, A. J., Batra, S. K. & Singh, P. K., 2015, In : Oncotarget. 6, 22, p. 19118-19131 14 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

Shukla, S. K., Dasgupta, A., Mehla, K., Gunda, V., Vernucci, E., Souchek, J., Goode, G., King, R., Mishra, A., Rai, I., Nagarajan, S., Chaika, N. V., Yu, F. & Singh, P. K., 2015, In : Oncotarget. 6, 38, p. 41146-41161 16 p.

Research output: Contribution to journalArticle

29 Scopus citations

Targeted therapy for glioblastoma: Lessons learned and future directions

Shonka, N. A., Gupta, S. & Singh, P. K., Jul 1 2015, In : Current Cancer Therapy Reviews. 11, 1, p. 44-58 15 p.

Research output: Contribution to journalArticle

2014

MUC1: A novel metabolic master regulator

Mehla, K. & Singh, P. K., Apr 2014, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1845, 2, p. 126-135 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin

Liu, X., Caffrey, T. C., Steele, M. M., Mohr, A., Singh, P., Radhakrishnan, P., Kelly, D. L., Wen, Y. & Hollingsworth, M. A., Jun 30 2014, In : Oncogenesis. 3, e107.

Research output: Contribution to journalArticle

21 Scopus citations

Structure and function of human DnaJ homologue subfamily A member 1 (DNAJA1) and its relationship to pancreatic cancer

Stark, J. L., Mehla, K., Chaika, N., Acton, T. B., Xiao, R., Singh, P. K., Montelione, G. T. & Powers, R., Mar 4 2014, In : Biochemistry. 53, 8, p. 1360-1372 13 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012

Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma

Chaika, N. V., Yu, F., Purohit, V., Mehla, K., Lazenby, A. J., DiMaio, D., Anderson, J. M., Yeh, J. J., Johnson, K. R., Hollingsworth, M. A. & Singh, P. K., Mar 7 2012, In : PloS one. 7, 3, e32996.

Research output: Contribution to journalArticle

50 Scopus citations

Exome sequencing and advances in crop improvement

Singh, D., Singh, P. K., Chaudhary, S., Mehla, K. & Kumar, S., 2012, In : Advances in Genetics. 79, p. 87-121 35 p.

Research output: Contribution to journalArticle

6 Scopus citations

Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism

Torres, M. P., Rachagani, S., Purohit, V., Pandey, P., Joshi, S., Moore, E. D., Johansson, S. L., Singh, P. K., Ganti, A. K. & Batra, S. K., Oct 1 2012, In : Cancer Letters. 323, 1, p. 29-40 12 p.

Research output: Contribution to journalArticle

84 Scopus citations

MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer

Chaika, N. V., Gebregiworgis, T., Lewallen, M. E., Purohit, V., Radhakrishnan, P., Liu, X., Zhang, B., Mehla, K., Brown, R. B., Caffrey, T., Yu, F., Johnson, K. R., Powers, R., Hollingsworth, M. A. & Singh, P. K., Aug 21 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 34, p. 13787-13792 6 p.

Research output: Contribution to journalArticle

109 Scopus citations

Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis

Dey, P., Rachagani, S., Chakraborty, S., Singh, P. K., Zhao, X., Gurumurthy, C. B., Anderson, J. M., Lele, S., Hollingsworth, M. A., Band, V. & Batra, S. K., Nov 15 2012, In : Clinical Cancer Research. 18, 22, p. 6188-6198 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras

Eggers, J. P., Grandgenett, P. M., Collisson, E. C., Lewallen, M. E., Tremayne, J., Singh, P. K., Swanson, B. J., Andersen, J. M., Caffrey, T. C., High, R. R., Ouellette, M. & Hollingsworth, M. A., Oct 1 2011, In : Clinical Cancer Research. 17, 19, p. 6140-6150 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Regulation of aerobic glycolysis by microRNAs in cancer

Singh, P. K., Mehla, K., Hollingsworth, M. A. & Johnson, K. R., 2011, In : Molecular and Cellular Pharmacology. 3, 3, p. 125-134 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2010

CRTC3 links catecholamine signalling to energy balance

Song, Y., Altarejos, J., Goodarzi, M. O., Inoue, H., Guo, X., Berdeaux, R., Kim, J. H., Goode, J., Igata, M., Paz, J. C., Hogan, M. F., Singh, P. K., Goebel, N., Vera, L., Miller, N., Cui, J., Jones, M. R., Chen, Y. D. I., Taylor, K. D., Hsueh, W. A. & 2 others, Rotter, J. I. & Montminy, M., Dec 16 2010, In : Nature. 468, 7326, p. 933-939 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF

Behrens, M. E., Grandgenett, P. M., Bailey, J. M., Singh, P. K., Yi, C. H., Yu, F. & Hollingsworth, M. A., Oct 21 2010, In : Oncogene. 29, 42, p. 5667-5677 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
2008

MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells

Chaturvedi, P., Singh, A. P., Chakraborty, S., Chauhan, S. C., Bafna, S., Meza, J. L., Singh, P. K., Hollingsworth, M. A., Mehta, P. P. & Batra, S. K., Apr 1 2008, In : Cancer Research. 68, 7, p. 2065-2070 6 p.

Research output: Contribution to journalArticle

109 Scopus citations

Phosphorylation of MUC1 by met modulates interaction with p53 and MMP1 expression

Singh, P. K., Behrens, M. E., Eggers, J. P., Cerny, R. L., Bailey, J. M., Shanmugam, K., Gendler, S. J., Bennett, E. P. & Hollingsworth, M. A., Oct 3 2008, In : Journal of Biological Chemistry. 283, 40, p. 26985-26995 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

Sonic hedgehog promotes desmoplasia in pancreatic cancer

Bailey, J. M., Swanson, B. J., Hamada, T., Eggers, J. P., Singh, P. K., Caffery, T., Ouellette, M. M. & Hollingsworth, M. A., Oct 1 2008, In : Clinical Cancer Research. 14, 19, p. 5995-6004 10 p.

Research output: Contribution to journalArticle

313 Scopus citations