Paul L Sorgen, PhD

Professor, Biochemistry & Molecular Biology
Courtesy Professor, Eppley Institute for Cancer Research
Member, Fred & Pamela Buffett Cancer Center
Member, Center for Heart and Vascular Research

Phone402-559-7557

Source: Scopus
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BUILDING TOWARDS A MEMBRANE PROTEIN COMPLEX
Sorgen, P. L.
National Institutes of Health
6/1/00 → …
Project: Research project
Mechanisms by which phosphorylation and protein partners regulate Cx45
Sorgen, P. L.
Project: Research project
Phosphorylation and gating of cardiac connexin channels
Sorgen, P. L.
National Institutes of Health
4/1/16 → 1/31/20
Project: Research project
Regulation of EHD protein function by molecular partner interactions
Caplan, S. H. & Sorgen, P. L.
National Institutes of Health
6/1/10 → 5/31/15
Project: Research project
Mechanisms of Gap Junction Regulation
Sorgen, P. L.
National Institutes of Health
6/1/06 → 1/31/20
Project: Research project

2486 Citations
29 h-Index
65 Article
3 Chapter
3 Review article
1 Letter

Calmodulin directly interacts with the cx43 carboxyl-terminus and cytoplasmic loop containing three oddd-linked mutants (M147t, r148q, and t154a) that retain α-helical structure, but exhibit loss-of-function and cellular trafficking defects
Zheng, L., Chenavas, S., Kieken, F., Trease, A., Brownell, S., Anbanandam, A., Sorgen, P. L. & Spagnol, G., Oct 2020, In: Biomolecules. 10, 10, p. 1-23 23 p., 1452.
Research output: Contribution to journal › Article › peer-review

Open Access
Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome
Roychoudhury, S., Pramanik, S., Harris, H. L., Tarpley, M., Sarkar, A., Spagnol, G., Sorgen, P. L., Chowdhury, D., Band, V., Klinkebiel, D. & Bhakat, K. K., May 26 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 21, A44.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Scopus citations
Inhibition of Pyk2 and Src activity improves Cx43 gap junction intercellular communication
Zheng, L., Trease, A. J., Katsurada, K., Spagnol, G., Li, H., Shi, W., Duan, B., Patel, K. P. & Sorgen, P. L., Dec 2020, In: Journal of Molecular and Cellular Cardiology. 149, p. 27-40 14 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells
Banerjee, K., Gautam, S. K., Kshirsagar, P., Ross, K. A., Spagnol, G., Sorgen, P., Wannemuehler, M. J., Narasimhan, B., Solheim, J. C., Kumar, S., Batra, S. K. & Jain, M., 2019, In: Genes and Cancer. 10, 3-4, p. 52-62 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations
Phosphorylation of Cx43 residue Y313 by Src contributes to blocking the interaction with Drebrin and disassembling gap junctions
Zheng, L., Li, H., Cannon, A., Trease, A. J., Spagnol, G., Zheng, H., Radio, S., Patel, K., Batra, S. & Sorgen, P. L., Jan 2019, In: Journal of Molecular and Cellular Cardiology. 126, p. 36-49 14 p.
Research output: Contribution to journal › Article › peer-review
5 Scopus citations