• 595 Citations
  • 13 h-Index
20022020

Research output per year

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Research Output

  • 595 Citations
  • 13 h-Index
  • 26 Article
  • 6 Review article
  • 1 Comment/debate
  • 1 Editorial
2020

Exogenous Flupirtine as Potential Treatment for CLN3 Disease

Maalouf, K., Makoukji, J., Saab, S., Makhoul, N. J., Carmona, A. V., Kinarivala, N., Ghanem, N., Trippier, P. C. & Boustany, R. M., Aug 11 2020, In : Cells. 9, 8

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer's Disease

Morsy, A. & Trippier, P. C., May 9 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4252-4264 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Current and Emerging Pharmacological Targets for the Treatment of Alzheimer's Disease

Morsy, A. & Trippier, P. C., 2019, In : Journal of Alzheimer's Disease. 72, s1, p. S145-S176

Research output: Contribution to journalReview article

6 Scopus citations

Current Status of Healthy Aging and Dementia Research: A Symposium Summary

Center Biotechnology and Genetics Core Facility, 2019, In : Journal of Alzheimer's disease : JAD. 72, s1, p. S11-S35

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
6 Scopus citations
2018

AKR1C3 inhibitor KV-37 exhibits antineoplastic effects and potentiates enzalutamide in combination therapy in prostate adenocarcinoma cells

Verma, K., Gupta, N., Zang, T., Wangtrakluldee, P., Srivastava, S. K., Penning, T. M. & Trippier, P. C., Sep 2018, In : Molecular cancer therapeutics. 17, 9, p. 1833-1845 13 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

DARK Classics in Chemical Neuroscience: Methamphetamine

Abbruscato, T. J. & Trippier, P. C., Oct 17 2018, In : ACS Chemical Neuroscience. 9, 10, p. 2373-2378 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses

Makoukji, J., Saadeh, F., Mansour, K. A., El-Sitt, S., Al Ali, J., Kinarivala, N., Trippier, P. C. & Boustany, R. M., Sep 2018, In : Annals of Clinical and Translational Neurology. 5, 9, p. 1089-1103 15 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Molecule of the Month: Relating Organic Chemistry Principles to Drug Action

Trippier, P. C., Jul 10 2018, In : Journal of Chemical Education. 95, 7, p. 1112-1117 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

Kinarivala, N., Patel, R., Boustany, R. M., Al-Ahmad, A. & Trippier, P. C., Dec 14 2017, In : Journal of Medicinal Chemistry. 60, 23, p. 9739-9756 18 p.

Research output: Contribution to journalArticle

14 Scopus citations

Passage Variation of PC12 Cells Results in Inconsistent Susceptibility to Externally Induced Apoptosis

Kinarivala, N., Shah, K., Abbruscato, T. J. & Trippier, P. C., Jan 18 2017, In : ACS Chemical Neuroscience. 8, 1, p. 82-88 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Small molecule inhibitors for acute myeloid leukemia: Where is the field heading?

Trippier, P. C., Sep 2017, In : Future Medicinal Chemistry. 9, 13, p. 1453-1456 4 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5

Wang, H., Huwaimel, B., Verma, K., Miller, J., Germain, T. M., Kinarivala, N., Pappas, D., Brookes, P. S. & Trippier, P. C., 2017, In : ChemMedChem. 12, 13, p. 1033-1044 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor β/δ agonists with neuroprotective activity

Kinarivala, N., Suh, J. H., Botros, M., Webb, P. & Trippier, P. C., Apr 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 8, p. 1889-1893 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Progress in the Development of Small Molecule Therapeutics for the Treatment of Neuronal Ceroid Lipofuscinoses (NCLs)

Kinarivala, N. & Trippier, P. C., May 26 2016, In : Journal of Medicinal Chemistry. 59, 10, p. 4415-4427 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Selecting good 'drug-like' properties to optimize small molecule blood-brain barrier penetration

Trippier, P. C., Apr 1 2016, In : Current medicinal chemistry. 23, 14, p. 1392-1407 16 p.

Research output: Contribution to journalReview article

13 Scopus citations

Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines

Verma, K., Zang, T., Gupta, N., Penning, T. M. & Trippier, P. C., Aug 11 2016, In : ACS Medicinal Chemistry Letters. 7, 8, p. 774-779 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Small molecule drug discovery for pediatric diseases

Trippier, P. C., Apr 1 2016, In : Mini-Reviews in Medicinal Chemistry. 16, 6, p. 428-429 2 p.

Research output: Contribution to journalEditorial

2015

Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)

Zang, T., Verma, K., Chen, M., Jin, Y., Trippier, P. C. & Penning, T. M., Jun 5 2015, In : Chemico-Biological Interactions. 234, p. 339-348 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Exploration of relative chemoselectivity in the hydrodechlorination of 2-chloropyridines

Kinarivala, N. & Trippier, P. C., Sep 24 2014, In : Tetrahedron Letters. 55, 39, p. 5386-5389 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis

Trippier, P. C., Zhao, K. T., Fox, S. G., Schiefer, I. T., Benmohamed, R., Moran, J., Kirsch, D. R., Morimoto, R. I. & Silverman, R. B., Sep 17 2014, In : ACS Chemical Neuroscience. 5, 9, p. 823-829 7 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2013

Synthetic Strategies for the Biotinylation of Bioactive Small Molecules

Trippier, P. C., Feb 2013, In : ChemMedChem. 8, 2, p. 190-203 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Target- and mechanism-based therapeutics for neurodegenerative diseases: Strength in numbers

Trippier, P. C., Jansen Labby, K., Hawker, D. D., Mataka, J. J. & Silverman, R. B., Apr 25 2013, In : Journal of Medicinal Chemistry. 56, 8, p. 3121-3147 27 p.

Research output: Contribution to journalReview article

86 Scopus citations
2012

Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin

Angelov, P., Chau, Y. K. S., Fryer, P. J., Moloney, M. G., Thompson, A. L. & Trippier, P. C., May 7 2012, In : Organic and Biomolecular Chemistry. 10, 17, p. 3472-3485 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1

Trippier, P. C., Benmohammed, R., Kirsch, D. R. & Silverman, R. B., Nov 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 21, p. 6647-6650 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: Bisphenylboronic acids

Trippier, P. C., Balzarini, J. & McGuigan, C., 2011, In : Antiviral Chemistry and Chemotherapy. 21, 3, p. 129-142 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol

Klaić, L., Trippier, P. C., Mishra, R. K., Morimoto, R. I. & Silverman, R. B., Dec 14 2011, In : Journal of the American Chemical Society. 133, 49, p. 19634-19637 4 p.

Research output: Contribution to journalArticle

32 Scopus citations
2010

Boronic acids in medicinal chemistry: Anticancer, antibacterial and antiviral applications

Trippier, P. C. & McGuigan, C., Sep 2010, In : MedChemComm. 1, 3, p. 183-198 16 p.

Research output: Contribution to journalReview article

157 Scopus citations

Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: Monophenylboronic acids

Trippier, P. C., McGuigan, C. & Balzarini, J., 2010, In : Antiviral Chemistry and Chemotherapy. 20, 6, p. 249-257 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2004

The oxazolomycins: a structurally novel class of bioactive compounds.

Moloney, M. G., Trippier, P. C., Yaqoob, M. & Wang, Z., Oct 2004, In : Current drug discovery technologies. 1, 3, p. 181-199 19 p.

Research output: Contribution to journalArticle

42 Scopus citations
2003

A multicomponent coupling strategy suitable for the synthesis of the triene component of the oxazolomycin antibiotics

Bulger, P. G., Moloney, M. G. & Trippier, P. C., Nov 7 2003, In : Organic and Biomolecular Chemistry. 1, 21, p. 3726-3737 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
2002

A multicomponent coupling strategy for the synthesis of the triene component of the oxazolomycin antibiotics

Bulger, P. G., Moloney, M. G. & Trippier, P. C., 2002, In : Synlett. 11, p. 1871-1873 3 p.

Research output: Contribution to journalArticle

14 Scopus citations